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Conserved domains on  [gi|71981758|ref|NP_507941|]
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7-dehydrocholesterol reductase [Caenorhabditis elegans]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 81-457 9.63e-34

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 131.41  E-value: 9.63e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758    81 FLRFPLVLQCVPPVWDTVAWKFSAVHCAIQLIFYWVLP--HDQALVMSSAGDQMREVNSFFSCILTCLLYVLGASAGVYR 158
Cdd:pfam01222  52 FIKDPSLMVFPGLEWERYLWTVFLLWYFFQAVFYLTLPgkVVEGLPLSNGRKLPYKINAFWSFLLTLAAIGVLHYTQLFE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   159 GDLVYLHFNSIILIFAIFA------VLIWAALIATYHFGT--GNSVTTISEFWFGIENHPKILDIDLKSFIRTRFTFVIW 230
Cdd:pfam01222 132 LTYLYDNFVQIMSSAILFSfalaiyLYVRSLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGSLDIKMFFELRPGLLGW 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   231 PLFVISAMYFHKITYGQISTSLVCLSSVQLLYIFQFHWNEDLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVAT 310
Cdd:pfam01222 212 VFINLAALLKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVH 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   311 NRSVGVISNclfcAVAIGSMVFTA-----KCDRQKYEFRKSKGTLKVggvdaffisaKYRTDSGDANTNLLLGSGHWGVC 385
Cdd:pfam01222 292 PSELGWSTY----AVAIYALLLCGyyifrSANSQKNNFRTNPADPKL----------IYLKYIQTKTGSGLLTDGWWGFA 357

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71981758   386 RHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYWAQYCSKVKYRFLPGVF 457
Cdd:pfam01222 358 RHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
81-457 9.63e-34

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 131.41  E-value: 9.63e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758    81 FLRFPLVLQCVPPVWDTVAWKFSAVHCAIQLIFYWVLP--HDQALVMSSAGDQMREVNSFFSCILTCLLYVLGASAGVYR 158
Cdd:pfam01222  52 FIKDPSLMVFPGLEWERYLWTVFLLWYFFQAVFYLTLPgkVVEGLPLSNGRKLPYKINAFWSFLLTLAAIGVLHYTQLFE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   159 GDLVYLHFNSIILIFAIFA------VLIWAALIATYHFGT--GNSVTTISEFWFGIENHPKILDIDLKSFIRTRFTFVIW 230
Cdd:pfam01222 132 LTYLYDNFVQIMSSAILFSfalaiyLYVRSLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGSLDIKMFFELRPGLLGW 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   231 PLFVISAMYFHKITYGQISTSLVCLSSVQLLYIFQFHWNEDLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVAT 310
Cdd:pfam01222 212 VFINLAALLKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVH 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   311 NRSVGVISNclfcAVAIGSMVFTA-----KCDRQKYEFRKSKGTLKVggvdaffisaKYRTDSGDANTNLLLGSGHWGVC 385
Cdd:pfam01222 292 PSELGWSTY----AVAIYALLLCGyyifrSANSQKNNFRTNPADPKL----------IYLKYIQTKTGSGLLTDGWWGFA 357

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71981758   386 RHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYWAQYCSKVKYRFLPGVF 457
Cdd:pfam01222 358 RHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 384-456 1.95e-06

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 46.31  E-value: 1.95e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981758 384 VCRHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAftDENRCLIKYGQYWAQYCSKVKyRFLPGV 456
Cdd:COG2020  44 YVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLLLYVLRIRR--EERRLRARFGEEYRAYAARVP-RLIPRL 113
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
81-457 9.63e-34

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 131.41  E-value: 9.63e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758    81 FLRFPLVLQCVPPVWDTVAWKFSAVHCAIQLIFYWVLP--HDQALVMSSAGDQMREVNSFFSCILTCLLYVLGASAGVYR 158
Cdd:pfam01222  52 FIKDPSLMVFPGLEWERYLWTVFLLWYFFQAVFYLTLPgkVVEGLPLSNGRKLPYKINAFWSFLLTLAAIGVLHYTQLFE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   159 GDLVYLHFNSIILIFAIFA------VLIWAALIATYHFGT--GNSVTTISEFWFGIENHPKILDIDLKSFIRTRFTFVIW 230
Cdd:pfam01222 132 LTYLYDNFVQIMSSAILFSfalaiyLYVRSLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGSLDIKMFFELRPGLLGW 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   231 PLFVISAMYFHKITYGQISTSLVCLSSVQLLYIFQFHWNEDLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVAT 310
Cdd:pfam01222 212 VFINLAALLKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVH 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981758   311 NRSVGVISNclfcAVAIGSMVFTA-----KCDRQKYEFRKSKGTLKVggvdaffisaKYRTDSGDANTNLLLGSGHWGVC 385
Cdd:pfam01222 292 PSELGWSTY----AVAIYALLLCGyyifrSANSQKNNFRTNPADPKL----------IYLKYIQTKTGSGLLTDGWWGFA 357

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71981758   386 RHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYWAQYCSKVKYRFLPGVF 457
Cdd:pfam01222 358 RHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 384-456 1.95e-06

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 46.31  E-value: 1.95e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981758 384 VCRHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAftDENRCLIKYGQYWAQYCSKVKyRFLPGV 456
Cdd:COG2020  44 YVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLLLYVLRIRR--EERRLRARFGEEYRAYAARVP-RLIPRL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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