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Conserved domains on  [gi|453232630|ref|NP_507068|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 36-342 4.02e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 288.20  E-value: 4.02e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630   36 TYHAEIAGFSLSVFFNSVLLILISDMPRKTFGSYKYLMICFSICGIYFSCCDFWCKPYVHMSKNSFAIFNVLEETKLTQN 115
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  116 TGVIALELYCSCYAIIISLITIHFYYRYLSVMFPVKLVRFSVRNLPFWILLVILNASVWFLLNSLVNGPSEIQDAILIPE 195
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  196 IRQRACLERHEYTYVGNVFlYQDFETNTRKINIIAFLSFGIIGSVMTFSLATLGYFGAKTYFHLKKISSLA-VSYQEIQR 274
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVY-YPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGsEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232630  275 QLFQTLVIQTIIPITFLYTPVTLMYLFPVFGIQFVEIGYIAPPLVALYPCLEPLVAMYCIKSFRFRIL 342
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 36-342 4.02e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 288.20  E-value: 4.02e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630   36 TYHAEIAGFSLSVFFNSVLLILISDMPRKTFGSYKYLMICFSICGIYFSCCDFWCKPYVHMSKNSFAIFNVLEETKLTQN 115
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  116 TGVIALELYCSCYAIIISLITIHFYYRYLSVMFPVKLVRFSVRNLPFWILLVILNASVWFLLNSLVNGPSEIQDAILIPE 195
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  196 IRQRACLERHEYTYVGNVFlYQDFETNTRKINIIAFLSFGIIGSVMTFSLATLGYFGAKTYFHLKKISSLA-VSYQEIQR 274
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVY-YPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGsEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232630  275 QLFQTLVIQTIIPITFLYTPVTLMYLFPVFGIQFVEIGYIAPPLVALYPCLEPLVAMYCIKSFRFRIL 342
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 36-342 4.02e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 288.20  E-value: 4.02e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630   36 TYHAEIAGFSLSVFFNSVLLILISDMPRKTFGSYKYLMICFSICGIYFSCCDFWCKPYVHMSKNSFAIFNVLEETKLTQN 115
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  116 TGVIALELYCSCYAIIISLITIHFYYRYLSVMFPVKLVRFSVRNLPFWILLVILNASVWFLLNSLVNGPSEIQDAILIPE 195
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  196 IRQRACLERHEYTYVGNVFlYQDFETNTRKINIIAFLSFGIIGSVMTFSLATLGYFGAKTYFHLKKISSLA-VSYQEIQR 274
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVY-YPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGsEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232630  275 QLFQTLVIQTIIPITFLYTPVTLMYLFPVFGIQFVEIGYIAPPLVALYPCLEPLVAMYCIKSFRFRIL 342
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 37-341 1.31e-25

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 104.63  E-value: 1.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630   37 YHAEIAGFSLSVFFNSVLLILISDMPRKTFGSYKYLMICFSICGIYFSCCDFWCKPYVHMSKNSFAIFNVLEETKLTQNT 116
Cdd:pfam10319   8 YYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  117 GVIALELYCSCYAIIISLITIHFYYRYLSVMFPVKLVRFSvrnLPFWIL----LVILNASVWFLLNSLVNGPSEiqdail 192
Cdd:pfam10319  88 GQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYF---RPWGILisilFFLFHGSVWTAICYFLLRAND------ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  193 ipEIRQraclerheytYVGNVFLyQDFETNTRKINIIA-----------FLSFGIIGSVMTFSLATLGYFGAKTYFHLKK 261
Cdd:pfam10319 159 --EIRD----------YIREDFR-ETYGVDSMDINMLGalyweasdetvFRSWLGILLLTVISVYSIILYIVLGYKIMRK 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  262 ISSLAVSYQEI----QRQLFQTLVIQTIIPITFLYTPVTLMYLFPVFGIQF-VEIGYIAPPLVALYPCLEPLVAMYCIKS 336
Cdd:pfam10319 226 LNKMSVTMSKKtkrlQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLgRWNNYLEVIALSAFPFIDPLAIILCLPV 305


                  ....*
gi 453232630  337 FRFRI 341
Cdd:pfam10319 306 YRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 44-342 1.00e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 55.63  E-value: 1.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630   44 FSLSVFFNSVLLILISDMPRKTFGSYKYLMICFSICGIYFSCCDFWCKPYVHMSKNSFAIFNVLEETKLTQNTGVIALEL 123
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  124 YCSCYAIIISLITIHFYYRYLSVMFPVKLVRFSVRNLpFWILLVILNASVWFLLNSLVNGPSEIQDAILIPEIRQRacle 203
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLI-IIHYIPSLSQLIVIFLSPTDFLPVEALTKELHPNYNLT---- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232630  204 rhEYTYVGNVFLyqdfetntrkINIIAFLSFGIIGSVMTFSLATLGYFGAKTYFHLKKISSLAVSY-QEIQRQLFQTLVI 282
Cdd:pfam10317 164 --DYTVTGFSDL----------QSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTtKAQHRQLIKGLTI 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 453232630  283 QTIIPItFLYTPVTLMYLFPVFGIQFVEI-GYIAPPLVALYPCLEPLVAMYCIKSFRFRIL 342
Cdd:pfam10317 232 QALLPL-FSYIPGVTLYLLSQLTGTEFLIlEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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