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Conserved domains on  [gi|17564404|ref|NP_505857|]
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MAM domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAM super family cl46915
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 439-527 1.80e-03

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


The actual alignment was detected with superfamily member cd06263:

Pssm-ID: 99706  Cd Length: 157  Bit Score: 39.28  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564404 439 CDFDSDMCmynNYVNESMSVSPWQLGSNRIGNPHTGVREGSG-----FLYVGTDSPADSKIVNyiLESPDLSVDEDFH-L 512
Cdd:cd06263   1 CDFEDGLC---GWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGtgsghYLYVESSSGREGQKAR--LLSPLLPPPRSSHcL 75

                        90
                ....*....|....*.
gi 17564404 513 TMDIYRRSNDI-TLQI 527
Cdd:cd06263  76 SFWYHMYGSGVgTLNV 91
 
Name Accession Description Interval E-value
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 439-527 1.80e-03

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 39.28  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564404 439 CDFDSDMCmynNYVNESMSVSPWQLGSNRIGNPHTGVREGSG-----FLYVGTDSPADSKIVNyiLESPDLSVDEDFH-L 512
Cdd:cd06263   1 CDFEDGLC---GWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGtgsghYLYVESSSGREGQKAR--LLSPLLPPPRSSHcL 75

                        90
                ....*....|....*.
gi 17564404 513 TMDIYRRSNDI-TLQI 527
Cdd:cd06263  76 SFWYHMYGSGVgTLNV 91
 
Name Accession Description Interval E-value
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 439-527 1.80e-03

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 39.28  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564404 439 CDFDSDMCmynNYVNESMSVSPWQLGSNRIGNPHTGVREGSG-----FLYVGTDSPADSKIVNyiLESPDLSVDEDFH-L 512
Cdd:cd06263   1 CDFEDGLC---GWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGtgsghYLYVESSSGREGQKAR--LLSPLLPPPRSSHcL 75

                        90
                ....*....|....*.
gi 17564404 513 TMDIYRRSNDI-TLQI 527
Cdd:cd06263  76 SFWYHMYGSGVgTLNV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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