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Conserved domains on  [gi|17570127|ref|NP_508727|]
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TAFII28-like protein domain-containing protein [Caenorhabditis elegans]

Protein Classification

transcription initiation factor TFIID subunit 11 family protein( domain architecture ID 10520364)

transcription initiation factor TFIID subunit 11 (TAF11) family protein family protein similar to Drosophila melanogaster transcription initiation factor TFIID subunit 11 (TAF11), a component of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription

CATH:  1.10.20.10
Gene Ontology:  GO:0046982|GO:0051123|GO:0005669
PubMed:  31751889|14969724|19308322
SCOP:  4000797

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAFII28 pfam04719
hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of ...
 238-326 7.28e-41

hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. The conserved region is found at the C-terminal of most member proteins. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four alpha helices and three loops arranged as in histone H3.


:

Pssm-ID: 428086  Cd Length: 86  Bit Score: 138.00  E-value: 7.28e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127   238 VLLSNFSQEQLERYESYRRSSFQKSTIRRLISQYTGGvNVGQSVVIAIAGLAKVFVGEVVEEALDIRDINEEeaSNPLQP 317
Cdd:pfam04719   1 LLLSNFSEEQLDRYEVFRRSSFNKAVIKKLINSVLGQ-SVSQNVAIAVAGIAKVFVGEIVEEARDVQEEWGE--SGPLQP 77


                  ....*....
gi 17570127   318 HHIRQAFLR 326
Cdd:pfam04719  78 KHIREAYRR 86
 
Name Accession Description Interval E-value
TAFII28 pfam04719
hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of ...
 238-326 7.28e-41

hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. The conserved region is found at the C-terminal of most member proteins. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four alpha helices and three loops arranged as in histone H3.


Pssm-ID: 428086  Cd Length: 86  Bit Score: 138.00  E-value: 7.28e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127   238 VLLSNFSQEQLERYESYRRSSFQKSTIRRLISQYTGGvNVGQSVVIAIAGLAKVFVGEVVEEALDIRDINEEeaSNPLQP 317
Cdd:pfam04719   1 LLLSNFSEEQLDRYEVFRRSSFNKAVIKKLINSVLGQ-SVSQNVAIAVAGIAKVFVGEIVEEARDVQEEWGE--SGPLQP 77


                  ....*....
gi 17570127   318 HHIRQAFLR 326
Cdd:pfam04719  78 KHIREAYRR 86
HFD_TAF11 cd08048
histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and ...
 243-331 8.91e-36

histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and similar proteins; TAF11, also called TATA Binding Protein (TBP) associated factor 11, TFIID subunit p30-beta, or transcription initiation factor TFIID 28 kDa subunit (TAF(II)28, TAFII-28, TAFII28), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF11 interacts with the ligand binding domains of the nuclear receptors for vitamin D3 and thyroid hormone. TAF11 also directly interacts with TFIIA, acting as a bridging factor that stabilizes the TFIIA-TBP-DNA complex.


Pssm-ID: 467028  Cd Length: 87  Bit Score: 124.97  E-value: 8.91e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127 243 FSQEQLERYESYRRSSFQKSTIRRLISQYTGGVnVGQSVVIAIAGLAKVFVGEVVEEALDIRDiNEEEASNPLQPHHIRQ 322
Cdd:cd08048   1 FTEEQLERYEAFRRSKFNKSAIKRLMQSVLGQS-VSQNVVIVMAGIAKVFVGELVETARDVQE-EWGEATGPLQPKHLRE 78


                ....*....
gi 17570127 323 AFLRLGEQG 331
Cdd:cd08048  79 AYRRLKAEG 87
TAF40 COG5251
Transcription initiation factor TFIID, subunit TAF11 [Transcription];
224-327 1.67e-18

Transcription initiation factor TFIID, subunit TAF11 [Transcription];


Pssm-ID: 227576  Cd Length: 199  Bit Score: 82.40  E-value: 1.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127 224 DDEEENELSRLKTqvLLSNFSQEQLERYESYRRSSFQKSTIRRLISQYTGGvNVGQSVVIAIAGLAKVFVGEVVEEALDI 303
Cdd:COG5251  83 DENELAQDERFKL--LVTNLDEEQTNRYEVFRRTSLNKTQVKKLASTVANQ-TVSPNIRIFLQGVGKVFVGEIIELAMIV 159

                        90       100
                ....*....|....*....|....
gi 17570127 304 RdiNEEEASNPLQPHHIRQAFLRL 327
Cdd:COG5251 160 Q--NKWLTSGPLIPFHKREAYRYK 181
 
Name Accession Description Interval E-value
TAFII28 pfam04719
hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of ...
 238-326 7.28e-41

hTAFII28-like protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. The conserved region is found at the C-terminal of most member proteins. The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits. The conserved region contains four alpha helices and three loops arranged as in histone H3.


Pssm-ID: 428086  Cd Length: 86  Bit Score: 138.00  E-value: 7.28e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127   238 VLLSNFSQEQLERYESYRRSSFQKSTIRRLISQYTGGvNVGQSVVIAIAGLAKVFVGEVVEEALDIRDINEEeaSNPLQP 317
Cdd:pfam04719   1 LLLSNFSEEQLDRYEVFRRSSFNKAVIKKLINSVLGQ-SVSQNVAIAVAGIAKVFVGEIVEEARDVQEEWGE--SGPLQP 77


                  ....*....
gi 17570127   318 HHIRQAFLR 326
Cdd:pfam04719  78 KHIREAYRR 86
HFD_TAF11 cd08048
histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and ...
 243-331 8.91e-36

histone-fold domain found in transcription initiation factor TFIID subunit 11 (TAF11) and similar proteins; TAF11, also called TATA Binding Protein (TBP) associated factor 11, TFIID subunit p30-beta, or transcription initiation factor TFIID 28 kDa subunit (TAF(II)28, TAFII-28, TAFII28), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF11 interacts with the ligand binding domains of the nuclear receptors for vitamin D3 and thyroid hormone. TAF11 also directly interacts with TFIIA, acting as a bridging factor that stabilizes the TFIIA-TBP-DNA complex.


Pssm-ID: 467028  Cd Length: 87  Bit Score: 124.97  E-value: 8.91e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127 243 FSQEQLERYESYRRSSFQKSTIRRLISQYTGGVnVGQSVVIAIAGLAKVFVGEVVEEALDIRDiNEEEASNPLQPHHIRQ 322
Cdd:cd08048   1 FTEEQLERYEAFRRSKFNKSAIKRLMQSVLGQS-VSQNVVIVMAGIAKVFVGELVETARDVQE-EWGEATGPLQPKHLRE 78


                ....*....
gi 17570127 323 AFLRLGEQG 331
Cdd:cd08048  79 AYRRLKAEG 87
TAF40 COG5251
Transcription initiation factor TFIID, subunit TAF11 [Transcription];
224-327 1.67e-18

Transcription initiation factor TFIID, subunit TAF11 [Transcription];


Pssm-ID: 227576  Cd Length: 199  Bit Score: 82.40  E-value: 1.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570127 224 DDEEENELSRLKTqvLLSNFSQEQLERYESYRRSSFQKSTIRRLISQYTGGvNVGQSVVIAIAGLAKVFVGEVVEEALDI 303
Cdd:COG5251  83 DENELAQDERFKL--LVTNLDEEQTNRYEVFRRTSLNKTQVKKLASTVANQ-TVSPNIRIFLQGVGKVFVGEIIELAMIV 159

                        90       100
                ....*....|....*....|....
gi 17570127 304 RdiNEEEASNPLQPHHIRQAFLRL 327
Cdd:COG5251 160 Q--NKWLTSGPLIPFHKREAYRYK 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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