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Conserved domains on  [gi|17560554|ref|NP_506398|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box domain-containing protein( domain architecture ID 12198939)

F-box domain-containing protein with an FTH domain, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 131-269 7.20e-29

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 107.28  E-value: 7.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560554   131 KKYMDCVVEALRSAENLSSRNVKTSCLSSAEISQILPIFPAKNLEYIEFFEC-DFAGYEQLVHLEQWKKAERCIKCSE-- 207
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSEsDEDQFEEIVELEQWKNAKSLKIEGSsl 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17560554   208 LNIPMEFFLQFKRVKVDIE--PGEDPTVIRDVIDNSNNLESVLIQCCSMNinyINEVVSVFNLK 269
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDsfSVEDAIKIRDILLKSSTFQSCTIRSPDLN---PIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-40 2.15e-04

A Receptor for Ubiquitination Targets;


:

Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.19  E-value: 2.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17560554      1 MPLDVMNKIVNTLGFINSLVLMKVSKKLSGFVKDTKFEID 40
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 131-269 7.20e-29

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 107.28  E-value: 7.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560554   131 KKYMDCVVEALRSAENLSSRNVKTSCLSSAEISQILPIFPAKNLEYIEFFEC-DFAGYEQLVHLEQWKKAERCIKCSE-- 207
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSEsDEDQFEEIVELEQWKNAKSLKIEGSsl 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17560554   208 LNIPMEFFLQFKRVKVDIE--PGEDPTVIRDVIDNSNNLESVLIQCCSMNinyINEVVSVFNLK 269
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDsfSVEDAIKIRDILLKSSTFQSCTIRSPDLN---PIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-40 2.15e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.19  E-value: 2.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17560554      1 MPLDVMNKIVNTLGFINSLVLMKVSKKLSGFVKDTKFEID 40
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-43 2.88e-04

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 37.85  E-value: 2.88e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 17560554   1 MPLDVMNKIVNTLGFINSLVLMKVSKKLSGFVKDTKFEIDELE 43
Cdd:cd22150   4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 131-269 7.20e-29

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 107.28  E-value: 7.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560554   131 KKYMDCVVEALRSAENLSSRNVKTSCLSSAEISQILPIFPAKNLEYIEFFEC-DFAGYEQLVHLEQWKKAERCIKCSE-- 207
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSEsDEDQFEEIVELEQWKNAKSLKIEGSsl 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17560554   208 LNIPMEFFLQFKRVKVDIE--PGEDPTVIRDVIDNSNNLESVLIQCCSMNinyINEVVSVFNLK 269
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDsfSVEDAIKIRDILLKSSTFQSCTIRSPDLN---PIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-40 2.15e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.19  E-value: 2.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17560554      1 MPLDVMNKIVNTLGFINSLVLMKVSKKLSGFVKDTKFEID 40
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-43 2.88e-04

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 37.85  E-value: 2.88e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 17560554   1 MPLDVMNKIVNTLGFINSLVLMKVSKKLSGFVKDTKFEIDELE 43
Cdd:cd22150   4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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