NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17550406|ref|NP_509042|]
View 

Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat and calponin homology domain-containing protein( domain architecture ID 11469455)

leucine-rich repeat (LRR) and calponin homology (CH) domain-containing protein may participate in protein-protein interactions and/or may cross-link actin filaments into bundles and networks; similar to DISP complex protein LRCH3

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-257 6.23e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.21  E-value: 6.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  80 LDLHDNRMSTLPADFSAFDCLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDGLFDLP-LKALILANNKITCI 158
Cdd:COG4886 118 LDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 159 PEGIRRLaPTLAHLDFSKNDIRSLQSQLRYLTSLEVLKISRNRVEDFPaELCSSLKLRTLDLSHNNLSYLPaDFVKMTDL 238
Cdd:COG4886 198 PEPLGNL-TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNL 274

                       170
                ....*....|....*....
gi 17550406 239 RYLQLECNPLRSPSMDIIE 257
Cdd:COG4886 275 KTLDLSNNQLTDLKLKELE 293
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 520-621 2.57e-18

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21205:

Pssm-ID: 469584 [Multi-domain]  Cd Length: 107  Bit Score: 80.81  E-value: 2.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 520 VESARKLMREKLGPTFSLNKGDisfslQLSDGQELCKFINKLHPESIS---LASSTDSSIATTRSKMNVDRFLQYCRKIG 596
Cdd:cd21205   3 IEQLRKSIESRLKVTLPDDLGE-----ALMDGVVLCHLANHVRPRSVPsihVPSPAVPKLSMAKCRRNVENFLEACRKLG 77

                        90       100
                ....*....|....*....|....*
gi 17550406 597 VPETTLCSQMDIISKRNPQKVARTV 621
Cdd:cd21205  78 VPEERLCSPGDILEEKGLVRVAVTV 102
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-257 6.23e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.21  E-value: 6.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  80 LDLHDNRMSTLPADFSAFDCLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDGLFDLP-LKALILANNKITCI 158
Cdd:COG4886 118 LDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 159 PEGIRRLaPTLAHLDFSKNDIRSLQSQLRYLTSLEVLKISRNRVEDFPaELCSSLKLRTLDLSHNNLSYLPaDFVKMTDL 238
Cdd:COG4886 198 PEPLGNL-TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNL 274

                       170
                ....*....|....*....
gi 17550406 239 RYLQLECNPLRSPSMDIIE 257
Cdd:COG4886 275 KTLDLSNNQLTDLKLKELE 293
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 520-621 2.57e-18

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 80.81  E-value: 2.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 520 VESARKLMREKLGPTFSLNKGDisfslQLSDGQELCKFINKLHPESIS---LASSTDSSIATTRSKMNVDRFLQYCRKIG 596
Cdd:cd21205   3 IEQLRKSIESRLKVTLPDDLGE-----ALMDGVVLCHLANHVRPRSVPsihVPSPAVPKLSMAKCRRNVENFLEACRKLG 77

                        90       100
                ....*....|....*....|....*
gi 17550406 597 VPETTLCSQMDIISKRNPQKVARTV 621
Cdd:cd21205  78 VPEERLCSPGDILEEKGLVRVAVTV 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-223 1.39e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 1.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 108 NRFRTIPTCICsLEQLTFIDFSSNDISHLpDGLFDLP-LKALILANNKITCI-------------------PEG------ 161
Cdd:cd21340  34 NKITKIENLEF-LTNLTHLYLQNNQIEKI-ENLENLVnLKKLYLGGNRISVVeglenltnleelhienqrlPPGekltfd 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17550406 162 ---IRRLAPTLAHLDFSKNDIRSLqSQLRYLTSLEVLKISRNRVEDFpAELCSSLK----LRTLDLSHN 223
Cdd:cd21340 112 prsLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL-EELLDLLSswpsLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-248 6.75e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   90 LPADFSAFDCLISCIASSNRFR-TIPTCICSLEQLTFIDFSSNDIS-HLPDGLFDLP-LKALILANNKITC-IPEGIRrl 165
Cdd:PLN00113 396 IPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPsLQMLSLARNKFFGgLPDSFG-- 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  166 APTLAHLDFSKNDIR-SLQSQLRYLTSLEVLKISRNRVE-DFPAELCSSLKLRTLDLSHNNLS-YLPADFVKMTDLRYLQ 242
Cdd:PLN00113 474 SKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLD 553


                 ....*.
gi 17550406  243 LECNPL 248
Cdd:PLN00113 554 LSQNQL 559
LRR_9 pfam14580
Leucine-rich repeat;
119-206 2.30e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.00  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   119 SLEQLTFIDFSSNDISHLpDGLFDLP-LKALILANNKITCIPEGIRRLAPTLAHLDFSKNDIRSLQS--QLRYLTSLEVL 195
Cdd:pfam14580  40 TLDQFDTIDFSDNEIRKL-DGFPLLRrLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDldPLASLKKLTFL 118

                          90
                  ....*....|.
gi 17550406   196 KISRNRVEDFP 206
Cdd:pfam14580 119 SLLRNPVTNKP 129
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 543-626 1.08e-06

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 47.67  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   543 SFSLQLSDGQELCKFINKLHPESISLAsstdsSIATTRSKM--NVDRFLQYCR-KIGVPETTLCSQmDIIsKRNPQKVAR 619
Cdd:pfam00307  26 NFTTDLRDGLALCALLNKLAPGLVDKK-----KLNKSEFDKleNINLALDVAEkKLGVPKVLIEPE-DLV-EGDNKSVLT 98


                  ....*..
gi 17550406   620 TVLTVAK 626
Cdd:pfam00307  99 YLASLFR 105
SCP1 COG5199
Calponin [Cytoskeleton];
547-621 3.65e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 47.61  E-value: 3.65e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17550406 547 QLSDGQELCKFINKLHPESISLASSTDSSIattrSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTV 621
Cdd:COG5199  39 LLKDGVRLCRILNEASPLDIKYKESKMPFV----QMENISSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICL 109
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 527-632 4.29e-05

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 42.69  E-value: 4.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406    527 MREKLGPTFSLNKGDisFSLQLSDGQELCKFINKLHPESISLAsSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQm 606
Cdd:smart00033   7 VNSLLAEYDKPPVTN--FSSDLKDGVALCALLNSLSPGLVDKK-KVAASLSRFKKIENINLALSFAEKLGGKVVLFEPE- 82

                           90       100
                   ....*....|....*....|....*.
gi 17550406    607 DIISKRNpqkvartvLTVAKLQQLQS 632
Cdd:smart00033  83 DLVEGPK--------LILGVIWTLIS 100
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-257 6.23e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.21  E-value: 6.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  80 LDLHDNRMSTLPADFSAFDCLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDGLFDLP-LKALILANNKITCI 158
Cdd:COG4886 118 LDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDLSNNQITDL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 159 PEGIRRLaPTLAHLDFSKNDIRSLQSQLRYLTSLEVLKISRNRVEDFPaELCSSLKLRTLDLSHNNLSYLPaDFVKMTDL 238
Cdd:COG4886 198 PEPLGNL-TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNL 274

                       170
                ....*....|....*....
gi 17550406 239 RYLQLECNPLRSPSMDIIE 257
Cdd:COG4886 275 KTLDLSNNQLTDLKLKELE 293
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-250 1.57e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.50  E-value: 1.57e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  74 LLDTVFLDLHDNRmstlpaDFSAFDCLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDGLFDLP-LKALILAN 152
Cdd:COG4886  95 LTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSN 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 153 NKITCIPEGIRRLaPTLAHLDFSKNDIRSLQSQLRYLTSLEVLKISRNRVEDFPAELCSSLKLRTLDLSHNNLSYLPaDF 232
Cdd:COG4886 169 NQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-EL 246

                       170
                ....*....|....*...
gi 17550406 233 VKMTDLRYLQLECNPLRS 250
Cdd:COG4886 247 GNLTNLEELDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
112-250 1.67e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 1.67e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 112 TIPTCICSLEQLTFIDFSSND-ISHLPDglfdlpLKALILANNKITCIPEGIRRLaPTLAHLDFSKNDIRSLQSQLRYLT 190
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNEeLSNLTN------LESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLT 159

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 191 SLEVLKISRNRVEDFPAELCSSLKLRTLDLSHNNLSYLPADFVKMTDLRYLQLECNPLRS 250
Cdd:COG4886 160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-244 1.73e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  80 LDLHDNRMSTLPADFSAFDCLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDGLFDLP-LKALILANNKITCI 158
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQLTDL 243

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 159 PEgIRRLaPTLAHLDFSKNDIRSLqSQLRYLTSLEVLKISRNRVEDFPAELCSSLKLRTLDLSHNNLSYLPADFVKMTDL 238
Cdd:COG4886 244 PE-LGNL-TNLEELDLSNNQLTDL-PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320


                ....*.
gi 17550406 239 RYLQLE 244
Cdd:COG4886 321 TTLLLL 326
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 520-621 2.57e-18

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 80.81  E-value: 2.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 520 VESARKLMREKLGPTFSLNKGDisfslQLSDGQELCKFINKLHPESIS---LASSTDSSIATTRSKMNVDRFLQYCRKIG 596
Cdd:cd21205   3 IEQLRKSIESRLKVTLPDDLGE-----ALMDGVVLCHLANHVRPRSVPsihVPSPAVPKLSMAKCRRNVENFLEACRKLG 77

                        90       100
                ....*....|....*....|....*
gi 17550406 597 VPETTLCSQMDIISKRNPQKVARTV 621
Cdd:cd21205  78 VPEERLCSPGDILEEKGLVRVAVTV 102
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 520-626 1.32e-16

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 75.45  E-value: 1.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 520 VESARKLMREKLGPTFSLNKGDISFSLQlsDGQELCKFINKLHPESISLASSTDSSIAttRSKMNVDRFLQYCRKIGVPE 599
Cdd:cd00014   1 EEELLKWINEVLGEELPVSITDLFESLR--DGVLLCKLINKLSPGSIPKINKKPKSPF--KKRENINLFLNACKKLGLPE 76

                        90       100
                ....*....|....*....|....*..
gi 17550406 600 TTLCSQMDIISKRNPQKVARTVLTVAK 626
Cdd:cd00014  77 LDLFEPEDLYEKGNLKKVLGTLWALAL 103
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-232 7.01e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 7.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  67 EAFSNIALLDTvfLDLHDNRMSTLPADFSAFDCLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDgLFDLP-L 145
Cdd:COG4886 176 EELGNLTNLKE--LDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTnL 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 146 KALILANNKITCIPEGIRrlAPTLAHLDFSKNDIRSLQSQLRYLTSLEVLKISRNRVEDFPAELCSSLKLRTLDLSHNNL 225
Cdd:COG4886 253 EELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330


                ....*..
gi 17550406 226 SYLPADF 232
Cdd:COG4886 331 KGLLVTL 337
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-223 1.39e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 1.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 108 NRFRTIPTCICsLEQLTFIDFSSNDISHLpDGLFDLP-LKALILANNKITCI-------------------PEG------ 161
Cdd:cd21340  34 NKITKIENLEF-LTNLTHLYLQNNQIEKI-ENLENLVnLKKLYLGGNRISVVeglenltnleelhienqrlPPGekltfd 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17550406 162 ---IRRLAPTLAHLDFSKNDIRSLqSQLRYLTSLEVLKISRNRVEDFpAELCSSLK----LRTLDLSHN 223
Cdd:cd21340 112 prsLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDL-EELLDLLSswpsLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-248 6.75e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   90 LPADFSAFDCLISCIASSNRFR-TIPTCICSLEQLTFIDFSSNDIS-HLPDGLFDLP-LKALILANNKITC-IPEGIRrl 165
Cdd:PLN00113 396 IPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPsLQMLSLARNKFFGgLPDSFG-- 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  166 APTLAHLDFSKNDIR-SLQSQLRYLTSLEVLKISRNRVE-DFPAELCSSLKLRTLDLSHNNLS-YLPADFVKMTDLRYLQ 242
Cdd:PLN00113 474 SKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLD 553


                 ....*.
gi 17550406  243 LECNPL 248
Cdd:PLN00113 554 LSQNQL 559
CH_LRCH3 cd21272
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 548-627 2.06e-10

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 3; Leucine-rich repeat and calponin homology domain-containing protein 3 (LRCH3) is part of the DISP (DOCK7-Induced Septin disPlacement) complex. It may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH3 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409121  Cd Length: 109  Bit Score: 58.08  E-value: 2.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 548 LSDGQELCKFINKLHPES---ISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTVLTV 624
Cdd:cd21272  26 LTDGVVLCHLANHVRPRSvpsIHVPSPAVPKLTMAKCRRNVENFLEACRRIGVPQEQLCLPLHILEEKGLSQVAVTVQAL 105


                ...
gi 17550406 625 AKL 627
Cdd:cd21272 106 LEL 108
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
74-251 2.36e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 2.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   74 LLDTV-FLDLHDNRMSTLPADFSAfdCLISCIASSNRFRTIPTCICslEQLTFIDFSSNDI----SHLPDGLFDLplkal 148
Cdd:PRK15370 239 LPDTIqEMELSINRITELPERLPS--ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIrtlpAHLPSGITHL----- 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  149 ILANNKITCIPEgirRLAPTLAHLDFSKNDIRSLQSQLRylTSLEVLKISRNRVEDFPAELCSSLKlrTLDLSHNNLSYL 228
Cdd:PRK15370 310 NVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPTIT--TLDVSRNALTNL 382

                        170       180
                 ....*....|....*....|....
gi 17550406  229 PADFVKMtdLRYLQLECNPL-RSP 251
Cdd:PRK15370 383 PENLPAA--LQIMQASRNNLvRLP 404
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 548-622 7.20e-10

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 56.83  E-value: 7.20e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17550406 548 LSDGQELCKFINKLHPESISL---ASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKrNPQKVARTVL 622
Cdd:cd21273  29 LSNGAVLCQLANQLRPRSVSIihvPSPAVPKLSKAKCRKNVENFIEACRKMGVPEVDLCSPSDVLLQ-GPAAVLRTVL 105
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-250 8.94e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 8.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 131 NDISHLPdGLFDLP-LKALILANNKITCIpEGIRRLaPTLAHLDFSKNDIRSLqSQLRYLTSLEVLKISRNRVED----- 204
Cdd:cd21340  34 NKITKIE-NLEFLTnLTHLYLQNNQIEKI-ENLENL-VNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgeklt 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17550406 205 F-PAELCSSLK-LRTLDLSHNNLSYLpADFVKMTDLRYLQLECNPLRS 250
Cdd:cd21340 110 FdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISD 156
CH_LRCH1 cd21270
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 548-624 5.02e-09

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 1; Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1), also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. LRCH1 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409119  Cd Length: 112  Bit Score: 54.47  E-value: 5.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 548 LSDGQELCKFINKLHPES---ISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIIsKRNPQKVARTVLTV 624
Cdd:cd21270  29 LMDGVVLCHLVNHVRPRSvasIHVPSPAVPKLSMAKCRRNVENFLEACRKIGVPEADLCSPYDIL-QLNLRGIRKTVETL 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 521-621 6.21e-09

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 53.91  E-value: 6.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 521 ESARKLMREKLGPtfSLNKGDisFSLQLSDGQELCKFINKLHPESISLASStdssiattrSKM------NVDRFLQYCRK 594
Cdd:cd21210   3 QEAREWIEEVLGE--KLAQGD--LLDALKDGVVLCKLANRILPADIRKYKE---------SKMpfvqmeNISAFLNAARK 69

                        90       100
                ....*....|....*....|....*..
gi 17550406 595 IGVPETTLCSQMDIISKRNPQKVARTV 621
Cdd:cd21210  70 LGVPENDLFQTVDLFERKNPAQVLQCL 96
CH_LRCH2 cd21271
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 548-621 1.92e-08

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2; Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) may play a role in the organization of the cytoskeleton. It contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409120  Cd Length: 111  Bit Score: 52.62  E-value: 1.92e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17550406 548 LSDGQELCKFINKLHPES---ISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTV 621
Cdd:cd21271  30 LMDGVVLCHLANHIRPRSvgsIHVPSPAVPKLSMAKCRRNVENFLDACRKLGVPEDKLCLPHHILEEKGLVKVSVTV 106
LRR_9 pfam14580
Leucine-rich repeat;
119-206 2.30e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.00  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   119 SLEQLTFIDFSSNDISHLpDGLFDLP-LKALILANNKITCIPEGIRRLAPTLAHLDFSKNDIRSLQS--QLRYLTSLEVL 195
Cdd:pfam14580  40 TLDQFDTIDFSDNEIRKL-DGFPLLRrLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDldPLASLKKLTFL 118

                          90
                  ....*....|.
gi 17550406   196 KISRNRVEDFP 206
Cdd:pfam14580 119 SLLRNPVTNKP 129
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-225 2.51e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 2.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  80 LDLHDNRMSTLPADFSAfdclisciassnrfRTIPTCICSLEQLtfiDFSSNDISHlpDGLFDLP--------LKALILA 151
Cdd:cd00116 113 LKLNNNGLGDRGLRLLA--------------KGLKDLPPALEKL---VLGRNRLEG--ASCEALAkalranrdLKELNLA 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 152 NNKITciPEGIRRLAPTLAH------LDFSKNDIRSLQSQ-----LRYLTSLEVLKISRNRVEDFP-AELCSSLK----- 214
Cdd:cd00116 174 NNGIG--DAGIRALAEGLKAncnlevLDLNNNGLTDEGASalaetLASLKSLEVLNLGDNNLTDAGaAALASALLspnis 251

                       170
                ....*....|.
gi 17550406 215 LRTLDLSHNNL 225
Cdd:cd00116 252 LLTLSLSCNDI 262
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 548-621 4.95e-08

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 51.16  E-value: 4.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 548 LSDGQELCKFINKLHPESISlasstdsSIATtrSKM------NVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTV 621
Cdd:cd21207  32 LKDGVILCKLINILKPGSVK-------KINT--SKMafklmeNIENFLTACKGYGVPKTDLFQTVDLYEKKNIPQVTNCL 102
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-209 1.22e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.09  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   79 FLDLHDNRMSTLPADFSAfdCLISCIASSNRFRTIP-TCICSLEQLTFIDfssNDISHLPDglfDLP--LKALILANNKI 155
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPeTLPPGLKTLEAGE---NALTSLPA---SLPpeLQVLDVSKNQI 358

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17550406  156 TCIPEgirRLAPTLAHLDFSKNDIRSLQSQLRylTSLEVLKISRNRVEDFPAEL 209
Cdd:PRK15370 359 TVLPE---TLPPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
190-248 5.86e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.86e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17550406   190 TSLEVLKISRNRVEDFPAELCSSLK-LRTLDLSHNNLSYL-PADFVKMTDLRYLQLECNPL 248
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 543-626 1.08e-06

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 47.67  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   543 SFSLQLSDGQELCKFINKLHPESISLAsstdsSIATTRSKM--NVDRFLQYCR-KIGVPETTLCSQmDIIsKRNPQKVAR 619
Cdd:pfam00307  26 NFTTDLRDGLALCALLNKLAPGLVDKK-----KLNKSEFDKleNINLALDVAEkKLGVPKVLIEPE-DLV-EGDNKSVLT 98


                  ....*..
gi 17550406   620 TVLTVAK 626
Cdd:pfam00307  99 YLASLFR 105
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-267 1.42e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 1.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 122 QLTFIDFSSNDISH-----LPDGLFDLP-LKALILANNKITciPEGIRRLAPTLAH------LDFSKNDI-----RSLQS 184
Cdd:COG5238 265 TVETLYLSGNQIGAegaiaLAKALQGNTtLTSLDLSVNRIG--DEGAIALAEGLQGnktlhtLNLAYNGIgaqgaIALAK 342

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 185 QLRYLTSLEVLKISRNRVEDFPAE-LCSSLK----LRTLDLSHNNLS-----YLpADFVKMTDLRYLQLECNPLRSPSMD 254
Cdd:COG5238 343 ALQENTTLHSLDLSDNQIGDEGAIaLAKYLEgnttLRELNLGKNNIGkqgaeAL-IDALQTNRLHTLILDGNLIGAEAQQ 421

                       170
                ....*....|...
gi 17550406 255 IIEMGIVHIfKWL 267
Cdd:COG5238 422 RLEQLLERI-KSV 433
LRR_8 pfam13855
Leucine rich repeat;
167-225 2.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17550406   167 PTLAHLDFSKNDIRSL-QSQLRYLTSLEVLKISRNRVEDFPAELCSSL-KLRTLDLSHNNL 225
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
CH_TAGLN2 cd21280
calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis ...
 540-627 2.56e-06

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409129 [Multi-domain]  Cd Length: 137  Bit Score: 47.18  E-value: 2.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 540 GDISFSLQLSDGQELCKFINKLHPESISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVAR 619
Cdd:cd21280  31 GRENFQNWLKDGTVLCHLINSLYPKGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMASVQR 110


                ....*...
gi 17550406 620 TVLTVAKL 627
Cdd:cd21280 111 TLMNLGGL 118
SCP1 COG5199
Calponin [Cytoskeleton];
547-621 3.65e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 47.61  E-value: 3.65e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17550406 547 QLSDGQELCKFINKLHPESISLASSTDSSIattrSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTV 621
Cdd:COG5199  39 LLKDGVRLCRILNEASPLDIKYKESKMPFV----QMENISSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICL 109
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 135-246 6.74e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 6.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 135 HLPDGLFDLP--LKALILANNKITciPEGIRRLA------PTLAHLDFSKND-----IRSLQSQLRYLTSLEVLKISRNR 201
Cdd:cd00116 127 LLAKGLKDLPpaLEKLVLGRNRLE--GASCEALAkalranRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNG 204

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17550406 202 VED----FPAELCSSLK-LRTLDLSHNNLSYLPA----DFVKMTD--LRYLQLECN 246
Cdd:cd00116 205 LTDegasALAETLASLKsLEVLNLGDNNLTDAGAaalaSALLSPNisLLTLSLSCN 260
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
80-253 7.22e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 7.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   80 LDLHDNRMSTLPADFSAfdcLISCIASSNRFRTIPTCICSLEQLTFIDFSSNDISHLPDGLFDLplkalILANNKITCIP 159
Cdd:PRK15387 307 LSVSDNQLASLPALPSE---LCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKL-----WAYNNRLTSLP 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  160 EgirrLAPTLAHLDFSKNDIRSLQSqlrYLTSLEVLKISRNRVEDFPAeLCSSLklRTLDLSHNNLSYLPADFVKMTDLR 239
Cdd:PRK15387 379 A----LPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLPM-LPSGL--LSLSVYRNQLTRLPESLIHLSSET 448

                        170
                 ....*....|....
gi 17550406  240 YLQLECNPLRSPSM 253
Cdd:PRK15387 449 TVNLEGNPLSERTL 462
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 548-628 3.77e-05

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 43.80  E-value: 3.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 548 LSDGQELCKFINKLH---------------PESISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKR 612
Cdd:cd21204  32 LRNGVVLCQLAQKIQeaaekareagkkngpPPSYKLKCNENAKPGSFFARDNVANFLRWCRKLGVDEVLLFESEDLVLHK 111

                        90
                ....*....|....*.
gi 17550406 613 NPQKVARTVLTVAKLQ 628
Cdd:cd21204 112 NPRQVLLCLLELARIA 127
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 527-632 4.29e-05

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 42.69  E-value: 4.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406    527 MREKLGPTFSLNKGDisFSLQLSDGQELCKFINKLHPESISLAsSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQm 606
Cdd:smart00033   7 VNSLLAEYDKPPVTN--FSSDLKDGVALCALLNSLSPGLVDKK-KVAASLSRFKKIENINLALSFAEKLGGKVVLFEPE- 82

                           90       100
                   ....*....|....*....|....*.
gi 17550406    607 DIISKRNpqkvartvLTVAKLQQLQS 632
Cdd:smart00033  83 DLVEGPK--------LILGVIWTLIS 100
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-251 5.91e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 5.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  113 IPTCICSLEQLTFIDFSSNDIS-HLPDGLFDL--PLKALILANNKIT-CIPEGirrLAPTLAHLDFSKN--------DIR 180
Cdd:PLN00113  85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTssSLRYLNLSNNNFTgSIPRG---SIPNLETLDLSNNmlsgeipnDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  181 SLqSQLRYL------------------TSLEVLKISRNR-VEDFPAEL--CSSLK----------------------LRT 217
Cdd:PLN00113 162 SF-SSLKVLdlggnvlvgkipnsltnlTSLEFLTLASNQlVGQIPRELgqMKSLKwiylgynnlsgeipyeiggltsLNH 240

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 17550406  218 LDLSHNNLS-YLPADFVKMTDLRYLQLECNPLRSP 251
Cdd:PLN00113 241 LDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGP 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-226 1.16e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406   82 LHDNRMS-TLPADFSAFDCLISCIASSNRFR-TIPTCICSLEQLTFIDFSSNDIS-HLPDGLFDLPLKALILANNKIT-C 157
Cdd:PLN00113 411 LQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgA 490

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17550406  158 IPEGIRRLaPTLAHLDFSKNDIRS-LQSQLRYLTSLEVLKISRNRVE-DFPAELCSSLKLRTLDLSHNNLS 226
Cdd:PLN00113 491 VPRKLGSL-SELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS 560
CH_TAGLN-like cd21209
calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family ...
 540-627 4.59e-04

calponin homology (CH) domain found in the transgelin family; The transgelin (TAGLN) family includes transgelin, transgelin-2 and transgelin-3. Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. It may participate in the development and progression of multiple cancers. Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409058 [Multi-domain]  Cd Length: 119  Bit Score: 40.19  E-value: 4.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 540 GDISFSLQLSDGQELCKFINKLHPESISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVAR 619
Cdd:cd21209  26 GRLGFQKWLKDGTVLCKLINSLYPEGSKPVKKIQSSKMAFKQMEQISQFLKAAEDYGVRTTDIFQTVDLWEGKDMAAVQR 105


                ....*...
gi 17550406 620 TVLTVAKL 627
Cdd:cd21209 106 TLMALGSL 113
CH_AtKIN14-like cd21203
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ...
 521-598 4.75e-04

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409052 [Multi-domain]  Cd Length: 112  Bit Score: 40.09  E-value: 4.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 521 ESARKLMREKLGPTFSLNKGDISFSLQLSDGQELCKFINKLHPESIS--LASSTDSSIATT---RSKMNVDRFLQYCRKI 595
Cdd:cd21203   3 YEAAEWIQNVLGVLVLPDPSEEEFRLCLRDGVVLCKLLNKLQPGAVPkvVESPDDPDGAAGsafQYFENVRNFLVAIEEM 82


                ...
gi 17550406 596 GVP 598
Cdd:cd21203  83 GLP 85
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 548-602 7.54e-04

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 39.63  E-value: 7.54e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17550406 548 LSDGQELCKFINKLHPESISLASSTDSSIAttrsKM-NVDRFLQYCRKIGVPETTL 602
Cdd:cd21208  26 LEDGILLCELINAIKPGSIKKINRLPTPIA----GLdNLNLFLKACEDLGLKDSQL 77
CH_TAGLN3 cd21281
calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal ...
 540-624 2.95e-03

calponin homology (CH) domain found in transgelin-3; Transgelin-3, also called neuronal protein 22 (NP22), or neuronal protein NP25, may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurons. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409130 [Multi-domain]  Cd Length: 119  Bit Score: 38.02  E-value: 2.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 540 GDISFSLQLSDGQELCKFINKLHPESISLASSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVAR 619
Cdd:cd21281  26 GRQNFQKWLMDGTILCRLINSLYPPGKEPIKKISETKMAFKQMEKISQFLQAAEAYGVITTDIFQTVDLWEGKDMAAVQR 105


                ....*
gi 17550406 620 TVLTV 624
Cdd:cd21281 106 TLMAL 110
CH_CNN cd21211
calponin homology (CH) domain found in the calponin family; Calponin is an actin ...
 543-627 3.45e-03

calponin homology (CH) domain found in the calponin family; Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and many types of non-muscle cells. There are three calponin isoforms, calponin-1, -2, -3. All of them are actin-binding proteins with functions in inhibiting actin-activated myosin ATPase and stabilizing the actin cytoskeleton. Calponin-1 is specifically expressed in smooth muscle cells and plays a role in fine-tuning smooth muscle contractility. Calponin-2 is expressed in both smooth muscle and non-muscle cells and regulates multiple actin cytoskeleton-based functions. Calponin-3 is expressed in the brain and participates in actin cytoskeleton-based activities in embryonic development and myogenesis. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409060 [Multi-domain]  Cd Length: 108  Bit Score: 37.67  E-value: 3.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 543 SFSLQLSDGQELCKFINKLHPESIslaSSTDSSIATTRSKMNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTVL 622
Cdd:cd21211  23 NFQKGLKDGIILCELINKLQPGSV---KKINESMQNWHQLENIGNFIKAIVSYGMKPHDIFEANDLFENGNMTQVQVTLL 99


                ....*
gi 17550406 623 TVAKL 627
Cdd:cd21211 100 ALAGK 104
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-248 4.80e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 4.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  113 IPTCICSLEQLTFIDFSSNDIS-HLPDGLFDLP-LKALILANNKITC-IPEGIRRLaPTLAHLDFSKNDIR-SLQSQLRY 188
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQnLEILHLFSNNFTGkIPVALTSL-PRLQVLQLWSNKFSgEIPKNLGK 354

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17550406  189 LTSLEVLKISRNRVE-DFPAELCSSLKLRTLDLSHNNL-SYLPADFVKMTDLRYLQLECNPL 248
Cdd:PLN00113 355 HNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSF 416
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-231 4.85e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 4.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406  80 LDLHDNRMSTLPaDFSAFDCLISCIASSNRFRTIPTCiCSLEQLTFIDFSSNDISHL-------PDGLFDLPLKALILAN 152
Cdd:COG4886 233 LDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLklkelelLLGLNSLLLLLLLLNL 310

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17550406 153 NKITCIPEGIRRLAPTLAHLDFSKNDIRSLQSQLRYLTSLEVLKISRNRVEDFPAELCSSLKLRTLDLSHNNLSYLPAD 231
Cdd:COG4886 311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 527-626 5.49e-03

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 37.68  E-value: 5.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550406 527 MREKLGPTFS-LNKGDIS---FSLQLSDGQELCKFINKL----------HPESISLAS---------STDSSIATTRSKM 583
Cdd:cd21268  12 MKEDLAEWLNtLYNLDITadnFFEKLETGVLLCKHANNVtraarefqaqHPERASPLKlpprevifyRPSAKPGSFQARD 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 17550406 584 NVDRFLQYCRK-IGVPETTLCSQMDIISKRNPQKVARTVLTVAK 626
Cdd:cd21268  92 NVSNFINWCRQlLGIPEVLLFETDDLVLRKNEKNFVLCLLEVAR 135
LRR_8 pfam13855
Leucine rich repeat;
122-179 7.78e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17550406   122 QLTFIDFSSNDISHLPDGLF-DLP-LKALILANNKITCI-PEGIRRLaPTLAHLDFSKNDI 179
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkGLSnLKVLDLSNNLLTTLsPGAFSGL-PSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 190-225 8.05e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17550406   190 TSLEVLKISRNRVEDFPAeLCSSLKLRTLDLSHNNL 225
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 174-248 8.07e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 8.07e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17550406  174 FSKNDIrslqSQLRYLTSLevlKISRNRVE-DFPAELCSSLKLRTLDLSHNNLS-YLPADFVKMTDLRYLQLECNPL 248
Cdd:PLN03150 433 FIPNDI----SKLRHLQSI---NLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 214-248 9.15e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17550406   214 KLRTLDLSHNNLSYLPAdFVKMTDLRYLQLECNPL 248
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNK 35
CH_PIX cd21202
calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak ...
 548-626 9.87e-03

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409051 [Multi-domain]  Cd Length: 114  Bit Score: 36.36  E-value: 9.87e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17550406 548 LSDGQELCKFINKLHPESISLASSTDSSIATTRSkmNVDRFLQYCRKIGVPETTLCSQMDIISKRNPQKVARTVLTVAK 626
Cdd:cd21202  34 LKNGVVLCRLVNRLKPGTVEKIYDEPTTEEECLY--NFESFLKACQELGILAEEIFDPNDLYSGGNFQKVLSTLERLEK 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH