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Conserved domains on  [gi|72000596|ref|NP_505858|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

serpentine receptor Srsx( domain architecture ID 10563404)

serpentine receptor Srsx belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Gene Ontology:  GO:0004930
PubMed:  18050473|7585938

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
19-275 3.66e-92

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 274.09  E-value: 3.66e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596    19 ALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHLCGHFVFNFQLFYQGPGSQELCFWLLLPSTIGLLMSGPLLL 98
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596    99 SMGIDRLIACQLPVFYRQLCSRPsfYLCIQLSFPIIYTSYITVISFLQRDSETMVICQVPLAMSGNSFELFNQGGLLINV 178
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSSK--YLFIQLIFPVIYSSFITVYGFLQRDDETIIVCAPPLALPGTAFTIFTLSSLFINV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596   179 AVVLIYFTTYIKLKKVTAN-ASQLKTVFKSILYTVIFVILGWCTVTVVNIGCIHLVENIENQHIISIYAGIGLNLACVSN 257
Cdd:pfam10320 159 IVLIVYIILIIIFKNKKQSqNSDSKKVFKSLQVTVVIFIFGWFTSTIANTVFLYLTEDGEVEVIIQMYAGFFVLLSFSQN 238
                         250
                  ....*....|....*...
gi 72000596   258 VFVFYTINSEYRSAIRKL 275
Cdd:pfam10320 239 FFVTYWRSSEYRKAFRSL 256
 
Name Accession Description Interval E-value
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
19-275 3.66e-92

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 274.09  E-value: 3.66e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596    19 ALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHLCGHFVFNFQLFYQGPGSQELCFWLLLPSTIGLLMSGPLLL 98
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596    99 SMGIDRLIACQLPVFYRQLCSRPsfYLCIQLSFPIIYTSYITVISFLQRDSETMVICQVPLAMSGNSFELFNQGGLLINV 178
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSSK--YLFIQLIFPVIYSSFITVYGFLQRDDETIIVCAPPLALPGTAFTIFTLSSLFINV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596   179 AVVLIYFTTYIKLKKVTAN-ASQLKTVFKSILYTVIFVILGWCTVTVVNIGCIHLVENIENQHIISIYAGIGLNLACVSN 257
Cdd:pfam10320 159 IVLIVYIILIIIFKNKKQSqNSDSKKVFKSLQVTVVIFIFGWFTSTIANTVFLYLTEDGEVEVIIQMYAGFFVLLSFSQN 238
                         250
                  ....*....|....*...
gi 72000596   258 VFVFYTINSEYRSAIRKL 275
Cdd:pfam10320 239 FFVTYWRSSEYRKAFRSL 256
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
12-271 4.56e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 47.23  E-value: 4.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596  12 ALFYLLCALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMlhLCGHFVFNFQLF-----YQGPGSQELC-FWLLLP 85
Cdd:cd15304   4 ALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADM--LLGFLVMPVSMLtilygYRWPLPSKLCaVWIYLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596  86 ---STIGLLMsgplLLSMGIDRLIACQLPVFYRQLCSRPSFYLCIQLSFPIIYTSYITVISF-LQRDSEtmVICQVPLAM 161
Cdd:cd15304  82 vlfSTASIMH----LCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFgLQDDSK--VFKEGSCLL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596 162 SGNSFELFNQ-GGLLINVAVVLI-YFTTYIKLKKVTANASQLKTVFKSILYtvIFVILgWCTVTVVNIGCIHLVENIeNQ 239
Cdd:cd15304 156 ADENFVLIGSfVAFFIPLTIMVItYFLTIKSLQQSISNEQKASKVLGIVFF--LFVVM-WCPFFITNVMAVICKESC-NE 231
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 72000596 240 HII----SIYAGIGLnLACVSNVFVFYTINSEYRSA 271
Cdd:cd15304 232 VVIggllNVFVWIGY-LSSAVNPLVYTLFNKTYRSA 266
 
Name Accession Description Interval E-value
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
19-275 3.66e-92

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 274.09  E-value: 3.66e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596    19 ALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHLCGHFVFNFQLFYQGPGSQELCFWLLLPSTIGLLMSGPLLL 98
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596    99 SMGIDRLIACQLPVFYRQLCSRPsfYLCIQLSFPIIYTSYITVISFLQRDSETMVICQVPLAMSGNSFELFNQGGLLINV 178
Cdd:pfam10320  81 MIGIDRLIAVKFPIFYRLLSSSK--YLFIQLIFPVIYSSFITVYGFLQRDDETIIVCAPPLALPGTAFTIFTLSSLFINV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596   179 AVVLIYFTTYIKLKKVTAN-ASQLKTVFKSILYTVIFVILGWCTVTVVNIGCIHLVENIENQHIISIYAGIGLNLACVSN 257
Cdd:pfam10320 159 IVLIVYIILIIIFKNKKQSqNSDSKKVFKSLQVTVVIFIFGWFTSTIANTVFLYLTEDGEVEVIIQMYAGFFVLLSFSQN 238
                         250
                  ....*....|....*...
gi 72000596   258 VFVFYTINSEYRSAIRKL 275
Cdd:pfam10320 239 FFVTYWRSSEYRKAFRSL 256
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
12-271 4.56e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 47.23  E-value: 4.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596  12 ALFYLLCALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMlhLCGHFVFNFQLF-----YQGPGSQELC-FWLLLP 85
Cdd:cd15304   4 ALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADM--LLGFLVMPVSMLtilygYRWPLPSKLCaVWIYLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596  86 ---STIGLLMsgplLLSMGIDRLIACQLPVFYRQLCSRPSFYLCIQLSFPIIYTSYITVISF-LQRDSEtmVICQVPLAM 161
Cdd:cd15304  82 vlfSTASIMH----LCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFgLQDDSK--VFKEGSCLL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596 162 SGNSFELFNQ-GGLLINVAVVLI-YFTTYIKLKKVTANASQLKTVFKSILYtvIFVILgWCTVTVVNIGCIHLVENIeNQ 239
Cdd:cd15304 156 ADENFVLIGSfVAFFIPLTIMVItYFLTIKSLQQSISNEQKASKVLGIVFF--LFVVM-WCPFFITNVMAVICKESC-NE 231
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 72000596 240 HII----SIYAGIGLnLACVSNVFVFYTINSEYRSA 271
Cdd:cd15304 232 VVIggllNVFVWIGY-LSSAVNPLVYTLFNKTYRSA 266
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
11-127 3.88e-03

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 38.04  E-value: 3.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596  11 IALFYLLCALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHLCGHFVFN--FQLFYQGPGSQELCFWLLLPSTI 88
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSlvSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 72000596  89 GLLMSGPLLLSMGIDRLIACQLPVFYRQLCSRPSFYLCI 127
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLI 119
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
11-117 9.12e-03

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 37.16  E-value: 9.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000596  11 IALFYLLCALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHlcGHFVFNFQLFYQ----GPGSQELC-FWLLLp 85
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLV--ALLVMPFSAVYTllgyWPFGPVLCrFWIAL- 78
                        90       100       110
                ....*....|....*....|....*....|...
gi 72000596  86 sTIGLLMSGPL-LLSMGIDRLIACQLPVFYRQL 117
Cdd:cd14967  79 -DVLCCTASILnLCAISLDRYLAITRPLRYRQL 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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