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Conserved domains on  [gi|212646556|ref|NP_506518|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-316 1.10e-86

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 263.55  E-value: 1.10e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556    8 LSIIEQSLSILSFLTNSLLIFLVFTSSPKTMGSYKYIMIFTSVFEMAYGLVHFLIKPEIISKDSYVLEETNSQKSLIPLS 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   88 VARMLLLSYNGSYAIALINFNIHFIFRYFVMTGN--AKRVTGKVIWIWLSIPFLYSIFYSAPTHFLLHSSESMDRVIKSE 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPgkLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  166 VEYLKHLPIEDVVYYAFNFFETTENSTqKSTNWTNIYGISFMMLVISTSFSITIIFAAKGYFEVKKLSSIAtshSSASKT 245
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212646556  246 LQAQLFYSLVIQTVIPVILIHFPTTIILINAFFGIGREVHGHILTVSICLFPAIDSLPSMIIIRPYRLAIK 316
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-316 1.10e-86

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 263.55  E-value: 1.10e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556    8 LSIIEQSLSILSFLTNSLLIFLVFTSSPKTMGSYKYIMIFTSVFEMAYGLVHFLIKPEIISKDSYVLEETNSQKSLIPLS 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   88 VARMLLLSYNGSYAIALINFNIHFIFRYFVMTGN--AKRVTGKVIWIWLSIPFLYSIFYSAPTHFLLHSSESMDRVIKSE 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPgkLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  166 VEYLKHLPIEDVVYYAFNFFETTENSTqKSTNWTNIYGISFMMLVISTSFSITIIFAAKGYFEVKKLSSIAtshSSASKT 245
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212646556  246 LQAQLFYSLVIQTVIPVILIHFPTTIILINAFFGIGREVHGHILTVSICLFPAIDSLPSMIIIRPYRLAIK 316
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-316 1.10e-86

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 263.55  E-value: 1.10e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556    8 LSIIEQSLSILSFLTNSLLIFLVFTSSPKTMGSYKYIMIFTSVFEMAYGLVHFLIKPEIISKDSYVLEETNSQKSLIPLS 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   88 VARMLLLSYNGSYAIALINFNIHFIFRYFVMTGN--AKRVTGKVIWIWLSIPFLYSIFYSAPTHFLLHSSESMDRVIKSE 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPgkLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  166 VEYLKHLPIEDVVYYAFNFFETTENSTqKSTNWTNIYGISFMMLVISTSFSITIIFAAKGYFEVKKLSSIAtshSSASKT 245
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212646556  246 LQAQLFYSLVIQTVIPVILIHFPTTIILINAFFGIGREVHGHILTVSICLFPAIDSLPSMIIIRPYRLAIK 316
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 17-315 1.57e-21

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 93.08  E-value: 1.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   17 ILSFLTNSLLIFLVFTSSPKTMGSYKYIMIFTSVFEMAYGLVHFLIKPEIIS---------KDSYVLEETNSQKSLIpls 87
Cdd:pfam10319  16 VLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSyrycfvvfvSDGPFFEYSELGQHAL--- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   88 VARMLLLSynGSYAIALInfniHFIFRYFVMTgNAKRVTGKVIWIWLSIPFLYSIFY----SAPTHFLLHSSESMDRVIK 163
Cdd:pfam10319  93 SARCSFIS--ASYAVLLI----HFIYRYLVLF-NPQLTRHYFRPWGILISILFFLFHgsvwTAICYFLLRANDEIRDYIR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  164 SEVEYLKHLPIEDVVYYAFNFFETTENSTQKStnWTNIygisfMMLVISTSFSITIIFAAkGYFEVKKLSSIATSHSSAS 243
Cdd:pfam10319 166 EDFRETYGVDSMDINMLGALYWEASDETVFRS--WLGI-----LLLTVISVYSIILYIVL-GYKIMRKLNKMSVTMSKKT 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212646556  244 KTLQAQLFYSLVIQTVIPVILIHFPTTIILINAFFGI--GREVHgHILTVSICLFPAIDSLPSMIIIRPYRLAI 315
Cdd:pfam10319 238 KRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIdlGRWNN-YLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 8-317 7.18e-17

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 79.52  E-value: 7.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556    8 LSIIEQSLSILSFLTNSLLIFLVFTSSPKTMGSYKYIMIFTSVFEMAYGLVHFLIKPEIISKDSYVLEETNSQKSLIPLS 87
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   88 VARMLLLSYNGSYAIALINFNIHFIFRYFVMTGNA-KRVTGKVIWIWLSIPFLYS--IFYSAPTHFLlhssesmdrviKS 164
Cdd:pfam10317  81 FCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDpKRKKLILLIIIHYIPSLSQliVIFLSPTDFL-----------PV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  165 EVEYLKHLPIEDVVYYAFNFFETTenstqksTNWTNIYGISFMMLVISTSFSITIIFAAKGyfeVKKLSSIATSHSSASK 244
Cdd:pfam10317 150 EALTKELHPNYNLTDYTVTGFSDL-------QSFPALINTLIMTIPVFPIPIIILILRRKI---LKLLNSNSVNMSPTTK 219

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212646556  245 TLQAQLFYSLVIQTVIPVILIHFPTTIILINAFFGIGREVHGHILTVSICLFPAIDSLPSMIIIRPYRLAIKR 317
Cdd:pfam10317 220 AQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 8-321 1.55e-09

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 58.32  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556    8 LSIIEQSLSILSFLTNSLLIFLVFTSSPKTMGSYKYIM----IFTSVFEMAYGL--VHFLIKPEIISKDSYVLEETNsqk 81
Cdd:pfam10318   6 LSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLlnlhFWSALLDLSLSFltIPYIFLPALAGYPLGLLSYLG--- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556   82 slIPLSVARMLLLSYNGSYAIALINFnihFIFRYFVMTGNAKRVTGKVI-WIWLSIPFLYSIFYSAPTHFLLHSSESMDR 160
Cdd:pfam10318  83 --VPTPIQFYIGVTSLALVGVSIILL---FENRYSILFTNKKRITWKKTrVLYLIFNYIIALLFLIPIYLNIPDQEAAKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  161 VIkseveyLKHLP-IEDVVYYAFNFFETTENSTqkstnWTNIYGISFMMLVISTSFSITIIFAAKGYFEVKKlssiatSH 239
Cdd:pfam10318 158 KV------LKKLPcLPPEFFDNPPVFVLAIDST-----YFLICIVLLILILIIQILFFVFLTIYYLFKSVKS------SL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646556  240 SSASKTLQAQLFYSLVIQTVIPVILIHFPTTIILINAFFGIGREVHGHILTVSICLFPAIDSLPSMIIIRPYRLAIKRVL 319
Cdd:pfam10318 221 SKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300


                  ..
gi 212646556  320 KY 321
Cdd:pfam10318 301 KK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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