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Conserved domains on  [gi|17564568|ref|NP_506442|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

serpentine receptor Srsx( domain architecture ID 10563404)

serpentine receptor Srsx belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Gene Ontology:  GO:0004930
PubMed:  18050473|7585938

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
14-284 3.69e-83

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 252.51  E-value: 3.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    14 MVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLIFRLRFQSLNGRECFLYNIPYSLAIMFQSWLFL 93
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    94 SMALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIVFFVNFIFVTEEDAPYCAYMLTMDDGVFEIISTSVVACNILT 173
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITVYGFLQRDDETIIVCAPPLALPGTAFTIFTLSSLFINVIV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   174 LLITIVSVFVAIRKSQdmrnhrhssvtrrnSTVEERRKVFRSTFYMMSIYIFCWMTSSICFRVLFYMFENETNIVPYMPY 253
Cdd:pfam10320 161 LIVYIILIIIFKNKKQ--------------SQNSDSKKVFKSLQVTVVIFIFGWFTSTIANTVFLYLTEDGEVEVIIQMY 226
                         250       260       270
                  ....*....|....*....|....*....|.
gi 17564568   254 LAIITMPNFCQAYFVTYFRSPRFRKAYREHF 284
Cdd:pfam10320 227 AGFFVLLSFSQNFFVTYWRSSEYRKAFRSLW 257
 
Name Accession Description Interval E-value
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
14-284 3.69e-83

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 252.51  E-value: 3.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    14 MVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLIFRLRFQSLNGRECFLYNIPYSLAIMFQSWLFL 93
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    94 SMALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIVFFVNFIFVTEEDAPYCAYMLTMDDGVFEIISTSVVACNILT 173
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITVYGFLQRDDETIIVCAPPLALPGTAFTIFTLSSLFINVIV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   174 LLITIVSVFVAIRKSQdmrnhrhssvtrrnSTVEERRKVFRSTFYMMSIYIFCWMTSSICFRVLFYMFENETNIVPYMPY 253
Cdd:pfam10320 161 LIVYIILIIIFKNKKQ--------------SQNSDSKKVFKSLQVTVVIFIFGWFTSTIANTVFLYLTEDGEVEVIIQMY 226
                         250       260       270
                  ....*....|....*....|....*....|.
gi 17564568   254 LAIITMPNFCQAYFVTYFRSPRFRKAYREHF 284
Cdd:pfam10320 227 AGFFVLLSFSQNFFVTYWRSSEYRKAFRSLW 257
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
8-265 2.78e-13

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 68.85  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   8 AIIGPMMVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLIFRLRFQSLNGRE--CFLYNIPYSLAI 85
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDalCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  86 MFQSWLFLSMALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIVFFVNFIF--VTEEDAPYCAYMLTMDDGVFEIIS 163
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGwgVYDYGGYCCCCLCWPDLTLSKAYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 164 TSVVACNILTLLITIVSVFVAIR---KSQDMRNHRHSSVTRRNSTVEERRKVFRSTFYMMSIYIFCWMTSSICFrvLFYM 240
Cdd:cd00637 163 IFLFVLLFLLPLLVIIVCYVRIFrklRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILL--LLDV 240
                       250       260
                ....*....|....*....|....*
gi 17564568 241 FENETNIVPYMPYLAIITMPNFCQA 265
Cdd:cd00637 241 FGPDPSPLPRILYFLALLLAYLNSA 265
 
Name Accession Description Interval E-value
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
14-284 3.69e-83

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 252.51  E-value: 3.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    14 MVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLIFRLRFQSLNGRECFLYNIPYSLAIMFQSWLFL 93
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    94 SMALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIVFFVNFIFVTEEDAPYCAYMLTMDDGVFEIISTSVVACNILT 173
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITVYGFLQRDDETIIVCAPPLALPGTAFTIFTLSSLFINVIV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   174 LLITIVSVFVAIRKSQdmrnhrhssvtrrnSTVEERRKVFRSTFYMMSIYIFCWMTSSICFRVLFYMFENETNIVPYMPY 253
Cdd:pfam10320 161 LIVYIILIIIFKNKKQ--------------SQNSDSKKVFKSLQVTVVIFIFGWFTSTIANTVFLYLTEDGEVEVIIQMY 226
                         250       260       270
                  ....*....|....*....|....*....|.
gi 17564568   254 LAIITMPNFCQAYFVTYFRSPRFRKAYREHF 284
Cdd:pfam10320 227 AGFFVLLSFSQNFFVTYWRSSEYRKAFRSLW 257
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
8-265 2.78e-13

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 68.85  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   8 AIIGPMMVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLIFRLRFQSLNGRE--CFLYNIPYSLAI 85
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDalCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  86 MFQSWLFLSMALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIVFFVNFIF--VTEEDAPYCAYMLTMDDGVFEIIS 163
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGwgVYDYGGYCCCCLCWPDLTLSKAYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 164 TSVVACNILTLLITIVSVFVAIR---KSQDMRNHRHSSVTRRNSTVEERRKVFRSTFYMMSIYIFCWMTSSICFrvLFYM 240
Cdd:cd00637 163 IFLFVLLFLLPLLVIIVCYVRIFrklRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILL--LLDV 240
                       250       260
                ....*....|....*....|....*
gi 17564568 241 FENETNIVPYMPYLAIITMPNFCQA 265
Cdd:cd00637 241 FGPDPSPLPRILYFLALLLAYLNSA 265
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
13-251 4.23e-11

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 62.62  E-value: 4.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  13 MMVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELK-TLIFRLRFQSLNGRE-CFLYNIPYSLAIMFQSW 90
Cdd:cd15203  10 IIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTLTKNWPFGSIlCKLVPSLQGVSIFVSTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  91 LFLSMALDLCFCIMIPIKHMLWPKTKYILIMCI--MPTCCAL-IVFFVNFIFVTEEDAPYCAYMLTMDDGVFEI-----I 162
Cdd:cd15203  90 TLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIwiLSLLLSLpLAIFQELSDVPIEILPYCGYFCTESWPSSSSrliytI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 163 STSVVACNILTLLITI--VSVFVAIRKSQDMRN-HRHSSVTRRNSTVEERRKVFRSTFYMMSIYIFCWMTSSIcFRVLFY 239
Cdd:cd15203 170 SVLVLQFVIPLLIISFcyFRISLKLRKRVKKKRgKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNL-FNLLRD 248
                       250
                ....*....|..
gi 17564568 240 MFENETNIVPYM 251
Cdd:cd15203 249 FEPLPQIDGRHF 260
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
15-251 1.84e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 45.66  E-value: 1.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  15 VLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINI-AELKTLIFRLRFQSLNGRE-CFLYNIPYSLAIMFQSWLF 92
Cdd:cd14969  12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVvGYPLSFYSNLSGRWSFGDPgCVIYGFAVTFLGLVSISTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  93 LSMALDLCFCIMIPIKhMLWPKTKYILIMCIMPTCCALIVFFVNFI----FVTEEDAPYCAymLTMDDGVFEIISTSV-- 166
Cdd:cd14969  92 AALAFERYLVIVRPLK-AFRLSKRRALILIAFIWLYGLFWALPPLFgwssYVPEGGGTSCS--VDWYSKDPNSLSYIVsl 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 167 -VACNILTLLITIVSvFVAIRKSqdMRNHRHSSVTRRNSTVEER-----RKVFRSTFYMMSIYIFCWMTSSICfrVLFYM 240
Cdd:cd14969 169 fVFCFFLPLAIIIFC-YYKIYRT--LRKMSKRAARRKNSAITKRtkkaeKKVAKMVLVMIVAFLIAWTPYAVV--SLYVS 243
                       250
                ....*....|.
gi 17564568 241 FENETNIVPYM 251
Cdd:cd14969 244 FGGESTIPPLL 254
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
15-279 5.19e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 44.55  E-value: 5.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  15 VLGIFGNVNVIVAVARKKVLRTKGAMLIFvLAISHLVINIAELKTLIFRL--RFQSLNGRECFLYNIPYS--LAIMFQS- 89
Cdd:cd14978  12 IFGIIGNILNLVVLTRKSMRSSTNVYLAA-LAVSDILVLLSALPLFLLPYiaDYSSSFLSYFYAYFLPYIypLANTFQTa 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  90 --WLFLSMALDLCFCIMIPIKHMLWPKTKY----ILIMCIMPTCCALIVFFVNFIFVTEEDAPYCAYMLTMDDGVFE--- 160
Cdd:cd14978  91 svWLTVALTVERYIAVCHPLKARTWCTPRRarrvILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNety 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 161 -------IISTSVVACNILTLLITIVSVFVAIRKSQDMRNHRHSSVTRRNSTVEERRKVFRSTFYMMSIYIFCWMTSSIc 233
Cdd:cd14978 171 llkyyfwLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGI- 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17564568 234 FRVLFYMFENETNIVPYMPYLAI---ITMPNFCQAYFVTYFRSPRFRKA 279
Cdd:cd14978 250 LNILEAIFGESFLSPIYQLLGDIsnlLVVLNSAVNFIIYCLFSSKFRRT 298
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
15-278 6.89e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 43.82  E-value: 6.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  15 VLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHlviniaELKTLIfrLRFQSLNgreCFLYNIPYSLAI--------- 85
Cdd:cd14970  12 VVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVAD------ELFLLG--LPFLATS---YLLGYWPFGEVMckivlsvda 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  86 --MFQSWLFLS-MALDLCFCIMIPIKHMLW--PKTKYILIMCIMPTCCALIVFFVNF--IFVTEEDAPYCAYML---TMD 155
Cdd:cd14970  81 ynMFTSIFCLTvMSVDRYLAVVHPVKSLRFrtPRKAKLVSLCVWALSLVLGLPVIIFarTLQEEGGTISCNLQWpdpPDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 156 DGVFEIISTSVVACNILTLLITIVSVFVAIR-KSQDMRNHRHSSVTRRNstveeRRKVFRSTFYMMSIYIFCWMTSSICF 234
Cdd:cd14970 161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRlRSSRNLSTSGAREKRRA-----RRKVTRLVLVVVAVFVVCWLPFHVFQ 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 17564568 235 RVLFYMFENETNIVPYMPYLAIITM-PNFCQAYFVTYFRSPRFRK 278
Cdd:cd14970 236 IVRLLIDPPETLTVVGVFLFCIALSyANSCLNPILYAFLDENFRK 280
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
15-232 3.47e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 41.64  E-value: 3.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  15 VLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAE--LKTLIFRLRFQSLNGRECFLYNIPYSLAIMFQSWLF 92
Cdd:cd14964  10 CLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVlvLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  93 LSMALDLCFCIMIPIKHMLWPKTKYIL-IMCIMPTCCALIVFFvnFIFVTEEDAPYCAYMLTMDDGVFEIISTsVVACNI 171
Cdd:cd14964  90 LVLTYHRYFALCGPLKYTRLSSPGKTRvIILGCWGVSLLLSIP--PLVGKGAIPRYNTLTGSCYLICTTIYLT-WGFLLV 166
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17564568 172 LTLLITIVSVFVAIRKSQDMRNHRHSSVTRRNSTVEERRKVFRSTFYMMSIYIFCWMTSSI 232
Cdd:cd14964 167 SFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSI 227
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
5-228 6.05e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 40.94  E-value: 6.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   5 TIEAIIGPMMVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLIFRLRFQSLNGRECFLYnIPYSLA 84
Cdd:cd15056   2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCL-VRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  85 IMfqswLFLSMALDLCFCIMIPIKHMLWPKTKY---ILIMCIMPTCCALIVFFVNFIFVTEE----------------DA 145
Cdd:cd15056  81 VL----LTTASIMHLCCIALDRYYAICCQPLVYkmtPLRVAVMLGGCWVIPTFISFLPIMQGwnhigiedliafncasGS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 146 PYCAYMLTMDdgvFEIIStSVVACNILTLLITI--VSVFVA-------IRKSQDMRNHRHSSVTRRNSTVEERRKVFRST 216
Cdd:cd15056 157 TSCVFMVNKP---FAIIC-STVAFYIPALLMVLayYRIYVAareqahqIRSLQRAGSSNHEADQHRNSRMRTETKAAKTL 232
                       250
                ....*....|..
gi 17564568 217 FYMMSIYIFCWM 228
Cdd:cd15056 233 GIIMGCFCVCWA 244
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
6-279 1.08e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 40.05  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   6 IEAIIGPMMVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINI-----AELKTLIFRLRFQSLngrECFLYNip 80
Cdd:cd14985   3 IPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLtlplwATYTANQYDWPFGAF---LCKVSS-- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  81 YSLAI-MFQSWLFLS-MALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIVFFVNFIF-----VTEEDAPYCAYMLT 153
Cdd:cd14985  78 YVISVnMFASIFLLTcMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLrslqaIENLNKTACIMLYP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 154 MDDGVFEIISTSvvacNILTL---LITIVSVFVAIRKSQDMRNHRhssvTRRNstVEERRKVFRSTFYMMSIYIFCWMTS 230
Cdd:cd14985 158 HEAWHFGLSLEL----NILGFvlpLLIILTCYFHIARSLRKRYER----TGKN--GRKRRKSLKIIFALVVAFLVCWLPF 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17564568 231 SIcFRVLFYMF--------ENETNIVPYMPYLAIITMPNFCQAYFVTYFRSPRFRKA 279
Cdd:cd14985 228 HF-FKFLDFLAqlgairpcFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQK 283
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
20-228 2.25e-03

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 39.20  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    20 GNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAelkTLIFRLRFQSLNGR------ECFLYNIPYSLAIMFQSWLFL 93
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLL---TLPFWLVYYLNHGDwpfgsaLCKIVGALFVVNGYASILLLT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568    94 SMALDLCFCIMIPIKHMLWPKTKYILIMCIMPTCCALIV-----FFVNFIFVTEEDAPYCAYMLTMDDGVFEI--ISTSV 166
Cdd:pfam00001  78 AISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLslpplLFGWTLTVPEGNVTVCFIDFPEDLSKPVSytLLISV 157
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17564568   167 VACNILTLLITIVSVFVAIRKsqdmrnHRHSSVTRRNSTVEERRKVFRSTFYMMSIYIFCWM 228
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTL------RKSASKQKSSERTQRRRKALKTLAVVVVVFILCWL 213
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
8-227 4.74e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 38.13  E-value: 4.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568   8 AIIGPMMVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVIN-IAELKTLIFRLRFQSLNGRecFLYNIPYSLAI- 85
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWVAGD--VLCRIVKYLQVv 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568  86 -MFQS-WLFLSMALDLCFCIMIPIKHMLWPKTKYILIMcIMPTCCALIVFFVNFIFVTEEDA-----------------P 146
Cdd:cd14986  83 gLFAStYILVSMSLDRYQAIVKPMSSLKPRKRARLMIV-VAWVLSFLFSIPQLVIFVERELGdgvhqcwssfytpwqrkV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564568 147 YCAYMLTMddgVFEIISTSVVACNIL---TLLITIVSVFVAIRKSQDMRNHRHSSVTRRNSTVEE-RRKVFRSTFYMMSI 222
Cdd:cd14986 162 YITWLATY---VFVIPLIILSYCYGRilrTIWIRSRQKTDRPIAPTAMSCRSVSCVSSRVSLISRaKIKTIKMTLVIILA 238

                ....*
gi 17564568 223 YIFCW 227
Cdd:cd14986 239 FILCW 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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