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Conserved domains on  [gi|17565362|ref|NP_507202|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

Srw family chemoreceptor( domain architecture ID 10563412)

Srw family chemoreceptor belongs to the G-protein coupled receptor (GPCR) superfamily and plays a role in chemoreception

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
 39-336 1.69e-81

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


:

Pssm-ID: 402097  Cd Length: 318  Bit Score: 250.97  E-value: 1.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362    39 YFNFSISVVGVIANIFHLIVLGRKSMRALTVNTFMMGIAICEFVRMMCYVIMRIPKYYRKYQKFKfgrfCVPPDSYLTIC 118
Cdd:pfam10324   1 KVEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYENSE----CIPPDSYLKVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   119 IVNNSSILFNSIQDPLISIAVAMAVLRTVSLKYPMSSK------------ILLIIRGITIPFWALDFSQTQVTVESDPWR 186
Cdd:pfam10324  77 LDWILESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKiqklskpkfgliIIIIVFILSLPISIFYYFRYEIVEVGGIWK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   187 LPDDCKHFAEG---RFYFSTTTSL--QNQGFV----LLIQGILFKLILSLVLPIATLILIHDIKMRNKVSSVGSSASN-- 255
Cdd:pfam10324 157 PPPNCAGFPPNyteTRYVLVVSELftANDGLLlkifLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSKnk 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   256 -DRSTNLVVFMTISFIIALAPQGVLYLIKFTYKNDEGVVSTIETLNNFHAFVPLANGTIHIIINFFISSMYRRTVNELLG 334
Cdd:pfam10324 237 sDRTTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFG 316


                  ..
gi 17565362   335 LK 336
Cdd:pfam10324 317 CK 318
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
 39-336 1.69e-81

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 250.97  E-value: 1.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362    39 YFNFSISVVGVIANIFHLIVLGRKSMRALTVNTFMMGIAICEFVRMMCYVIMRIPKYYRKYQKFKfgrfCVPPDSYLTIC 118
Cdd:pfam10324   1 KVEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYENSE----CIPPDSYLKVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   119 IVNNSSILFNSIQDPLISIAVAMAVLRTVSLKYPMSSK------------ILLIIRGITIPFWALDFSQTQVTVESDPWR 186
Cdd:pfam10324  77 LDWILESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKiqklskpkfgliIIIIVFILSLPISIFYYFRYEIVEVGGIWK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   187 LPDDCKHFAEG---RFYFSTTTSL--QNQGFV----LLIQGILFKLILSLVLPIATLILIHDIKMRNKVSSVGSSASN-- 255
Cdd:pfam10324 157 PPPNCAGFPPNyteTRYVLVVSELftANDGLLlkifLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSKnk 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   256 -DRSTNLVVFMTISFIIALAPQGVLYLIKFTYKNDEGVVSTIETLNNFHAFVPLANGTIHIIINFFISSMYRRTVNELLG 334
Cdd:pfam10324 237 sDRTTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFG 316


                  ..
gi 17565362   335 LK 336
Cdd:pfam10324 317 CK 318
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 39-329 3.63e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 86.53  E-value: 3.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362  39 YFNFSISVVGVIANIFHLIVLGRKSMRAlTVNTFMMGIAICEFVRMMCYVIMRIPKYYRKYqkfkfgrfCVPPDSYLTIC 118
Cdd:cd14978   5 YVLPVICIFGIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADY--------SSSFLSYFYAY 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362 119 IVNNSSILFNSIQDPLISIAVAMAVLRTVSLKYPMSSK--------------ILLIIRGITIPFWALDFSQTQVTVESDP 184
Cdd:cd14978  76 FLPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARtwctprrarrviliIIIFSLLLNLPRFFEYEVVECENCNNNS 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362 185 WRLPDDCKHFAEGRFYFStttslqnqgFVLLIQGILFKLILSLVLPIATLILIHDIKMRNKV---------SSVGSSASN 255
Cdd:cd14978 156 YYYVIPTLLRQNETYLLK---------YYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRrrllrrrrrLLSRSQRRE 226

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17565362 256 DRSTNLVVFMTISFIIALAPQGVLYLIKFTYKNDEG--VVSTIETLNNFHAFVplaNGTIHIIINFFISSMYRRTV 329
Cdd:cd14978 227 RRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLspIYQLLGDISNLLVVL---NSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
 39-336 1.69e-81

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 250.97  E-value: 1.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362    39 YFNFSISVVGVIANIFHLIVLGRKSMRALTVNTFMMGIAICEFVRMMCYVIMRIPKYYRKYQKFKfgrfCVPPDSYLTIC 118
Cdd:pfam10324   1 KVEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYENSE----CIPPDSYLKVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   119 IVNNSSILFNSIQDPLISIAVAMAVLRTVSLKYPMSSK------------ILLIIRGITIPFWALDFSQTQVTVESDPWR 186
Cdd:pfam10324  77 LDWILESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKiqklskpkfgliIIIIVFILSLPISIFYYFRYEIVEVGGIWK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   187 LPDDCKHFAEG---RFYFSTTTSL--QNQGFV----LLIQGILFKLILSLVLPIATLILIHDIKMRNKVSSVGSSASN-- 255
Cdd:pfam10324 157 PPPNCAGFPPNyteTRYVLVVSELftANDGLLlkifLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSKnk 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362   256 -DRSTNLVVFMTISFIIALAPQGVLYLIKFTYKNDEGVVSTIETLNNFHAFVPLANGTIHIIINFFISSMYRRTVNELLG 334
Cdd:pfam10324 237 sDRTTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFG 316


                  ..
gi 17565362   335 LK 336
Cdd:pfam10324 317 CK 318
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 39-329 3.63e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 86.53  E-value: 3.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362  39 YFNFSISVVGVIANIFHLIVLGRKSMRAlTVNTFMMGIAICEFVRMMCYVIMRIPKYYRKYqkfkfgrfCVPPDSYLTIC 118
Cdd:cd14978   5 YVLPVICIFGIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADY--------SSSFLSYFYAY 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362 119 IVNNSSILFNSIQDPLISIAVAMAVLRTVSLKYPMSSK--------------ILLIIRGITIPFWALDFSQTQVTVESDP 184
Cdd:cd14978  76 FLPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARtwctprrarrviliIIIFSLLLNLPRFFEYEVVECENCNNNS 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565362 185 WRLPDDCKHFAEGRFYFStttslqnqgFVLLIQGILFKLILSLVLPIATLILIHDIKMRNKV---------SSVGSSASN 255
Cdd:cd14978 156 YYYVIPTLLRQNETYLLK---------YYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRrrllrrrrrLLSRSQRRE 226

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17565362 256 DRSTNLVVFMTISFIIALAPQGVLYLIKFTYKNDEG--VVSTIETLNNFHAFVplaNGTIHIIINFFISSMYRRTV 329
Cdd:cd14978 227 RRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLspIYQLLGDISNLLVVL---NSAVNFIIYCLFSSKFRRTF 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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