T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868    47 LHYLLLGLNPRELYQISFKLARIDEKKYKFNGN----FNEGDyyphknseiPMEDTEEIVHSDGYQTGARWMKTGVYFPK 122
Cdd:pfam00907  32 LKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGkwvvAGKAE---------PHSPPRVYIHPDSPATGSHWMKQPVSFDK 102

                          90       100
                  ....*....|....*....|....*.
gi 17550868   123 IGISKEQPDKERCLLLESLHAYFPVL 148
Cdd:pfam00907 103 LKLTNNKEDKNGHIILNSMHKYQPRL 128

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868    47 LHYLLLGLNPRELYQISFKLARIDEKKYKFNGN----FNEGDyyphknseiPMEDTEEIVHSDGYQTGARWMKTGVYFPK 122
Cdd:pfam00907  32 LKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGkwvvAGKAE---------PHSPPRVYIHPDSPATGSHWMKQPVSFDK 102

                          90       100
                  ....*....|....*....|....*.
gi 17550868   123 IGISKEQPDKERCLLLESLHAYFPVL 148
Cdd:pfam00907 103 LKLTNNKEDKNGHIILNSMHKYQPRL 128

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868    47 LHYLLLGLNPRELYQISFKLARIDEKKYKFNGN----FNEGDyyphknseiPMEDTEEIVHSDGYQTGARWMKTGVYFPK 122
Cdd:pfam00907  32 LKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGkwvvAGKAE---------PHSPPRVYIHPDSPATGSHWMKQPVSFDK 102

                          90       100
                  ....*....|....*....|....*.
gi 17550868   123 IGISKEQPDKERCLLLESLHAYFPVL 148
Cdd:pfam00907 103 LKLTNNKEDKNGHIILNSMHKYQPRL 128

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868  53 GLNPRELYQISFKLARIDEKKYKFNGNfneGDYYPHKNSEI-PMEDTEEIVHSDGYQTGARWMKTGVYFPKIGISKEQPD 131
Cdd:cd20681  40 GLEPDARYCVLLEMVLASDCRFKYSGN---GGWVPAGGAEPqPPLPRRIYIHPDSPATGDHWMSQPISFSKVKLTNNTLD 116

                        90
                ....*....|....*...
gi 17550868 132 KERCLLLESLHAYFPVLV 149
Cdd:cd20681 117 PQGNIVLTSMHKYQPRIH 134

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868  51 LLGLNPRELYQISFKLARIDEKKYKFNGNFNEgdyyPHKNSEiPMEDTEEIVHSDGYQTGARWMKTGVYFPKIGISKEQP 130
Cdd:cd20190  38 VTGLDPEAKYLFLLDVVPVDNARYKWNKRRWE----PSGKAE-PHLPDRVYIHPDSPAPGAHWMRQPISFHKLKLTNNTL 112

                        90
                ....*....|....*.
gi 17550868 131 DKERCLLLESLHAYFP 146
Cdd:cd20190 113 DPHGHLILHSMHKYQP 128

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868  32 EQMLTKRKKTNISQdLHYLLLGLNPRELYQISFKLARIDEKKYKFNGNfnegDYYPHKNSEIPMEDTEEIvHSDGYQTGA 111
Cdd:cd20196  20 EMIITKAGRRMFPQ-LRVSVSGLDPEARYLLLLDVVPVDGSRYRWQGN----SWEASGKAEPRLPDRVYI-HPDSPATGA 93

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17550868 112 RWMKTGVYFPKIGISKEQPDKERCLLLESLHAYFP 146
Cdd:cd20196  94 HWMRQPISFHRAKLTNNTLDPHGHIILHSMHRYQP 128

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868  29 HFLEQMLTKRKKtNISQDLHYLLLGLNPRELYQISFKLARIDEKKYKFNGnfneGDYYPHKNSEIPMEDTEEIVHSDGYQ 108
Cdd:cd20204  18 HQTEMIITKQGR-RMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQG----GKWVPCGKADTNVQGNRVYMHPDSPN 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 17550868 109 TGARWMKTGVYFPKIGISKEQ---PDKERCLLLESLHAYFPVL 148
Cdd:cd20204  93 TGAHWMRQEISFGKLKLTNNKgasNNNGQMVVLQSLHKYQPRL 135

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550868  53 GLNPRELYQISFKLARIDEKKYKFNgnFNEGDYYPHKNSEIPMEdTEEIVHSDGYQTGARWMKTGVYFPKIGISKEQPDK 132
Cdd:cd20191  42 GLDPHAQYIVAMDIVPVDNKRYRYV--YHSSKWMVAGNADAPVP-PRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDD 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 17550868 133 ERCLLLESLHAYFP---VLVFTTSSGISLEVPVWSQKFVTTMT 172
Cdd:cd20191 119 QGHIILHSMHKYQPrvhVIRKDSSTDLSPKKPVPPGEGVKTFS 161