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Conserved domains on  [gi|72000323|ref|NP_506072|]
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LRP X(cross)-hybridizing [Caenorhabditis elegans]

Protein Classification

LDL receptor domain-containing protein( domain architecture ID 10059841)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism

Gene Ontology:  GO:0005886|GO:0007338
PubMed:  6091915|7603991

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 208-244 2.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 2.03e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 72000323 208 CTENEFACCAmpQSCIHVSKRCDGHPDCADGEDENNC 244
Cdd:cd00112   1 CPPNEFRCAN--GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 247-285 1.30e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 72000323 247 CARDEFACvKSEHCIPANKRCDGVaDDCEDGSnlDEIGC 285
Cdd:cd00112   1 CPPNEFRC-ANGRCIPSSWVCDGE-DDCGDGS--DEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 293-328 2.98e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 2.98e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 72000323 293 GKFVCGTSRggvsCVDLDMHCDGKKDCLNGEDEMNC 328
Cdd:cd00112   4 NEFRCANGR----CIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 208-244 2.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 2.03e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 72000323 208 CTENEFACCAmpQSCIHVSKRCDGHPDCADGEDENNC 244
Cdd:cd00112   1 CPPNEFRCAN--GRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
206-244 2.67e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 2.67e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 72000323   206 DTCTENEFACCAmpQSCIHVSKRCDGHPDCADGEDENNC 244
Cdd:pfam00057   1 STCSPNEFQCGS--GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 207-241 6.43e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 6.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 72000323    207 TCTENEFACCamPQSCIHVSKRCDGHPDCADGEDE 241
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 247-285 1.30e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 72000323 247 CARDEFACvKSEHCIPANKRCDGVaDDCEDGSnlDEIGC 285
Cdd:cd00112   1 CPPNEFRC-ANGRCIPSSWVCDGE-DDCGDGS--DEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 293-328 2.98e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 2.98e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 72000323 293 GKFVCGTSRggvsCVDLDMHCDGKKDCLNGEDEMNC 328
Cdd:cd00112   4 NEFRCANGR----CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 247-278 3.49e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 3.49e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 72000323    247 CARDEFACvKSEHCIPANKRCDGVaDDCEDGS 278
Cdd:smart00192   2 CPPGEFQC-DNGRCIPSSWVCDGV-DDCGDGS 31
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
247-285 3.49e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 3.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 72000323   247 CARDEFACVKSEhCIPANKRCDGvADDCEDGSnlDEIGC 285
Cdd:pfam00057   3 CSPNEFQCGSGE-CIPRSWVCDG-DPDCGDGS--DEENC 37
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 208-244 2.03e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 2.03e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 72000323 208 CTENEFACCAmpQSCIHVSKRCDGHPDCADGEDENNC 244
Cdd:cd00112   1 CPPNEFRCAN--GRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
206-244 2.67e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 2.67e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 72000323   206 DTCTENEFACCAmpQSCIHVSKRCDGHPDCADGEDENNC 244
Cdd:pfam00057   1 STCSPNEFQCGS--GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 207-241 6.43e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 6.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 72000323    207 TCTENEFACCamPQSCIHVSKRCDGHPDCADGEDE 241
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 247-285 1.30e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.30e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 72000323 247 CARDEFACvKSEHCIPANKRCDGVaDDCEDGSnlDEIGC 285
Cdd:cd00112   1 CPPNEFRC-ANGRCIPSSWVCDGE-DDCGDGS--DEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 293-328 2.98e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.96  E-value: 2.98e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 72000323 293 GKFVCGTSRggvsCVDLDMHCDGKKDCLNGEDEMNC 328
Cdd:cd00112   4 NEFRCANGR----CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 247-278 3.49e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 3.49e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 72000323    247 CARDEFACvKSEHCIPANKRCDGVaDDCEDGS 278
Cdd:smart00192   2 CPPGEFQC-DNGRCIPSSWVCDGV-DDCGDGS 31
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
247-285 3.49e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 3.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 72000323   247 CARDEFACVKSEhCIPANKRCDGvADDCEDGSnlDEIGC 285
Cdd:pfam00057   3 CSPNEFQCGSGE-CIPRSWVCDG-DPDCGDGS--DEENC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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