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Conserved domains on  [gi|392926249|ref|NP_509061|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
12-470 2.26e-47

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17357:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 447  Bit Score: 170.13  E-value: 2.26e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  12 AAIASFCANWSFAFQITYVNTSVDTFYKLARTAYkQSRECYTCQLPENDWLaqWSVTVSMFYPGTILGFLMVPFLTKWIG 91
Cdd:cd17357    1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTL-VDRYGLNLSDSELDLL--WSLIVSIFFIGGAIGSFISAFLANRFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  92 VKRAQGIMCIAATIGVGVHFLALSFLSLgevtfaTILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQS 171
Cdd:cd17357   78 RKNGLLISNALLVVSSLLMFLSKSAKSP------ELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 172 FATLLGLVLGSEEILPLGSSRFFIMQISaVIPILFLLFVLIITPPTPNYLSHFHPEcIHEAIHSKLFYHGTErsnsyRPL 251
Cdd:cd17357  152 LGILLGQVFGLPSVLGTETLWPYLLFFP-GIPALLQLAALPFFPESPKFLLISKGD-EEEAEKSLKFLRGIE-----DDV 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 252 ISNYEMMENKFTSKYANYGKSWRESFK------GFLIGAIVAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDTfTI 325
Cdd:cd17357  225 DQELEEIKKESEQMGDQKQVSLMQLLRdpslrlPLLLVLVVSASQQFSGINAIFFYSTFIF-------ENAGFSPQL-AE 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 326 LVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFT----TNKVIVSLCFAATKTFI---GIGCGGPA 398
Cdd:cd17357  297 WANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLflseQNSWMSYGCIVAIFLFIfffAIGLGPIP 376
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392926249 399 WFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAgPALVAAILIYLYLPETKGR 470
Cdd:cd17357  377 WFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAI-PCALFLLYLYRYLPETKGR 447
 
Name Accession Description Interval E-value
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
12-470 2.26e-47

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 170.13  E-value: 2.26e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  12 AAIASFCANWSFAFQITYVNTSVDTFYKLARTAYkQSRECYTCQLPENDWLaqWSVTVSMFYPGTILGFLMVPFLTKWIG 91
Cdd:cd17357    1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTL-VDRYGLNLSDSELDLL--WSLIVSIFFIGGAIGSFISAFLANRFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  92 VKRAQGIMCIAATIGVGVHFLALSFLSLgevtfaTILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQS 171
Cdd:cd17357   78 RKNGLLISNALLVVSSLLMFLSKSAKSP------ELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 172 FATLLGLVLGSEEILPLGSSRFFIMQISaVIPILFLLFVLIITPPTPNYLSHFHPEcIHEAIHSKLFYHGTErsnsyRPL 251
Cdd:cd17357  152 LGILLGQVFGLPSVLGTETLWPYLLFFP-GIPALLQLAALPFFPESPKFLLISKGD-EEEAEKSLKFLRGIE-----DDV 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 252 ISNYEMMENKFTSKYANYGKSWRESFK------GFLIGAIVAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDTfTI 325
Cdd:cd17357  225 DQELEEIKKESEQMGDQKQVSLMQLLRdpslrlPLLLVLVVSASQQFSGINAIFFYSTFIF-------ENAGFSPQL-AE 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 326 LVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFT----TNKVIVSLCFAATKTFI---GIGCGGPA 398
Cdd:cd17357  297 WANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLflseQNSWMSYGCIVAIFLFIfffAIGLGPIP 376
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392926249 399 WFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAgPALVAAILIYLYLPETKGR 470
Cdd:cd17357  377 WFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAI-PCALFLLYLYRYLPETKGR 447
Sugar_tr pfam00083
Sugar (and other) transporter;
8-479 1.28e-34

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 135.09  E-value: 1.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249    8 LVILAAIASFCANWSFAFqITYVNTSVDTFYKlaRTAYKQSRECYTcqlpendWLAQWSVTVSMFYPGTILGFLMVPFLT 87
Cdd:pfam00083   1 VALVAALGGFLFGYDTGV-IGAFLTLIDFFKN--FGLSKSVSSLAA-------LSVLSGLIVSIFSVGCFIGSLFAGKLG 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249   88 KWIGVKRAQGIMCIAATIGVgvhflALSFLSLGEVTFaTILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQ 167
Cdd:pfam00083  71 DRFGRKKSLLIANVLFVIGA-----VLQGAAKGKWSV-YQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQ 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  168 VSQSFATLLGLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVLIITPPTPNYLshFHPECIHEAIHSKLFYHGTERSNs 247
Cdd:pfam00083 145 LAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWL--VEKGRLEEAREVLAKLRGVPDVD- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  248 yRPLISNYEMMENKFTSKYANYGKSWRESFKG--FLIGAIVAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDtftI 325
Cdd:pfam00083 222 -RELDEIKDSLEAGQEAEKASWKELFSTKTRRqrLLIGVMLQIFQQLTGINAIFYYSTTIF-------ENLGLSDS---F 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  326 LVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAN--IGAVVFTTNK--------VIVSLCFAAtkTFIGIGCG 395
Cdd:pfam00083 291 LVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFviLGIVALLGVSksdwagivAIVFIALFI--AFFAMGWG 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  396 GPAWFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:pfam00083 369 PVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEI 448

                  ....
gi 392926249  476 QNML 479
Cdd:pfam00083 449 DELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
52-475 2.54e-29

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 120.52  E-value: 2.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249   52 YTCQLPENDWLAQWSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGvgvhflALSFLSLGEVTFATILSIG 131
Cdd:TIGR00879  60 FTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIG------AILMGLAAFALSVEMLIVG 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  132 RLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVL 211
Cdd:TIGR00879 134 RVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGL 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  212 IITPPTPNYL-SHFHPEcihEAIHSKLFYHGT-----ERSNSYRPLISNYEMMENKFTSKYANYGKSWRESFKGFLIGAI 285
Cdd:TIGR00879 214 FFLPESPRWLvGKGRVE---EARKSLARLRGTsgedkELLDELELIDIKRSIEKRSVQPSWGSLFSSTRRIRRRLFLGVV 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  286 VAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDTfTILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVA 365
Cdd:TIGR00879 291 LQWFQQFTGINAIMYYSPTIF-------ENAGVSTDH-AFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAIC 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  366 N--IGAVVFT----TNKVIVSLCFAATKTFIG---IGCGGPAWFLTSELvdpeYAWIFQPLstGILLSTT------MIET 430
Cdd:TIGR00879 363 LfvLGILGASfvtgSSKSSGNVAIVFILLFIAffaMGWGPVPWVIVSEI----FPLSLRPK--GISIAVAanwlanFIVG 436
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 392926249  431 FFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:TIGR00879 437 FLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
67-478 1.07e-10

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 63.56  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  67 VTVSMFYPGTILGFLMVPFLTKWIGVKRAqgiMCIAATI----GVGVHFLALSFLSLGEVTFATILS--IGRLMIGLQAG 140
Cdd:PRK10077  59 FCVASALIGCIIGGALGGYCSNRFGRRDS---LKIAAVLffisALGSAWPEFGFTSIGPDNTGYVPEfvIYRIIGGIGVG 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 141 SSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLL-----GLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVLIITP 215
Cdd:PRK10077 136 LASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVvyfvnYFIARSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVP 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 216 PTPNYLSHFHPECIHEAIHSKLfyHGTERSNSYRPLISNYEMMENKFTSKYANYGKSWresfkgFLIGAIVAASYAFTGD 295
Cdd:PRK10077 216 ETPRYLMSRGKQEQAEGILRKI--MGNTLATQALQEIKHSLDHGRKTGGKLLMFGVGV------IVIGVMLSVFQQFVGI 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 296 DLI-----DTFSSnmlIGEEKSSKKIHqttdtfTILVsdglGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVA--NIG 368
Cdd:PRK10077 288 NVVlyyapEIFKT---LGASTDIALLQ------TIIV----GVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGmfSLG 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 369 AVVFTTNKVIVSLCFAATKT-FIGIGCGGPAWFLTSELVdPE--------YAWIFQPLSTGILLST-TMIETFFYLtVDN 438
Cdd:PRK10077 355 TAFYTQAPGIVALLSMLFYVaAFAMSWGPVCWVLLSEIF-PNairgkalaIAVAAQWIANYFVSWTfPMMDKNSWL-VAH 432
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 392926249 439 LVGGYSLLILAAgPALVAAILIYLYLPETKGRSSEEIQNM 478
Cdd:PRK10077 433 FHNGFSYWIYGC-MGVLAALFMWKFVPETKGKTLEEMEAL 471
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
59-411 7.09e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 7.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  59 NDWLAQWSVTVSMFypGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGVGVHFLALSFlslgevtfaTILSIGRLMIGLQ 138
Cdd:COG2814   43 SPAQAGLVVTAYLL--GAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL---------WLLLAARFLQGLG 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 139 AGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFFImqISAVIPILFLLFVLIITPPTP 218
Cdd:COG2814  112 AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL--VNAVLALLALLLLLRLLPESR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 219 NYLSHFHPECIHEAIHSKLFyhgtersnsyrplisnyemmenkftskyanygksWRESFKGFLIGAIVAASYAFTGDDLI 298
Cdd:COG2814  190 PAARARLRGSLRELLRRPRL----------------------------------LLLLLLAFLLGFGFFALFTYLPLYLQ 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 299 DTFssnmligeeksskkiHQTTDTFTILVSdGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAnIGAVVFTTNKVI 378
Cdd:COG2814  236 EVL---------------GLSASAAGLLLA-LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG-LLLLALAGSLWL 298
                        330       340       350
                 ....*....|....*....|....*....|...
gi 392926249 379 VSLCFAATkTFIGIGCGGPAWFLTSELVDPEYA 411
Cdd:COG2814  299 LLLALFLL-GFGFGLLFPLLQALVAELAPPEAR 330
 
Name Accession Description Interval E-value
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
12-470 2.26e-47

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 170.13  E-value: 2.26e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  12 AAIASFCANWSFAFQITYVNTSVDTFYKLARTAYkQSRECYTCQLPENDWLaqWSVTVSMFYPGTILGFLMVPFLTKWIG 91
Cdd:cd17357    1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTL-VDRYGLNLSDSELDLL--WSLIVSIFFIGGAIGSFISAFLANRFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  92 VKRAQGIMCIAATIGVGVHFLALSFLSLgevtfaTILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQS 171
Cdd:cd17357   78 RKNGLLISNALLVVSSLLMFLSKSAKSP------ELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 172 FATLLGLVLGSEEILPLGSSRFFIMQISaVIPILFLLFVLIITPPTPNYLSHFHPEcIHEAIHSKLFYHGTErsnsyRPL 251
Cdd:cd17357  152 LGILLGQVFGLPSVLGTETLWPYLLFFP-GIPALLQLAALPFFPESPKFLLISKGD-EEEAEKSLKFLRGIE-----DDV 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 252 ISNYEMMENKFTSKYANYGKSWRESFK------GFLIGAIVAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDTfTI 325
Cdd:cd17357  225 DQELEEIKKESEQMGDQKQVSLMQLLRdpslrlPLLLVLVVSASQQFSGINAIFFYSTFIF-------ENAGFSPQL-AE 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 326 LVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFT----TNKVIVSLCFAATKTFI---GIGCGGPA 398
Cdd:cd17357  297 WANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLflseQNSWMSYGCIVAIFLFIfffAIGLGPIP 376
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392926249 399 WFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAgPALVAAILIYLYLPETKGR 470
Cdd:cd17357  377 WFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAI-PCALFLLYLYRYLPETKGR 447
Sugar_tr pfam00083
Sugar (and other) transporter;
8-479 1.28e-34

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 135.09  E-value: 1.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249    8 LVILAAIASFCANWSFAFqITYVNTSVDTFYKlaRTAYKQSRECYTcqlpendWLAQWSVTVSMFYPGTILGFLMVPFLT 87
Cdd:pfam00083   1 VALVAALGGFLFGYDTGV-IGAFLTLIDFFKN--FGLSKSVSSLAA-------LSVLSGLIVSIFSVGCFIGSLFAGKLG 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249   88 KWIGVKRAQGIMCIAATIGVgvhflALSFLSLGEVTFaTILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQ 167
Cdd:pfam00083  71 DRFGRKKSLLIANVLFVIGA-----VLQGAAKGKWSV-YQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQ 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  168 VSQSFATLLGLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVLIITPPTPNYLshFHPECIHEAIHSKLFYHGTERSNs 247
Cdd:pfam00083 145 LAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWL--VEKGRLEEAREVLAKLRGVPDVD- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  248 yRPLISNYEMMENKFTSKYANYGKSWRESFKG--FLIGAIVAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDtftI 325
Cdd:pfam00083 222 -RELDEIKDSLEAGQEAEKASWKELFSTKTRRqrLLIGVMLQIFQQLTGINAIFYYSTTIF-------ENLGLSDS---F 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  326 LVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAN--IGAVVFTTNK--------VIVSLCFAAtkTFIGIGCG 395
Cdd:pfam00083 291 LVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFviLGIVALLGVSksdwagivAIVFIALFI--AFFAMGWG 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  396 GPAWFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:pfam00083 369 PVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEI 448

                  ....
gi 392926249  476 QNML 479
Cdd:pfam00083 449 DELF 452
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
52-475 2.54e-29

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 120.52  E-value: 2.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249   52 YTCQLPENDWLAQWSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGvgvhflALSFLSLGEVTFATILSIG 131
Cdd:TIGR00879  60 FTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIG------AILMGLAAFALSVEMLIVG 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  132 RLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVL 211
Cdd:TIGR00879 134 RVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGL 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  212 IITPPTPNYL-SHFHPEcihEAIHSKLFYHGT-----ERSNSYRPLISNYEMMENKFTSKYANYGKSWRESFKGFLIGAI 285
Cdd:TIGR00879 214 FFLPESPRWLvGKGRVE---EARKSLARLRGTsgedkELLDELELIDIKRSIEKRSVQPSWGSLFSSTRRIRRRLFLGVV 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  286 VAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDTfTILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVA 365
Cdd:TIGR00879 291 LQWFQQFTGINAIMYYSPTIF-------ENAGVSTDH-AFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAIC 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  366 N--IGAVVFT----TNKVIVSLCFAATKTFIG---IGCGGPAWFLTSELvdpeYAWIFQPLstGILLSTT------MIET 430
Cdd:TIGR00879 363 LfvLGILGASfvtgSSKSSGNVAIVFILLFIAffaMGWGPVPWVIVSEI----FPLSLRPK--GISIAVAanwlanFIVG 436
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 392926249  431 FFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:TIGR00879 437 FLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
65-475 6.21e-21

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 95.38  E-value: 6.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  65 WSVTVSMFYPGTILGFLMVPFLTKWIGVKRA---QGIMCIAATIGVGVHFLALSFlslgevtfaTILSIGRLMIGLQAGS 141
Cdd:cd17432   52 WSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTlllNNIFAIVAAILMGLSKIAKSF---------EMIIVGRFLVGINAGI 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 142 SLCLLPLYIIEISPAHYRSFLNnfqQVSQSFATL---LGLVLGSEEILPlGSSRFFIMQISAVIPILFLLFVLIITPPTP 218
Cdd:cd17432  123 SLNVVPMYLGESAPKNLRGAVG---LVPAIFITLgilLGQVLGLRELLG-NEEGWPLLLALTGVPALLQLLTLPFFPESP 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 219 NYLShFHPECIHEAIHSKLFYHGTERsnsYRPLISnyEMMENKFTSKYANYGKSWR----ESFKGFLIGAIV-AASYAFT 293
Cdd:cd17432  199 RYLL-IEKGDEEAARKALQRLRGKED---VDDEME--EMLEEQRAEKGVGTVSVLElfrdRSVRWQLISIIVlMAGQQLC 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 294 GDDLIDTFSSNMLIGEEKSSKKIHQTTdtftilvsDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAnigAVVFT 373
Cdd:cd17432  273 GINAIYFYADSIFLEAGIPEDKIQYVT--------VGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVW---CAVLT 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 374 tnkviVSLCFAATKTFI---------------GIGCGGPAWFLTSELVDPEY---AWIFqplsTGIL--LSTTMIETFFY 433
Cdd:cd17432  342 -----VALSLQNTVSWMpylsivcifayiasfGIGPAGVPFILTTEIFDQSSrpaAFMV----AGSLnwLSNFLVGLLFP 412
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 392926249 434 LTVDNLvGGYSLLILaAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:cd17432  413 FIQEGL-GAYCFLVF-AVICLLTAIYIFFVLPETKGKTFLEI 452
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
62-474 2.45e-20

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 93.41  E-value: 2.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  62 LAQWSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGvgvhFLALSFLSlgEVTFatiLSIGRLMIGLQAGS 141
Cdd:cd17358   40 VAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILG----WLLIAFAK--DVWM---LYLGRFLAGFGGGA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 142 SLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSeeILPlgssrFFIMQISAVIPILFLLFVLIITPPTPNYL 221
Cdd:cd17358  111 ASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGS--FLP-----WRTLALIGAIPPVVFLILLFFIPESPRWL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 222 SHFHPEciHEAIHSKLFYHGTERSNS-YRPLISNYEMMENKFTSKYANYGKSWRESFKGFLIGAIVAASYAFTGDDLIDT 300
Cdd:cd17358  184 AKKGRE--EEAEKSLQFLRGKDADISkEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIF 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 301 FSSNMLigeEKSSKKIhqTTDTFTILVsdglGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFTT------ 374
Cdd:cd17358  262 YASSIF---DEAGSGL--DPNTATIII----GVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYlqehga 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 375 -NKVIVSLCFAATKTFIG---IGCGGPAWFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAA 450
Cdd:cd17358  333 lLSSVSWLPLVGLVIYIIsfsIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFA 412
                        410       420
                 ....*....|....*....|....
gi 392926249 451 GPALVAAILIYLYLPETKGRSSEE 474
Cdd:cd17358  413 GICGLALVFVLLFVPETKGKSLEE 436
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
64-466 2.70e-20

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 92.25  E-value: 2.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  64 QWSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGvgvhflalSFLSLGEVTFATILsIGRLMIGLQAGSSL 143
Cdd:cd17315   35 LQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIG--------ALLSALAPNVWVLI-VGRFLLGLGVGLAS 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 144 CLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILpLGSSRFFIMQISAVIPILFLLFVLIITPPTpnylsh 223
Cdd:cd17315  106 VLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSL-SPPGWWRLMFALAAVPALLQLLLMFFLPES------ 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 224 fhpeciheaihsklfyhgtersnsyRPLIsnyemmenkftskyanygkswresfkgflIGAIVAASYAFTGDDLIDTFSS 303
Cdd:cd17315  179 -------------------------RALL-----------------------------VGVGLQLLQQLTGINAVMYYAP 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 304 NMLigeeKSSKKIHQttdtfTILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAN----IGAVVFTTNKVIV 379
Cdd:cd17315  205 TIF----KSAGGGTA-----SILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLlllaIAFLLPALAKAAG 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 380 SLCFAATKTFI---GIGCGGPAWFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVA 456
Cdd:cd17315  276 WLALLGILLYIaafAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLA 355
                        410
                 ....*....|
gi 392926249 457 AILIYLYLPE 466
Cdd:cd17315  356 LVFVFFFVPE 365
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
65-470 5.59e-17

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 83.15  E-value: 5.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  65 WSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAAtigvgvhFLALSFLSLGEV-TFATILSIGRLMIGLQAGSSL 143
Cdd:cd17431   52 WSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLA-------FAGAALMGLSKLaKSYEMLILGRFIIGLYCGLTT 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 144 CLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFFIMQISaVIPILFLLFVLIITPPTPNYL-S 222
Cdd:cd17431  125 GLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFILGTEELWPLLLGFT-IVPAILQLALLPFCPESPRYLlI 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 223 HFHPECIHEAIHSKLfyHGTERSNSyrplisnyEMMENKFTSKYANYGK--SWRESFKG------FLIGAIVAASYAFTG 294
Cdd:cd17431  204 NRNEEEEAKSVLKKL--RGTTDVSE--------DIQEMKEESRQMMREKkvTILELFRSssyrqpIIIAIVLQLSQQLSG 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 295 DDLIDTFSSNMLIGEEKSSKKIHqttdtfTIlvsdGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFTT 374
Cdd:cd17431  274 INAVFYYSTSIFEKAGVQQPVYA------TI----GAGVVNTIFTVVSLFLVERAGRRTLHLIGLGGMAICAILMTIALL 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 375 NK----------VIVSLCFAAtktFIGIGCGGPAWFLTSELVDPeyawifQPLSTGILLSTT------MIETFFYLTVDN 438
Cdd:cd17431  344 LLegypwmsyvsIVAIFGFVA---FFEIGPGPIPWFIVAELFSQ------GPRPAAMAVAGFsnwtsnFIVGMCFQYIAN 414
                        410       420       430
                 ....*....|....*....|....*....|..
gi 392926249 439 LVGGYSLLILaAGPALVAAILIYLYLPETKGR 470
Cdd:cd17431  415 LCGPYVFIIF-TVFLLTFFIFTYFKVPETKGK 445
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
89-475 1.08e-12

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 69.74  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  89 WIGVKRAQGIMCIAATIGVGVHFLALSFlslgevtfaTILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQV 168
Cdd:cd17437   58 WIGRRYTIALAALIFFVGALLMGVAPNY---------PVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEI 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 169 SQSFATLLGLVLG-SEEILPLGSSRFFIMQISAViPILFLLFVLIITPPTPNylshfhpeciheaihsklfyhgtersns 247
Cdd:cd17437  129 FINIGILLGYVSNyAFSGLPLHVGWRLMLGVGAV-PSLFLAIGVLAMPESPR---------------------------- 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 248 yrplisnyemmenkftskyanygksWRESFKGFLIGAI-VAASYAFTGDDLIDTFSSNMLigeekssKKIHQTTDTFTIL 326
Cdd:cd17437  180 -------------------------WTPAVRRMLIAALgIHFFQQASGIDAVVLYSPRIF-------KKAGIKSKDKLLL 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 327 VSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVA-------------NIGAVVFTTNKVIVSLC-FAAtktFIGI 392
Cdd:cd17437  228 ATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSltalatsltfidrNGGGLTWALVLAITAVCsFVA---FFSI 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 393 GCGGPAWFLTSElvdpeyawIF------QPLSTGI----LLSTTMIETFFYLTVDNLVGGYSLLIlaAGPALVAAILIYL 462
Cdd:cd17437  305 GAGPITWVYSSE--------IFplrlraQGASLGVvvnrLMSGTVSMTFLSMSKAITTGGTFFLF--AGVAAAAWVFFYF 374
                        410
                 ....*....|...
gi 392926249 463 YLPETKGRSSEEI 475
Cdd:cd17437  375 FLPETKGKSLEEI 387
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
53-475 2.35e-12

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 68.53  E-value: 2.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  53 TCQLPENDWLAQWSVTVSMFYPGTILGFLMVPFLT-KWIGVK-RAQGIMCIAATIGVGVhflalsfLSLGEVTFATILSI 130
Cdd:cd17362   25 SPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAgALIDRLgRRKELILAALLYLVGS-------LVTGLAPSYPVLLV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 131 GRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFfiMQISAVIPILFLLFV 210
Cdd:cd17362   98 GRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRY--MYGLAAPPALLLGIG 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 211 LIITPPTPNYlshfhpeciheaihsklfyhgteRSNSYRPLIsnyemmenkftskyanygkswresfkgflIGAIVAASY 290
Cdd:cd17362  176 MWFLPPSPRW-----------------------QGNYRKPLI-----------------------------IGLGLVLFQ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 291 AFTGDDLIDTFSSNMLigeekSSKKIHQTTDTftILVSDGLGLVLFFASLFGIYLADRFGRRKLVL--VGLFGTCVANIG 368
Cdd:cd17362  204 QITGQPSVLYYAATIF-----KSAGFSAASDA--TLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLggVSGMVVSLFLLA 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 369 AVVFTTNKVIV---SLCFAATKTFIG---IGCGGPAWFLTSElvdpeyawIFqPLST---GILLSTTM------IETFFY 433
Cdd:cd17362  277 AYNLFVQMGPAglaWLSLVALLLYVGayqISFGPISWLMVSE--------IF-PLRVrgrAIALAVLVnfgsnaLVSLAF 347
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 392926249 434 LTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:cd17362  348 LPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
69-466 5.66e-12

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 67.30  E-value: 5.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  69 VSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGVGVHFLALSFlslgevtfaTILSIGRLMIGLQAGSSLCLLPL 148
Cdd:cd17360   41 VSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNK---------EVLIVGRVLVGLGVGIASMTVPL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 149 YIIEISPAHYRSFL---NN-FQQVSQSFATLLGLVLgseEILPLGssrFFIMQISAVIPILFLLFVLIITPPTPnylshf 224
Cdd:cd17360  112 YIAEAAPPRIRGRLvtiNVlFITGGQFVAYVINGAF---SYLPGG---WRWMLGLAAVPAVLQFIGLLFLPESP------ 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 225 hpeciheaihsklfyhgtersnsyrplisnyemmenkftskyanygkSWRESFKGFLIGAIVAASYAFTGDDLIDTFSSN 304
Cdd:cd17360  180 -----------------------------------------------RWPSTRRALIVGCGLQAFQQFSGINTVMYYSAT 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 305 MLigeEKSSKKIHQTTdtftILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAnigAVVFTTNKVIVSL-CF 383
Cdd:cd17360  213 IL---QMAGFKDNQNA----IWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVA---LVVLAVWLALVGLiLY 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 384 AAtktFIGIGCGGPAWFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVAAILIYLY 463
Cdd:cd17360  283 LA---FFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLIFIYFC 359

                 ...
gi 392926249 464 LPE 466
Cdd:cd17360  360 VPE 362
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
63-478 7.18e-12

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 67.28  E-value: 7.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  63 AQWSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGVGVHFLALSFLSLgevtfatiLSIGRLMIGLQAGSS 142
Cdd:cd17356   45 SRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQ--------LIVGRIIAGLGVGFA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 143 LCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLG--LVLGSEEILPLGSSRFFI-MQIsavIPILFLLFVLIITPPTPN 219
Cdd:cd17356  117 SVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAycINYGTHKLDGSAQWRIPLgLQI---VWGLLLLIGMFFLPESPR 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 220 YLshfhpeciheaihsklfyhgtersnsYRplisnyemmenkftskyanygkswresfkgFLIGAIVAASYAFTGDDLID 299
Cdd:cd17356  194 WL--------------------------YR------------------------------TILGIMLQLFQQLTGINYFF 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 300 TFSSNML--IGEEKSSKkihqttdtftILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAN--IGAV----- 370
Cdd:cd17356  218 YYGTTIFqsTGLTGSSP----------LLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLfiYAAVgvryl 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 371 ----------VFTTNKVIVSLCFaatktFIG---IGCGGPAWFLTSELVDPEYAwifqplSTGILLSTT-------MIET 430
Cdd:cd17356  288 ipnpqsgtsnKSAGNGMIVFICL-----FIFsfaTTWGPIAWVYVAEVFPLRVR------SKGMALATAfnwlwnfLISF 356
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 392926249 431 FFYLTVDNLvgGYSLLILAAGPALVAAILIYLYLPETKGRSSEEIQNM 478
Cdd:cd17356  357 FTPFIIGSI--GFKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDEL 402
xylE PRK10077
D-xylose transporter XylE; Provisional
67-478 1.07e-10

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 63.56  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  67 VTVSMFYPGTILGFLMVPFLTKWIGVKRAqgiMCIAATI----GVGVHFLALSFLSLGEVTFATILS--IGRLMIGLQAG 140
Cdd:PRK10077  59 FCVASALIGCIIGGALGGYCSNRFGRRDS---LKIAAVLffisALGSAWPEFGFTSIGPDNTGYVPEfvIYRIIGGIGVG 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 141 SSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLL-----GLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVLIITP 215
Cdd:PRK10077 136 LASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVvyfvnYFIARSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVP 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 216 PTPNYLSHFHPECIHEAIHSKLfyHGTERSNSYRPLISNYEMMENKFTSKYANYGKSWresfkgFLIGAIVAASYAFTGD 295
Cdd:PRK10077 216 ETPRYLMSRGKQEQAEGILRKI--MGNTLATQALQEIKHSLDHGRKTGGKLLMFGVGV------IVIGVMLSVFQQFVGI 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 296 DLI-----DTFSSnmlIGEEKSSKKIHqttdtfTILVsdglGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVA--NIG 368
Cdd:PRK10077 288 NVVlyyapEIFKT---LGASTDIALLQ------TIIV----GVINLTFTVLAIMTVDKFGRKPLQIIGALGMAIGmfSLG 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 369 AVVFTTNKVIVSLCFAATKT-FIGIGCGGPAWFLTSELVdPE--------YAWIFQPLSTGILLST-TMIETFFYLtVDN 438
Cdd:PRK10077 355 TAFYTQAPGIVALLSMLFYVaAFAMSWGPVCWVLLSEIF-PNairgkalaIAVAAQWIANYFVSWTfPMMDKNSWL-VAH 432
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 392926249 439 LVGGYSLLILAAgPALVAAILIYLYLPETKGRSSEEIQNM 478
Cdd:PRK10077 433 FHNGFSYWIYGC-MGVLAALFMWKFVPETKGKTLEEMEAL 471
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
125-466 9.22e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 57.19  E-value: 9.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 125 ATILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLG-----LVLGSEEILPLGSSRFFIMQIS 199
Cdd:cd17359   89 FTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAyivnyLIANAGGADWLGAEGWRWMLGL 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 200 AVIPILFLLFVLIITPPTPNYLshfhpeciheaihsklfyhgtersnsyrplisnyeMMENKftskyanygkswresfKG 279
Cdd:cd17359  169 EAIPAILFLLGMLFIPESPRWL-----------------------------------VSKGK----------------PI 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 280 FLIGAIVAASYAFTGDDLIDTFSSNMLI---GEEKSSkkihqttdtftILVSDGLGLVLFFASLFGIYLADRFGRRKLVL 356
Cdd:cd17359  198 LIIGIGLAIFQQFVGINVIFYYGPEIFQnagFSENAA-----------LLQTIGIGVVNVIFTIIAILLVDKVGRKPLLL 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 357 VGLFGTCVA-NIGAVVFTTNK------VIVSLCFAATKTFIGIGCGGPAWFLTSELVDPEYAWIFQPLSTGILLSTTMIE 429
Cdd:cd17359  267 IGSIGMAISlLLIGTAFYFAPgsqasgIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLV 346
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 392926249 430 TFFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPE 466
Cdd:cd17359  347 SLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
320-475 2.36e-08

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 55.96  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 320 TDTFTILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFTTnkvivSLCFAATKTFIGIGCGGPAW 399
Cdd:cd17436  226 SNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGLWIT-----LLCLMAFVSAFSIGFGPMTW 300
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392926249 400 FLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEI 475
Cdd:cd17436  301 LVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
59-411 7.09e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 7.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  59 NDWLAQWSVTVSMFypGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGVGVHFLALSFlslgevtfaTILSIGRLMIGLQ 138
Cdd:COG2814   43 SPAQAGLVVTAYLL--GAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL---------WLLLAARFLQGLG 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 139 AGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFFImqISAVIPILFLLFVLIITPPTP 218
Cdd:COG2814  112 AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL--VNAVLALLALLLLLRLLPESR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 219 NYLSHFHPECIHEAIHSKLFyhgtersnsyrplisnyemmenkftskyanygksWRESFKGFLIGAIVAASYAFTGDDLI 298
Cdd:COG2814  190 PAARARLRGSLRELLRRPRL----------------------------------LLLLLLAFLLGFGFFALFTYLPLYLQ 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 299 DTFssnmligeeksskkiHQTTDTFTILVSdGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAnIGAVVFTTNKVI 378
Cdd:COG2814  236 EVL---------------GLSASAAGLLLA-LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG-LLLLALAGSLWL 298
                        330       340       350
                 ....*....|....*....|....*....|...
gi 392926249 379 VSLCFAATkTFIGIGCGGPAWFLTSELVDPEYA 411
Cdd:COG2814  299 LLLALFLL-GFGFGLLFPLLQALVAELAPPEAR 330
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
63-462 8.39e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 8.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  63 AQWSVTVSMFYPGTILGFLMVPFLTKWIGVKRaqgiMCIAATIGVGVHFLALSFLSLGEVTFatilsIGRLMIGLQAGSS 142
Cdd:cd06174   31 SQLGLLFALFSLGYALLQPLAGLLADRFGRRP----VLLLGLLLFALGALLFAFAPSFWLLL-----LGRFLLGLGSGLI 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 143 LCLLPLYIIEISPAHYRSFLNNFQQVSQSFATLLGLVLGSEEILPLGSSRFFIMQISAVIPILFLLFVLIITPPTPnyls 222
Cdd:cd06174  102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP---- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 223 hfhpeciHEAIHSKLFYHGTERSNSYRPLISNyemmenkftskyanygkswresfKGFLIGAIVAASYAFtgddlidTFS 302
Cdd:cd06174  178 -------ESARAKNEEASSKSVLKLLKRVLKN-----------------------PGLWLLLLAIFLVNL-------AYY 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 303 SNMLIGEEKSSKKIHQTTDTFTILVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFTTNKVIVSLC 382
Cdd:cd06174  221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 383 FaatktFIGIGCGGPA---WFLTSELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVAAIL 459
Cdd:cd06174  301 L-----LLGFGLGGLLplsFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375

                 ...
gi 392926249 460 IYL 462
Cdd:cd06174  376 LLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
326-476 8.61e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 8.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 326 LVSDGLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFTTnkvIVSLCFAATKTFIGIGCGGPAWF-LTSE 404
Cdd:COG2814   49 LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALaLIAD 125
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392926249 405 LVDPE-----YAWIFQPLSTGILLSTTMIetffyLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEEIQ 476
Cdd:COG2814  126 LVPPErrgraLGLLGAGLGLGPALGPLLG-----GLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR 197
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
11-474 1.04e-05

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 47.91  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  11 LAAIASFCANWSFAFQITYVNTSVDTFYKLARTAYKQSREcytcqlpENDWLAqwsvtvSMFYPGTILGFLMVPFLTKWI 90
Cdd:cd17434    2 LAVFSAVLGNFSFGYALVYTSPVIPALEQGDDPRLHLNVH-------QISWFG------SVFTLGAAAGGLSAMFLNDRL 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  91 GvkRAQGIMCIAATIGVGvhflalsFLSLGEVTFATILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQVSQ 170
Cdd:cd17434   69 G--RKLSIMFSAVPSALG-------YLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMA 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 171 SFATLLGLVLGSeeILPlgssrFFIMQISAVIPILFLLFVLIITPPTPNYLSHFHPEciHEAIHSKLFYHGTERSnsyrp 250
Cdd:cd17434  140 VFGSLALYALGL--LLP-----WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKD--EKALKALAWLRGPNTD----- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 251 LISNYEMMENKFTSKYANYgkSWRES-----FKGFLIGAIVAASYAFTGDDLIDTFSSNMLigeeKSSKKIHQTTDTFTI 325
Cdd:cd17434  206 YMTEFEQIKDNIRKQSSRL--SWAELktpsyYKPILIAVVMRFLQQLTGITPILVYLEPIF----HLTAVILEPKYDAAL 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 326 lvsdgLGLVLFFASLFGIYLADRFGRRKLVLVGlfgtcvaniGAVVFTTNKVIVSLCFAATKTFI---GIGCGGPAWFLT 402
Cdd:cd17434  280 -----VGAVRLLSVAIAASLMDKAGRKILLFTS---------AFLMFAANLSMGLIPLIAAMLFImgyAMGWGPITWLLM 345
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392926249 403 SELVDPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEE 474
Cdd:cd17434  346 SEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLEQ 417
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
78-181 4.91e-05

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 45.83  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  78 LGFLMVPFLTKWIG-----VKRAQGIMCIAATIGVGVHFLAL--SFLSLGEVTFATILsIGRLMIGLQAGSSLCLLPLYI 150
Cdd:cd17368   48 VGFFMRPIGAIVLGayadrIGRKPAMTLTLAIMALGTLLIALapTYATIGIAAPLLVL-LARLLQGFAAGGEVGGVTAYL 126
                         90       100       110
                 ....*....|....*....|....*....|.
gi 392926249 151 IEISPAHYRSFLNNFQQVSQSFATLLGLVLG 181
Cdd:cd17368  127 VEAAPPGRRGFYTSWQSASQQVAIVAGALVG 157
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
69-466 2.07e-04

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 43.78  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  69 VSMFYPGTILGFLMVPFLTKWIGvkRAQGIMCIaatigvGVHFLALSFLSLGEVTFATILsIGRLMIGLQAGSSLCLLPL 148
Cdd:cd17361   57 TSSLYLAGLVASLLASYVTRKWG--RKPSMLIG------GVLFLVGAALNAAAQNIAMLI-VGRILLGFGVGFGNQAVPL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 149 YIIEISPAHYRSFLNNFQQvsqsFATLLGLV------LGSEEILPLGssrffiMQIS---AVIPILFLLFVLIITPPTPN 219
Cdd:cd17361  128 YLSEMAPAKLRGALNIGFQ----LAITIGILianlinYGTSKIKPNG------WRLSlglAAVPALILLLGSLFLPETPN 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 220 ylshfHPEciheaihsklfyhgtersnsyrplisnyemmenkftskyanygkswresfkgFLIGAIVAASYAFTGDDLID 299
Cdd:cd17361  198 -----SPQ----------------------------------------------------LVIAILIPFFQQLTGINVIM 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 300 TFSSNML--IGEEKSSKKIHQTTdtftilvsdgLGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANI---------- 367
Cdd:cd17361  221 FYAPVLFqtLGFGSDASLISAVI----------TGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVaigillavkf 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 368 --GAVVFTTNKVIVSLCFAATKTFIGIGCGGPAWFLTSELVDPEYAWIFQPLSTGI-LLSTTMIETFFYLTVDNLvgGYS 444
Cdd:cd17361  291 gdGGELPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVnFLFTFVIAQAFLSMLCAM--KFG 368
                        410       420
                 ....*....|....*....|..
gi 392926249 445 LLILAAGPALVAAILIYLYLPE 466
Cdd:cd17361  369 IFLFFAGWVVVMSLFVYFLLPE 390
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
127-474 6.40e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 42.17  E-value: 6.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 127 ILSIGRLMIGLQAGSSLCLLPLYIIEISPAHYRSFLNNFQQ----VSQSFATLLGLVLGSEEILPLGSsrffimqisaVI 202
Cdd:cd17433   96 MLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQlmvvIGIMGAYLAGLVLDWRWLAVLGS----------IP 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 203 PILFLLFVLIItPPTPNYLSHFHPEciHEAIHSKLFYHGTERSNSYRP--LISNYEMMENKFT-SKYANYGkswreSFKG 279
Cdd:cd17433  166 PTLMLLLMCFM-PETPRFLLTQHRR--QEAMAALRFLRGPDQGWEWECigIEQSFHLEEQSFSlALLKQPG-----IYKP 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 280 FLIGAIVAASYAFTGDDLIdtfssnMLIGEEKSSKKIHQTTDTFTILVsdGLGLVLFFAslFGIYLADRFGRRKLVLVGl 359
Cdd:cd17433  238 LIIGVSLMAFQQLTGINAV------MFYAETIFEEAKFKDSSVASVIV--AAIQVLFTA--VAALIMDRAGRKVLLVLS- 306
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 360 fgtcvaniGAVVFTTNKVIVSLCFAATKTFI---GIGCGGPAWFLTSELVdPEYAwifQPLSTGILLSTTMIETFF---- 432
Cdd:cd17433  307 --------GVVMVFSTAAFGWLAVGSMGFFIagfAVGWGPIPWLVMSEIF-PLHV---RGVASGICVLTNWLMAFLvtke 374
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 392926249 433 YLTVDNLVGGYSLLILAAGPALVAAILIYLYLPETKGRSSEE 474
Cdd:cd17433  375 FSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLEQ 416
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
333-464 7.58e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.79  E-value: 7.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 333 LVLFFASLFGIYLADRFG---RRKLVLVGLFGTCVAnIGAVVFTTNKVIVSLCFAATktFIGIGCGGPAWF-LTSELVDP 408
Cdd:cd17319  226 LAGAIGMILGGRLSDRLLrgaRRLVIIIGLLLAAVG-LLLAYLTTSPVVAVILLSLA--GFGIGAASPVFWsLPADLLPG 302
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 409 EYA--------------WIFQPLSTGILLSTTmietffyltvdnlvGGYSLLILAAGPALVAAILIYLYL 464
Cdd:cd17319  303 EAAatagglinsggnlgGFVAPLLIGYLVDAT--------------GSYTAAFLFLAAVALLAALLVLLL 358
2_A_01_02 TIGR00880
Multidrug resistance protein;
324-467 9.00e-04

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 39.56  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  324 TILVSdGLGLVLFFASLFGIYLADRFGRRKLVLVGLFgtcVANIGAVVFTTNKVIVSLCFAatKTFIGIGcGGPAWFLTS 403
Cdd:TIGR00880   1 GLLLA-GYALGQLIYSPLSGLLTDRFGRKPVLLVGLF---IFVLSTAMFALSSNITVLIIA--RFLQGFG-AAFALVAGA 73
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392926249  404 ELV-----DPEYAWIFQPLSTGILLSTTMIETFFYLTVDNLVGGYSLLILAAGpALVAAILIYLYLPET 467
Cdd:TIGR00880  74 ALIadiypPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAIL-ALAAFILLAFLLPET 141
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
63-396 1.04e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.38  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  63 AQWSVTVSMFYPGTILGFLMVPFLTKWIGVKRAQGIMCIAATIGVGVHFLALSFlslgevtfaTILSIGRLMIGLQAGSS 142
Cdd:COG0738   43 AQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY---------PLLLLALFLLGLGLGLL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 143 LCLLPLYIIEISPAHYRSFLnNFQQVSQSFATLLGLVLGSeEILPLGSSRFFIMQISAVIPILFLLFVLIitpptpnYLS 222
Cdd:COG0738  114 DVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGG-LLILLGLSLSWHLPYLILAVLLLLLALLF-------LRS 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 223 HFhPECIHEaihsklfyhgtersnsyrplisnyemmENKFTSKYANYGKSWResFKGFLIGAIVAASYAFTgDDLIDTFS 302
Cdd:COG0738  185 KL-PEIEEE---------------------------EEEAAGSAASLKSLLK--NPRLLLGGLAIFLYVGA-EGAIGDWL 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 303 SNMLigeekssKKIHQTTDTFTilvsdGLGLVLFFAS-----LFGIYLADRFGRRKLVLVGLFGTCVAnIGAVVFTTNKV 377
Cdd:COG0738  234 PLYL-------KDVLGLSEATA-----ALGLSLFWGGmtigrFLGGFLLKRFGPVRLLRLSALLAAVG-LLLALLAPGPW 300
                        330
                 ....*....|....*....
gi 392926249 378 IVSLCFAAtktfIGIGCGG 396
Cdd:COG0738  301 LALIGLAL----VGLGLSL 315
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
331-468 1.20e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 331 LGLVLFFASLFGIYLADRFGRR-KLVLVGLFGTCVANIGAVVFTTNKVIVSLCFAATkTFIGIGCGGPAWFLTSELVDPE 409
Cdd:COG2271  225 PFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFPKK 303
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392926249 410 -----YAWIFQPLSTGILLSTTMIETFFYLTvdnlvgGYSL-LILAAGPALVAAILIYLYLPETK 468
Cdd:COG2271  304 argtaSGLVNTFGFLGGALGPLLVGYLLDAT------GYQAaFLLLAALALLAALLALLLLRETR 362
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
332-409 1.99e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 332 GLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVAnIGAVVFTTNKVIVSLCFAatktFIGIGCG--GPAWF-LTSELVDP 408
Cdd:cd17325  245 GLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA-LLLLPLATSFWLLLLLLA----LLGLGLGlvFPATLaLLADIVPP 319

                 .
gi 392926249 409 E 409
Cdd:cd17325  320 E 320
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
322-466 7.17e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249  322 TFTILVSDGLGLVLFFASLFGiYLADRFGRRKLVLVG--LFGTCVaniGAVVFTTNkvIVSLCFAATKTFIGIGCGGPAW 399
Cdd:TIGR00895  53 QLGFLFSAGLIGMAFGALFFG-PLADRIGRRRVLLWSilLFSVFT---LLCALATN--VTQLLILRFLAGLGLGGLMPNL 126
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392926249  400 F-LTSELVDPEYAWIFQPL---------STGILLSTTMIETFfyltvdnlvGGYSLLILAAGPALVAAILIYLYLPE 466
Cdd:TIGR00895 127 NaLVSEYAPKRFRGTAVGLmfcgypigaAVGGFLAGWLIPVF---------GWRSLFYVGGIAPLLLLLLLMRFLPE 194
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
332-468 7.38e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 332 GLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGAVVFTTnkvIVSLCFAATKTFIGIGCGGPAWF-LTSELVDPEy 410
Cdd:cd17325   41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS---YWQLLLARFLQGLASAAVWPAAMaLIADIAPPE- 116
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392926249 411 awifqplSTGILLSTTMIETFFYLTVDNLVGGY--------SLLILAAGPALVAAILIYLYLPETK 468
Cdd:cd17325  117 -------ERGRAMGIFSSAIGLGFLIGPLLGGLladalgyrAPFLVCAALALLALVLALLLLPEPR 175
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
331-410 7.67e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 38.49  E-value: 7.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392926249 331 LGLVLFFASLFGIYLADRFGRRKLVLVGLFGTCVANIGaVVFTTNkVIVSLCFAATKTFIGIGCGGPAWFLTSELVDPEY 410
Cdd:cd17379   42 LNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVL-MAFSPN-YPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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