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Conserved domains on  [gi|17561454|ref|NP_507752|]
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PAZ domain-containing protein [Caenorhabditis elegans]

Protein Classification

PAZ domain-containing protein( domain architecture ID 11671)

PAZ (Piwi Argonaut and Zwille) domain-containing protein similar to PAZ domain region of argonaute proteins which play central roles in RNA silencing processes, as essential components of the RNA-induced silencing complex (RISC) that is responsible for the gene silencing phenomenon known as RNA interference (RNAi)

Gene Ontology:  GO:0005515|GO:0003676
PubMed:  14615802|12414724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAZ super family cl00301
PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two ...
 17-115 1.39e-07

PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a nucleic-acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes. This parent model also contains structures of an archaeal PAZ domain.


The actual alignment was detected with superfamily member cd02846:

Pssm-ID: 469713 [Multi-domain]  Cd Length: 114  Bit Score: 47.70  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561454  17 HLEYLSNIKKLAETITV-PTGIDVKISIKKHMPkknfgNVEVVYQHG---RRKTGIIQLSNNDAY-LMFGPRR--QMITV 89
Cdd:cd02846   1 AQPVIEFLKEFLGFDTPlGLSDNDRRKLKKALK-----GLKVEVTHRgntNRKYKIKGLSAEPASqQTFELKDgeKEISV 75

                        90       100
                ....*....|....*....|....*.
gi 17561454  90 EEHFRRRYNVELRHPKLRLFHFTNET 115
Cdd:cd02846  76 ADYFKEKYNIRLKYPNLPCLQVGRKG 101
 
Name Accession Description Interval E-value
PAZ_argonaute_like cd02846
PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex ...
 17-115 1.39e-07

PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the Piwi and Dicer families. PAZ functions as a nucleic acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes.


Pssm-ID: 239212 [Multi-domain]  Cd Length: 114  Bit Score: 47.70  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561454  17 HLEYLSNIKKLAETITV-PTGIDVKISIKKHMPkknfgNVEVVYQHG---RRKTGIIQLSNNDAY-LMFGPRR--QMITV 89
Cdd:cd02846   1 AQPVIEFLKEFLGFDTPlGLSDNDRRKLKKALK-----GLKVEVTHRgntNRKYKIKGLSAEPASqQTFELKDgeKEISV 75

                        90       100
                ....*....|....*....|....*.
gi 17561454  90 EEHFRRRYNVELRHPKLRLFHFTNET 115
Cdd:cd02846  76 ADYFKEKYNIRLKYPNLPCLQVGRKG 101
 
Name Accession Description Interval E-value
PAZ_argonaute_like cd02846
PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex ...
 17-115 1.39e-07

PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the Piwi and Dicer families. PAZ functions as a nucleic acid binding domain, with a strong preference for single-stranded nucleic acids (RNA or DNA) or RNA duplexes with single-stranded 3' overhangs. It has been suggested that the PAZ domain provides a unique mode for the recognition of the two 3'-terminal nucleotides in single-stranded nucleic acids and buries the 3' OH group, and that it might recognize characteristic 3' overhangs in siRNAs within RISC (RNA-induced silencing) and other complexes.


Pssm-ID: 239212 [Multi-domain]  Cd Length: 114  Bit Score: 47.70  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561454  17 HLEYLSNIKKLAETITV-PTGIDVKISIKKHMPkknfgNVEVVYQHG---RRKTGIIQLSNNDAY-LMFGPRR--QMITV 89
Cdd:cd02846   1 AQPVIEFLKEFLGFDTPlGLSDNDRRKLKKALK-----GLKVEVTHRgntNRKYKIKGLSAEPASqQTFELKDgeKEISV 75

                        90       100
                ....*....|....*....|....*.
gi 17561454  90 EEHFRRRYNVELRHPKLRLFHFTNET 115
Cdd:cd02846  76 ADYFKEKYNIRLKYPNLPCLQVGRKG 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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