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Heat shock protein 90 [Caenorhabditis elegans]
Protein Classification
HSP90 family protein ( domain architecture ID 1903338 )
HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction
List of domain hits
Name
Accession
Description
Interval
E-value
HSP90 super family
cl46693 Hsp90 protein;
6-702
0e+00
Hsp90 protein;
PTZ00272 :Pssm-ID: 481033
Cd Length: 701
Bit Score: 917.14
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 6 ETFAFQAEI A QLMSLIINTFYSNKEI Y LRELISNASDA L DKIRYQ A LT E PS E L DTGKE L F I KIT P N KE E KTLT IM D T GIG 85
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEI F LRELISNASDA C DKIRYQ S LT D PS V L GESPR L C I RVV P D KE N KTLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 86 MTKADLVNNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSA F LVAD K V V VTSKNN D D D SY Q WESSAGG S F VVRPFND 165
Cdd:PTZ00272 83 MTKADLVNNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSA Y LVAD R V T VTSKNN S D E SY V WESSAGG T F TITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 166 PEVT RGT K I VM H I KEDQ IDF LE E R KI KE IV KKHS Q FIGY P I K L -- VVEK E R E KEV EDEE AVEAK DE EKK E GE VE N V ADDA 243
Cdd:PTZ00272 163 SDMK RGT R I TL H L KEDQ MEY LE P R RL KE LI KKHS E FIGY D I E L mv EKTT E K E VTD EDEE DTKKA DE DGE E PK VE E V KEGD 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 244 DK KK T K KI K E K YFED E EL -- NK T KP I WTR N P D D ISN EEYA E FYK SL SNDWED HL A V KHFSVEGQLEFR ALL FVP Q RAPFD 321
Cdd:PTZ00272 243 EG KK K K TK K V K EVTK E YE vq NK H KP L WTR D P K D VTK EEYA A FYK AI SNDWED PA A T KHFSVEGQLEFR SIM FVP K RAPFD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 322 L FE NK K SK N S IKLYVRRVFIM E NCE E L M P EY L N F I KGVVDSEDLPLNISRE M LQQ S KILKVIRKN L VKKC M E LI DEVAE D 401
Cdd:PTZ00272 323 M FE PN K KR N N IKLYVRRVFIM D NCE D L C P DW L G F V KGVVDSEDLPLNISRE N LQQ N KILKVIRKN I VKKC L E MF DEVAE N 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 402 K DNF K K FYEQFGKN L KLGIHED ST NRKKL SDF LR - YST SA G D E P T S LK E YV S RMK EN Q TQ IYYITG E SK DVVAA S A F V E R 480
Cdd:PTZ00272 403 K EDY K Q FYEQFGKN I KLGIHED TA NRKKL MEL LR f YST ES G E E M T T LK D YV T RMK AG Q KS IYYITG D SK KKLET S P F I E Q 482
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 481 VKS RG F EVL Y M CD PIDEY CV QQ L K EYDG KK LVSV TKEG LELP E T EEEK KKF EE D K V A Y E N LCK VI K DI L EK KVEKV G VS N 560
Cdd:PTZ00272 483 ARR RG L EVL F M TE PIDEY VM QQ V K DFED KK FACL TKEG VHFE E S EEEK QQR EE E K A A C E K LCK TM K EV L GD KVEKV I VS E 562
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 561 RL VS SPC CI VTSE Y GWSA N ME R IM KA QALRDSS TMG YM AA KK HL E I NP D H A I M K T LR D RV EV D K NDK T VKDLV V LLF E T A 640
Cdd:PTZ00272 563 RL ST SPC IL VTSE F GWSA H ME Q IM RN QALRDSS MAQ YM MS KK TM E L NP R H P I I K E LR R RV GA D E NDK A VKDLV F LLF D T S 642
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559162 641 LL A SGF S LE E P QSH A S RI Y RMIKLGL DIGDD E I E DSAV P SSC TA E A KIEGA eed A S R ME E VD 702
Cdd:PTZ00272 643 LL T SGF Q LE D P TGY A E RI N RMIKLGL SLDEE E E E AAEA P VAE TA P A EVTAG --- T S S ME Q VD 701
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
6-702
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 917.14
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 6 ETFAFQAEI A QLMSLIINTFYSNKEI Y LRELISNASDA L DKIRYQ A LT E PS E L DTGKE L F I KIT P N KE E KTLT IM D T GIG 85
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEI F LRELISNASDA C DKIRYQ S LT D PS V L GESPR L C I RVV P D KE N KTLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 86 MTKADLVNNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSA F LVAD K V V VTSKNN D D D SY Q WESSAGG S F VVRPFND 165
Cdd:PTZ00272 83 MTKADLVNNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSA Y LVAD R V T VTSKNN S D E SY V WESSAGG T F TITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 166 PEVT RGT K I VM H I KEDQ IDF LE E R KI KE IV KKHS Q FIGY P I K L -- VVEK E R E KEV EDEE AVEAK DE EKK E GE VE N V ADDA 243
Cdd:PTZ00272 163 SDMK RGT R I TL H L KEDQ MEY LE P R RL KE LI KKHS E FIGY D I E L mv EKTT E K E VTD EDEE DTKKA DE DGE E PK VE E V KEGD 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 244 DK KK T K KI K E K YFED E EL -- NK T KP I WTR N P D D ISN EEYA E FYK SL SNDWED HL A V KHFSVEGQLEFR ALL FVP Q RAPFD 321
Cdd:PTZ00272 243 EG KK K K TK K V K EVTK E YE vq NK H KP L WTR D P K D VTK EEYA A FYK AI SNDWED PA A T KHFSVEGQLEFR SIM FVP K RAPFD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 322 L FE NK K SK N S IKLYVRRVFIM E NCE E L M P EY L N F I KGVVDSEDLPLNISRE M LQQ S KILKVIRKN L VKKC M E LI DEVAE D 401
Cdd:PTZ00272 323 M FE PN K KR N N IKLYVRRVFIM D NCE D L C P DW L G F V KGVVDSEDLPLNISRE N LQQ N KILKVIRKN I VKKC L E MF DEVAE N 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 402 K DNF K K FYEQFGKN L KLGIHED ST NRKKL SDF LR - YST SA G D E P T S LK E YV S RMK EN Q TQ IYYITG E SK DVVAA S A F V E R 480
Cdd:PTZ00272 403 K EDY K Q FYEQFGKN I KLGIHED TA NRKKL MEL LR f YST ES G E E M T T LK D YV T RMK AG Q KS IYYITG D SK KKLET S P F I E Q 482
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 481 VKS RG F EVL Y M CD PIDEY CV QQ L K EYDG KK LVSV TKEG LELP E T EEEK KKF EE D K V A Y E N LCK VI K DI L EK KVEKV G VS N 560
Cdd:PTZ00272 483 ARR RG L EVL F M TE PIDEY VM QQ V K DFED KK FACL TKEG VHFE E S EEEK QQR EE E K A A C E K LCK TM K EV L GD KVEKV I VS E 562
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 561 RL VS SPC CI VTSE Y GWSA N ME R IM KA QALRDSS TMG YM AA KK HL E I NP D H A I M K T LR D RV EV D K NDK T VKDLV V LLF E T A 640
Cdd:PTZ00272 563 RL ST SPC IL VTSE F GWSA H ME Q IM RN QALRDSS MAQ YM MS KK TM E L NP R H P I I K E LR R RV GA D E NDK A VKDLV F LLF D T S 642
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559162 641 LL A SGF S LE E P QSH A S RI Y RMIKLGL DIGDD E I E DSAV P SSC TA E A KIEGA eed A S R ME E VD 702
Cdd:PTZ00272 643 LL T SGF Q LE D P TGY A E RI N RMIKLGL SLDEE E E E AAEA P VAE TA P A EVTAG --- T S S ME Q VD 701
HSP90
pfam00183 Hsp90 protein;
184-702
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 785.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 184 DF LEE R KIKE I VKK H S Q FI GY PI K L V VEKE R E K EV E DEE AV E AKD EE K --- KEGE VE NVADDAD KKKTKK I KE KYF E D E E 260
Cdd:pfam00183 1 EY LEE K KIKE L VKK Y S E FI NF PI Y L W VEKE E E V EV P DEE EE E EEE EE E eed DDPK VE EEDEEEE KKKTKK V KE TVW E W E L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 261 LNKTKPIWTRNP DDISN EEYAEFYKSLS N DWED H LAVKHFSVEG QL EF RA LLF V P Q RAPFDLFENKK S KN S IKLYVRRVF 340
Cdd:pfam00183 81 LNKTKPIWTRNP KEVTE EEYAEFYKSLS K DWED P LAVKHFSVEG EV EF KS LLF I P K RAPFDLFENKK K KN N IKLYVRRVF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 341 I MENC E E L M PEYLNF I KGVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K CMELID E V AE D K DNF KKF YEQ FGKNLKLGI 420
Cdd:pfam00183 161 I TDDF E D L I PEYLNF V KGVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K ALDMFK E I AE E K EDY KKF WKE FGKNLKLGI 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 421 H EDS T NR K KL SDF LR YST S A - GDE P TSL KE YVSRMKE N Q TQ IYYITGESK DV V AA S A F V ER V K SR G F EVLY MC DPIDEY C 499
Cdd:pfam00183 241 I EDS S NR N KL AKL LR FYS S K s GDE L TSL DD YVSRMKE G Q KH IYYITGESK EE V EN S P F L ER L K KK G Y EVLY LT DPIDEY A 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 500 VQQLKE Y DGKKLV S V T KEGLEL P E T EEEKKK F EE D K VAY E N L C K VI KD I L EK KVEKV G VSNRLV S SPC CI VTS E YGWSAN 579
Cdd:pfam00183 321 VQQLKE F DGKKLV N V A KEGLEL E E D EEEKKK D EE L K KEF E P L T K WL KD V L GD KVEKV V VSNRLV D SPC VL VTS Q YGWSAN 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 580 MERIMKAQALR - DSS TMG YM AA KK H LEINP D H A I M K T L RD RVE V DK N DKT V KDL VV LL F ETALL A SGFSLE E P Q S H ASRI 658
Cdd:pfam00183 401 MERIMKAQALR k DSS MSS YM SS KK T LEINP R H P I I K E L LK RVE A DK D DKT A KDL AL LL Y ETALL R SGFSLE D P A S F ASRI 480
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 17559162 659 YRM I KLGL D I GD DEI ED savpssct A E AK IE GA EE DASRME E VD 702
Cdd:pfam00183 481 YRM L KLGL G I DE DEI VE -------- E E DE IE EE EE EEEEEP E EE 516
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
4-666
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 743.09
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 4 NA ET FA FQAE IA QL MS L I I NTF YSNKEI Y LRELISNASDA L DK I R YQ ALT E P SELDTGKE L F I K I TPN KE E KTLTI M D T G 83
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEI F LRELISNASDA I DK L R FL ALT D P ELKEEDGD L K I R I EVD KE A KTLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 84 IGMT KADLVN NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSAF L VADKV V V TSK -- NN D DDSYQ WES SAG G SFV 159
Cdd:COG0326 82 IGMT REEVIE NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSAF M VADKV E V VTR sa GE D AEAVR WES DGD G EYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 160 VRPFNDP E vt RGT K I VM H I KED QID FLEE RKIK EI V KK H S Q FI GY PIK L vvekerekevedeeaveakde E KK E G E V E nv 239
Cdd:COG0326 162 IEEAEKA E -- RGT E I TL H L KED AEE FLEE WRLR EI I KK Y S D FI PV PIK M --------------------- E GE E E E T E -- 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 240 addadkkktkkikekyf EDE EL N KTKPI WTR NPDD I SN EEY A EFYK S L SN D W ED H L AVK H FS VEG QL E FRA LL FV P QR AP 319
Cdd:COG0326 217 ----------------- EDE TI N SATAL WTR SKSE I TD EEY K EFYK H L FH D F ED P L FWI H LN VEG PF E YTG LL YI P KK AP 279
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 320 FDL F e NKKS K NS IKLYV R RVFIM ENC E E L M PEYL N F IK GVVDS E DLPLN I SRE M LQ QSKI LK V IRK NLV KK CMELIDEV A 399
Cdd:COG0326 280 FDL Y - DRDR K GG IKLYV K RVFIM DDA E D L L PEYL R F VR GVVDS P DLPLN V SRE I LQ EDRQ LK K IRK AIT KK VLDELEKL A 358
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 400 E - D KDNFK KF YEQ FG KN LK L G IH ED ST NR K K LS D F LR YSTSAGDEPTS L K EYV S RMKE N Q TQ IYYITGES KDVVAA S AFV 478
Cdd:COG0326 359 K n D REKYE KF WKE FG LV LK E G AL ED FK NR E K IA D L LR FESTKEGGYVT L A EYV E RMKE G Q KK IYYITGES REAAEQ S PHL 438
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 479 E RV K SR G F EVL YMC DPIDE YCVQQ L K E Y DGKK LV SV TKEG L E L PET EE E K KKF EE DK v AYEN L CKVI K DI L EK KV EK V G V 558
Cdd:COG0326 439 E IF K AK G I EVL LLT DPIDE FLISH L E E F DGKK FK SV DSGD L D L DKL EE K K ESE EE EE - EFKP L LERF K EA L GD KV KD V R V 517
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 559 S N RL VS SP C C I V TS E YGW S AN ME RIM KA qalrdsst MG -- YMA AK KH LEINP D H AIM K T L RD rvev DKNDKTV KDL VV LL 636
Cdd:COG0326 518 S A RL TD SP A C L V AD E GDM S RR ME KML KA -------- MG qd MPE AK PI LEINP N H PLV K K L AA ---- EEDEELF KDL AE LL 585
650 660 670
....*....|....*....|....*....|
gi 17559162 637 FET ALLA S G FS LE E P QSHAS R IYRMIKLG L 666
Cdd:COG0326 586 YDQ ALLA E G GL LE D P AAFVK R LNKLLEKA L 615
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
16-202
5.21e-109
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 327.94
E-value: 5.21e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 16 QL MS LII NTF YSNKEI Y LRELISNASDALDK I RY QA LT E PS E LD TGK EL F I K I T P N KE EK TLTI M DTGIGMTK AD L V NNL 95
Cdd:cd16927 2 QL LD LII HSL YSNKEI F LRELISNASDALDK L RY LS LT D PS L LD DDP EL E I R I S P D KE NR TLTI S DTGIGMTK EE L I NNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 96 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSAF L VADKV V VT S K NN - DD DS Y Q WES SA GGS FVVRPFND p E VT RGTK 173
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSAF M VADKV T VT T K SA g DD EG Y R WES DG GGS YTIEEAEG - E LG RGTK 160
170 180
....*....|....*....|....*....
gi 17559162 174 I VM H I KED QID FLEE RK IKE I VKK H S Q FI 202
Cdd:cd16927 161 I TL H L KED AKE FLEE AR IKE L VKK Y S D FI 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
28-179
2.32e-09
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 55.35
E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 28 NKEIY LR ELI SN AS D ALD K IRYQ altepseldt G KELFIKITPNKEEKTL T IM D T G I G MTKA DL vnnlgtiaksg T K A F M 107
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTPE ---------- G GRITVTLERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559162 108 EALQAGADISM IG QF G V G FYSAFLVADKV vvtsknndddsyqwessa GG SFV V rpfn DP E VTR GT KIVMHIK 179
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLVELH ------------------ GG EIS V ---- ES E PGG GT TFTITLP 109
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
6-702
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 917.14
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 6 ETFAFQAEI A QLMSLIINTFYSNKEI Y LRELISNASDA L DKIRYQ A LT E PS E L DTGKE L F I KIT P N KE E KTLT IM D T GIG 85
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEI F LRELISNASDA C DKIRYQ S LT D PS V L GESPR L C I RVV P D KE N KTLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 86 MTKADLVNNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSA F LVAD K V V VTSKNN D D D SY Q WESSAGG S F VVRPFND 165
Cdd:PTZ00272 83 MTKADLVNNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSA Y LVAD R V T VTSKNN S D E SY V WESSAGG T F TITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 166 PEVT RGT K I VM H I KEDQ IDF LE E R KI KE IV KKHS Q FIGY P I K L -- VVEK E R E KEV EDEE AVEAK DE EKK E GE VE N V ADDA 243
Cdd:PTZ00272 163 SDMK RGT R I TL H L KEDQ MEY LE P R RL KE LI KKHS E FIGY D I E L mv EKTT E K E VTD EDEE DTKKA DE DGE E PK VE E V KEGD 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 244 DK KK T K KI K E K YFED E EL -- NK T KP I WTR N P D D ISN EEYA E FYK SL SNDWED HL A V KHFSVEGQLEFR ALL FVP Q RAPFD 321
Cdd:PTZ00272 243 EG KK K K TK K V K EVTK E YE vq NK H KP L WTR D P K D VTK EEYA A FYK AI SNDWED PA A T KHFSVEGQLEFR SIM FVP K RAPFD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 322 L FE NK K SK N S IKLYVRRVFIM E NCE E L M P EY L N F I KGVVDSEDLPLNISRE M LQQ S KILKVIRKN L VKKC M E LI DEVAE D 401
Cdd:PTZ00272 323 M FE PN K KR N N IKLYVRRVFIM D NCE D L C P DW L G F V KGVVDSEDLPLNISRE N LQQ N KILKVIRKN I VKKC L E MF DEVAE N 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 402 K DNF K K FYEQFGKN L KLGIHED ST NRKKL SDF LR - YST SA G D E P T S LK E YV S RMK EN Q TQ IYYITG E SK DVVAA S A F V E R 480
Cdd:PTZ00272 403 K EDY K Q FYEQFGKN I KLGIHED TA NRKKL MEL LR f YST ES G E E M T T LK D YV T RMK AG Q KS IYYITG D SK KKLET S P F I E Q 482
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 481 VKS RG F EVL Y M CD PIDEY CV QQ L K EYDG KK LVSV TKEG LELP E T EEEK KKF EE D K V A Y E N LCK VI K DI L EK KVEKV G VS N 560
Cdd:PTZ00272 483 ARR RG L EVL F M TE PIDEY VM QQ V K DFED KK FACL TKEG VHFE E S EEEK QQR EE E K A A C E K LCK TM K EV L GD KVEKV I VS E 562
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 561 RL VS SPC CI VTSE Y GWSA N ME R IM KA QALRDSS TMG YM AA KK HL E I NP D H A I M K T LR D RV EV D K NDK T VKDLV V LLF E T A 640
Cdd:PTZ00272 563 RL ST SPC IL VTSE F GWSA H ME Q IM RN QALRDSS MAQ YM MS KK TM E L NP R H P I I K E LR R RV GA D E NDK A VKDLV F LLF D T S 642
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559162 641 LL A SGF S LE E P QSH A S RI Y RMIKLGL DIGDD E I E DSAV P SSC TA E A KIEGA eed A S R ME E VD 702
Cdd:PTZ00272 643 LL T SGF Q LE D P TGY A E RI N RMIKLGL SLDEE E E E AAEA P VAE TA P A EVTAG --- T S S ME Q VD 701
HSP90
pfam00183 Hsp90 protein;
184-702
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 785.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 184 DF LEE R KIKE I VKK H S Q FI GY PI K L V VEKE R E K EV E DEE AV E AKD EE K --- KEGE VE NVADDAD KKKTKK I KE KYF E D E E 260
Cdd:pfam00183 1 EY LEE K KIKE L VKK Y S E FI NF PI Y L W VEKE E E V EV P DEE EE E EEE EE E eed DDPK VE EEDEEEE KKKTKK V KE TVW E W E L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 261 LNKTKPIWTRNP DDISN EEYAEFYKSLS N DWED H LAVKHFSVEG QL EF RA LLF V P Q RAPFDLFENKK S KN S IKLYVRRVF 340
Cdd:pfam00183 81 LNKTKPIWTRNP KEVTE EEYAEFYKSLS K DWED P LAVKHFSVEG EV EF KS LLF I P K RAPFDLFENKK K KN N IKLYVRRVF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 341 I MENC E E L M PEYLNF I KGVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K CMELID E V AE D K DNF KKF YEQ FGKNLKLGI 420
Cdd:pfam00183 161 I TDDF E D L I PEYLNF V KGVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K ALDMFK E I AE E K EDY KKF WKE FGKNLKLGI 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 421 H EDS T NR K KL SDF LR YST S A - GDE P TSL KE YVSRMKE N Q TQ IYYITGESK DV V AA S A F V ER V K SR G F EVLY MC DPIDEY C 499
Cdd:pfam00183 241 I EDS S NR N KL AKL LR FYS S K s GDE L TSL DD YVSRMKE G Q KH IYYITGESK EE V EN S P F L ER L K KK G Y EVLY LT DPIDEY A 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 500 VQQLKE Y DGKKLV S V T KEGLEL P E T EEEKKK F EE D K VAY E N L C K VI KD I L EK KVEKV G VSNRLV S SPC CI VTS E YGWSAN 579
Cdd:pfam00183 321 VQQLKE F DGKKLV N V A KEGLEL E E D EEEKKK D EE L K KEF E P L T K WL KD V L GD KVEKV V VSNRLV D SPC VL VTS Q YGWSAN 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 580 MERIMKAQALR - DSS TMG YM AA KK H LEINP D H A I M K T L RD RVE V DK N DKT V KDL VV LL F ETALL A SGFSLE E P Q S H ASRI 658
Cdd:pfam00183 401 MERIMKAQALR k DSS MSS YM SS KK T LEINP R H P I I K E L LK RVE A DK D DKT A KDL AL LL Y ETALL R SGFSLE D P A S F ASRI 480
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 17559162 659 YRM I KLGL D I GD DEI ED savpssct A E AK IE GA EE DASRME E VD 702
Cdd:pfam00183 481 YRM L KLGL G I DE DEI VE -------- E E DE IE EE EE EEEEEP E EE 516
PRK05218
PRK05218 heat shock protein 90; Provisional
4-666
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 758.49
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 4 NA ET FA FQAE IA QL MS L I I NTF YSNKEI Y LRELISNASDA L DK I R YQ ALT E P SELDTGKE L F I K I TPN KE EK TLTI M D T G 83
Cdd:PRK05218 2 AM ET GE FQAE VK QL LH L M I HSL YSNKEI F LRELISNASDA I DK L R FE ALT D P ALYEGDGD L K I R I SFD KE AR TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 84 IGMT KADLVN NLGTIAKSGTK A F M E A L Q -- AGA D ISM IGQFGVGFYSAF L VADKV V V TSK -- NNDDDSYQ WES SAG G SFV 159
Cdd:PRK05218 82 IGMT REEVIE NLGTIAKSGTK E F L E K L K gd QKK D SQL IGQFGVGFYSAF M VADKV T V ITR sa GPAAEAVR WES DGE G EYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 160 VRPFNDP E vt RGT K I VM H I KED QID FL E E RK I KE I V KK H S Q FI GY PIKL vvekerekevedeeaveakde EK K E G E V env 239
Cdd:PRK05218 162 IEEIEKE E -- RGT E I TL H L KED EDE FL D E WR I RS I I KK Y S D FI PV PIKL --------------------- EK E E E E T --- 215
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 240 addadkkktkkikekyfedee L N KTKPI WTR NPDD I SN EEY A EFYK S L SN D WE D H L AVK H FS VEG QL E FRA LL FV P QR AP 319
Cdd:PRK05218 216 --------------------- I N SASAL WTR SKSE I TD EEY K EFYK H L AH D FD D P L FWI H NN VEG PF E YTG LL YI P KK AP 274
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 320 FDLF e N KKS K NSI KLYV R RVFIM ENC EEL M PEYL N F I KGV V DSEDLPLN I SRE M LQ QSKIL K V IRK NLV KK CMELIDEV A 399
Cdd:PRK05218 275 FDLF - N RDR K GGL KLYV K RVFIM DDA EEL L PEYL R F V KGV I DSEDLPLN V SRE I LQ EDRVV K K IRK AIT KK VLDELEKL A 353
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 400 E - D KDNFK KF YEQ FG KN LK L G IH ED ST NR K KL SDF LR YSTSAGDEPT SL K EYV S RMKE N Q TQ IYYITG E S KDVVAA S AFV 478
Cdd:PRK05218 354 K n D REKYE KF WKE FG PV LK E G LY ED FA NR E KL AKL LR FASTHEGKYV SL A EYV E RMKE G Q KK IYYITG D S REAAKN S PHL 433
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 479 E RV K SR G F EVL YMC DPIDE YCVQQ L K E Y DGK KLV SV TKEG L E - LP E T EEEK KKF EE DKVAYEN L CKVI K DI L EK KV EK V G 557
Cdd:PRK05218 434 E LF K KK G I EVL LLT DPIDE FWISY L E E F DGK PFK SV ARGD L D l GK E D EEEK EEK EE AEEEFKP L LERL K EA L GD KV KD V R 513
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 558 V S N RL VS SP C C I V TS E YGW S AN ME RIM KA QA lrdsst MGYMAA K KH LEINP D H AIM K T L R D rvev DKNDKTV KDL VV LL F 637
Cdd:PRK05218 514 L S H RL TD SP A C L V AD E GDM S TQ ME KLL KA AG ------ QEVPES K PI LEINP N H PLV K K L A D ---- EADEAKF KDL AE LL Y 583
650 660
....*....|....*....|....*....
gi 17559162 638 ET ALLA S G F SLE E P QSHAS R IYRMIKLG L 666
Cdd:PRK05218 584 DQ ALLA E G G SLE D P AAFVK R LNELLLKL L 612
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
4-666
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 743.09
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 4 NA ET FA FQAE IA QL MS L I I NTF YSNKEI Y LRELISNASDA L DK I R YQ ALT E P SELDTGKE L F I K I TPN KE E KTLTI M D T G 83
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEI F LRELISNASDA I DK L R FL ALT D P ELKEEDGD L K I R I EVD KE A KTLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 84 IGMT KADLVN NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSAF L VADKV V V TSK -- NN D DDSYQ WES SAG G SFV 159
Cdd:COG0326 82 IGMT REEVIE NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSAF M VADKV E V VTR sa GE D AEAVR WES DGD G EYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 160 VRPFNDP E vt RGT K I VM H I KED QID FLEE RKIK EI V KK H S Q FI GY PIK L vvekerekevedeeaveakde E KK E G E V E nv 239
Cdd:COG0326 162 IEEAEKA E -- RGT E I TL H L KED AEE FLEE WRLR EI I KK Y S D FI PV PIK M --------------------- E GE E E E T E -- 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 240 addadkkktkkikekyf EDE EL N KTKPI WTR NPDD I SN EEY A EFYK S L SN D W ED H L AVK H FS VEG QL E FRA LL FV P QR AP 319
Cdd:COG0326 217 ----------------- EDE TI N SATAL WTR SKSE I TD EEY K EFYK H L FH D F ED P L FWI H LN VEG PF E YTG LL YI P KK AP 279
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 320 FDL F e NKKS K NS IKLYV R RVFIM ENC E E L M PEYL N F IK GVVDS E DLPLN I SRE M LQ QSKI LK V IRK NLV KK CMELIDEV A 399
Cdd:COG0326 280 FDL Y - DRDR K GG IKLYV K RVFIM DDA E D L L PEYL R F VR GVVDS P DLPLN V SRE I LQ EDRQ LK K IRK AIT KK VLDELEKL A 358
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 400 E - D KDNFK KF YEQ FG KN LK L G IH ED ST NR K K LS D F LR YSTSAGDEPTS L K EYV S RMKE N Q TQ IYYITGES KDVVAA S AFV 478
Cdd:COG0326 359 K n D REKYE KF WKE FG LV LK E G AL ED FK NR E K IA D L LR FESTKEGGYVT L A EYV E RMKE G Q KK IYYITGES REAAEQ S PHL 438
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 479 E RV K SR G F EVL YMC DPIDE YCVQQ L K E Y DGKK LV SV TKEG L E L PET EE E K KKF EE DK v AYEN L CKVI K DI L EK KV EK V G V 558
Cdd:COG0326 439 E IF K AK G I EVL LLT DPIDE FLISH L E E F DGKK FK SV DSGD L D L DKL EE K K ESE EE EE - EFKP L LERF K EA L GD KV KD V R V 517
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 559 S N RL VS SP C C I V TS E YGW S AN ME RIM KA qalrdsst MG -- YMA AK KH LEINP D H AIM K T L RD rvev DKNDKTV KDL VV LL 636
Cdd:COG0326 518 S A RL TD SP A C L V AD E GDM S RR ME KML KA -------- MG qd MPE AK PI LEINP N H PLV K K L AA ---- EEDEELF KDL AE LL 585
650 660 670
....*....|....*....|....*....|
gi 17559162 637 FET ALLA S G FS LE E P QSHAS R IYRMIKLG L 666
Cdd:COG0326 586 YDQ ALLA E G GL LE D P AAFVK R LNKLLEKA L 615
PTZ00130
PTZ00130 heat shock protein 90; Provisional
2-700
7.71e-165
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 494.56
E-value: 7.71e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 2 SENA E TFAF Q A E IAQ LM SL I I N TF Y SN KE IY LRELISNA S DAL D KIR YQA L TEP S E L DTG K E L F I K I TP NKE EKT L T I M D 81
Cdd:PTZ00130 62 TSGI E QHQY Q T E VTR LM DI I V N SL Y TQ KE VF LRELISNA A DAL E KIR FLS L SDE S V L GEE K K L E I R I SA NKE KNI L S I T D 141
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 82 TGIGMTK A DL V NNLGTIAKSGT KA F M EA L - QA G A D I S M IGQFGVGFYSAFLVADKV V V TS KNN D D DS Y Q WES S A GGS F VV 160
Cdd:PTZ00130 142 TGIGMTK E DL I NNLGTIAKSGT SN F L EA I s KS G G D M S L IGQFGVGFYSAFLVADKV I V YT KNN N D EQ Y I WES T A DAK F TI 221
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 161 rp FN DP E --- VT RGT K I VM H I KED QIDFLEER K IKEIVK K H SQFI G YPI K L VV E KEREK EV EDEE A V E AKDEEKKEGEVE 237
Cdd:PTZ00130 222 -- YK DP R gst LK RGT R I SL H L KED ATNLMNDK K LVDLIS K Y SQFI Q YPI Y L LH E NVYTE EV LADI A K E MENDPNYDSVKV 299
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 238 NVA DD AD KK KTKKI K EKY f EDEEL N KT KPIW T R N P DDISN E E Y AE F YKS LS NDWEDH L AVK HF SV EG QL EF RA L LFV P Q R 317
Cdd:PTZ00130 300 EET DD PN KK TRTVE K KVK - KWKLM N EQ KPIW L R P P KELTD E D Y KK F FSV LS GFNDEP L YHI HF FA EG EI EF KC L IYI P S R 378
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 318 AP FDLFENKKSK NSIKLYVRRV FIMENCE E LM P E Y LN F I KGVVDS E DLPLN I SRE M LQQ S KILK VIR K NL V K K CM ----- 392
Cdd:PTZ00130 379 AP SINDHLFTKQ NSIKLYVRRV LVADEFV E FL P R Y MS F V KGVVDS D DLPLN V SRE Q LQQ N KILK AVS K RI V R K IL dtfrt 458
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 393 -------------- EL ID E VA E D K ----------- DNF K KF Y EQFG K N LK L G IH ED ST NR K K LSDF L RYS T SAGDEPT SL 447
Cdd:PTZ00130 459 lykegkknketlra EL AK E TD E E K kkeiqkkinep STY K LI Y KEYR K Y LK T G CY ED DI NR N K IVKL L LFK T MLHPKSI SL 538
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 448 KE Y VSR MK EN Q TQ IYY IT G E S KDVVAASAFVERV K SRGFE V LYMCDPI DE Y CVQ QLK EYDGKK LV S VT K EGLELPE TE E E 527
Cdd:PTZ00130 539 DT Y IEN MK PD Q KF IYY AS G D S YEYLSKIPQLQIF K KKNID V VFLTESV DE S CVQ RVQ EYDGKK FK S IQ K GEITFEL TE D E 618
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 528 KKK F E ED K VA Y EN L CK VI K D I L EKKVE KV GV S N RLV SS PC CI V TS E Y G W S AN ME RI MK AQ a LRD S STMGY M AAK K H LEIN 607
Cdd:PTZ00130 619 KKK E E KV K KM Y KA L ID VI S D T L RNQIF KV EI S R RLV DA PC AV V ST E W G L S GQ ME KL MK IN - VNN S DQIKA M SGQ K I LEIN 697
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 608 PDH A IM KT L RD R VEVDKN D KTVKDLVVLLFET A L LASGF S LE EPQSH A SRI Y RM I KLG L DIGDDEIE D SAV P SSCTAEAK 687
Cdd:PTZ00130 698 PDH P IM ID L LK R SVSNPK D SQLTESIKIIYQS A K LASGF D LE DTADL A QIV Y DH I NQK L GVDNNLKI D DLD P AIFETKKI 777
730
....*....|...
gi 17559162 688 IEGAEE D ASRME E 700
Cdd:PTZ00130 778 EQEDSP D GQKFH E 790
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
16-202
5.21e-109
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 327.94
E-value: 5.21e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 16 QL MS LII NTF YSNKEI Y LRELISNASDALDK I RY QA LT E PS E LD TGK EL F I K I T P N KE EK TLTI M DTGIGMTK AD L V NNL 95
Cdd:cd16927 2 QL LD LII HSL YSNKEI F LRELISNASDALDK L RY LS LT D PS L LD DDP EL E I R I S P D KE NR TLTI S DTGIGMTK EE L I NNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 96 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSAF L VADKV V VT S K NN - DD DS Y Q WES SA GGS FVVRPFND p E VT RGTK 173
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSAF M VADKV T VT T K SA g DD EG Y R WES DG GGS YTIEEAEG - E LG RGTK 160
170 180
....*....|....*....|....*....
gi 17559162 174 I VM H I KED QID FLEE RK IKE I VKK H S Q FI 202
Cdd:cd16927 161 I TL H L KED AKE FLEE AR IKE L VKK Y S D FI 189
PRK14083
PRK14083 HSP90 family protein; Provisional
9-463
7.12e-35
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 140.46
E-value: 7.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 9 A FQ AEIAQLMS L IINTF YS NKEI Y L REL IS NA S DA ldk I RYQALTE P S el DT G K elf I K I TPNK - EEK TL TIM D T GIG M T 87
Cdd:PRK14083 4 R FQ VDLRGVID L LSRHL YS SPRV Y V REL LQ NA V DA --- I TARRALD P T -- AP G R --- I R I ELTD a GGG TL IVE D N GIG L T 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 88 KADLVNN L G TI AK S GTKA fm E A L QAGAD i SMI GQFG V G FY S A FLVAD KV VV T S KNND D - DSYQ W ESS A G G SFV VR PFNDP 166
Cdd:PRK14083 76 EEEVHEF L A TI GR S SKRD -- E N L GFARN - DFL GQFG I G LL S C FLVAD EI VV V S RSAK D g PAVE W RGK A D G TYS VR KLETE 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 167 EVTR GT KIVMHIKE D QIDF LE ERKIK E IV KK HSQFIGY PI klvvekerekevedeeaveakdeekkegevenvaddadkk 246
Cdd:PRK14083 153 RAEP GT TVYLRPRP D AEEW LE RETVE E LA KK YGSLLPV PI ---------------------------------------- 192
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 247 ktkkikek YF E D E E -- L N K T K P I WTR NPD D ISNE ----- E Y A E fy KS L SNDWE D H -- L A V KHFSV EG qlefra LLF V - P Q 316
Cdd:PRK14083 193 -------- RV E G E K gg V N E T P P P WTR DYP D PETR reall A Y G E -- EL L GFTPL D V ip L D V PSGGL EG ------ VAY V l P Y 256
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 317 RAPF dlfe NKKS K NSI kl Y VR R VFIM E NC E E L M P EYLN F IKG VV DSED L PLNI SRE M L QQSKI L KVI R KN L --- VK K C me 393
Cdd:PRK14083 257 AVSP ---- AARR K HRV -- Y LK R MLLS E EA E N L L P DWAF F VRC VV NTDE L RPTA SRE A L YEDDA L AAV R EE L gea IR K W -- 328
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17559162 394 LI DEVAE D KDNFKKF yeqfgknlk L GI H --------- E D STNRKKLSDF L RYS T SA G DE pt S L K E Y vsr MKENQT q I Y Y 463
Cdd:PRK14083 329 LI GLATT D PERLRRL --------- L AV H hlgvkalas H D DELLRLILPW L PFE T TD G RM -- T L A E I --- RRRHGV - I R Y 392
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
28-179
2.32e-09
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 55.35
E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 28 NKEIY LR ELI SN AS D ALD K IRYQ altepseldt G KELFIKITPNKEEKTL T IM D T G I G MTKA DL vnnlgtiaksg T K A F M 107
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTPE ---------- G GRITVTLERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559162 108 EALQAGADISM IG QF G V G FYSAFLVADKV vvtsknndddsyqwessa GG SFV V rpfn DP E VTR GT KIVMHIK 179
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLVELH ------------------ GG EIS V ---- ES E PGG GT TFTITLP 109
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
28-182
1.41e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 44.67
E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 28 NK E IY LR ELI SN AS D AL dk IRYQ A ltepseld TGK E LFIKITP n KE E K TLT IM D T GIG MTKA DL vnnlgti AKSGTK a F M 107
Cdd:pfam02518 1 GD E LR LR QVL SN LL D NA -- LKHA A -------- KAG E ITVTLSE - GG E L TLT VE D N GIG IPPE DL ------- PRIFEP - F S 61
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17559162 108 E alqag AD ISMI G QF G V G FY safl VAD K V V vtsknndddsyqwe SSA GG SFV V R pfnd P E VTR GT KIVMHIKED Q 182
Cdd:pfam02518 62 T ----- AD KRGG G GT G L G LS ---- IVR K L V -------------- ELL GG TIT V E ---- S E PGG GT TVTLTLPLA Q 109
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
30-150
9.08e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 42.70
E-value: 9.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 30 E IY L R ELI S N AS DA ldkiryqaltepseldtg KELF IKI TP NK EE --- KTLT I M D T G I GM TKAD L V N N L G t I A K S GTK af 106
Cdd:pfam13589 2 E GA L A ELI D N SI DA ------------------ DATN IKI EV NK NR ggg TEIV I E D D G H GM SPEE L I N A L R - L A T S AKE -- 60
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 17559162 107 mealq A GADISMI G QF G V G FYS A F L V - AD K VV VTSK NNDDD S - YQW 150
Cdd:pfam13589 61 ----- A KRGSTDL G RY G I G LKL A S L S l GA K LT VTSK KEGKS S t LTL 101
HATPase_MORC-like
cd16931 Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
33-143
3.17e-03
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Pssm-ID: 340408 [Multi-domain]
Cd Length: 118
Bit Score: 38.16
E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559162 33 LR EL IS NA S DA LD kiryqaltepseld T GKEL FI - K I TPNKEEKT L TIM D T G I GMT KADLVNNLG tiaksgtka F MEALQ 111
Cdd:cd16931 16 VA EL VD NA R DA DA -------------- T RLDI FI d D I NLLRGGFM L SFL D D G N GMT PEEAHHMIS --------- F GFSDK 72
90 100 110
....*....|....*....|....*....|....
gi 17559162 112 AGA D ISM IG QF G V GF Y S AF -- L VA D KV V V T S K NN 143
Cdd:cd16931 73 RSD D HDH IG RY G N GF K S GS mr L GR D VI V F T K K DE 106
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
