Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , ...
234-303
1.30e-03
Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their carbon requirements from two-carbon compounds, by bypassing the two carboxylation steps of the citric acid cycle.
The actual alignment was detected with superfamily member pfam15617:
Pssm-ID: 451263 Cd Length: 320 Bit Score: 39.85 E-value: 1.30e-03
C-C_Bond_Lyase of the TIM-Barrel fold; This family of TIM-Barrel fold C-C bond lyase is ...
234-303
1.30e-03
C-C_Bond_Lyase of the TIM-Barrel fold; This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.
Pssm-ID: 406131 Cd Length: 320 Bit Score: 39.85 E-value: 1.30e-03
C-C_Bond_Lyase of the TIM-Barrel fold; This family of TIM-Barrel fold C-C bond lyase is ...
234-303
1.30e-03
C-C_Bond_Lyase of the TIM-Barrel fold; This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.
Pssm-ID: 406131 Cd Length: 320 Bit Score: 39.85 E-value: 1.30e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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