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Conserved domains on  [gi|25151037|ref|NP_508291|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
73-149 8.41e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 8.41e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25151037  73 RLQETTNFDRKNVRFVSYSHDGAVMAVFANGCTLWVYREDQDMLNCELHEERGWdkILSVEFSPdDSHLLVTGSRDQ 149
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSP-DGKLLASGSDDG 310
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-45 1.71e-03

A Receptor for Ubiquitination Targets;


:

Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 25151037      5 LNELVLDYIGKQLNAKDLLRLSMANKALRGFFDNECYWQKL 45
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
FtnA super family cl42346
Ferritin [Inorganic ion transport and metabolism];
182-264 6.15e-03

Ferritin [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1528:

Pssm-ID: 441137  Cd Length: 158  Bit Score: 37.42  E-value: 6.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151037 182 LATWFDN------SHFLYMQSGGERDRMRIFMSSVNFSDEIIVY-----PILSFDT--KIVKILVAQHVSpRTRRITQIA 248
Cdd:COG1528  27 MAAWCDEkglpgfANFFRVQAQEERTHAMKFFDYLNDRGGRVELpaidaPPNEFESllEVFEAALEHEQK-VTKSINELV 105

                        90
                ....*....|....*.
gi 25151037 249 DQAQEEGKTLTQKLID 264
Cdd:COG1528 106 DLAREEKDYATENFLQ 121
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-149 8.41e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 8.41e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25151037  73 RLQETTNFDRKNVRFVSYSHDGAVMAVFANGCTLWVYREDQDMLNCELHEERGWdkILSVEFSPdDSHLLVTGSRDQ 149
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSP-DGKLLASGSDDG 310
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-45 1.71e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 25151037      5 LNELVLDYIGKQLNAKDLLRLSMANKALRGFFDNECYWQKL 45
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
FtnA COG1528
Ferritin [Inorganic ion transport and metabolism];
182-264 6.15e-03

Ferritin [Inorganic ion transport and metabolism];


Pssm-ID: 441137  Cd Length: 158  Bit Score: 37.42  E-value: 6.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151037 182 LATWFDN------SHFLYMQSGGERDRMRIFMSSVNFSDEIIVY-----PILSFDT--KIVKILVAQHVSpRTRRITQIA 248
Cdd:COG1528  27 MAAWCDEkglpgfANFFRVQAQEERTHAMKFFDYLNDRGGRVELpaidaPPNEFESllEVFEAALEHEQK-VTKSINELV 105

                        90
                ....*....|....*.
gi 25151037 249 DQAQEEGKTLTQKLID 264
Cdd:COG1528 106 DLAREEKDYATENFLQ 121
Nonheme_Ferritin cd01055
nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a ...
 182-264 7.98e-03

nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.


Pssm-ID: 153113  Cd Length: 156  Bit Score: 37.08  E-value: 7.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151037 182 LATWFDN------SHFLYMQSGGERDRMRIFMSSVNFSDEIIVY-----PILSFDTkIVKILVA--QHVSPRTRRITQIA 248
Cdd:cd01055  25 MAAWFDSkgldgfANFFRVQAQEEREHAMKFFDYLNDRGGRVELpaieaPPSEFES-LLEVFEAalEHEQKVTESINNLV 103

                        90
                ....*....|....*.
gi 25151037 249 DQAQEEGKTLTQKLID 264
Cdd:cd01055 104 DLALEEKDYATFNFLQ 119
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-149 8.41e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 8.41e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25151037  73 RLQETTNFDRKNVRFVSYSHDGAVMAVFANGCTLWVYREDQDMLNCELHEERGWdkILSVEFSPdDSHLLVTGSRDQ 149
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--VNSVAFSP-DGKLLASGSDDG 310
FBOX smart00256
A Receptor for Ubiquitination Targets;
5-45 1.71e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 25151037      5 LNELVLDYIGKQLNAKDLLRLSMANKALRGFFDNECYWQKL 45
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
WD40 COG2319
WD40 repeat [General function prediction only];
85-149 5.15e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 5.15e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25151037  85 VRFVSYSHDGAVMAVFANGCTLWVYREDQDMLNCELHEERGWdkILSVEFSPdDSHLLVTGSRDQ 149
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--VRSVAFSP-DGRLLASGSADG 268
FtnA COG1528
Ferritin [Inorganic ion transport and metabolism];
182-264 6.15e-03

Ferritin [Inorganic ion transport and metabolism];


Pssm-ID: 441137  Cd Length: 158  Bit Score: 37.42  E-value: 6.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151037 182 LATWFDN------SHFLYMQSGGERDRMRIFMSSVNFSDEIIVY-----PILSFDT--KIVKILVAQHVSpRTRRITQIA 248
Cdd:COG1528  27 MAAWCDEkglpgfANFFRVQAQEERTHAMKFFDYLNDRGGRVELpaidaPPNEFESllEVFEAALEHEQK-VTKSINELV 105

                        90
                ....*....|....*.
gi 25151037 249 DQAQEEGKTLTQKLID 264
Cdd:COG1528 106 DLAREEKDYATENFLQ 121
Nonheme_Ferritin cd01055
nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a ...
 182-264 7.98e-03

nonheme-containing ferritins; Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.


Pssm-ID: 153113  Cd Length: 156  Bit Score: 37.08  E-value: 7.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151037 182 LATWFDN------SHFLYMQSGGERDRMRIFMSSVNFSDEIIVY-----PILSFDTkIVKILVA--QHVSPRTRRITQIA 248
Cdd:cd01055  25 MAAWFDSkgldgfANFFRVQAQEEREHAMKFFDYLNDRGGRVELpaieaPPSEFES-LLEVFEAalEHEQKVTESINNLV 103

                        90
                ....*....|....*.
gi 25151037 249 DQAQEEGKTLTQKLID 264
Cdd:cd01055 104 DLALEEKDYATFNFLQ 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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