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Conserved domains on  [gi|133957891|ref|NP_506358|]
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Phosphatidylinositol 4-kinase type 2 [Caenorhabditis elegans]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
59-244 1.28e-23

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member pfam00454:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 241  Bit Score: 98.56  E-value: 1.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133957891   59 GSSGSYFVY---GLEGEIVGVFKPKDEEPFASLNPKWPkffQRMLCFCCFGRACLIPNTGYLSEAAASIVSEMLQLDVVP 135
Cdd:pfam00454   1 GYGGIYKVGddlRQDELILQVFKLMDEELSKDNLDLRR---LKPYSVIPLGPKCGIIEWVPNSETLAYILDEYGENGVPP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133957891  136 TTrIVKLASPSFFYSR----FFGHYDVRPKEGSFQLYVNGYESGNTVFARWNydknllsdeegaKFQLLFQKMCIVDYVI 211
Cdd:pfam00454  78 TA-MVKILHSALNYPKlkleFESRISLPPKVGLLQWFVKKSPDAEEWGEARK------------NFVRSCAGYSVLDYIL 144
                         170       180       190
                  ....*....|....*....|....*....|...
gi 133957891  212 RNTDRHMDNLLVRHVPGEeinLAAIDNGLAFPV 244
Cdd:pfam00454 145 GNGDRHLDNILVDKTTGK---LFHIDFGLCLPD 174
 
Name Accession Description Interval E-value
PI3_PI4_kinase pfam00454
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
59-244 1.28e-23

Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.


Pssm-ID: 395364 [Multi-domain]  Cd Length: 241  Bit Score: 98.56  E-value: 1.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133957891   59 GSSGSYFVY---GLEGEIVGVFKPKDEEPFASLNPKWPkffQRMLCFCCFGRACLIPNTGYLSEAAASIVSEMLQLDVVP 135
Cdd:pfam00454   1 GYGGIYKVGddlRQDELILQVFKLMDEELSKDNLDLRR---LKPYSVIPLGPKCGIIEWVPNSETLAYILDEYGENGVPP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133957891  136 TTrIVKLASPSFFYSR----FFGHYDVRPKEGSFQLYVNGYESGNTVFARWNydknllsdeegaKFQLLFQKMCIVDYVI 211
Cdd:pfam00454  78 TA-MVKILHSALNYPKlkleFESRISLPPKVGLLQWFVKKSPDAEEWGEARK------------NFVRSCAGYSVLDYIL 144
                         170       180       190
                  ....*....|....*....|....*....|...
gi 133957891  212 RNTDRHMDNLLVRHVPGEeinLAAIDNGLAFPV 244
Cdd:pfam00454 145 GNGDRHLDNILVDKTTGK---LFHIDFGLCLPD 174
 
Name Accession Description Interval E-value
PI3_PI4_kinase pfam00454
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
59-244 1.28e-23

Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.


Pssm-ID: 395364 [Multi-domain]  Cd Length: 241  Bit Score: 98.56  E-value: 1.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133957891   59 GSSGSYFVY---GLEGEIVGVFKPKDEEPFASLNPKWPkffQRMLCFCCFGRACLIPNTGYLSEAAASIVSEMLQLDVVP 135
Cdd:pfam00454   1 GYGGIYKVGddlRQDELILQVFKLMDEELSKDNLDLRR---LKPYSVIPLGPKCGIIEWVPNSETLAYILDEYGENGVPP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133957891  136 TTrIVKLASPSFFYSR----FFGHYDVRPKEGSFQLYVNGYESGNTVFARWNydknllsdeegaKFQLLFQKMCIVDYVI 211
Cdd:pfam00454  78 TA-MVKILHSALNYPKlkleFESRISLPPKVGLLQWFVKKSPDAEEWGEARK------------NFVRSCAGYSVLDYIL 144
                         170       180       190
                  ....*....|....*....|....*....|...
gi 133957891  212 RNTDRHMDNLLVRHVPGEeinLAAIDNGLAFPV 244
Cdd:pfam00454 145 GNGDRHLDNILVDKTTGK---LFHIDFGLCLPD 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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