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Conserved domains on  [gi|17550194|ref|NP_510450|]
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Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Caenorhabditis elegans]

Protein Classification

succinate--CoA ligase [ADP/GDP-forming] subunit alpha( domain architecture ID 11488210)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 5-322 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


:

Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 515.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    5 QIANNARTLQKGAARFYNSTYNNLKINKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHL--GLPVFKNV 82
Cdd:PTZ00187   1 LKGAAFMILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   83 SEARNKTGADASVIYVPASAAGSAIEEAMDAEIPLVVCITEGIPQHDMVRVKSRLLKQNKTRLVGPNCPGIISADQCKIG 162
Cdd:PTZ00187  81 KEAKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  163 IMPGHIHKRGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEE 242
Cdd:PTZ00187 161 IMPGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  243 EAAAYLKEHNsgaNRKPVVSFIAGVTAPPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAFLGKI 322
Cdd:PTZ00187 241 EAAEWIKNNP---IKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 5-322 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 515.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    5 QIANNARTLQKGAARFYNSTYNNLKINKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHL--GLPVFKNV 82
Cdd:PTZ00187   1 LKGAAFMILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   83 SEARNKTGADASVIYVPASAAGSAIEEAMDAEIPLVVCITEGIPQHDMVRVKSRLLKQNKTRLVGPNCPGIISADQCKIG 162
Cdd:PTZ00187  81 KEAKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  163 IMPGHIHKRGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEE 242
Cdd:PTZ00187 161 IMPGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  243 EAAAYLKEHNsgaNRKPVVSFIAGVTAPPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAFLGKI 322
Cdd:PTZ00187 241 EAAEWIKNNP---IKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 30-318 1.55e-173

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 482.25  E-value: 1.55e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  30 INKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEE 109
Cdd:COG0074   4 VNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADAILE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194 110 AMDAEIPLVVCITEGIPQHDMVRVKsRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVH 189
Cdd:COG0074  84 AIDAGIKLIVCITEGIPVLDMVRVK-RYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEAVW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194 190 QTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEHNSganrKPVVSFIAGVTA 269
Cdd:COG0074 163 QLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT----KPVVAYIAGRTA 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17550194 270 PPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAF 318
Cdd:COG0074 239 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 30-315 4.83e-157

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 440.32  E-value: 4.83e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    30 INKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEE 109
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   110 AMDAEIPLVVCITEGIPQHDMVRVKsRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVH 189
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVK-RYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   190 QTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEHNSganrKPVVSFIAGVTA 269
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS----KPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 17550194   270 PPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMA 315
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLA 283
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 31-124 2.08e-34

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 121.16  E-value: 2.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    31 NKDTKVIVQGFTGK--QGT-FHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAI 107
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 17550194   108 EEAMDAEIPLVVCITEG 124
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 30-125 2.59e-32

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 115.68  E-value: 2.59e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194     30 INKDTKVIVQGFTGKQGTFHGKQM---LEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSA 106
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 17550194    107 IEEAMDAEIPLVVCITEGI 125
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 5-322 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 515.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    5 QIANNARTLQKGAARFYNSTYNNLKINKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHL--GLPVFKNV 82
Cdd:PTZ00187   1 LKGAAFMILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   83 SEARNKTGADASVIYVPASAAGSAIEEAMDAEIPLVVCITEGIPQHDMVRVKSRLLKQNKTRLVGPNCPGIISADQCKIG 162
Cdd:PTZ00187  81 KEAKKATGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  163 IMPGHIHKRGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEE 242
Cdd:PTZ00187 161 IMPGHIHKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  243 EAAAYLKEHNsgaNRKPVVSFIAGVTAPPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAFLGKI 322
Cdd:PTZ00187 241 EAAEWIKNNP---IKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 30-318 1.55e-173

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 482.25  E-value: 1.55e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  30 INKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEE 109
Cdd:COG0074   4 VNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADAILE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194 110 AMDAEIPLVVCITEGIPQHDMVRVKsRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVH 189
Cdd:COG0074  84 AIDAGIKLIVCITEGIPVLDMVRVK-RYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEAVW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194 190 QTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEHNSganrKPVVSFIAGVTA 269
Cdd:COG0074 163 QLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMT----KPVVAYIAGRTA 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17550194 270 PPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAF 318
Cdd:COG0074 239 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 30-321 4.39e-173

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 481.21  E-value: 4.39e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   30 INKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEE 109
Cdd:PRK05678   5 INKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAADAILE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  110 AMDAEIPLVVCITEGIPQHDMVRVKsRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVH 189
Cdd:PRK05678  85 AIDAGIDLIVCITEGIPVLDMLEVK-AYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYEAVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  190 QTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEHNSganrKPVVSFIAGVTA 269
Cdd:PRK05678 164 QLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVT----KPVVGYIAGVTA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17550194  270 PPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAFLGK 321
Cdd:PRK05678 240 PPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKGL 291
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 30-315 4.83e-157

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 440.32  E-value: 4.83e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    30 INKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEE 109
Cdd:TIGR01019   3 LDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAIFE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   110 AMDAEIPLVVCITEGIPQHDMVRVKsRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVH 189
Cdd:TIGR01019  83 AIDAGIELIVCITEGIPVHDMLKVK-RYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAVH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   190 QTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEHNSganrKPVVSFIAGVTA 269
Cdd:TIGR01019 162 QLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMS----KPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 17550194   270 PPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMA 315
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLA 283
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 30-318 1.74e-155

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 437.09  E-value: 1.74e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   30 INKDTKVIVQGFTGKQGTFHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAIEE 109
Cdd:PLN00125   9 VDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPFAAAAILE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  110 AMDAEIPLVVCITEGIPQHDMVRVKSRLLKQNKTRLVGPNCPGIISADQCKIGIMPGHIHKRGCIGIVSRSGTLTYEAVH 189
Cdd:PLN00125  89 AMEAELDLVVCITEGIPQHDMVRVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYEAVF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  190 QTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKGIILIGEIGGSAEEEAAAYLKEhnSGANrKPVVSFIAGVTA 269
Cdd:PLN00125 169 QTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKE--SGTE-KPVVAFIAGLTA 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 17550194  270 PPGRRMGHAGAIISGGKGTAADKINALREAGVVVTDSPAKLGTSMATAF 318
Cdd:PLN00125 246 PPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVF 294
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 31-124 2.08e-34

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 121.16  E-value: 2.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    31 NKDTKVIVQGFTGK--QGT-FHGKQMLEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSAI 107
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 17550194   108 EEAMDAEIPLVVCITEG 124
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 177-302 1.06e-33

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 120.44  E-value: 1.06e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   177 VSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFNGTNFIDCLNVFLEDPETKG-IILIGEIGGSAEEEAAAYLKEHN-SG 254
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKViLLDIVLGYGACEDPAGGLLKAIKeAR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 17550194   255 ANRKPVVSFIAGVTAPPGRRMGHAGAIISGGKGTAADKINALREAGVV 302
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGAV 128
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 30-125 2.59e-32

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 115.68  E-value: 2.59e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194     30 INKDTKVIVQGFTGKQGTFHGKQM---LEYNTKVVGGVNANKAGTEHLGLPVFKNVSEARNKTGADASVIYVPASAAGSA 106
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 17550194    107 IEEAMDAEIPLVVCITEGI 125
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 70-318 5.26e-21

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 93.35  E-value: 5.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   70 GTEHLGLPVFKNVSEARNK-TGADASVIYVP-ASAAGSAIEEAMDAEIPLVVCITEGIPQHDMVRVKSRLLKQNKTrLVG 147
Cdd:PLN02522  57 GQEEIAIPVHGSIEAACKAhPTADVFINFASfRSAAASSMEALKQPTIRVVAIIAEGVPESDTKQLIAYARANNKV-VIG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  148 PNCPGIISADQCKIG--------IMPGHIHKRGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFNGTNFIDCLN 219
Cdd:PLN02522 136 PATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGIAIGGDVFPGSTLSDHVL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  220 VFLEDPETKGIILIGEIGGSAEEEAAAYLKehnSGANRKPVVSFIAGVTA---PPGRRMGHAGAIISGGKGTAADKINAL 296
Cdd:PLN02522 216 RFNNIPQIKMIVVLGELGGRDEYSLVEALK---QGKVSKPVVAWVSGTCArlfKSEVQFGHAGAKSGGDMESAQAKNKAL 292

                        250       260
                 ....*....|....*....|..
gi 17550194  297 REAGVVVTDSPAKLGTSMATAF 318
Cdd:PLN02522 293 KDAGAIVPTSFEALEAAIKETF 314
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 171-318 3.36e-06

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 45.92  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   171 RGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGgdpfNGT--NFIDCLNVFLEDPETKGiiligeiggsaeeeAAAYL 248
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEAdvDFADLLEYLADDPETRV--------------ILLYL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   249 KEHNSG----------ANRKPVVSFIAGVTaPPGRRMG--HAGAIISGGKGTAAdkinALREAGVVVTDSPAKLgTSMAT 316
Cdd:pfam13607  63 EGIRDGrrflraarraARRKPVVVLKAGRS-EAGARAAasHTGALAGSDAVYDA----AFRQAGVIRVDDLEEL-FDAAE 136


                  ..
gi 17550194   317 AF 318
Cdd:pfam13607 137 AL 138
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 51-154 2.02e-04

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 40.21  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194    51 KQMLEYNTKVVGgVNANKagTEHLGLPVFKNVSEArnKTGADASVIYVPASAAGSAIEEAMDAEIPLVVCITeGIpQHDM 130
Cdd:pfam13380  21 RYLLEHGYPVIP-VNPKA--KEILGEPVYPSLADP--PEPVDLVDVFRPPEAVPEIVEEALALGAKAVWLQP-GI-ENEE 93

                          90       100
                  ....*....|....*....|....
gi 17550194   131 VRvksRLLKQNKTRLVGPNCPGII 154
Cdd:pfam13380  94 AA---AIARAAGIRVVGDRCLGVE 114
PRK06091 PRK06091
membrane protein FdrA; Validated
 91-276 1.21e-03

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 40.41  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194   91 ADASVIYVPASAAGSAIEEAMDAEIPlVVCITEGIPQHDMVRVKSRllKQNKTRLV-GPNC-PGIISADQCKIG-IMPgh 167
Cdd:PRK06091 118 ANLALISVAGEYAAELAEQALDRNLN-VMMFSDNVTLEDEIRLKTR--AREKGLLVmGPDCgTAMIAGTPLAFAnVMP-- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550194  168 ihkRGCIGIVSRSGTLTYEAVHQTTQVGFGQTLCVGIGGDPFN----GTNFIDCLNVFLEDPETKGIILIGE-IGGSAEE 242
Cdd:PRK06091 193 ---EGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSaevgGISALTALEMLSADEKSEVIAFVSKpPAEAVRL 269

                        170       180       190
                 ....*....|....*....|....*....|....
gi 17550194  243 EAAAYLKEHNsganrKPVVSFIAGVTaPPGRRMG 276
Cdd:PRK06091 270 KIINAMKATG-----KPVVALFLGYT-PAVARDE 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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