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Conserved domains on  [gi|193209150|ref|NP_507519|]
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MFS domain-containing protein [Caenorhabditis elegans]

Protein Classification

OFA family MFS transporter( domain architecture ID 13024068)

OFA (oxalate:formate antiporter) family major facilitator superfamily (MFS) transporter similar to OFA, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation, to generate an electrochemical proton gradient that is the source of energy for ATP synthesis in this cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 23-450 8.60e-97

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 296.44  E-value: 8.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  23 RICVILFGAVSIHLTIGTYHTFGNMLPYMASYMrnftDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSStFSPRVSAFIGC 102
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 103 FLVTSSVALSAYAIQhsFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNP 182
Cdd:cd17353   76 ILFGLGFILSAFAIS--LPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 183 LNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESileeddedmdedyerPVFDNDEDTT 262
Cdd:cd17353  154 VGVPTT-----------------FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVD---------------PLANNAENSP 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 263 IQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFI-EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIA 341
Cdd:cd17353  202 RDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 342 LSTATCLASVFLLTMPMTRELgKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQ 421
Cdd:cd17353  282 LSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA 360

                        410       420
                 ....*....|....*....|....*....
gi 193209150 422 FYLKAIGYTYLFIITSIFPFCAFIFISCI 450
Cdd:cd17353  361 YVLYTGGYNAAFIIAAALSLVALALALLL 389
 
Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 23-450 8.60e-97

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 296.44  E-value: 8.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  23 RICVILFGAVSIHLTIGTYHTFGNMLPYMASYMrnftDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSStFSPRVSAFIGC 102
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 103 FLVTSSVALSAYAIQhsFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNP 182
Cdd:cd17353   76 ILFGLGFILSAFAIS--LPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 183 LNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESileeddedmdedyerPVFDNDEDTT 262
Cdd:cd17353  154 VGVPTT-----------------FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVD---------------PLANNAENSP 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 263 IQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFI-EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIA 341
Cdd:cd17353  202 RDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 342 LSTATCLASVFLLTMPMTRELgKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQ 421
Cdd:cd17353  282 LSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA 360

                        410       420
                 ....*....|....*....|....*....
gi 193209150 422 FYLKAIGYTYLFIITSIFPFCAFIFISCI 450
Cdd:cd17353  361 YVLYTGGYNAAFIIAAALSLVALALALLL 389
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
 27-445 9.88e-50

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 173.79  E-value: 9.88e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150   27 ILFGAVSIHLTIGTYHTFGNMLPYMASYMRnftdpSVRIEHMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVT 106
Cdd:TIGR00890   5 VLVGTVIMCFTSGYVYTWTLLAPPLGRYFG-----VGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  107 SSVALsaYAIQHSFALFFIVYGLLfGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNplnlp 186
Cdd:TIGR00890  80 LGFTF--YAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVIN----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  187 atkdgyflqpelLHRVPALFTKLAVIYGIMQAMALIVVCDPPFRKSRStesileeddedmdedyerpvfdNDEDTTIQMT 266
Cdd:TIGR00890 152 ------------LEGVPAAFIYMGIIFLLVIVLGAFLIGYPPGQLIKT----------------------NIEVSVKDYT 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  267 SSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTAT 346
Cdd:TIGR00890 198 VWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVF 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  347 CLASVFLLTMPMTRELGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKA 426
Cdd:TIGR00890 278 GISAVGMAAMLFIPMLNDVLFLATVALVFFTWGGTISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTE 357

                         410
                  ....*....|....*....
gi 193209150  427 IGYTYLFIITSIFPFCAFI 445
Cdd:TIGR00890 358 IGFEYTFIVTGAFALTSLA 376
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
26-446 3.37e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 86.09  E-value: 3.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  26 VILFGAVSIHLTIGTYHTFGNMLPYMASYMrNFTDPSVriehMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLV 105
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQL----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 106 TSSVALSAYAiqHSFALFfIVYGLLFGLGSGIAYVTAVSTAINW-APDKIGVISGIVAAGFGLSSSIFAPIQTMIVNPLN 184
Cdd:COG2223   81 GIGLLLLALA--VSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 185 LPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESILeeddedmdedyerpvfdndedttiq 264
Cdd:COG2223  158 WRNA-----------------FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL------------------------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 265 MTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAF-SIASVANAIARIGWGYLTDRTSFQIALS 343
Cdd:COG2223  196 RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLL 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 344 TATCLASVFLLTMPMTReLGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFY 423
Cdd:COG2223  276 IVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354

                        410       420
                 ....*....|....*....|....
gi 193209150 424 LKAIG-YTYLFIITSIFPFCAFIF 446
Cdd:COG2223  355 LDATGsYTAAFLVFAVLALVALVL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
80-415 2.79e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150   80 FAMVIGGLTSSTFSPRVSAFIGcfLVTSSVALSAYAIQHSFALFFIVyGLLFGLGSGIAYVTAVSTAINWAPDKI-GVIS 158
Cdd:pfam07690  47 LAQPLAGRLSDRFGRRRVLLIG--LLLFALGLLLLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPPEErGRAL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  159 GIVAAGFGLSSSIFAPIQTMIVNPLNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESI 238
Cdd:pfam07690 124 GLVSAGFGLGAALGPLLGGLLASLFGWRAA-----------------FLILAILSLLAAVLLLLPRPPPESKRPKPAEEA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  239 LEEDDEDMDEDYERPVFDndedttiqmtssemlksptfycLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIA 318
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLW----------------------LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  319 SVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTF-ICMGATHALFITATVKCFGNRH 397
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgFGFGLVFPALNALVSDLAPKEE 324

                         330
                  ....*....|....*...
gi 193209150  398 KANNYGYLILSTTTSGIL 415
Cdd:pfam07690 325 RGTASGLYNTAGSLGGAL 342
 
Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 23-450 8.60e-97

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 296.44  E-value: 8.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  23 RICVILFGAVSIHLTIGTYHTFGNMLPYMASYMrnftDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSStFSPRVSAFIGC 102
Cdd:cd17353    1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 103 FLVTSSVALSAYAIQhsFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNP 182
Cdd:cd17353   76 ILFGLGFILSAFAIS--LPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 183 LNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESileeddedmdedyerPVFDNDEDTT 262
Cdd:cd17353  154 VGVPTT-----------------FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVD---------------PLANNAENSP 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 263 IQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFI-EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIA 341
Cdd:cd17353  202 RDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 342 LSTATCLASVFLLTMPMTRELgKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQ 421
Cdd:cd17353  282 LSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA 360

                        410       420
                 ....*....|....*....|....*....
gi 193209150 422 FYLKAIGYTYLFIITSIFPFCAFIFISCI 450
Cdd:cd17353  361 YVLYTGGYNAAFIIAAALSLVALALALLL 389
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
 27-445 9.88e-50

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 173.79  E-value: 9.88e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150   27 ILFGAVSIHLTIGTYHTFGNMLPYMASYMRnftdpSVRIEHMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVT 106
Cdd:TIGR00890   5 VLVGTVIMCFTSGYVYTWTLLAPPLGRYFG-----VGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  107 SSVALsaYAIQHSFALFFIVYGLLfGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNplnlp 186
Cdd:TIGR00890  80 LGFTF--YAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVIN----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  187 atkdgyflqpelLHRVPALFTKLAVIYGIMQAMALIVVCDPPFRKSRStesileeddedmdedyerpvfdNDEDTTIQMT 266
Cdd:TIGR00890 152 ------------LEGVPAAFIYMGIIFLLVIVLGAFLIGYPPGQLIKT----------------------NIEVSVKDYT 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  267 SSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTAT 346
Cdd:TIGR00890 198 VWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVF 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  347 CLASVFLLTMPMTRELGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKA 426
Cdd:TIGR00890 278 GISAVGMAAMLFIPMLNDVLFLATVALVFFTWGGTISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTE 357

                         410
                  ....*....|....*....
gi 193209150  427 IGYTYLFIITSIFPFCAFI 445
Cdd:TIGR00890 358 IGFEYTFIVTGAFALTSLA 376
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
26-446 3.37e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 86.09  E-value: 3.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  26 VILFGAVSIHLTIGTYHTFGNMLPYMASYMrNFTDPSVriehMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLV 105
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQL----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 106 TSSVALSAYAiqHSFALFfIVYGLLFGLGSGIAYVTAVSTAINW-APDKIGVISGIVAAGFGLSSSIFAPIQTMIVNPLN 184
Cdd:COG2223   81 GIGLLLLALA--VSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 185 LPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESILeeddedmdedyerpvfdndedttiq 264
Cdd:COG2223  158 WRNA-----------------FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL------------------------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 265 MTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAF-SIASVANAIARIGWGYLTDRTSFQIALS 343
Cdd:COG2223  196 RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLL 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 344 TATCLASVFLLTMPMTReLGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFY 423
Cdd:COG2223  276 IVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354

                        410       420
                 ....*....|....*....|....
gi 193209150 424 LKAIG-YTYLFIITSIFPFCAFIF 446
Cdd:COG2223  355 LDATGsYTAAFLVFAVLALVALVL 378
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 83-444 1.21e-13

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 72.06  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  83 VIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAIQHSFAlfFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVA 162
Cdd:cd17314   56 PILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPL--SYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPT 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 163 AGFGLSSSIFAPIQTMIVnplnlpatkdgyflqpellhrvpaLFTKLAVIYGIMQAMALIVVcdppfrksrsteSILEED 242
Cdd:cd17314  134 TGYSLGLVLGSPLLRILW------------------------VFYGLALVYTILGILAAIVL------------SVVSLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 243 DEDMDEDYERPVFDNDEDTtiqMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAF-SIASVA 321
Cdd:cd17314  178 GFKEPPDNQARLHVQKKKT---QTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLmSIYGLF 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 322 NAIARIGWGYLTDRTSFQIALSTAT-CLASVFLLTMPMTRELGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKAN 400
Cdd:cd17314  255 NAFGRLLWGIVADFFGGRLSTLSILlTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFAT 334

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 193209150 401 NYGYLILSTTTSGILLAAI-SQFYLKAIGYTYLFIITSIFPFCAF 444
Cdd:cd17314  335 LYGILLFAPAIGSILGPMLgAKFYDRTPSYISAVYIYAVIVFLAS 379
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 68-448 1.97e-12

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 68.35  E-value: 1.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  68 MMWIP-TFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYGLLFGLGSGIAYVTAVSTA 146
Cdd:cd17352   40 IAWIGsLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFA--TSLWQLYLTYGVLGGLGLGLIYSPAIVIV 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 147 INWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVnplnlpatkDGYFLQPELLhrvpalftklavIYGIMqaMALIVVCd 226
Cdd:cd17352  118 GQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLL---------DNYGWRGALL------------ILGGL--CLNLCVC- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 227 ppfrksrstesileeddedmdedyerpvfdndedttiqMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIE 306
Cdd:cd17352  174 --------------------------------------GLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGI 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 307 DDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCL--ASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHAL 384
Cdd:cd17352  216 DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLliLGLSLLAFPLATTYVGLIVFSVLFG--FCSGSYSSL 293

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193209150 385 FITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIG-YTYLFIITSIFPFCAFIFIS 448
Cdd:cd17352  294 TPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAFYFCGACLLLSGVLLF 358
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 71-410 1.54e-09

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 59.59  E-value: 1.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  71 IPTFQGCFPFAMVIGGLTS-------STFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYGLLFGLGSGIAYVTAV 143
Cdd:cd17355   37 RAVISLAFTVGLLAFGLAQpfvgrllDRFGPRRVMLLGLLLLAAGLVLLALA--TSLWQLYLLWGLLGGGGAGTLAAVAF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 144 STAINWAPD-KIGVISGIVAAGFGLSSSIFAPIQTMIVNPLNLPATkdgyflqpellhrvpalftklAVIYGIMQAMALI 222
Cdd:cd17355  115 ATVAAWWFErRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA---------------------LLVLALLALLVLV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 223 VVCDPPFRKSRSTesileeddedmdedyERPVFDNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGE 302
Cdd:cd17355  174 PVLLLLRRRPADL---------------ALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 303 SFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTFiCMGATH 382
Cdd:cd17355  239 DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGL-GWGATV 317

                        330       340
                 ....*....|....*....|....*...
gi 193209150 383 ALFITATVKCFGNRHKANNYGYLILSTT 410
Cdd:cd17355  318 PLTAALAARYFGARSYGTLFGLVFAPHQ 345
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 86-407 1.21e-06

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 50.33  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  86 GLTSSTFSPRVSAFIGCFLVTSSVALSAYAIQH-----SFALFFiVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGI 160
Cdd:cd17354   58 GLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTGlisdlSFWLMC-LCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGI 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 161 VAAGFGLSSSIFAPIQTMIvnplnlpatkdgyflqpeLLHRVPALFTKLAVIYGIMQAMALIVVcdppfrksrstesile 240
Cdd:cd17354  137 PKGCYGLSGAIGSQLYKAL------------------FFHDSARVFLFLAVLPAVVGLLAWFSV---------------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 241 eddedmdedyerpvfdndedTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFmAMAFSIASV 320
Cdd:cd17354  183 --------------------RIVSIEEGEFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQSLTGPSNT-STLVSLFSI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 321 ANAIARIGWGYLTD---------RTSFQIALSTATCLASVFLLTMPMtreLGKMAFLFWLVGtfICMGATHALFITATVK 391
Cdd:cd17354  242 FSFLGRLLSGLLSDlfvrkfrlpRPSRMVLLLLILSLGHLLQAFGLP---SGALYVASALIG--FGYGGLFSIAPTIVSE 316

                        330
                 ....*....|....*.
gi 193209150 392 CFGNRHKANNYGYLIL 407
Cdd:cd17354  317 LFGLKNFGTNYGFLML 332
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-447 2.27e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.48  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  74 FQGCFPFAMVIGGLTSSTFSPRVSAFIGcfLVTSSVALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTAINWAPDK 153
Cdd:COG2271   54 FFLGYALGQIPAGLLADRFGRRRVLAIG--LLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 154 I-GVISGIVAAGFGLSSSIFAPIQTMIVNPLNLPATkdgyFLqpellhrVPALftkLAVIYGIMQAMALIVVcdppfrks 232
Cdd:COG2271  131 ErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA----FL-------ILGL---PGLLLALLRFWLLALA-------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 233 rstesileeddedmdedyerpvfdndedttiqmtssemlksptFYCLFASLFCCSFYANMFynLYKTYGESFIEddmfMA 312
Cdd:COG2271  189 -------------------------------------------YFLVYFALYGFLTWLPTY--LVEVRGLSLAQ----AG 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 313 MAFSIASVANAIARIGWGYLTDRT--SFQIALSTATCLASVFLLTMPMTRELgkMAFLFWLVGTFICMGATHALFITATV 390
Cdd:COG2271  220 LLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSP--ALAIALLFLAGFGLGGAFGLLWALAA 297

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 193209150 391 KCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIFI 447
Cdd:COG2271  298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 69-446 5.39e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 5.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  69 MWIPTFQGCFPFAMVIGGLTSSTFSPRVSA--FIGCFLVTSSVALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTA 146
Cdd:cd06174   31 SQLGLLFALFSLGYALLQPLAGLLADRFGRrpVLLLGLLLFALGALLFAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALI 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 147 INWAPDKI-GVISGIVAAGFGLSSSIFAPIqtmivnplnlpatkdGYFLQPELLHRVPALFTKLAVIYGIMQAMALIVVC 225
Cdd:cd06174  110 ADLFPERErGRALGLLQAFGSVGGILGPLL---------------GGILASSLGFGWRAVFLIAAALALLAAILLLLVVP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 226 DPPFRKSRSTESILEEddedmdedyerpvfdndedTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFI 305
Cdd:cd06174  175 DPPESARAKNEEASSK-------------------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 306 EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVgTFICMGATHALF 385
Cdd:cd06174  236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL-LGFGLGGLLPLS 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193209150 386 ITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKA-IGYTYLFIITSIFPFCAFIF 446
Cdd:cd06174  315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAIL 376
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
77-399 5.51e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.25  E-value: 5.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  77 CFPFAMVIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYgLLFGLGSGIAYVTAVSTAINWAPDKIGV 156
Cdd:COG2807   65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA--PSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 157 ISGIVAAGFGLSSSIFAPIQTMIVNPLNLPatkdgyflqpellhrvPALftklaVIYGIMQAMALIVVCdPPFRKSRSTE 236
Cdd:COG2807  142 MTGLYTAAMGLGAALAAGLTVPLAAALGWR----------------GAL-----AVWALLALLALLLWL-PLLRRRPAAA 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 237 SileeddedmdedyerpvfdndeDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFS 316
Cdd:COG2807  200 A----------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLS 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 317 IASVANAIARIGWGYLTDRTSFQ----IALSTATCLASVFLLTMPMTrelgkmAFLFWLVGTFICMGATHALFITATVKC 392
Cdd:COG2807  258 LFQLAGIPGSLLVPLLADRLGDRrpllLLLGLLGLAGLLGLLLAPGS------LPWLWAVLLGLGQGGLFPLALTLIGLR 331


                 ....*..
gi 193209150 393 FGNRHKA 399
Cdd:COG2807  332 ARTPAEA 338
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
76-399 9.76e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 9.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  76 GCFPFAMVIGGLTSSTFS---PRVSAFIGCFLVTSsVALSAYAIQHSFALFfIVYGLLFGLGSGIAYVTAVSTAINWAP- 151
Cdd:COG2814   52 TAYLLGAALGAPLAGRLAdrfGRRRVLLLGLLLFA-LGSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPp 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 152 DKIGVISGIVAAGFGLSSSIFAPIQTMIVNPLNLPAtkdgyflqpellhrvpaLFTKLAVIYGIMQAMALIVVCDP-PFR 230
Cdd:COG2814  130 ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW-----------------VFLVNAVLALLALLLLLRLLPESrPAA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 231 KSRSTESILeeddedmdedyerpvfdndedttiqmtssEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIE-DDM 309
Cdd:COG2814  193 RARLRGSLR-----------------------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSAS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 310 FMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHALFITAT 389
Cdd:COG2814  244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG--FGFGLLFPLLQALV 321

                        330
                 ....*....|
gi 193209150 390 VKCFGNRHKA 399
Cdd:COG2814  322 AELAPPEARG 331
MFS_1 pfam07690
Major Facilitator Superfamily;
80-415 2.79e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150   80 FAMVIGGLTSSTFSPRVSAFIGcfLVTSSVALSAYAIQHSFALFFIVyGLLFGLGSGIAYVTAVSTAINWAPDKI-GVIS 158
Cdd:pfam07690  47 LAQPLAGRLSDRFGRRRVLLIG--LLLFALGLLLLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFPPEErGRAL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  159 GIVAAGFGLSSSIFAPIQTMIVNPLNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRKSRSTESI 238
Cdd:pfam07690 124 GLVSAGFGLGAALGPLLGGLLASLFGWRAA-----------------FLILAILSLLAAVLLLLPRPPPESKRPKPAEEA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  239 LEEDDEDMDEDYERPVFDndedttiqmtssemlksptfycLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIA 318
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLW----------------------LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  319 SVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTF-ICMGATHALFITATVKCFGNRH 397
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgFGFGLVFPALNALVSDLAPKEE 324

                         330
                  ....*....|....*...
gi 193209150  398 KANNYGYLILSTTTSGIL 415
Cdd:pfam07690 325 RGTASGLYNTAGSLGGAL 342
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 76-171 3.10e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.93  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  76 GCFPFAMVIGGLtSSTFSPRVSAFIGCFLVTSSVALSAYAIQHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAP-DKI 154
Cdd:cd17321  216 AMLVAAPLAGRL-ADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPkEKA 294

                         90
                 ....*....|....*..
gi 193209150 155 GVISGIVAAGFGLSSSI 171
Cdd:cd17321  295 GAASGILNTARQLGGAL 311
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
265-447 1.19e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 265 MTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALST 344
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 345 ATCLASVFLLTMPMTRELGkmAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYL 424
Cdd:COG2814   81 GLLLFALGSLLCALAPSLW--LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180
                 ....*....|....*....|...
gi 193209150 425 KAIGYTYLFIITSIFPFCAFIFI 447
Cdd:COG2814  159 DLFGWRWVFLVNAVLALLALLLL 181
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 80-447 1.65e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  80 FAMVIGGLTSSTFSPRVSAFIGcfLVTSSVALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTAI-NWAPDKIGVIS 158
Cdd:cd17325   46 LFSPPAGRLSDRFGRKRLLLLG--LLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIAdIAPPEERGRAM 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 159 GIVAAGFGLSSSIFAPIqtmivnplnlpatkdGYFLQPELLHRVPALFtkLAVIYGImqAMALIVVCDPPFRKSRSTESI 238
Cdd:cd17325  123 GIFSSAIGLGFLIGPLL---------------GGLLADALGYRAPFLV--CAALALL--ALVLALLLLPEPRPPPNKRAV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 239 LEEDDEDMDEdyerpvfdndedttiqmtssEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIE-DDMFMAMAFSI 317
Cdd:cd17325  184 SAARLRSGLR--------------------LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGA 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 318 ASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHALFITATVKCFGNRH 397
Cdd:cd17325  244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG--LGLGLVFPATLALLADIVPPEG 321

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 193209150 398 KANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIFI 447
Cdd:cd17325  322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_1 pfam07690
Major Facilitator Superfamily;
279-447 2.40e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  279 LFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPM 358
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  359 TRELGKMAFLFWLVGtfICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSI 438
Cdd:pfam07690  82 ASSLWLLLVLRVLQG--LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159


                  ....*....
gi 193209150  439 FPFCAFIFI 447
Cdd:pfam07690 160 LSLLAAVLL 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
311-446 4.63e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 311 MAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHALFITATV 390
Cdd:COG2271   47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLG--LGEAGFFPAALKLIA 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193209150 391 KCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIF 446
Cdd:COG2271  125 EWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 80-171 5.41e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  80 FAMVIGGLTSSTFSPRVSAFIGCFLVTssVALSAYAIQHSFALFFIVYGLLFGLGSGiAYV--TAVSTAINWAPDKIGVI 157
Cdd:cd17355  260 VGRLLSGWLGDRYSPRRLLAASYALRA--LGLALLLLLPFPPLALLLFAALFGLGWG-ATVplTAALAARYFGARSYGTL 336

                         90
                 ....*....|....
gi 193209150 158 SGIVAAGFGLSSSI 171
Cdd:cd17355  337 FGLVFAPHQLGSAL 350
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 90-180 5.90e-03

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 38.64  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  90 STFSPRVSAFIGCFLVTSSVALSAYAIQHSFALFfiVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSS 169
Cdd:cd17428   63 SSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIF--SYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGL 140

                         90
                 ....*....|.
gi 193209150 170 SIFAPIQTMIV 180
Cdd:cd17428  141 FIYAALQRELI 151
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
76-446 6.41e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 6.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  76 GCFPFAMVIGGLTSSTFSPRVSAFIGC------FLVTSSVALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTAINW 149
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYkrglllGLLLMALGLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAAL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 150 APDKIGVISGIVAAGFGLSSSIFAPIQTMIvnplnlpatkdgyflqpeLLHRVPALFTKLAVIYGIMQAMALIVVCDPPF 229
Cdd:COG0738  125 GPETAASRLNLLHAFFSLGALLGPLLGGLL------------------ILLGLSLSWHLPYLILAVLLLLLALLFLRSKL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 230 RKSRSTEsileeddedmdedyerpvfdnDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDM 309
Cdd:COG0738  187 PEIEEEE---------------------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSE 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150 310 FMA-MAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRelGKMAFLFWLVGTFICMGATHALFITA 388
Cdd:COG0738  246 ATAaLGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP--GPWLALIGLALVGLGLSLMFPTIFSL 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 193209150 389 TVKCFGNRHkANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIF 446
Cdd:COG0738  324 ALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 84-180 7.08e-03

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 38.64  E-value: 7.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  84 IGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAA 163
Cdd:cd17424   57 LGSLISNHLSCQVGIILGGLLASTGLILSSFA--TSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMS 134

                         90
                 ....*....|....*..
gi 193209150 164 GFGLSSSIFAPIQTMIV 180
Cdd:cd17424  135 GSGIGTFILAPVVQLLI 151
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 80-169 9.78e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 38.25  E-value: 9.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193209150  80 FAMVIGG-LTSSTFSPRVSAFIGCFLVTSS-VALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTAINWAPDK---- 153
Cdd:cd06176  274 LGMLLAGfLLSRRLGKKRTAALGCLLSALGfLLLALAGLLGNPWLFRPGV-FLLGLGNGLFTVGALTLMMDLTGEGtagl 352

                         90
                 ....*....|....*..
gi 193209150 154 -IGVISGIVAAGFGLSS 169
Cdd:cd06176  353 fMGLWGAAQALARGLGT 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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