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Conserved domains on  [gi|17560658|ref|NP_507001|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

serpentine receptor domain-containing protein( domain architecture ID 27798)

serpentine receptor domain-containing protein which belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srh super family cl11665
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-311 1.74e-35

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10318:

Pssm-ID: 416353  Cd Length: 302  Bit Score: 130.74  E-value: 1.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658     6 SPDWYFYAMHFSAIVTTPVNISGIMIILFCQTRQLSSLRWHLLVFQIFSMISDFSLNVGTLPVIFSPFPIGRPHGvytlI 85
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLG----L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    86 FQKFGFetSTEAQCILVFVSIYLTAGSVEFLFLLRYQaILPSGHPHKLSTFISVLLLSIWQVFLITMMLISFkLAVPDQQ 165
Cdd:pfam10318  78 LSYLGV--PTPIQFYIGVTSLALVGVSIILLFENRYS-ILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIY-LNIPDQE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658   166 VARALFAQLHPELQYLMTDEHVFIVCVVVELIHVIFLFSCFFRLGIGMVTVIVLIWMSSRSLKSIQISLTTKRMHLQLIK 245
Cdd:pfam10318 154 AAKLKVLKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFI 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17560658   246 SLCQQIIVPILAFYIPIIVVVVPLMLSIPNsQLSFFISLICLSYHTFFGTLSMLYFNPHYRQWVIS 311
Cdd:pfam10318 234 ALIIQVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLS 298
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-311 1.74e-35

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 130.74  E-value: 1.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658     6 SPDWYFYAMHFSAIVTTPVNISGIMIILFCQTRQLSSLRWHLLVFQIFSMISDFSLNVGTLPVIFSPFPIGRPHGvytlI 85
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLG----L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    86 FQKFGFetSTEAQCILVFVSIYLTAGSVEFLFLLRYQaILPSGHPHKLSTFISVLLLSIWQVFLITMMLISFkLAVPDQQ 165
Cdd:pfam10318  78 LSYLGV--PTPIQFYIGVTSLALVGVSIILLFENRYS-ILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIY-LNIPDQE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658   166 VARALFAQLHPELQYLMTDEHVFIVCVVVELIHVIFLFSCFFRLGIGMVTVIVLIWMSSRSLKSIQISLTTKRMHLQLIK 245
Cdd:pfam10318 154 AAKLKVLKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFI 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17560658   246 SLCQQIIVPILAFYIPIIVVVVPLMLSIPNsQLSFFISLICLSYHTFFGTLSMLYFNPHYRQWVIS 311
Cdd:pfam10318 234 ALIIQVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLS 298
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-311 1.74e-35

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 130.74  E-value: 1.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658     6 SPDWYFYAMHFSAIVTTPVNISGIMIILFCQTRQLSSLRWHLLVFQIFSMISDFSLNVGTLPVIFSPFPIGRPHGvytlI 85
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLG----L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    86 FQKFGFetSTEAQCILVFVSIYLTAGSVEFLFLLRYQaILPSGHPHKLSTFISVLLLSIWQVFLITMMLISFkLAVPDQQ 165
Cdd:pfam10318  78 LSYLGV--PTPIQFYIGVTSLALVGVSIILLFENRYS-ILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIY-LNIPDQE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658   166 VARALFAQLHPELQYLMTDEHVFIVCVVVELIHVIFLFSCFFRLGIGMVTVIVLIWMSSRSLKSIQISLTTKRMHLQLIK 245
Cdd:pfam10318 154 AAKLKVLKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFI 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17560658   246 SLCQQIIVPILAFYIPIIVVVVPLMLSIPNsQLSFFISLICLSYHTFFGTLSMLYFNPHYRQWVIS 311
Cdd:pfam10318 234 ALIIQVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLS 298
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 1-309 3.00e-15

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 75.27  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658     1 MQIDMS-PDWYFYAMHFSAIVTTPVNISGIMIILFcQTRQLSSLRWHLLVFQIFSMISDFSLNVGTLPVIFspFPIgrpH 79
Cdd:pfam10327   1 MNIDFTvPFWLILYYHIIGTISLILNLLGIYLIIF-KSGKIDNFRYYLLYFQISCTLTDIHLTFLMQPIPL--FPI---I 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    80 GVYTLIFQKFGFETSTEAQCILVFVSIYLTAGSVEFLFLLRYQAILPSGHPHKLSTFISVLLLSIWQVFLITMMLISFKL 159
Cdd:pfam10327  75 AGYCNGFLATVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658   160 AV-PDQQVA--RALFAQLHPELQYL----MTDEHV-FIVCVVVELIHVIFLFSCFFRLGIGMVTVIvliwmssRSLKSiQ 231
Cdd:pfam10327 155 GLsREEQLEyvKENYPEYLSQFSSLpnfaIYDYNPwLIVFGILAIFGGSLSFLILVYLTVDMFRML-------KRLRK-K 226

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17560658   232 ISLTTKRMHLQLIKSLCQQIIVPILAFyIPIIVVVVPLMLSIPNSQLSFFISLICLSYHTFFGTLSMLYFNPHYRQWV 309
Cdd:pfam10327 227 ISAQTYQKHRAALRSLIAQFATSPVCI-LPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 9-310 7.76e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 46.77  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658     9 WYFYAMHFsaIVTTPVNISGIMIILFCQTRQLSSLRWHLL---VFQIFSMISDFSLNVgtlPVIFSPFPIG-RPHGVYTL 84
Cdd:pfam10317   2 SIYYPIFF--ILGLILNLLLLYLIIFKSPKSLKTYRILLLntaITQIISCILAFFTQQ---RIIPNGVSMAlISYGPCKY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    85 IFQKFGFETSTEAQC--ILVFVSIYLTagsveflFLLRYQaILPSGHPHKLSTFISVLLLSIwqVFLITMMLISFKLAVP 162
Cdd:pfam10317  77 FGPWFCYSGYSLLQHflLHSGWSLLLT-------FYYRYY-ILKHVDPKRKKLILLIIIHYI--PSLSQLIVIFLSPTDF 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658   163 DQQVARALfaQLHPELQYlmtDEHVFIVcvVVELIHVIFLFS-CFFRLGIGMVTVIVLIW----MSSRSLKSIQISLTTK 237
Cdd:pfam10317 147 LPVEALTK--ELHPNYNL---TDYTVTG--FSDLQSFPALINtLIMTIPVFPIPIIILILrrkiLKLLNSNSVNMSPTTK 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17560658   238 RMHLQLIKSLCQQIIVPILaFYIPIIVVVVPLMLSIPNSQLSFFISLICLSYHTFFGTLSMLYFNPHYRQWVI 310
Cdd:pfam10317 220 AQHRQLIKGLTIQALLPLF-SYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 15-285 7.51e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 40.90  E-value: 7.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    15 HFSAIVTTPVNISGIMIILFCQTRQLSSLRWHLLVFQIFSMIsdFS-LNVGTLPVIFSpfpigrpHG---VYTLIFQKFG 90
Cdd:pfam10326   6 YIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIF--FSiLEFIVKPFIHS-------YNssfIVFVDLKDLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658    91 FETSTeAQCILVF------VSIYLTAgsVEFLFllRYQAILPSGHPHKLSTFISVLLLSIWQVFLITMMLISFKLAVPDQ 164
Cdd:pfam10326  77 LSKSV-GQILLALycgfygVSISLLA--VQFIY--RYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560658   165 QVARALFAQLHPELQyLMTDEHVFIVCV----------VVELIHVIFLFSCFFRLGIGMVTVI---VLIWMSSRSLKSiQ 231
Cdd:pfam10326 152 ETDEYLREELLENYN-LDIDEVAYVGPVyyptdengskVIRWRSLIGLLIMTFIIGISFSIIIycgIKMYFKMKKLKS-L 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17560658   232 ISLTTKRMHLQLIKSLCQQIIVPILAFYIPIIVVVVPLMLSIPNSQLSFFISLI 285
Cdd:pfam10326 230 GSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITAT 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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