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Conserved domains on  [gi|392922332|ref|NP_507075|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-317 8.60e-102

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 301.68  E-value: 8.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   11 FYAGNIGFGLSITFNLIVLVLISEMPKRIFGNYKYLMFAFSTVGIFFSCCDFFIKPNMHITKTSFIIFTDLKRSGYSYST 90
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   91 AQIALAILCSSYGLVLTMLAIHFFYRYLSVKSPSNLSIFSLKAAPIWVISLSVNFVIWFFCFFNLNSPSPMKDEELIPEF 170
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332  171 WEAYCLKSNEYTYTGPHYYYTDnSTGEWKFHIPSFVAEGYTAGNIAIAIILLSIFGVKTYNHLYKLGGMSSLNSREIQSQ 250
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392922332  251 LFKTLVVQTIFPSIFLFFPVSCLVLFPVFGIRIGENANLIMISFSIYPCFEPLVAICCIKTFRRRLL 317
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-317 8.60e-102

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 301.68  E-value: 8.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   11 FYAGNIGFGLSITFNLIVLVLISEMPKRIFGNYKYLMFAFSTVGIFFSCCDFFIKPNMHITKTSFIIFTDLKRSGYSYST 90
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   91 AQIALAILCSSYGLVLTMLAIHFFYRYLSVKSPSNLSIFSLKAAPIWVISLSVNFVIWFFCFFNLNSPSPMKDEELIPEF 170
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332  171 WEAYCLKSNEYTYTGPHYYYTDnSTGEWKFHIPSFVAEGYTAGNIAIAIILLSIFGVKTYNHLYKLGGMSSLNSREIQSQ 250
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392922332  251 LFKTLVVQTIFPSIFLFFPVSCLVLFPVFGIRIGENANLIMISFSIYPCFEPLVAICCIKTFRRRLL 317
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-317 8.60e-102

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 301.68  E-value: 8.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   11 FYAGNIGFGLSITFNLIVLVLISEMPKRIFGNYKYLMFAFSTVGIFFSCCDFFIKPNMHITKTSFIIFTDLKRSGYSYST 90
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   91 AQIALAILCSSYGLVLTMLAIHFFYRYLSVKSPSNLSIFSLKAAPIWVISLSVNFVIWFFCFFNLNSPSPMKDEELIPEF 170
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332  171 WEAYCLKSNEYTYTGPHYYYTDnSTGEWKFHIPSFVAEGYTAGNIAIAIILLSIFGVKTYNHLYKLGGMSSLNSREIQSQ 250
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392922332  251 LFKTLVVQTIFPSIFLFFPVSCLVLFPVFGIRIGENANLIMISFSIYPCFEPLVAICCIKTFRRRLL 317
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-316 5.86e-27

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 108.10  E-value: 5.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   11 FYAGNIGFGLSITFNLIVLVLISEMPKRIFGNYKYLMFAFSTVGIFFSCCDFFIKPNMHITKTSFIIF-TDLKRSGYSyS 89
Cdd:pfam10319   8 YYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFvSDGPFFEYS-E 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   90 TAQIALAILCSSYGLVLTMLAIHFFYRYLSVKSPSNLSIFSLkaaPIW----VISLSVNFVIWFF-CFFNLNSPSPMKDe 164
Cdd:pfam10319  87 LGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFR---PWGilisILFFLFHGSVWTAiCYFLLRANDEIRD- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332  165 ELIPEFWEAYCLKSNEYTYTGPHYYytdNSTGEWKFHipSFVAEGYTAGNIAIAIILLSIFGVKTYNHLYKLGGMSSLNS 244
Cdd:pfam10319 163 YIREDFRETYGVDSMDINMLGALYW---EASDETVFR--SWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKT 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392922332  245 REIQSQLFKTLVVQTIFPSIFLFFPvsCLVLF--PVFGIRIGENANLI-MISFSIYPCFEPLVAICCIKTFRRRL 316
Cdd:pfam10319 238 KRLQKQLLKALIVQTIIPICISFSP--CVLAWysPIFGIDLGRWNNYLeVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 18-317 2.85e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 63.34  E-value: 2.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   18 FGLSITFNLIVLVLISEMPKRIFGNYKYLMFAFSTVGIFFSCCDFFIKPNMHITKTSFIIFTDLKRSGYSYSTAQIALAI 97
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332   98 LCSSYGLVLTMLAIHFFYRYLSVKSPSnLSIFSLKAAPIWVISLSVNFVIWFFcfFNLNSPSPMKDEELI--PEFweayc 175
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHVD-PKRKKLILLIIIHYIPSLSQLIVIF--LSPTDFLPVEALTKElhPNY----- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922332  176 lKSNEYTYTGPHYYytdnstgewkFHIPSFVAEGYTAGNIAIAIILLSIFGVKTYNHLYKLGGMSSLNSREIQSQLFKTL 255
Cdd:pfam10317 161 -NLTDYTVTGFSDL----------QSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGL 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392922332  256 VVQTIFPSIFLFFPVSCLVLFPVFGIRIGENANLIMISFSIYPCFEPLVAICCIKTFRRRLL 317
Cdd:pfam10317 230 TIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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