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Conserved domains on  [gi|392927717|ref|NP_510193|]
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Skp1-related protein [Caenorhabditis elegans]

Protein Classification

S-phase kinase-associated 1 family protein( domain architecture ID 13034552)

S-phase kinase-associated 1 (SKP1) family protein is a BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein that is part of an SCF (SKP1-cullin-F-box) protein ligase complex that is involved in ubiquitination and subsequent proteasomal degradation of target proteins

Gene Ontology:  GO:0005515|GO:0019005|GO:0016567
PubMed:  17120193|27521773

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-129 1.62e-40

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349631  Cd Length: 120  Bit Score: 131.95  E-value: 1.62e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717   9 LYKLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLipadqlQPIQLE-IPATVMRKVIEWCDHHKHDPPYDE---SEPE 84
Cdd:cd18322    1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDD------DPIPLPnVTSKILKKVIEWCEHHKDDPPPEIdldSEKR 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 392927717  85 TNDIPDWDASFLMVRHNMLFDIIRAARDFTVPGLFAMCCRVVGQN 129
Cdd:cd18322   75 TDDIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANM 119
 
Name Accession Description Interval E-value
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-129 1.62e-40

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 131.95  E-value: 1.62e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717   9 LYKLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLipadqlQPIQLE-IPATVMRKVIEWCDHHKHDPPYDE---SEPE 84
Cdd:cd18322    1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDD------DPIPLPnVTSKILKKVIEWCEHHKDDPPPEIdldSEKR 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 392927717  85 TNDIPDWDASFLMVRHNMLFDIIRAARDFTVPGLFAMCCRVVGQN 129
Cdd:cd18322   75 TDDIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANM 119
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 8-113 2.29e-32

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 110.85  E-value: 2.29e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717     8 ILYKLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLIPADqlqPIQLE-IPATVMRKVIEWCDHHKHDPPYDEsepETN 86
Cdd:smart00512   2 KYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNN---PIPLPnVTSKILSKVIEYCEHHVDDPPSVA---DKD 75

                           90       100
                   ....*....|....*....|....*..
gi 392927717    87 DIPDWDASFLMVRHNMLFDIIRAARDF 113
Cdd:smart00512  76 DIPTWDAEFLKIDQETLFELILAANYL 102
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 11-147 6.40e-17

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 73.05  E-value: 6.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717  11 KLRSTDGQRFLADRRtigmIGRIEDLFRNAgLDLIPADQLQPIQLEIPATVMRKVIEWCDHHKHDPPYDESEPE---TND 87
Cdd:COG5201    5 ELESIDGEIFRVDEN----IAERSILIKNM-LCDSTACNYPIPAPNVRSSVLMKVQEWMEHHTSSLSEDENDLEirkSKP 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392927717  88 IPDWDASFLMVRHNMLFDIIRAARDFTVPGLFAMCCRVV-----GQNPREIID--GLVND--EEEEQPV 147
Cdd:COG5201   80 SDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVaemirGKSPEEIREtfNIENDftPEEERRI 148
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
11-73 2.94e-05

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 39.59  E-value: 2.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392927717   11 KLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLIPADQlqpiqleIPATVMRKVIEWCDHHK 73
Cdd:pfam03931   4 VLQSSDGESFEVEEAVARKSKTIKHMIEDDGDDPIPLPN-------VTSKILEKVIEYCKHHR 59
 
Name Accession Description Interval E-value
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-129 1.62e-40

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 131.95  E-value: 1.62e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717   9 LYKLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLipadqlQPIQLE-IPATVMRKVIEWCDHHKHDPPYDE---SEPE 84
Cdd:cd18322    1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDD------DPIPLPnVTSKILKKVIEWCEHHKDDPPPEIdldSEKR 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 392927717  85 TNDIPDWDASFLMVRHNMLFDIIRAARDFTVPGLFAMCCRVVGQN 129
Cdd:cd18322   75 TDDIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANM 119
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 8-113 2.29e-32

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 110.85  E-value: 2.29e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717     8 ILYKLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLIPADqlqPIQLE-IPATVMRKVIEWCDHHKHDPPYDEsepETN 86
Cdd:smart00512   2 KYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNN---PIPLPnVTSKILSKVIEYCEHHVDDPPSVA---DKD 75

                           90       100
                   ....*....|....*....|....*..
gi 392927717    87 DIPDWDASFLMVRHNMLFDIIRAARDF 113
Cdd:smart00512  76 DIPTWDAEFLKIDQETLFELILAANYL 102
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 11-147 6.40e-17

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 73.05  E-value: 6.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927717  11 KLRSTDGQRFLADRRtigmIGRIEDLFRNAgLDLIPADQLQPIQLEIPATVMRKVIEWCDHHKHDPPYDESEPE---TND 87
Cdd:COG5201    5 ELESIDGEIFRVDEN----IAERSILIKNM-LCDSTACNYPIPAPNVRSSVLMKVQEWMEHHTSSLSEDENDLEirkSKP 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392927717  88 IPDWDASFLMVRHNMLFDIIRAARDFTVPGLFAMCCRVV-----GQNPREIID--GLVND--EEEEQPV 147
Cdd:COG5201   80 SDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVaemirGKSPEEIREtfNIENDftPEEERRI 148
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
11-73 2.94e-05

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 39.59  E-value: 2.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392927717   11 KLRSTDGQRFLADRRTIGMIGRIEDLFRNAGLDLIPADQlqpiqleIPATVMRKVIEWCDHHK 73
Cdd:pfam03931   4 VLQSSDGESFEVEEAVARKSKTIKHMIEDDGDDPIPLPN-------VTSKILEKVIEYCKHHR 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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