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Conserved domains on  [gi|72001383|ref|NP_507864|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-307 3.45e-96

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 287.13  E-value: 3.45e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    10 ASDELYSGILHILTCIEIPLHTFGAYLIVMKTPKKMKTVKASMLFLHFAGALVDIYLSFIAIPVLTLPVCSGYPLGFSLV 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    90 LGIPTSVQVYIGVSCVGVIGVSVLIFFESRYHQLIIGSSgGISWK--RLIYILFHYLLSATFIAPAFLDIPSEEYGRVFT 167
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKK-RITWKktRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383   168 FEKIPCIPSDIPFRPGYFVLATDNLIFCLCLSLMLSFVVPQVVFFVASIFRFLSNTVSH--SQTTTRLQRQFFIAMCIQL 245
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSslSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72001383   246 FIPFVVIFSPALFVVLAIRYDYYNQAANNMAMAAIAFHGVFTTLTMIMVHTPYRHATLEMLH 307
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-307 3.45e-96

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 287.13  E-value: 3.45e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    10 ASDELYSGILHILTCIEIPLHTFGAYLIVMKTPKKMKTVKASMLFLHFAGALVDIYLSFIAIPVLTLPVCSGYPLGFSLV 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    90 LGIPTSVQVYIGVSCVGVIGVSVLIFFESRYHQLIIGSSgGISWK--RLIYILFHYLLSATFIAPAFLDIPSEEYGRVFT 167
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKK-RITWKktRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383   168 FEKIPCIPSDIPFRPGYFVLATDNLIFCLCLSLMLSFVVPQVVFFVASIFRFLSNTVSH--SQTTTRLQRQFFIAMCIQL 245
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSslSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72001383   246 FIPFVVIFSPALFVVLAIRYDYYNQAANNMAMAAIAFHGVFTTLTMIMVHTPYRHATLEMLH 307
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-307 3.45e-96

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 287.13  E-value: 3.45e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    10 ASDELYSGILHILTCIEIPLHTFGAYLIVMKTPKKMKTVKASMLFLHFAGALVDIYLSFIAIPVLTLPVCSGYPLGFSLV 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    90 LGIPTSVQVYIGVSCVGVIGVSVLIFFESRYHQLIIGSSgGISWK--RLIYILFHYLLSATFIAPAFLDIPSEEYGRVFT 167
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKK-RITWKktRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383   168 FEKIPCIPSDIPFRPGYFVLATDNLIFCLCLSLMLSFVVPQVVFFVASIFRFLSNTVSH--SQTTTRLQRQFFIAMCIQL 245
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSslSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72001383   246 FIPFVVIFSPALFVVLAIRYDYYNQAANNMAMAAIAFHGVFTTLTMIMVHTPYRHATLEMLH 307
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
19-300 2.79e-07

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 51.39  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    19 LHILTCIEIPLHTFGAYLIVMKTPKkMKTVKASMLFLHFAGALVDIYLSFIAIPVLTLPVCSGYPLGF-SLVLGIPTSVQ 97
Cdd:pfam10327  15 YHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFlATVFGISSHYL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383    98 VYIGVSCVGVIGVSVLIFFESRyHQLI--IGSSGGIS--WKRLIYILFHYLLSATFIAPAFLDIPSEE---YGR------ 164
Cdd:pfam10327  94 MTIFVFLLSFQLESLLLCFVRK-HQAIakILSKHVIPkwLYIFLYILCHIFPFLTAFLFYQSGLSREEqleYVKenypey 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383   165 VFTFEKIPcipsdipfrpgYFVLATDN---LIFCLCLSLMLSFVVPQVVFFVASIFRFLSNTVSH-SQTTTRLQRQFFIA 240
Cdd:pfam10327 173 LSQFSSLP-----------NFAIYDYNpwlIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKiSAQTYQKHRAALRS 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001383   241 MCIQLFIPFVVIFSPALFVVLAIRYDYYNQAANNMAMAAIAFHGVFTTLTMIMVHTPYRH 300
Cdd:pfam10327 242 LIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRK 301
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
190-262 9.43e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 40.52  E-value: 9.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 72001383   190 DNLIFCLCLSLMLSFVVPQVVFFVASIFRFLSNTVSH-SQTTTRLQRQFFIAMCIQLFIPFVVIFSPALFVVLA 262
Cdd:pfam10326 193 RSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLgSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLL 266
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
221-259 7.18e-03

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 37.61  E-value: 7.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 72001383   221 SNTVSHSQTTTRLQRQFFIAMCIQLFIPFVVIFSPALFV 259
Cdd:pfam10319 228 KMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLA 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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