NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|392920381|ref|NP_505703|]
View 

Acid-sensing ion channel 1 [Caenorhabditis elegans]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 10467616)

amiloride-sensitive sodium channel family protein such as mammalian acid-sensing ion channel 5, Drosophila melanogaster sodium channel protein Nach, and Caenorhabditis elegans degenerin-like protein del-10

CATH:  1.10.3590.10|2.60.470.10|1.10.287.770|1.10.287.820
Gene Ontology:  GO:0005272|GO:0006814|GO:0016020
PubMed:  7929098|8181670|8905643
SCOP:  4006059
TCDB:  1.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
44-418 4.33e-31

Amiloride-sensitive sodium channel;


:

Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 127.28  E-value: 4.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381   44 FAEDTSMLGFRYLHTRYKTWFRVLWGFVVVFFIGLTFYQVFERVTYYFiKNPLTTrrSYETLP---NMYFPTIGVCNKMQ 120
Cdd:pfam00858   1 FCENTSIHGVRYIKSKDGFLRRLFWLLLFLASLIFLIYLISLLFEKYL-SYPVIT--VIEEILyvwNVPFPAVTICNLNP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  121 IKASSVASKNPDL-------------LRGMCSVLDESSSNSSRFDELDKFDDVDILSLYRNSFQSA----DDLFVSCEF- 182
Cdd:pfam00858  78 FRYSALKELSLFYdnlsfllylkfkfLEKILKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLglrcEDLIVSCSFg 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  183 GKSGSCQDEIRPIYTPFGLCYS--------VSPNKTILRPGPETTLSLVLNLEVHE-IIPGTVVEPGVVLSIYDGASSLS 253
Cdd:pfam00858 158 GEKEDCSANFTPILTEYGNCYTfnskdngsKLYPRRLKGAGSGRGLSLILNIQQSEtYSPLDYQAAGFKVSIHSPGEPPD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  254 HYSEGIHLEAGKVVTIPV--NEVRKLRLHESSCGSTKMESFSEKEYSKAACEWSVSVKQIEKECGCIPIRNPIYRGVFDN 331
Cdd:pfam00858 238 VDKRGFSVPPGTETSVGIqpTEITTLKRPYGNCTFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGTKTG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  332 KNDP-LNNSTEIPKKKykkwkkrniprctlRQEIECVQeklnirphiddsiCPDDCDDISFSSIVfggklSSSEIVSMLP 410
Cdd:pfam00858 318 ADIPcLLNYEDHLLEV--------------NEGLSCQD-------------CLPPCNETEYETEI-----SYSTWPSLSS 365


                  ....*...
gi 392920381  411 SDWEDTKE 418
Cdd:pfam00858 366 QLFLLYYE 373
ASC super family cl47603
Amiloride-sensitive sodium channel;
784-836 1.42e-05

Amiloride-sensitive sodium channel;


The actual alignment was detected with superfamily member pfam00858:

Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 48.32  E-value: 1.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392920381  784 NLLHIKFYFAHFKQETILQERSYNLFLLLAEIGGTIGLYVGATLLTAAETLVF 836
Cdd:pfam00858 387 NLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
 
Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
44-418 4.33e-31

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 127.28  E-value: 4.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381   44 FAEDTSMLGFRYLHTRYKTWFRVLWGFVVVFFIGLTFYQVFERVTYYFiKNPLTTrrSYETLP---NMYFPTIGVCNKMQ 120
Cdd:pfam00858   1 FCENTSIHGVRYIKSKDGFLRRLFWLLLFLASLIFLIYLISLLFEKYL-SYPVIT--VIEEILyvwNVPFPAVTICNLNP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  121 IKASSVASKNPDL-------------LRGMCSVLDESSSNSSRFDELDKFDDVDILSLYRNSFQSA----DDLFVSCEF- 182
Cdd:pfam00858  78 FRYSALKELSLFYdnlsfllylkfkfLEKILKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLglrcEDLIVSCSFg 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  183 GKSGSCQDEIRPIYTPFGLCYS--------VSPNKTILRPGPETTLSLVLNLEVHE-IIPGTVVEPGVVLSIYDGASSLS 253
Cdd:pfam00858 158 GEKEDCSANFTPILTEYGNCYTfnskdngsKLYPRRLKGAGSGRGLSLILNIQQSEtYSPLDYQAAGFKVSIHSPGEPPD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  254 HYSEGIHLEAGKVVTIPV--NEVRKLRLHESSCGSTKMESFSEKEYSKAACEWSVSVKQIEKECGCIPIRNPIYRGVFDN 331
Cdd:pfam00858 238 VDKRGFSVPPGTETSVGIqpTEITTLKRPYGNCTFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGTKTG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  332 KNDP-LNNSTEIPKKKykkwkkrniprctlRQEIECVQeklnirphiddsiCPDDCDDISFSSIVfggklSSSEIVSMLP 410
Cdd:pfam00858 318 ADIPcLLNYEDHLLEV--------------NEGLSCQD-------------CLPPCNETEYETEI-----SYSTWPSLSS 365


                  ....*...
gi 392920381  411 SDWEDTKE 418
Cdd:pfam00858 366 QLFLLYYE 373
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 172-328 1.14e-05

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 48.96  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  172 SADDLFVSCEFGKSgSCQDE-IRPIYTP-FGLCYSVS--PNKTIL---RPGPETTLSLVLNLEVHEIIPGTVVEPGVVLS 244
Cdd:TIGR00859 221 QLEDFILTCRFDGE-SCDARnFTHFHHPmYGNCYTFNsgENSNLLtssMPGAENGLKLVLDIEQDEYLPLLSTEAGARVM 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  245 IYDGASSLSHYSEGIHLEAGKVVTIPVNEVRKLRLHE--SSCGSTKM----ESFSEKEYSKAACEWSVSVKQIEKECGCI 318
Cdd:TIGR00859 300 VHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGpyGDCTENGSdvpvENLYNSSYSIQACLRSCFQRYMVENCGCA 379

                         170
                  ....*....|
gi 392920381  319 PIRNPIYRGV 328
Cdd:TIGR00859 380 YYHYPLPGGA 389
ASC pfam00858
Amiloride-sensitive sodium channel;
784-836 1.42e-05

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 48.32  E-value: 1.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392920381  784 NLLHIKFYFAHFKQETILQERSYNLFLLLAEIGGTIGLYVGATLLTAAETLVF 836
Cdd:pfam00858 387 NLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 784-839 1.23e-03

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 42.41  E-value: 1.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392920381  784 NLLHIKFYFAHFKQETILQERSYNLFLLLAEIGGTIGLYVGATLLTAAETLVFLCE 839
Cdd:TIGR00859 467 GIAKLNIFFEELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIID 522
 
Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
44-418 4.33e-31

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 127.28  E-value: 4.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381   44 FAEDTSMLGFRYLHTRYKTWFRVLWGFVVVFFIGLTFYQVFERVTYYFiKNPLTTrrSYETLP---NMYFPTIGVCNKMQ 120
Cdd:pfam00858   1 FCENTSIHGVRYIKSKDGFLRRLFWLLLFLASLIFLIYLISLLFEKYL-SYPVIT--VIEEILyvwNVPFPAVTICNLNP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  121 IKASSVASKNPDL-------------LRGMCSVLDESSSNSSRFDELDKFDDVDILSLYRNSFQSA----DDLFVSCEF- 182
Cdd:pfam00858  78 FRYSALKELSLFYdnlsfllylkfkfLEKILKSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLglrcEDLIVSCSFg 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  183 GKSGSCQDEIRPIYTPFGLCYS--------VSPNKTILRPGPETTLSLVLNLEVHE-IIPGTVVEPGVVLSIYDGASSLS 253
Cdd:pfam00858 158 GEKEDCSANFTPILTEYGNCYTfnskdngsKLYPRRLKGAGSGRGLSLILNIQQSEtYSPLDYQAAGFKVSIHSPGEPPD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  254 HYSEGIHLEAGKVVTIPV--NEVRKLRLHESSCGSTKMESFSEKEYSKAACEWSVSVKQIEKECGCIPIRNPIYRGVFDN 331
Cdd:pfam00858 238 VDKRGFSVPPGTETSVGIqpTEITTLKRPYGNCTFDDEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGTKTG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  332 KNDP-LNNSTEIPKKKykkwkkrniprctlRQEIECVQeklnirphiddsiCPDDCDDISFSSIVfggklSSSEIVSMLP 410
Cdd:pfam00858 318 ADIPcLLNYEDHLLEV--------------NEGLSCQD-------------CLPPCNETEYETEI-----SYSTWPSLSS 365


                  ....*...
gi 392920381  411 SDWEDTKE 418
Cdd:pfam00858 366 QLFLLYYE 373
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 172-328 1.14e-05

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 48.96  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  172 SADDLFVSCEFGKSgSCQDE-IRPIYTP-FGLCYSVS--PNKTIL---RPGPETTLSLVLNLEVHEIIPGTVVEPGVVLS 244
Cdd:TIGR00859 221 QLEDFILTCRFDGE-SCDARnFTHFHHPmYGNCYTFNsgENSNLLtssMPGAENGLKLVLDIEQDEYLPLLSTEAGARVM 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381  245 IYDGASSLSHYSEGIHLEAGKVVTIPVNEVRKLRLHE--SSCGSTKM----ESFSEKEYSKAACEWSVSVKQIEKECGCI 318
Cdd:TIGR00859 300 VHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGpyGDCTENGSdvpvENLYNSSYSIQACLRSCFQRYMVENCGCA 379

                         170
                  ....*....|
gi 392920381  319 PIRNPIYRGV 328
Cdd:TIGR00859 380 YYHYPLPGGA 389
ASC pfam00858
Amiloride-sensitive sodium channel;
784-836 1.42e-05

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 48.32  E-value: 1.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392920381  784 NLLHIKFYFAHFKQETILQERSYNLFLLLAEIGGTIGLYVGATLLTAAETLVF 836
Cdd:pfam00858 387 NLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 784-839 1.23e-03

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 42.41  E-value: 1.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392920381  784 NLLHIKFYFAHFKQETILQERSYNLFLLLAEIGGTIGLYVGATLLTAAETLVFLCE 839
Cdd:TIGR00859 467 GIAKLNIFFEELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIID 522
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
 44-137 2.00e-03

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 41.75  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920381   44 FAEDTSMLGFRYLHTRYKTWFRVLWGFVVVFFIGLTFYQVFERVTYYFiKNPLTTRRS--YETLPnmyFPTIGVCNKMQI 121
Cdd:TIGR00867   2 FCYKTTFHGIPMVATASNSFSRAFWVALFLICLLMFAYQAYILISKYF-QYEKIVDIQlkFETAP---FPAITVCNLNPY 77

                          90
                  ....*....|....*.
gi 392920381  122 KASSVASkNPDLLRGM 137
Cdd:TIGR00867  78 KYSLVRS-VPEISETL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH