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Conserved domains on  [gi|392921896|ref|NP_506605|]
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Kelch repeat protein [Caenorhabditis elegans]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
181-424 1.87e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.59  E-value: 1.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 181 KPIGRLPDPRANFAVASSKTNLYVIGGTHNGQFLNKFEYYNQKKN-----ARCMGANLNHkrtkPAAGFHNGALYVVGGY 255
Cdd:COG3055    4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNtwselAPLPGPPRHH----AAAVAQDGKLYVFGGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 256 D-----SIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACYGEIFVLGGFNGKSNEESIEKISASGNEFEIFGEMEGGR 330
Cdd:COG3055   80 TganpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 331 SGF-GACVFQGRIYIAGGwsntrntlksvRSYDPYTKTWRDEPSMKNARKAFTLHATNEAIYAIRGydeESALLDQIERF 409
Cdd:COG3055  160 DHLaAAVLPDGKILVIGG-----------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG---ESGFSDEVEAY 225

                        250
                 ....*....|....*
gi 392921896 410 DPKKLKWSIVPSKPH 424
Cdd:COG3055  226 DPATNTWTALGELPT 240
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
181-424 1.87e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.59  E-value: 1.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 181 KPIGRLPDPRANFAVASSKTNLYVIGGTHNGQFLNKFEYYNQKKN-----ARCMGANLNHkrtkPAAGFHNGALYVVGGY 255
Cdd:COG3055    4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNtwselAPLPGPPRHH----AAAVAQDGKLYVFGGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 256 D-----SIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACYGEIFVLGGFNGKSNEESIEKISASGNEFEIFGEMEGGR 330
Cdd:COG3055   80 TganpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 331 SGF-GACVFQGRIYIAGGwsntrntlksvRSYDPYTKTWRDEPSMKNARKAFTLHATNEAIYAIRGydeESALLDQIERF 409
Cdd:COG3055  160 DHLaAAVLPDGKILVIGG-----------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG---ESGFSDEVEAY 225

                        250
                 ....*....|....*
gi 392921896 410 DPKKLKWSIVPSKPH 424
Cdd:COG3055  226 DPATNTWTALGELPT 240
PHA03098 PHA03098
kelch-like protein; Provisional
 135-425 6.48e-26

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 110.24  E-value: 6.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 135 EKHRFTGKDGDAFLEPNMdpvLIADQAQSAHKPLLIGSFDPKTQKYKPIGRLPDpRANFAVASSKTNLYVIGGT-HNGQF 213
Cdd:PHA03098 234 SKKYNLNKILPRSSTFGS---IIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-VYCFGSVVLNNVIYFIGGMnKNNLS 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 214 LNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNGALYVVGG-YDSIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACY 292
Cdd:PHA03098 310 VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVN 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 293 GEIFVLGG-FNGKSNEESIEKISASGNEFEIFGEMEGGRSGFGACVFQGRIYIAGGWSNTRN--TLKSVRSYDPYTKTWR 369
Cdd:PHA03098 390 NLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNikVYNIVESYNPVTNKWT 469

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 392921896 370 DEPSMKNARKAFTLHATNEAIYAIRGYDEESAlLDQIERFDPKKLKWSIVPSKPHV 425
Cdd:PHA03098 470 ELSSLNFPRINASLCIFNNKIYVVGGDKYEYY-INEIEVYDDKTNTWTLFCKFPKV 524
Kelch smart00612
Kelch domain;
249-293 5.79e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.96  E-value: 5.79e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 392921896   249 LYVVGGYD-SIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACYG 293
Cdd:smart00612   2 IYVVGGFDgGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 330-375 2.05e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.39  E-value: 2.05e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392921896  330 RSGFGACVFQGRIYIAGGWSNTRNtLKSVRSYDPYTKTWRDEPSMK 375
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQS-LNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
181-424 1.87e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 137.59  E-value: 1.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 181 KPIGRLPDPRANFAVASSKTNLYVIGGTHNGQFLNKFEYYNQKKN-----ARCMGANLNHkrtkPAAGFHNGALYVVGGY 255
Cdd:COG3055    4 SSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNtwselAPLPGPPRHH----AAAVAQDGKLYVFGGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 256 D-----SIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACYGEIFVLGGFNGKSNEESIEKISASGNEFEIFGEMEGGR 330
Cdd:COG3055   80 TganpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 331 SGF-GACVFQGRIYIAGGwsntrntlksvRSYDPYTKTWRDEPSMKNARKAFTLHATNEAIYAIRGydeESALLDQIERF 409
Cdd:COG3055  160 DHLaAAVLPDGKILVIGG-----------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG---ESGFSDEVEAY 225

                        250
                 ....*....|....*
gi 392921896 410 DPKKLKWSIVPSKPH 424
Cdd:COG3055  226 DPATNTWTALGELPT 240
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
173-410 1.07e-35

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 132.97  E-value: 1.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 173 FDPKTQKYKPIGRLP-DPRANFAVASSKTNLYVIGGTH----NGQFLNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNG 247
Cdd:COG3055   43 YDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 248 ALYVVGGYD-SIYLSSVELYDLEEGTWKNGPSLNNCRAN-AAVVACYGEIFVLGGFNGksneesiekiSASGNEFEIFGE 325
Cdd:COG3055  123 KIYVVGGWDdGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNG----------SGFSNTWTTLAP 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 326 MEGGRSGFGACVFQGRIYIAGGwsnTRNTLKSVRSYDPYTKTWRDEPSMKNARKAFTLHATNEAIYAIRGYDEE---SAL 402
Cdd:COG3055  193 LPTARAGHAAAVLGGKILVFGG---ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrTPL 269


                 ....*...
gi 392921896 403 LDQIERFD 410
Cdd:COG3055  270 VTSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 135-425 6.48e-26

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 110.24  E-value: 6.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 135 EKHRFTGKDGDAFLEPNMdpvLIADQAQSAHKPLLIGSFDPKTQKYKPIGRLPDpRANFAVASSKTNLYVIGGT-HNGQF 213
Cdd:PHA03098 234 SKKYNLNKILPRSSTFGS---IIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-VYCFGSVVLNNVIYFIGGMnKNNLS 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 214 LNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNGALYVVGG-YDSIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACY 292
Cdd:PHA03098 310 VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVN 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 293 GEIFVLGG-FNGKSNEESIEKISASGNEFEIFGEMEGGRSGFGACVFQGRIYIAGGWSNTRN--TLKSVRSYDPYTKTWR 369
Cdd:PHA03098 390 NLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNikVYNIVESYNPVTNKWT 469

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 392921896 370 DEPSMKNARKAFTLHATNEAIYAIRGYDEESAlLDQIERFDPKKLKWSIVPSKPHV 425
Cdd:PHA03098 470 ELSSLNFPRINASLCIFNNKIYVVGGDKYEYY-INEIEVYDDKTNTWTLFCKFPKV 524
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
271-424 9.55e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 91.76  E-value: 9.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 271 GTWKNGPSLNNCRANAAVVACYGEIFVLGGFNGKSNEESIEKISASGNEFEIFGEMEG-GRSGFGACVFQGRIYIAGGWS 349
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392921896 350 ---NTRNTLKSVRSYDPYTKTWRDEPSMKNARKAFTLHATNEAIYAIRGYDEESALLDqIERFDPKKLKWSIVPSKPH 424
Cdd:COG3055   81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAW-VEVYDPATGTWTQLAPLPT 157
Kelch smart00612
Kelch domain;
249-293 5.79e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.96  E-value: 5.79e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 392921896   249 LYVVGGYD-SIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVACYG 293
Cdd:smart00612   2 IYVVGGFDgGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
341-388 4.39e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.65  E-value: 4.39e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 392921896   341 RIYIAGGWSNTrNTLKSVRSYDPYTKTWRDEPSMKNARKAFTLHATNE 388
Cdd:smart00612   1 KIYVVGGFDGG-QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 330-375 2.05e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.39  E-value: 2.05e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392921896  330 RSGFGACVFQGRIYIAGGWSNTRNtLKSVRSYDPYTKTWRDEPSMK 375
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQS-LNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 237-280 1.07e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.77  E-value: 1.07e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 392921896  237 RTKPAAGFHNGALYVVGGYDSI-YLSSVELYDLEEGTWKNGPSLN 280
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNqSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
202-247 1.19e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 53.72  E-value: 1.19e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 392921896   202 LYVIGGTHNGQFLNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNG 247
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
295-340 2.95e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 2.95e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 392921896   295 IFVLGGFNGKSNEESIEKISASGNEFEIFGEMEGGRSGFGACVFQG 340
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 189-234 3.62e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.53  E-value: 3.62e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392921896  189 PRANFAVASSKTNLYVIGGTHNGQFLNKFEYYNQKKNARCMGANLN 234
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
330-378 3.77e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.56  E-value: 3.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392921896  330 RSGFGACVFQGRIYIAGGWSNTRNTLKSVRSYDPYTKTWRDEPSMKNAR 378
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
168-267 8.21e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 50.15  E-value: 8.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 168 LLIG--SFDPKTQKYKPIGRLPDPRANFAVASSKTNLYVIGGTHNgqFLNKFEYYNQKKNA-RCMGaNLNHKRTKPAAGF 244
Cdd:COG3055  173 LVIGgrNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTwTALG-ELPTPRHGHAAVL 249

                         90       100
                 ....*....|....*....|....*...
gi 392921896 245 HNGALYVVGGYD-----SIYLSSVELYD 267
Cdd:COG3055  250 TDGKVYVIGGETkpgvrTPLVTSAEVYD 277
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 377-423 8.68e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 45.30  E-value: 8.68e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 392921896  377 ARKAFTLHATNEAIYAIRGYDEESALlDQIERFDPKKLKWSIVPSKP 423
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSL-NSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 283-326 8.38e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.60  E-value: 8.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392921896  283 RANAAVVACYGEIFVLGGFNGKSNEESIEKISASGNEFEIFGEM 326
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
PHA02713 PHA02713
hypothetical protein; Provisional
 251-347 1.51e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 47.31  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 251 VVGGYD--SIYLSSVELYDLEEGTWKNGPSL--NNCRANAAVVAcyGEIFVLGGFNGKSNEESIEKISASGNEFEIFGEM 326
Cdd:PHA02713 308 IAGGYNfnNPSLNKVYKINIENKIHVELPPMikNRCRFSLAVID--DTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDM 385

                         90       100
                 ....*....|....*....|.
gi 392921896 327 EGGRSGFGACVFQGRIYIAGG 347
Cdd:PHA02713 386 PIALSSYGMCVLDQYIYIIGG 406
PLN02193 PLN02193
nitrile-specifier protein
 172-300 2.21e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.49  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 172 SFDPKTQKYK---PIGRLPDPRANFAVASSKTNLYVIGGTHNGQFLNKFEYYN--QKKNARCM--GANLNhkrTKPAAGF 244
Cdd:PLN02193 248 SFDTTTNEWKlltPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNivDKKWFHCStpGDSFS---IRGGAGL 324

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392921896 245 H--NGALYVVGGYDSIYLSSVELYDLEEGTWKN------GPSLNNCRANAAVVAcygEIFVLGG 300
Cdd:PLN02193 325 EvvQGKVWVVYGFNGCEVDDVHYYDPVQDKWTQvetfgvRPSERSVFASAAVGK---HIVIFGG 385
PLN02153 PLN02153
epithiospecifier protein
 200-382 2.71e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.13  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 200 TNLYVIGGTHNGQFLNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNGA-----LYVVGGYDS-------IYLSSVELYD 267
Cdd:PLN02153  86 TKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGGPEARTFHSMAsdenhVYVFGGVSKgglmktpERFRTIEAYN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 268 LEEGTWKNGPSLNNC---RANAAVVACYGEIFVLGGF------NGKSNEES-----IEKISASGNEFEIFGEMEGGRSGF 333
Cdd:PLN02153 166 IADGKWVQLPDPGENfekRGGAGFAVVQGKIWVVYGFatsilpGGKSDYESnavqfFDPASGKWTEVETTGAKPSARSVF 245

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392921896 334 GACVFQGRIYIAGG--WSNTRNTLK----SVRSY--DPYTKTWR-----DEPSMKNARKAFT 382
Cdd:PLN02153 246 AHAVVGKYIIIFGGevWPDLKGHLGpgtlSNEGYalDTETLVWEklgecGEPAMPRGWTAYT 307
PHA02790 PHA02790
Kelch-like protein; Provisional
 202-418 3.12e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 46.19  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 202 LYVIGGTHNGQFLNKFEYYNQKKNARCMGANLNHKRTKPAAGFHNGALYVVGGYDSIylSSVELYDLEEGTWKNGPSLNN 281
Cdd:PHA02790 274 VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP--TSVERWFHGDAAWVNMPSLLK 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 282 CRANAAVVACYGEIFVLGGFNgkSNEESIEKISASGNEFEIFGEMEGGRSGFGACVFQGRIYIAGgwsntrntlKSVRSY 361
Cdd:PHA02790 352 PRCNPAVASINNVIYVIGGHS--ETDTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG---------RNAEFY 420

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 392921896 362 DPYTKTWR--DEPSMknARKAFTLHATNEAIYAIRGYdEESALLDQIERFDPKKLKWSI 418
Cdd:PHA02790 421 CESSNTWTliDDPIY--PRDNPELIIVDNKLLLIGGF-YRGSYIDTIEVYNNRTYSWNI 476
Kelch_6 pfam13964
Kelch motif;
377-424 1.04e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.63  E-value: 1.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 392921896  377 ARKAFTLHATNEAIYAIRGYDEESALLDQIERFDPKKLKWSIVPSKPH 424
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPT 48
Kelch_6 pfam13964
Kelch motif;
245-283 4.62e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 4.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392921896  245 HNGALYVVGGYD--SIYLSSVELYDLEEGTWKNGPSLNNCR 283
Cdd:pfam13964  10 VGGYIYVFGGYTnaSPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
246-290 8.25e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 8.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 392921896  246 NGALYVVGGYD---SIYLSSVELYDLEEGTWKNGPSLNNCRANAAVVA 290
Cdd:pfam13415   1 GDKLYIFGGLGfdgQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 240-279 1.34e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 1.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 392921896  240 PAAGFHNGALYVVGGYDSI---YLSSVELYDLEEGTWKNGPSL 279
Cdd:pfam07646   5 HASSVPGGKLYVVGGSDGLgdlSSSDVLVYDPETNVWTEVPRL 47
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
367-426 6.27e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 38.21  E-value: 6.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921896 367 TWRDEPSMKNARKAFTLHATNEAIYAIRGYDEESALlDQIERFDPKKLKWSIVPSKPHVP 426
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAS-NSFEVYDPATNTWSELAPLPGPP 60
Kelch_4 pfam13418
Galactose oxidase, central domain;
377-424 8.91e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 8.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392921896  377 ARKAFTLHATNEA-IYAIRGYDEESALLDQIERFDPKKLKWSIVPSKPH 424
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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