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Conserved domains on  [gi|1017465610|ref|NP_507052|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-294 1.10e-88

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 267.78  E-value: 1.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610   4 LGFFSNAFFGFILVYLTLFHIKRQFGSYKYLLVNFQLVGFCFASCEYLFHTFLHLYNASLIYFSLSHPLGFSNLTMEWMM 83
Cdd:pfam10326   7 IGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  84 AVYTGLYSSTICLLAIQSIYRYWALFDTPKLEYFNGIYYFIWVGYYTFFGILWSLTVGYFFAMDEFSMEYLSKEISLRYE 163
Cdd:pfam10326  87 ALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610 164 RNITDTPILDLIAYQGND-----FRWKNLTGALMMTDISTFQYTIIIVCGYNMYHGMQTKLSLLSAQHRRLHRQFFRALT 238
Cdd:pfam10326 167 LDIDEVAYVGPVYYPTDEngskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALV 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1017465610 239 IQVVSPTIILFCPVFFMIYVPFADLEMSFPSCIIQSGFTVYPALDSVIMMCCVSEY 294
Cdd:pfam10326 247 IQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEY 302
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-294 1.10e-88

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 267.78  E-value: 1.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610   4 LGFFSNAFFGFILVYLTLFHIKRQFGSYKYLLVNFQLVGFCFASCEYLFHTFLHLYNASLIYFSLSHPLGFSNLTMEWMM 83
Cdd:pfam10326   7 IGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  84 AVYTGLYSSTICLLAIQSIYRYWALFDTPKLEYFNGIYYFIWVGYYTFFGILWSLTVGYFFAMDEFSMEYLSKEISLRYE 163
Cdd:pfam10326  87 ALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610 164 RNITDTPILDLIAYQGND-----FRWKNLTGALMMTDISTFQYTIIIVCGYNMYHGMQTKLSLLSAQHRRLHRQFFRALT 238
Cdd:pfam10326 167 LDIDEVAYVGPVYYPTDEngskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALV 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1017465610 239 IQVVSPTIILFCPVFFMIYVPFADLEMSFPSCIIQSGFTVYPALDSVIMMCCVSEY 294
Cdd:pfam10326 247 IQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEY 302
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-294 1.10e-88

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 267.78  E-value: 1.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610   4 LGFFSNAFFGFILVYLTLFHIKRQFGSYKYLLVNFQLVGFCFASCEYLFHTFLHLYNASLIYFSLSHPLGFSNLTMEWMM 83
Cdd:pfam10326   7 IGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  84 AVYTGLYSSTICLLAIQSIYRYWALFDTPKLEYFNGIYYFIWVGYYTFFGILWSLTVGYFFAMDEFSMEYLSKEISLRYE 163
Cdd:pfam10326  87 ALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610 164 RNITDTPILDLIAYQGND-----FRWKNLTGALMMTDISTFQYTIIIVCGYNMYHGMQTKLSLLSAQHRRLHRQFFRALT 238
Cdd:pfam10326 167 LDIDEVAYVGPVYYPTDEngskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALV 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1017465610 239 IQVVSPTIILFCPVFFMIYVPFADLEMSFPSCIIQSGFTVYPALDSVIMMCCVSEY 294
Cdd:pfam10326 247 IQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEY 302
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 2-294 1.18e-28

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 112.34  E-value: 1.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610   2 GELGFFSNAFFgfilVYLTLFHIKRQFGSYKYLLVNFQLVGFCFASCEYLFHTFLHLYNASLIYFsLSHPLGFSNLTM-E 80
Cdd:pfam10319  15 GVLSFIVNPIF----IYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF-VSDGPFFEYSELgQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  81 WMMAVYTGLYSSTICLLAIQSIYRYWALFDTPKLE-YFNGIYYFIWVGYYTFFGILWSLTVGYFFAMDEFSMEYLSKEIS 159
Cdd:pfam10319  90 HALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRhYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610 160 LRYERNITDTPILDLIAYQG-NDFRWKNLTGALMMTDISTFQYTIIIVCGYNMYHGMQTKLSLLSAQHRRLHRQFFRALT 238
Cdd:pfam10319 170 ETYGVDSMDINMLGALYWEAsDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALI 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1017465610 239 IQVVSPTIILFCPVFFMIYVPFADLEMSFPSCIIQ-SGFTVYPALDSVIMMCCVSEY 294
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEvIALSAFPFIDPLAIILCLPVY 306
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 6-300 3.80e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 53.71  E-value: 3.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610   6 FFSNAFFGFILVYLTLFHIKRQFGSYKYLLVNFQLVGFCFASCEYLFHTFLHLYNASLIYFSLSHPLGFSNLTMEWMMAV 85
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  86 YTGLYSSTICLLAIQSIYRYWALFdtpKLEYFNGIYYFIWVGYYTFFgiLWSLTVGYFFAMDEFSMEYLSKEISLRYerN 165
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILK---HVDPKRKKLILLIIIHYIPS--LSQLIVIFLSPTDFLPVEALTKELHPNY--N 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610 166 ITDTPILDLIAYQgndfRWKNLTGALMMTDISTFQYTIIIVCGYNMYHGMQTKLSLLSAQHRRLHRQFFRALTIQVVSPT 245
Cdd:pfam10317 162 LTDYTVTGFSDLQ----SFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1017465610 246 IILFCPVFFMIYVPFADLEMSFPSCIIQSGFTVYPALDSVIMMCCVSEYFRIFKK 300
Cdd:pfam10317 238 FSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 11-257 1.62e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 46.00  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  11 FFGFilvYLTLFHIKRQFGSYKYLLVNFQlvgFCFASCEYLFHTFLHLYnaslIYFSLS--HPLGF-SNLTMEWMMAVYT 87
Cdd:pfam10318  22 IFGF---YCILFKTPKKMKSVKWSLLNLH---FWSALLDLSLSFLTIPY----IFLPALagYPLGLlSYLGVPTPIQFYI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610  88 GLYSSTICLLAIQSIY--RYWALFDTPKLEYFNGIYYFIWVGYYTFFGILwsLTVGYFFAMD-EFSMEYLSKEISLRYER 164
Cdd:pfam10318  92 GVTSLALVGVSIILLFenRYSILFTNKKRITWKKTRVLYLIFNYIIALLF--LIPIYLNIPDqEAAKLKVLKKLPCLPPE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017465610 165 NITDTPILDLIAyqgnDFRWKNLTGALMMTDISTFQYTIIIVCGYNMYHGMQTKLSllsAQHRRLHRQFFRALTIQVVSP 244
Cdd:pfam10318 170 FFDNPPVFVLAI----DSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLS---KKTRKLQKKFFIALIIQVSIP 242

                         250
                  ....*....|...
gi 1017465610 245 TIILFCPVFFMIY 257
Cdd:pfam10318 243 LIVILIPLIYILF 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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