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Conserved domains on  [gi|17569185|ref|NP_510550|]
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BLOC-1-related complex subunit 7 [Caenorhabditis elegans]

Protein Classification

BLOC-1-related complex subunit 7( domain architecture ID 582816)

BLOC-1-related complex subunit 7 (BORCS7/C10orf32) is part of the BORC complex that may play a role in lysosome movement and localization at the cell periphery

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORCS7 super family cl24603
BLOC-1-related complex sub-unit 7; This is a family of unknown function found in eukaryotes. ...
 6-92 7.03e-07

BLOC-1-related complex sub-unit 7; This is a family of unknown function found in eukaryotes. Family members include BORCS7 (BLOC-1-related complex sub-unit 7) also known as Diaskedin (from the Ancient Greek 'diaskedazo', meaning 'to disperse') or C10orf32. It constitutes sub-unit 7 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.


The actual alignment was detected with superfamily member pfam16088:

Pssm-ID: 465012  Cd Length: 103  Bit Score: 44.22  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569185     6 ESKTKLPQKILEIITDGSALLSIPMSSSQASETLLTSAKQFSHVEQVIDNTDKLLREIEQMVDGVTKNAEDMEKGLDIVC 85
Cdd:pfam16088  15 ESKKRLTERVQVNVNDISSVAKQIVKGSKSSEILMQTAKNFAQQEHAIDNTEESLKKMSLLTTHLNYQVEAIQKSAKQLE 94


                  ....*..
gi 17569185    86 DVQECLQ 92
Cdd:pfam16088  95 EVQEQLD 101
 
Name Accession Description Interval E-value
BORCS7 pfam16088
BLOC-1-related complex sub-unit 7; This is a family of unknown function found in eukaryotes. ...
 6-92 7.03e-07

BLOC-1-related complex sub-unit 7; This is a family of unknown function found in eukaryotes. Family members include BORCS7 (BLOC-1-related complex sub-unit 7) also known as Diaskedin (from the Ancient Greek 'diaskedazo', meaning 'to disperse') or C10orf32. It constitutes sub-unit 7 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.


Pssm-ID: 465012  Cd Length: 103  Bit Score: 44.22  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569185     6 ESKTKLPQKILEIITDGSALLSIPMSSSQASETLLTSAKQFSHVEQVIDNTDKLLREIEQMVDGVTKNAEDMEKGLDIVC 85
Cdd:pfam16088  15 ESKKRLTERVQVNVNDISSVAKQIVKGSKSSEILMQTAKNFAQQEHAIDNTEESLKKMSLLTTHLNYQVEAIQKSAKQLE 94


                  ....*..
gi 17569185    86 DVQECLQ 92
Cdd:pfam16088  95 EVQEQLD 101
 
Name Accession Description Interval E-value
BORCS7 pfam16088
BLOC-1-related complex sub-unit 7; This is a family of unknown function found in eukaryotes. ...
 6-92 7.03e-07

BLOC-1-related complex sub-unit 7; This is a family of unknown function found in eukaryotes. Family members include BORCS7 (BLOC-1-related complex sub-unit 7) also known as Diaskedin (from the Ancient Greek 'diaskedazo', meaning 'to disperse') or C10orf32. It constitutes sub-unit 7 of the BORC complex (BLOC-one-related complex). BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transport of lysosomes toward the cell periphery.


Pssm-ID: 465012  Cd Length: 103  Bit Score: 44.22  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569185     6 ESKTKLPQKILEIITDGSALLSIPMSSSQASETLLTSAKQFSHVEQVIDNTDKLLREIEQMVDGVTKNAEDMEKGLDIVC 85
Cdd:pfam16088  15 ESKKRLTERVQVNVNDISSVAKQIVKGSKSSEILMQTAKNFAQQEHAIDNTEESLKKMSLLTTHLNYQVEAIQKSAKQLE 94


                  ....*..
gi 17569185    86 DVQECLQ 92
Cdd:pfam16088  95 EVQEQLD 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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