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Conserved domains on  [gi|17566468|ref|NP_507895|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 145-283 2.18e-46

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 153.50  E-value: 2.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566468   145 KEFVEWLREITQSGSLLHTKRIRVIDCP-GDLLGVLSHCKPGFLEAIEF-YCFNSGKIDEITNLEQWKRAKSINIDSRRC 222
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSfSEVASILPYFDAGTLEEIELsSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17566468   223 DDIPIEHFFHFSRFTIRMGKLSVPDAIKIRDDLMKSAHFEYGIIDIYDELTPEAARVFNPN 283
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 20-65 7.78e-14

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 64.82  E-value: 7.78e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17566468  20 LFEMPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFKKVE 65
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 145-283 2.18e-46

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 153.50  E-value: 2.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566468   145 KEFVEWLREITQSGSLLHTKRIRVIDCP-GDLLGVLSHCKPGFLEAIEF-YCFNSGKIDEITNLEQWKRAKSINIDSRRC 222
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSfSEVASILPYFDAGTLEEIELsSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17566468   223 DDIPIEHFFHFSRFTIRMGKLSVPDAIKIRDDLMKSAHFEYGIIDIYDELTPEAARVFNPN 283
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 20-65 7.78e-14

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 64.82  E-value: 7.78e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17566468  20 LFEMPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFKKVE 65
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
23-63 4.66e-09

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 51.28  E-value: 4.66e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17566468     23 MPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFKK 63
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 20-62 8.90e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 8.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17566468    20 LFEMPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFK 62
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 145-283 2.18e-46

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 153.50  E-value: 2.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566468   145 KEFVEWLREITQSGSLLHTKRIRVIDCP-GDLLGVLSHCKPGFLEAIEF-YCFNSGKIDEITNLEQWKRAKSINIDSRRC 222
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSfSEVASILPYFDAGTLEEIELsSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17566468   223 DDIPIEHFFHFSRFTIRMGKLSVPDAIKIRDDLMKSAHFEYGIIDIYDELTPEAARVFNPN 283
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 20-65 7.78e-14

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 64.82  E-value: 7.78e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17566468  20 LFEMPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFKKVE 65
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
23-63 4.66e-09

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 51.28  E-value: 4.66e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17566468     23 MPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFKK 63
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 20-62 8.90e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 8.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17566468    20 LFEMPTEMVYKIAGKVDPFSRLTVRKVCRNLRNVIDDTDPGFK 62
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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