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Conserved domains on  [gi|72000300|ref|NP_505872|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
29-326 7.12e-90

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 271.72  E-value: 7.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300    29 ETEQFLEISSYALFFLTTPINFLGIYCIIFKTPNEMLPIKWCMLYLHLLATFSSLCLTGVMMPYVFIPACAGFTVGLLPY 108
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   109 LGVSTQLQGYIGIGCLGMLALSLPILFENRQRYLV-NSFKITRPISRIIFYGFNVLFVPISLFGVFAIFPEQQSARQAIL 187
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFtNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   188 RTLPCPTETYFTH-SVFVLSLNHTPIITYLCALSIVAVVQILFFGGHSLTYL-KTDARKLSVATRQLQKRFFLVICIQLV 265
Cdd:pfam10318 161 KKLPCLPPEFFDNpPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLfKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72000300   266 LPCIILFIPVVYFIYSMLSGYYNQALNNISFVTITLYGATATITMIFLHKPYKKFVFSSFP 326
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
29-326 7.12e-90

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 271.72  E-value: 7.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300    29 ETEQFLEISSYALFFLTTPINFLGIYCIIFKTPNEMLPIKWCMLYLHLLATFSSLCLTGVMMPYVFIPACAGFTVGLLPY 108
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   109 LGVSTQLQGYIGIGCLGMLALSLPILFENRQRYLV-NSFKITRPISRIIFYGFNVLFVPISLFGVFAIFPEQQSARQAIL 187
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFtNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   188 RTLPCPTETYFTH-SVFVLSLNHTPIITYLCALSIVAVVQILFFGGHSLTYL-KTDARKLSVATRQLQKRFFLVICIQLV 265
Cdd:pfam10318 161 KKLPCLPPEFFDNpPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLfKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72000300   266 LPCIILFIPVVYFIYSMLSGYYNQALNNISFVTITLYGATATITMIFLHKPYKKFVFSSFP 326
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
29-326 7.12e-90

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 271.72  E-value: 7.12e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300    29 ETEQFLEISSYALFFLTTPINFLGIYCIIFKTPNEMLPIKWCMLYLHLLATFSSLCLTGVMMPYVFIPACAGFTVGLLPY 108
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   109 LGVSTQLQGYIGIGCLGMLALSLPILFENRQRYLV-NSFKITRPISRIIFYGFNVLFVPISLFGVFAIFPEQQSARQAIL 187
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFtNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   188 RTLPCPTETYFTH-SVFVLSLNHTPIITYLCALSIVAVVQILFFGGHSLTYL-KTDARKLSVATRQLQKRFFLVICIQLV 265
Cdd:pfam10318 161 KKLPCLPPEFFDNpPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLfKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72000300   266 LPCIILFIPVVYFIYSMLSGYYNQALNNISFVTITLYGATATITMIFLHKPYKKFVFSSFP 326
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
28-321 4.61e-12

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 66.03  E-value: 4.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300    28 FETEQFLEISSYALFFLTTPINFLGIYCIIFKTPnEMLPIKWCMLYLHLLATFSSLCLTGVMMPYVFIPACAGFTVGLL- 106
Cdd:pfam10327   5 FTVPFWLILYYHIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLa 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   107 PYLGVSTQLQGYIGIGCLGMLALSLPILFENRQRYLVNsFKITRPISRIIFYGFNVLFVPISLFGVFAIFPEQQSARQA- 185
Cdd:pfam10327  84 TVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAK-ILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQl 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   186 --ILRTLPCPTETYFTHSVFVLSLNHtPIITYLCALSIVAVVQ----ILFFGGHSLTYLKTDARKLSVATRQLQKRFFLV 259
Cdd:pfam10327 163 eyVKENYPEYLSQFSSLPNFAIYDYN-PWLIVFGILAIFGGSLsfliLVYLTVDMFRMLKRLRKKISAQTYQKHRAALRS 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72000300   260 ICIQLVLPCIILFIPVVYFIYSMLSGYYNQALNNISFVTITLYGATATITMIFLHKPYKKFV 321
Cdd:pfam10327 242 LIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
34-322 5.08e-10

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 59.78  E-value: 5.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300    34 LEISSYALFFLTTPINFLGIYCIIFKTPNEMLPIKWCMLYLHLLATFSSlCLTGVMMPYVFIPACAGFTVGLLPYLGVST 113
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFS-ILEFIVKPFIHSYNSSFIVFVDLKDLGLSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   114 Q-LQGYIGIGClGMLALSLPIL-----FenrqRYLVnsfkITRPISRIIFYGFNVLF---VPISLFGVFAI-----FPEQ 179
Cdd:pfam10326  80 SvGQILLALYC-GFYGVSISLLavqfiY----RYLA----LCRPGKLKYFDGKKLILwflYPLIFGAIWGLlvyffLGPD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   180 QSARQAILRTLP-----CPTETYFTHSVF-------VLSLNHTPIITYLCALSIVAV--VQILFFGGHSLTYLKTDARKL 245
Cdd:pfam10326 151 EETDEYLREELLenynlDIDEVAYVGPVYyptdengSKVIRWRSLIGLLIMTFIIGIsfSIIIYCGIKMYFKMKKLKSLG 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72000300   246 SVATRQLQKRFFLVICIQLVLPCIILFIPVVYFIYSMLSGYYNQALNNISFVTITLYGATATITMIFLHKPYKKFVF 322
Cdd:pfam10326 231 SEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
34-321 6.36e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 41.00  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300    34 LEISSYALFFLTTPINFLGIYCIIFKTPNEMLPIKWCMLYLHLLATFSSLCLTGVMMPYVFIpacaGFTVGLLP-----Y 108
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPN----GVSMALISygpckY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   109 LGVSTQLQGYIGIGCLGMLA-LSLPILFENRQRYLVNSFKITRPISRIIFygfnVLFVPISLFGVFAIFPEQQSARQAIL 187
Cdd:pfam10317  77 FGPWFCYSGYSLLQHFLLHSgWSLLLTFYYRYYILKHVDPKRKKLILLII----IHYIPSLSQLIVIFLSPTDFLPVEAL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000300   188 RTLPCPTETYFTHSVF-VLSLNHTPIITYLCALSIVAV---VQILFFGGHSLTYLKTDARKLSVATRQLQKRFFLVICIQ 263
Cdd:pfam10317 153 TKELHPNYNLTDYTVTgFSDLQSFPALINTLIMTIPVFpipIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQ 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 72000300   264 LVLPCIILFIPVVYFIYSMLSGYYNQALNNISFVTITLYGATATITMIFLHKPYKKFV 321
Cdd:pfam10317 233 ALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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