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Conserved domains on  [gi|17563096|ref|NP_507571|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 7-292 1.10e-76

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 236.58  E-value: 1.10e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096     7 TFQHICALTSVFTNFLLMLLILTKSPSQLGTYKWLMLYTCLFELAYSSLDIFVEPTIRSFQSVSYVLQRLRRSLFGHDAT 86
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096    87 FFFL-----SYGF----------------CRFFKQNYIRGAKQSLLFVAPVVTGVAWGLLSWLTLNETPSKSEFLKTHFQ 145
Cdd:pfam10326  83 QILLalycgFYGVsisllavqfiyrylalCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096   146 QLYNMKIEECAYVAFHFWPVDAHGVTHPDAISFLCVAVMFLILGSSFASVIYFGIKCYQYISiQLGNVSSQsqATKTLQV 225
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMK-KLKSLGSE--KTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563096   226 QLFYSLIFQTAIPCIFMYLPTSAMFIIPMLDLGYDIRFPLLSMTIAIYPAIDPLPTIFIIKSYRRGL 292
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-292 1.10e-76

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 236.58  E-value: 1.10e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096     7 TFQHICALTSVFTNFLLMLLILTKSPSQLGTYKWLMLYTCLFELAYSSLDIFVEPTIRSFQSVSYVLQRLRRSLFGHDAT 86
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096    87 FFFL-----SYGF----------------CRFFKQNYIRGAKQSLLFVAPVVTGVAWGLLSWLTLNETPSKSEFLKTHFQ 145
Cdd:pfam10326  83 QILLalycgFYGVsisllavqfiyrylalCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096   146 QLYNMKIEECAYVAFHFWPVDAHGVTHPDAISFLCVAVMFLILGSSFASVIYFGIKCYQYISiQLGNVSSQsqATKTLQV 225
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMK-KLKSLGSE--KTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563096   226 QLFYSLIFQTAIPCIFMYLPTSAMFIIPMLDLGYDIRFPLLSMTIAIYPAIDPLPTIFIIKSYRRGL 292
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-292 1.10e-76

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 236.58  E-value: 1.10e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096     7 TFQHICALTSVFTNFLLMLLILTKSPSQLGTYKWLMLYTCLFELAYSSLDIFVEPTIRSFQSVSYVLQRLRRSLFGHDAT 86
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096    87 FFFL-----SYGF----------------CRFFKQNYIRGAKQSLLFVAPVVTGVAWGLLSWLTLNETPSKSEFLKTHFQ 145
Cdd:pfam10326  83 QILLalycgFYGVsisllavqfiyrylalCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096   146 QLYNMKIEECAYVAFHFWPVDAHGVTHPDAISFLCVAVMFLILGSSFASVIYFGIKCYQYISiQLGNVSSQsqATKTLQV 225
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMK-KLKSLGSE--KTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563096   226 QLFYSLIFQTAIPCIFMYLPTSAMFIIPMLDLGYDIRFPLLSMTIAIYPAIDPLPTIFIIKSYRRGL 292
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 12-290 1.30e-18

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 84.22  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096    12 CALtSVFTNFLLMLLILTKSPSQLGTYKWLMLYTCLFELAYSSLDIFVEPTIRSFQSVSYVLQR----LRRSLFGHDA-- 85
Cdd:pfam10319  15 GVL-SFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSdgpfFEYSELGQHAls 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096    86 ---TFFFLSYG-------------FCRFFKQNYIRGAKQSLLFVAPVVTGVAWGLLSWLTLNETPSKSEFLKTHFQQLYN 149
Cdd:pfam10319  94 arcSFISASYAvllihfiyrylvlFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096   150 MKIEECAYVAFHFWPVdahgvthPDAISFLCVAVMFLILGSSFASVIYFGIKCYQYISIQLGNVSSQSQATKTLQVQLFY 229
Cdd:pfam10319 174 VDSMDINMLGALYWEA-------SDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLK 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17563096   230 SLIFQTAIPCIFMYLPTSAMFIIPMLDLGYDIRFPLLSMT-IAIYPAIDPLPTIFIIKSYRR 290
Cdd:pfam10319 247 ALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 8-292 2.71e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 59.87  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096     8 FQHICALTSVFTNFLLMLLILTKSPSQLGTYKWLMLYTCLFELAYSSLDIFVEPTIRSfqsvsyvlqrlrrslfgHDATF 87
Cdd:pfam10317   4 YYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIP-----------------NGVSM 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096    88 FFLSYGFCRFFKQNYirgAKQSLLFVAPVVTGVAWGLL------SWLTLNETPSKSEFLKTHF----------------- 144
Cdd:pfam10317  67 ALISYGPCKYFGPWF---CYSGYSLLQHFLLHSGWSLLltfyyrYYILKHVDPKRKKLILLIIihyipslsqliviflsp 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096   145 -QQLYNMKIEECAYVAFHFWPVDAHGVThpDAISFLCVAVMFLILGSSFASVIyFGIKCYQYISIQLGNVSSQ-SQATKT 222
Cdd:pfam10317 144 tDFLPVEALTKELHPNYNLTDYTVTGFS--DLQSFPALINTLIMTIPVFPIPI-IILILRRKILKLLNSNSVNmSPTTKA 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17563096   223 LQVQLFYSLIFQTAIPCIFmYLPTSAMFIIpMLDLGYDIRFP--LLSMTIAIYPAIDPLPTIFIIKSYRRGL 292
Cdd:pfam10317 221 QHRQLIKGLTIQALLPLFS-YIPGVTLYLL-SQLTGTEFLILeyFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 177-298 7.03e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 49.85  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563096   177 SFLCVAVMFLILGSSFASVIYFGIKCYQYISIQLGnvSSQSQATKTLQVQLFYSLIFQTAIPCIFMYLPTSAMFIIPMLD 256
Cdd:pfam10318 183 STYFLICIVLLILILIIQILFFVFLTIYYLFKSVK--SSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 17563096   257 LgYDIRFP-LLSMTIAIYPAIDPLPTIFIIKSYRRGLTDVFRC 298
Cdd:pfam10318 261 Y-YNQALNnLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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