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Conserved domains on  [gi|17565074|ref|NP_505957|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 34-465 5.34e-125

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 368.85  E-value: 5.34e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  34 LWFANLIQYFCGLQMSLYFTSMWPYLLKLDPTAQLPFFGIILASFSIGQAVGSPIFGTWTQKTESFKVPVATGLVFCCVG 113
Cdd:cd17326   1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 114 NILYGILPTIMWEVQWLMLVSRVLIGFGAGNLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGV 193
Cdd:cd17326  81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 194 RVFN-TFDLDAYTSPAFVLSIVLIIMAVMIFFYFSEdyagvidekkedsdviippfdrraaVVCIFLWFVIQTIAVNIES 272
Cdd:cd17326 161 YVIGiKLRFNMYTAPAWLMAILGIINIILILFFFKE-------------------------VVCIFLFFVVLFIFANLET 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 273 LCSVFTIAMYNWTSHQAIVYGGYIETASCALSVSQYLVIGLTRVGKIDKRIQILFGCIVFCIYYVVLLPWPFypesllyn 352
Cdd:cd17326 216 IGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWGI-------- 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 353 pnvtdgactyewcqyvpkipfiayilVYVLCFGIAFPYIGNSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTF 432
Cdd:cd17326 288 --------------------------TGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTA 341

                       410       420       430
                ....*....|....*....|....*....|...
gi 17565074 433 FFNSSGYTWVSVEMLTFLIIGALSTCIFWKQMI 465
Cdd:cd17326 342 IYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 34-465 5.34e-125

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 368.85  E-value: 5.34e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  34 LWFANLIQYFCGLQMSLYFTSMWPYLLKLDPTAQLPFFGIILASFSIGQAVGSPIFGTWTQKTESFKVPVATGLVFCCVG 113
Cdd:cd17326   1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 114 NILYGILPTIMWEVQWLMLVSRVLIGFGAGNLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGV 193
Cdd:cd17326  81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 194 RVFN-TFDLDAYTSPAFVLSIVLIIMAVMIFFYFSEdyagvidekkedsdviippfdrraaVVCIFLWFVIQTIAVNIES 272
Cdd:cd17326 161 YVIGiKLRFNMYTAPAWLMAILGIINIILILFFFKE-------------------------VVCIFLFFVVLFIFANLET 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 273 LCSVFTIAMYNWTSHQAIVYGGYIETASCALSVSQYLVIGLTRVGKIDKRIQILFGCIVFCIYYVVLLPWPFypesllyn 352
Cdd:cd17326 216 IGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWGI-------- 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 353 pnvtdgactyewcqyvpkipfiayilVYVLCFGIAFPYIGNSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTF 432
Cdd:cd17326 288 --------------------------TGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTA 341

                       410       420       430
                ....*....|....*....|....*....|...
gi 17565074 433 FFNSSGYTWVSVEMLTFLIIGALSTCIFWKQMI 465
Cdd:cd17326 342 IYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
27-422 3.59e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.55  E-value: 3.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  27 RKSNWTSLWFANLIQYFCGLQMSLYFTSMWPYLLKLDPTAQLpfFGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATG 106
Cdd:COG2814   5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ--AGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 107 LVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTA 185
Cdd:COG2814  82 LLLFALGSLLCALAPSL-----WLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 186 FAfigdgvrvfntfDLDAYTSPAFVLSIVLIIMAVMIFFYFSEDYAgviDEKKEDSDVIIPPFDRRAAVVCIFLWFVIQT 265
Cdd:COG2814 157 LA------------DLFGWRWVFLVNAVLALLALLLLLRLLPESRP---AARARLRGSLRELLRRPRLLLLLLLAFLLGF 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 266 IAVNIESLCSVFTIAMYNWTSHQAivyGGYIETASCALSVSQYLVIGLTRvgKIDKRIQILFGCIVFCIYYVVLLPWPFY 345
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAA---GLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSL 296

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17565074 346 PesllynpnvtdgactyewcqyvpkiPFIAYILVYVLCFGIAFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVG 422
Cdd:COG2814 297 W-------------------------LLLLALFLLGFGFGLLFP----LLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
39-427 7.68e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.53  E-value: 7.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074    39 LIQYFCGLQMSLYFTSMWPYLLKLDPTAQLPFFGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNILYG 118
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   119 ILPTImwevqWLMLVSRVLIGFGAGNL-SALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDgvrvfn 197
Cdd:pfam07690  81 FASSL-----WLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   198 tfdldaYTSPAFVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFD--RRAAVVCIFLWFVIQTIAVNIeslcS 275
Cdd:pfam07690 150 ------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKalLRDPVLWLLLALLLFGFAFFG----L 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   276 VFTIAMYNWTSHQAIVYGGYIETASCALSVSQYLVIGLTrVGKIDKRIQILFGCIVFCIYYVVLLPWPFYPESLLynpnv 355
Cdd:pfam07690 220 LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL-SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLW----- 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17565074   356 tdgactyewcqyvpkipfiayILVYVLCFGIAFPYIGNSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAP 427
Cdd:pfam07690 294 ---------------------LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 72-441 6.21e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.98  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074    72 GIILASFSIGQAVGSPIFGtWTQKTESFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGF--GAGNLSALR 149
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMG-SVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL-----WVMAALWALNGIfqGMGWPPCGR 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   150 AYVAASSTLEdRNTAVS-LATGSQVTGMLTGPILQTAFAFIGDGVRVFntfdldaytspaFVLSIVLIIMAVMIFFYFSE 228
Cdd:TIGR00881 107 TVTKWFSRSE-RGTWVSfWNCSHNVGGGLLPPLVLFGIAELYSWHWVF------------IVPGIIAIIVSLICFLLLRD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   229 DYAG-----VIDEKKEDSDVIIPPFDRRAAVVCIFLWFVIQTIAVNIESLCSVFT----IAMYNWTSHQAI-VYGGYIET 298
Cdd:TIGR00881 174 SPQScglppAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVyvvrTGILDWSPLYLTqEKGFSKEK 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   299 ASCALSVsqYLVIGLTrvgkidkriqilfGCIVFCIYYVVLLPWPFYPESLLYNPNVTDGACTYeWCqyvpkIPFIAYIL 378
Cdd:TIGR00881 254 ASWAFTL--YELGGLV-------------GTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVY-WL-----NPAANPLM 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17565074   379 VYVLCFGIAFPYIG--NSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFfnSSGYTW 441
Cdd:TIGR00881 313 DLICLFALGFLVYGpqMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL--ADGFGW 375
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 34-465 5.34e-125

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 368.85  E-value: 5.34e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  34 LWFANLIQYFCGLQMSLYFTSMWPYLLKLDPTAQLPFFGIILASFSIGQAVGSPIFGTWTQKTESFKVPVATGLVFCCVG 113
Cdd:cd17326   1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 114 NILYGILPTIMWEVQWLMLVSRVLIGFGAGNLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGV 193
Cdd:cd17326  81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 194 RVFN-TFDLDAYTSPAFVLSIVLIIMAVMIFFYFSEdyagvidekkedsdviippfdrraaVVCIFLWFVIQTIAVNIES 272
Cdd:cd17326 161 YVIGiKLRFNMYTAPAWLMAILGIINIILILFFFKE-------------------------VVCIFLFFVVLFIFANLET 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 273 LCSVFTIAMYNWTSHQAIVYGGYIETASCALSVSQYLVIGLTRVGKIDKRIQILFGCIVFCIYYVVLLPWPFypesllyn 352
Cdd:cd17326 216 IGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWGI-------- 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 353 pnvtdgactyewcqyvpkipfiayilVYVLCFGIAFPYIGNSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTF 432
Cdd:cd17326 288 --------------------------TGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTA 341

                       410       420       430
                ....*....|....*....|....*....|...
gi 17565074 433 FFNSSGYTWVSVEMLTFLIIGALSTCIFWKQMI 465
Cdd:cd17326 342 IYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 48-459 5.24e-20

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 91.10  E-value: 5.24e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  48 MSLYFTSMWPYLLKLDPTAQLPFF-GIILASFSIGQAVGSPIFGTWTQKTESfKVPVATGLVFCCVGNILYGILPTImwe 126
Cdd:cd17330  12 FGIVFPVLPFYVREFNKLGASGYYvGLLQSSYSLGQFLASPLWGRLSDRYGR-KPVLLLSLAGSAVSYVLLGLSRNL--- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 127 vqWLMLVSRVLIGFGAGNLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDgvrvfntfdldaYTS 206
Cdd:cd17330  88 --WLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG------------YAL 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 207 PAFVLSIVLIIMAVMIFFyfsedyagvidekkedsdviIPPFDRRAAVVCIFLWFVIQTIAVNIeslcSVFTIAMYNWTS 286
Cdd:cd17330 154 PFLVAAALALLNLVLVLF--------------------FLPPLRRLLLVYFLIALAFAGLESVF----SLFLKDRFGFSP 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 287 HQAivyGGYIETASCALSVSQYLVIGLTRvGKIDKRIQILFGCIVFCIYYVVLLPWPFYPEsllynpnvtdgactyewcq 366
Cdd:cd17330 210 SQI---GLLLALVGIAGILAQLLLIPRLA-KRLGERKLLRLGLLLAIIGLLLLPFASSVPL------------------- 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 367 yvpkipFIAYILVYVLCFGIAFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYTWVSVEM 446
Cdd:cd17330 267 ------LVLAAAILAFGTGIVFP----ALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336

                       410
                ....*....|...
gi 17565074 447 LTFLIIGALSTCI 459
Cdd:cd17330 337 AGLLLIALFLLSL 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 72-455 2.82e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.39  E-value: 2.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKtESFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRA 150
Cdd:cd17325  34 GLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFAFATSY-----WQLLLARFLQGLASAaVWPAAMA 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDgvrvfntfdldaYTSPAFVLSIVLIIMAVMIFFYFSEDY 230
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG------------YRAPFLVCAALALLALVLALLLLPEPR 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 231 AGVIDEKKEDSDV---IIPPFDRRAAVVCIFLWFVIQTIAVNIESLCSVFTIAMYNWTSHQAivygGYIETASCALS-VS 306
Cdd:cd17325 176 PPPNKRAVSAARLrsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASaLS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 307 QYLVIGLTRvgKIDKRIQILFGCIVFciyyVVLLPWPFYPESLLynpnvtdgactyewcqyvpkiPFIAYILVYVLCFGI 386
Cdd:cd17325 252 QPPAGKLSD--RIGRKPLILIGLLLS----AVALLLLPLATSFW---------------------LLLLLLALLGLGLGL 304

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17565074 387 AFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYTWVSVEMLTFLIIGAL 455
Cdd:cd17325 305 VFP----ATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
27-422 3.59e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.55  E-value: 3.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  27 RKSNWTSLWFANLIQYFCGLQMSLYFTSMWPYLLKLDPTAQLpfFGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATG 106
Cdd:COG2814   5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQ--AGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 107 LVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTA 185
Cdd:COG2814  82 LLLFALGSLLCALAPSL-----WLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 186 FAfigdgvrvfntfDLDAYTSPAFVLSIVLIIMAVMIFFYFSEDYAgviDEKKEDSDVIIPPFDRRAAVVCIFLWFVIQT 265
Cdd:COG2814 157 LA------------DLFGWRWVFLVNAVLALLALLLLLRLLPESRP---AARARLRGSLRELLRRPRLLLLLLLAFLLGF 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 266 IAVNIESLCSVFTIAMYNWTSHQAivyGGYIETASCALSVSQYLVIGLTRvgKIDKRIQILFGCIVFCIYYVVLLPWPFY 345
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAA---GLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSL 296

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17565074 346 PesllynpnvtdgactyewcqyvpkiPFIAYILVYVLCFGIAFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVG 422
Cdd:COG2814 297 W-------------------------LLLLALFLLGFGFGLLFP----LLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
39-427 7.68e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.53  E-value: 7.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074    39 LIQYFCGLQMSLYFTSMWPYLLKLDPTAQLPFFGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNILYG 118
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   119 ILPTImwevqWLMLVSRVLIGFGAGNL-SALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDgvrvfn 197
Cdd:pfam07690  81 FASSL-----WLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   198 tfdldaYTSPAFVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFD--RRAAVVCIFLWFVIQTIAVNIeslcS 275
Cdd:pfam07690 150 ------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKalLRDPVLWLLLALLLFGFAFFG----L 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   276 VFTIAMYNWTSHQAIVYGGYIETASCALSVSQYLVIGLTrVGKIDKRIQILFGCIVFCIYYVVLLPWPFYPESLLynpnv 355
Cdd:pfam07690 220 LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL-SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLW----- 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17565074   356 tdgactyewcqyvpkipfiayILVYVLCFGIAFPYIGNSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAP 427
Cdd:pfam07690 294 ---------------------LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
72-462 3.05e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.63  E-value: 3.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAGNL-SALRA 150
Cdd:COG0738  46 GLLLFAFFLGYLLASLPAGRLIDRF-GYKRGLLLGLLLMALGLLLFALAPSY-----PLLLLALFLLGLGLGLLdVAANP 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 151 YVAASSTlEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGVRVFNTFdldaytspaFVLSIVLIIMAVMIFFYFSEDY 230
Cdd:COG0738 120 YVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPY---------LILAVLLLLLALLFLRSKLPEI 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 231 AGVIDEKKEDSDVIIPPFDRRAAVVCIFLWFVIQTIAVNIESLCSVFTIAMYNWTSHQAIVYGGYietASCALSVSQYLV 310
Cdd:COG0738 190 EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL---FWGGMTIGRFLG 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 311 IGLTRvgKIDKRIQILFGCI--VFCIYYVVLLPWPFypesllynpnvtdgactyewcqyvpkIPFIAYILVYvLCFGIAF 388
Cdd:COG0738 267 GFLLK--RFGPVRLLRLSALlaAVGLLLALLAPGPW--------------------------LALIGLALVG-LGLSLMF 317

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17565074 389 PyignsigTLFSEVL--GPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYTWVSVEMLTFLIIGALSTCIFWK 462
Cdd:COG0738 318 P-------TIFSLALdgLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 72-224 4.31e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.88  E-value: 4.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKTESFKVPVATGLVFCCVGNILYGILPTimwevQWLMLVSRVLIGFGAG-NLSALRA 150
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPS-----LALLLIAIVLFGLGLGlNLPLLTT 311

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17565074 151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGVRVFntfdldaytspaFVLSIVLIIMAVMIFF 224
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF------------LVGAAIALAAAVLLAL 373
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 33-220 2.69e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 52.58  E-value: 2.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  33 SLWFANLIQYFCGLQMSLYFTsMWPYLLKLDPTAQLPFF----GIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLV 108
Cdd:cd17504 178 NVLLANITALLAGFGMFMVFQ-LLPQLLQLPTPTGFGLGiteaGLLLLPGALVMLIAGPLAGRLIARV-GPRRVLLIGLV 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 109 FCCVGNILYGILPTIMWEVQWLMLVSRVLIGFGAGNLSALrayVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAF 188
Cdd:cd17504 256 ISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNI---VVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332

                       170       180       190
                ....*....|....*....|....*....|..
gi 17565074 189 IGDGVRVFNTFDLDAYTSPAFVLSIVLIIMAV 220
Cdd:cd17504 333 TYTVSITSGGVPTEGAYVLAFLIGAALALAAL 364
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
71-462 7.53e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 7.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  71 FGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFG-AGNLSALR 149
Cdd:COG2271  47 LGLLASAFFLGYALGQIPAGLLADRF-GRRRVLAIGLLLWGLATLLFGFATSF-----WQLLLLRFLLGLGeAGFFPAAL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 150 AYVAASSTLEDRNTAVSL-ATGSQVTGMLTGPILQTAFAFIGdgvrvfntfdldaYTSPAFVLSIVLIIMAVMIFFYfse 228
Cdd:COG2271 121 KLIAEWFPPKERGRALGIfNAGGPLGGALAPPLLGWLLAAFG-------------WRAAFLILGLPGLLLALLRFWL--- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 229 dyagvidekkedsdviippfdrrAAVVCIFLWFVIQTIAVNIeslcSVFTIAMYNWTSHQAIVYGGYIETASCALSvsqy 308
Cdd:COG2271 185 -----------------------LALAYFLVYFALYGFLTWL----PTYLVEVRGLSLAQAGLLLSLPFLAGIVGS---- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 309 LVIGL--TRVGKIDKRIqILFGCIVFCIYYVVLLPWPFypesllynpnvtdgactyewcqyvpkiPFIAYILVYVLCFGI 386
Cdd:COG2271 234 LLGGWlsDRLGRRRKLV-LAIGLLLAALALLLLALLPS---------------------------PALAIALLFLAGFGL 285

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17565074 387 AFPYIgnSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYTWVSVEMLTFLIIGALSTCIFWK 462
Cdd:COG2271 286 GGAFG--LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
28-461 1.09e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  28 KSNWTSLWFAnliqyFCGLQMSLYFTSMWPYL-------LKLDPTAqlpfFGIILASFSIGQAVGSPIFGTWTQKtesF- 99
Cdd:COG2223   1 SGRWRVLLLA-----TLAFFLAFGVWYLWSVLapplaeeFGLSAAQ----LGLLFAIPVLVGALLRIPLGFLVDR---Fg 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 100 -KVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRAYVAASSTLEDRNTAVSLATGSQVTG-M 176
Cdd:COG2223  69 pRRVLLIGLLLLGIGLLLLALAVSY-----WLLLLLGLLLGIGGGgSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGaA 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 177 LTGPILQTAFAFIGdgvrvfntfdldaYTSPAFVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFDRRAAVVC 256
Cdd:COG2223 144 VAAFLAPLLIAAFG-------------WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 257 IFLWFVIQTIAVNIESLCSVFTIAMYNWTSHQAIVYGGYIetascalsvsqYLVIGLTRV--GKI-DK--RIQILFGCIV 331
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF-----------ALLGALGRPlgGWLsDRigGRRVLLIVFA 279

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 332 FCIyyVVLLPWPFYPESLlynpnvtdgactyewcqyvpkIPFIAYILVYVLCFGIAFPYIGNSIGTLFsevlGPRQQGTM 411
Cdd:COG2223 280 LMA--LGLLLLALALGSL---------------------WLFLVLFLLLGLALGGGNGAVFALVPDIF----PTKNAGAV 332

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 17565074 412 QGVFAFFGSVGRCAAPLVTTFFFNSSG-YTWVsveMLTFLIIGALSTCIFW 461
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGALLDATGsYTAA---FLVFAVLALVALVLTL 380
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 72-455 2.99e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKTESFKVpVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRA 150
Cdd:cd17329  38 GLVLALSAVAGIVASLIGGRLADRFGRKPV-MLAGLLLRALGFALLGFAHSP-----WLFAIALVLTGFGGGlFEPASEA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAfigdgvrvfntfdLDAYTSPAFVLSIVLIIMAVMIFFYFSEDY 230
Cdd:cd17329 112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-------------LYSFRLLFLAAAVLFLLAALVLLFLLPETR 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 231 AGVIDEKKEDSDVIIPPFDRRAAVVCIFLWFV-IQTIAVNIESLCSVFTIAMYNWTSHQAivygGYIETASCALSV-SQY 308
Cdd:cd17329 179 PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFlISLIYFQLESTLPVYVVEILGLGESLL----GLLLALNALLIVlLQF 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 309 LVIGLtrVGKIDKRIQILFGCIVFCIYYVVLLPWPFYPesllynpnvtdgactyewcqyvpkiPFIAYILVYVLCFGIAF 388
Cdd:cd17329 255 PVARL--VERFRLRKILMIGILLFAIGFAVLAFANTLA-------------------------VLILAMIVLTLGEMLVF 307

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17565074 389 PyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYTWVSVEMLTFLIIGAL 455
Cdd:cd17329 308 P----AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 36-224 5.57e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.32  E-value: 5.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  36 FANLIQYFCGLQMSLYFTSMWPYLLKLDPTAqlpfFGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNI 115
Cdd:cd17321 175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ----AGLALLPLALAMLVAAPLAGRLADRF-GPRLVLVAGLLLTAVGLL 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 116 LYGILPTIMWevQWLMLVSRVLIGFGAG-NLSALRAYVAASSTLEDRNTAVSLATGSQVTGM-----LTGPILQTAFAFI 189
Cdd:cd17321 250 LLALLGADSS--VWLLLPGLVLLGLGLGlFATPLTNAALSSVPKEKAGAASGILNTARQLGGalgvaLLGALLTAGLSAN 327

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 17565074 190 GDGVRVFNTFD------LDAYTSPAFVLSIVLIIMAVMIFF 224
Cdd:cd17321 328 LGDSGVAALLSaaaaafAAGFHLAFLVAAALALLAALLALL 368
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 34-455 1.37e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  34 LWFANLIQYFCGLQMSLYFTSMwpYLLKLDPTAQLpffGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVG 113
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPAL--LQSFGLSASQL---GLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 114 NILYGILPTImwevqWLMLVSRVLIGFGAGNLSALR-AYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAfigdg 192
Cdd:cd06174  75 ALLFAFAPSF-----WLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----- 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 193 vrvfnTFDLDAYTSPAFVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFDRRAAVVCIFLWFVIQTIAVNIes 272
Cdd:cd06174 145 -----SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNL-- 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 273 lcsVFTIAMYNWTSHqAIVYGGYIETASCALSVSQYLVIGLTRV---GKIDKRIQILFGCIVFCIYYVVLLPWPFYPESL 349
Cdd:cd06174 218 ---AYYSFSTLLPLF-LLDLGGLSVAVAGLLLSLFGLAGALGSLllgLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL 293

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 350 LYnpnvtdgactyewcqyvpkipFIAYILVYVLCFGIAFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLV 429
Cdd:cd06174 294 LL---------------------LLLLLLLLGFGLGGLLP----LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348

                       410       420
                ....*....|....*....|....*..
gi 17565074 430 TTFFFNSS-GYTWVSVEMLTFLIIGAL 455
Cdd:cd06174 349 AGFLLAATfGLTGAFLVLAVLLLLAAI 375
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 34-455 6.14e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.28  E-value: 6.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  34 LWFANLIQYfcgLQMSLYFTSMWPYLLKLDPTAQLpfFGIILASFSIGQAVGSPIFGTWTQKTESFKVpVATGLVFCCVG 113
Cdd:cd17489   1 ILLANFFFF---LSFYLLLPVLPLYAHDLGGSEAV--AGLVVGLFTLAALLARPFAGRLLDRFGRKRL-LLIGLLIFALA 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 114 NILYGILPTImwevqWLMLVSRVLIGFG-AGNLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILqtafafigdG 192
Cdd:cd17489  75 TLLYLLATSV-----ALLLVLRLIHGIGwGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL---------G 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 193 VRVFNTFDLDaytsPAFVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFDRRAAVVCIFLwFVIQTiavnieS 272
Cdd:cd17489 141 LFLYQHLGFA----VLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALIL-FLASI------A 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 273 LCSVFT-IAMYnwTSHQAIVYGGYIETASCALSVSQYLVIGLTrVGKIDKRIQILFGCIVFCIYYVVLLPWPFYPESLLy 351
Cdd:cd17489 210 YGAISTfLPLY--AAERGISNAGLFFTVYAIALLLSRPFSGKL-SDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL- 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 352 npnvtdGActyewcqyvpkipfiayiLVYVLCFGIAFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTT 431
Cdd:cd17489 286 ------AA------------------VLYGLGFGLLFP----ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337

                       410       420
                ....*....|....*....|....
gi 17565074 432 FFFNSSGYTWVSVEMLTFLIIGAL 455
Cdd:cd17489 338 LVAELFGYRAMFLLAAVVVLLALV 361
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 72-227 9.07e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 9.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRA 150
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIGLLLSAVALLLLPLATSF-----WLLLLLLALLGLGLGlVFPATLA 311

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17565074 151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPILqtafafigdGVRVFNTFDLdaytSPAFVLSIVLIIMAVMIFFYFS 227
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL---------GGFLYDAFGF----ATPFLAAAALLLLAAVLFLLLR 375
Sugar_tr pfam00083
Sugar (and other) transporter;
72-194 1.00e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 44.57  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074    72 GIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFCCVGNILYGiLPTIMWEVqWLMLVSRVLIGFGAGNLSALR-A 150
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRF-GRKKSLLIANVLFVIGAVLQG-AAKGKWSV-YQLIVGRVLVGIGVGGASVLApM 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 17565074   151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGVR 194
Cdd:pfam00083 126 YISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDG 169
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 70-441 1.49e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 44.16  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  70 FFGIILASFSIGQAVGSPIFGTWTQKtesF-KVPVatgLVFCCVGNIL-YGIL---PTImwevqWLMLVSRVLIGFGAGN 144
Cdd:cd17388  39 HYGVLLALYALMQFIFAPILGALSDR---FgRRPV---LLLSLAGAALdYLLMafaPTL-----WWLYLGRIIAGITGAT 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 145 LSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGdgvrvfntfdldaYTSPAFVLSIVLIIMAVMIFF 224
Cdd:cd17388 108 GAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEIS-------------PRAPFLVAAGLNGLNFLLGLF 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 225 YFSEDYAGviDEKKEDSDVIIPPF-----DRRAAVVCIFL--WFVIQTIAVNIESLCSVFTIAMYNWTSHQA----IVYG 293
Cdd:cd17388 175 VLPESLPP--ERRRAFRWRRANPFgslrwLTGFPGLLGLLavFFLIQLIGQVPATTWVLFTEDRFDWSPTMVglslAVFG 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 294 gyietasCALSVSQYLVIGLTrVGKIDKRIQILFGCIVFCIYYVVLlpwPFYPESLLYNPnvtdgactyewcqyvpkipf 373
Cdd:cd17388 253 -------LLHALFQAFVTGPI-AKRLGEKRAILLGLAADALGFLLL---AFATQGWMVFP-------------------- 301

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17565074 374 iayILVYVLCFGIAFPyignSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYTW 441
Cdd:cd17388 302 ---ILILLALGGIAGP----ALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATW 362
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 72-182 1.57e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.65  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKtesF--KVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAGNLSAL- 148
Cdd:COG0477  52 GWIVSAYLLGRAIGLLLFGRLGDR---YgrKRVLLIGLLLFGLASLLCGLAPSP-----ELLIAARALQGIGAGGLMPGa 123

                        90       100       110
                ....*....|....*....|....*....|....
gi 17565074 149 RAYVAASSTLEDRNTAVSLATGSQVTGMLTGPIL 182
Cdd:COG0477 124 LALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 72-219 3.02e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.95  E-value: 3.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGtWTQKTESFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAG-NLSALRA 150
Cdd:cd17473 236 GLALAIASLAGAIGALLFG-RLKRRLGKRRLLAIGFALMALGFLLLALASGL-----WVVLLGAILAGLGFGlLLPTLNS 309

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17565074 151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGVrvfnTFDLDAYTSPAFVLSIVLIIMA 219
Cdd:cd17473 310 WAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL----SGAFLILGVLALVLAIVLLLLR 374
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 72-228 4.01e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.60  E-value: 4.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKTESFKVPVATgLVFCCVGNILYGILPTIMwevqwLMLVSRVLIGFGAGNLSALRAY 151
Cdd:cd17390  34 GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLIC-LLLTALGYVLLGFSTSLA-----LLFLSRIPLGIFKHTQSLCKAY 107

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17565074 152 VAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDGVRVfntfdldaytsPAFVLSIVLIIMAVMIFFYFSE 228
Cdd:cd17390 108 LSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYY-----------VALLCSAIFILNAGLVWFLLSK 173
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
43-224 4.31e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.55  E-value: 4.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  43 FCGLQMSLYFTSM-W--PYLLKLDPTAQLPffGIILASFSIGQAVGSPIFGTWTQKTESFKVPVATGLVFCCVGNILYGI 119
Cdd:COG2807 223 FFGLQSLLYYAVVaWlpPILRDAGLSAATA--GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 120 LPTimwevqWLMLVSRVLIGFGAGNLSALrAYVAASSTLEDRNTAVSLATGSQVTGML---TGPILqtaFAFIGDGvrvf 196
Cdd:COG2807 301 APG------SLPWLWAVLLGLGQGGLFPL-ALTLIGLRARTPAEAAALSGMAQSVGYLlaaLGPLL---VGALHDA---- 366

                       170       180
                ....*....|....*....|....*...
gi 17565074 197 ntfdLDAYTSPAFVLSIVLIIMAVMIFF 224
Cdd:COG2807 367 ----TGSWTAALLLLAALAVLMLVAGLL 390
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 72-441 6.21e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.98  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074    72 GIILASFSIGQAVGSPIFGtWTQKTESFKVPVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGF--GAGNLSALR 149
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMG-SVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL-----WVMAALWALNGIfqGMGWPPCGR 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   150 AYVAASSTLEdRNTAVS-LATGSQVTGMLTGPILQTAFAFIGDGVRVFntfdldaytspaFVLSIVLIIMAVMIFFYFSE 228
Cdd:TIGR00881 107 TVTKWFSRSE-RGTWVSfWNCSHNVGGGLLPPLVLFGIAELYSWHWVF------------IVPGIIAIIVSLICFLLLRD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   229 DYAG-----VIDEKKEDSDVIIPPFDRRAAVVCIFLWFVIQTIAVNIESLCSVFT----IAMYNWTSHQAI-VYGGYIET 298
Cdd:TIGR00881 174 SPQScglppAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVyvvrTGILDWSPLYLTqEKGFSKEK 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074   299 ASCALSVsqYLVIGLTrvgkidkriqilfGCIVFCIYYVVLLPWPFYPESLLYNPNVTDGACTYeWCqyvpkIPFIAYIL 378
Cdd:TIGR00881 254 ASWAFTL--YELGGLV-------------GTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVY-WL-----NPAANPLM 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17565074   379 VYVLCFGIAFPYIG--NSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFfnSSGYTW 441
Cdd:TIGR00881 313 DLICLFALGFLVYGpqMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL--ADGFGW 375
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 403-481 6.97e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.77  E-value: 6.97e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17565074 403 LGPRQQGTMQGVFAFFGSVGRCAAPLVTTFFFNSSGYtwvsVEMLTFLIIGALSTCIFWKQMIPLELIQKKESISNNNN 481
Cdd:cd17478 112 AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG----LGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSA 186
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 72-190 9.45e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 9.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  72 GIILASFSIGQAVGSPIFGTWTQKTESFKVpVATGLVFCCVGNILYGILPTImwevqWLMLVSRVLIGFGAGNLSALR-A 150
Cdd:cd17324  37 GLLVSAYALGYALGALLLGPLSDRIERRRL-LLVLLLLFILGNLLAALAPSF-----ALLLLARALAGLAHGGFWAIAaA 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 17565074 151 YVAASSTLEDRNTAVSLATGSQVTGMLTGPIL----------QTAFAFIG 190
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLggllgqllgwRAAFLAIA 160
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 50-460 1.02e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.44  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  50 LYFTSMW------PYLLK---LDPTaqlpFFGIILASFSIGQAVGSPIFGTWTQKtesFKVPVATGLVF--CCVGNILYG 118
Cdd:cd17331  11 LYATCYWlqqpvlPYLTKklgVDSV----VFGYLQTTFSVLQLVGGPLFGRFGDL---FGPRAALVLSFlsSALSYLLLA 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 119 ILPTImwevqWLMLVSRVLIGFGAGNLSAlRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILqtafafigdGVRVFNT 198
Cdd:cd17331  84 FASSV-----PMLFLSRLPSVFMHAMQAA-QMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFL---------GGLLTKK 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 199 FDldaYTSPAFVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFD----------RRAAVVCIFLWFVIQTIAV 268
Cdd:cd17331 149 FG---EQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNlkeilrllrlPGVAFLLLVKLLSGLPIGM 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 269 nIESLCSVFTIAMYNWTSHQAivygGYIETASCALS-VSQYLVIGLTRvGKIDKRIQILFGCIVFCIYYVVLlpwpfype 347
Cdd:cd17331 226 -FQSMFSLVAMDFFGLTPEEN----GYLMSYAGVLGmVVQGLLVGPLT-KRFGERSLLKLSVALLAIGYLLL-------- 291

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 348 sllynpnvtdgactyewcQYVPKIPFIAYILVYVLCFGIAFpyiGNSIGTLFSEVLGPRQQGTMQGVFAFFGSVGRCAAP 427
Cdd:cd17331 292 ------------------AFVTTVWQLLVLLLPLVIGGSVL---YTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSP 350

                       410       420       430
                ....*....|....*....|....*....|...
gi 17565074 428 LVTTFFFNSSGytWVSVEMLTFLIIGALSTCIF 460
Cdd:cd17331 351 TIGGALLQAYG--FPSFGLLGAAINGLLTVYLL 381
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 34-224 1.51e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  34 LWFANLIQYFCGLQMSLyFTSMWPYLLKLDPTAQLPFFGIILASFSIGQAVGSPIFGTWTQKTESFKVPVATGLVFCCVG 113
Cdd:cd06174 205 LWLLLLAIFLVNLAYYS-FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 114 NILYGILPTimwevQWLMLVSRVLIGFGAGNLSALR-AYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAFIGDG 192
Cdd:cd06174 284 LALLLLAPS-----LLLLLLLLLLLGFGLGGLLPLSfALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358

                       170       180       190
                ....*....|....*....|....*....|..
gi 17565074 193 VRVfntfdldaytspAFVLSIVLIIMAVMIFF 224
Cdd:cd06174 359 LTG------------AFLVLAVLLLLAAILLL 378
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 129-332 1.89e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 129 WLMLVSRVLIGFGAGNLSALRAYVAASSTLEDRNTAVSLATGSQVTGMLTGPILQTAFAfigdgvrvfntfDLDAYTSPA 208
Cdd:cd17391  90 WQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLA------------DLFGIRNVF 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 209 FVLSIVLIIMAVMIFFYFSEDYAGVIDEKKEDSDVIIPPFDRRAAVVCIFL-WFVIQTIAVNIESLCSVFTIAMYNWTSH 287
Cdd:cd17391 158 FITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVtTFIIQLANQSIEPILTLYIRQLMGDASN 237

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 17565074 288 QAIVYGgyIETASCALSVsqylVIGLTRVGKIDKRI---QILFGCIVF 332
Cdd:cd17391 238 LAFISG--LVFSATGVSS----LLSAPRLGKLGDRIghhRILLGALLA 279
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 52-225 3.93e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 39.53  E-value: 3.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  52 FTSMWPYLLKLD--PTAQLpffGIILASFSIGQAVGSPIFGTWTQKTESfKVPVATGLVFCCVGNILYGILPTIMWEVqW 129
Cdd:cd17345  22 FSLAQPYLIEQYglSKTEI---GLIGSALSIAYGLSKFVMGNLSDRSNP-KRFLAIGLILSAIINILIGFVPSATSSV-G 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 130 LMLVSRVLIGF--GAGNLSALRAYVAASSTLEdRNTAVSLATGSQ-VTGMLTGPILQTAFAFIGDGVRvfntfdLDAYTS 206
Cdd:cd17345  97 LMFILLFLNGWfqGMGWPPSGRTMVHWFSKKE-RGTWTSIWNISHnVGGGLVGPLAGLGLAIFGDGWW------RGAFIF 169

                       170
                ....*....|....*....
gi 17565074 207 PAfvlsIVLIIMAVMIFFY 225
Cdd:cd17345 170 PA----IIAIIVAVIVLFL 184
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
31-225 5.34e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 5.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074  31 WTSLWFANLIQYFCGLQMSLYFTSMWPYLLKLDPTAqlpfFGIILASFSIGQAVGSPIFGTWTQKTeSFKVPVATGLVFC 110
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAL----VGLLLALYFLAALLGAPLWPRLAKRF-GKKKAFIIGLLLA 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17565074 111 CVGNILYGILPtimWEVQWLMLVSRVLIGFGAG----NLSALRAYVAASSTLEDRNTAVSLATGSQ---------VTGML 177
Cdd:COG2211 305 ALGLLLLFFLG---PGNLWLLLVLAALAGIGLGailvLPWAMLADVVDYDEWKTGRRREGLYFGIFtfaiklgqaLAGAL 381

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 17565074 178 TGPILQtAFAFIGDGVRVFNTfdLDAYTSPAFVLSIVL-IIMAVMIFFY 225
Cdd:COG2211 382 AGLLLA-LFGYVAGAAQSPSA--LTGIRLLFFLLPAVLlLLAALLLLFY 427
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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