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Conserved domains on  [gi|32567283|ref|NP_507177|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-310 7.79e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 288.67  E-value: 7.79e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    10 ASEEFYLLCSHVITVIQFPLNLLGLYIVVFKTPSNMSKVKFSMLVMHFTIFWIDFYWNILCIPFVIYAAVAGYPLGVIVY 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    90 LGVPTIVVAYIGMTSLLLLIPAVVLFFEERYNRLIRRDADSQSRFIkRVIYFIIIYVLVLTGLIPAYSDSFNYEEQRLYI 169
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKT-RVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   170 LKEYPCIPPSFFEKPGFLILSDNPRKLAYTLLLFIIIFMLQTLYFLIRVLFHL--QKSKAHSEKTARMQKQLFKALCIQV 247
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLfkSVKSSLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32567283   248 SVPLVFAAVPCIYMNISAAFYYLNMMLSNFSLLWIQTHGICSTVTMLCVHKAYRGATVKLFCR 310
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-310 7.79e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 288.67  E-value: 7.79e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    10 ASEEFYLLCSHVITVIQFPLNLLGLYIVVFKTPSNMSKVKFSMLVMHFTIFWIDFYWNILCIPFVIYAAVAGYPLGVIVY 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    90 LGVPTIVVAYIGMTSLLLLIPAVVLFFEERYNRLIRRDADSQSRFIkRVIYFIIIYVLVLTGLIPAYSDSFNYEEQRLYI 169
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKT-RVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   170 LKEYPCIPPSFFEKPGFLILSDNPRKLAYTLLLFIIIFMLQTLYFLIRVLFHL--QKSKAHSEKTARMQKQLFKALCIQV 247
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLfkSVKSSLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32567283   248 SVPLVFAAVPCIYMNISAAFYYLNMMLSNFSLLWIQTHGICSTVTMLCVHKAYRGATVKLFCR 310
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-310 7.79e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 288.67  E-value: 7.79e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    10 ASEEFYLLCSHVITVIQFPLNLLGLYIVVFKTPSNMSKVKFSMLVMHFTIFWIDFYWNILCIPFVIYAAVAGYPLGVIVY 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    90 LGVPTIVVAYIGMTSLLLLIPAVVLFFEERYNRLIRRDADSQSRFIkRVIYFIIIYVLVLTGLIPAYSDSFNYEEQRLYI 169
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKT-RVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   170 LKEYPCIPPSFFEKPGFLILSDNPRKLAYTLLLFIIIFMLQTLYFLIRVLFHL--QKSKAHSEKTARMQKQLFKALCIQV 247
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLfkSVKSSLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32567283   248 SVPLVFAAVPCIYMNISAAFYYLNMMLSNFSLLWIQTHGICSTVTMLCVHKAYRGATVKLFCR 310
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
14-301 3.05e-16

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 77.97  E-value: 3.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    14 FYLLCSHVITVIQFPLNLLGLYIVVFKTPSnMSKVKFSMLVMHFTIFWIDFYWNILCIPFVIYAAVAGYPLGVIV-YLGV 92
Cdd:pfam10327  10 WLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLAtVFGI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    93 PTIVVAYIGMTSLLLLIPAVVLFFEERYNRL--IRRDADSQSRFIKRVIYFIIIYVLVLTGLIpaYSDSFNYEEQRLYIL 170
Cdd:pfam10327  89 SSHYLMTIFVFLLSFQLESLLLCFVRKHQAIakILSKHVIPKWLYIFLYILCHIFPFLTAFLF--YQSGLSREEQLEYVK 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   171 KEYPCIPPSFFEKPGFLILSDNPRKLAYTLLLFIIIFMLQTL--YFLIRVLFHLQKSKAH-SEKTARMQKQLFKALCIQV 247
Cdd:pfam10327 167 ENYPEYLSQFSSLPNFAIYDYNPWLIVFGILAIFGGSLSFLIlvYLTVDMFRMLKRLRKKiSAQTYQKHRAALRSLIAQF 246
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 32567283   248 SVPLVFAAVPCIYMNISAAFYYLNMMLSNFSLLWIQTHGICSTVTMLCVHKAYR 301
Cdd:pfam10327 247 ATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYR 300
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
17-267 8.81e-07

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 49.76  E-value: 8.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    17 LCSHVITVIQFPLNLLGLYIVVFKTPSNMSKVKFsmLVMHFTIFWIDF-YWNILCIPFV-IYAA-----VAGYPLGVIVY 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKY--LMIYFSIFGIFFsILEFIVKPFIhSYNSsfivfVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    90 LGVPTIVVaYIGMTSLLLLIPAVVLFFeeRYNRLIRrdADSQSRFIKRVIYFIIIYVLV------LTGLIPAYSDSFNYE 163
Cdd:pfam10326  81 VGQILLAL-YCGFYGVSISLLAVQFIY--RYLALCR--PGKLKYFDGKKLILWFLYPLIfgaiwgLLVYFFLGPDEETDE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   164 EQRLYILKEY-------PCIPPSFFEKPGFLILSDNPRKLAYTLLLFIIIF--MLQTLYFLIRVLFHLQKSKAH-SEKTA 233
Cdd:pfam10326 156 YLREELLENYnldidevAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGisFSIIIYCGIKMYFKMKKLKSLgSEKTR 235
                         250       260       270
                  ....*....|....*....|....*....|....
gi 32567283   234 RMQKQLFKALCIQVSVPLVFAAVPCIYMNISAAF 267
Cdd:pfam10326 236 KLQKQLFKALVIQTLIPTILMYIPVGILFLLPLF 269
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
21-253 3.11e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 38.69  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    21 VITVIQFPLNLLGLYIVVFKTPSNMSKvkFSMLVMHFTIFwidfywNILCIPFVIYA---------AVAGYPLGVIVYLG 91
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKT--YRILLLNTAIT------QIISCILAFFTqqriipngvSMALISYGPCKYFG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283    92 vPTI------VVAYIGMTSLLLLIpaVVLFFeeRYNRLIRRDADSQSRFIkrviYFIIIYVLVLTGLIPAYSDSFNYEEQ 165
Cdd:pfam10317  79 -PWFcysgysLLQHFLLHSGWSLL--LTFYY--RYYILKHVDPKRKKLIL----LIIIHYIPSLSQLIVIFLSPTDFLPV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   166 RLYILKEYPCIPPSFFEKPGFLILSDNPRKLAyTLLLFIIIFMLQTLYFLIR--VLFHLQK-SKAHSEKTARMQKQLFKA 242
Cdd:pfam10317 150 EALTKELHPNYNLTDYTVTGFSDLQSFPALIN-TLIMTIPVFPIPIIILILRrkILKLLNSnSVNMSPTTKAQHRQLIKG 228
                         250
                  ....*....|.
gi 32567283   243 LCIQVSVPLVF 253
Cdd:pfam10317 229 LTIQALLPLFS 239
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
194-278 3.56e-03

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 38.76  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567283   194 RKLAYTLLLFIIIFMLQTLYFLIRVLFHL---QKSKAHSEKTARMQKQLFKALCIQVSVPLVFAAVPCIYMNISAAFYY- 269
Cdd:pfam10319 196 RSWLGILLLTVISVYSIILYIVLGYKIMRklnKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGId 275

                  ....*....
gi 32567283   270 LNMMLSNFS 278
Cdd:pfam10319 276 LGRWNNYLE 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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