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Conserved domains on  [gi|17557234|ref|NP_505654|]
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Glucosamine 6-phosphate N-acetyltransferase [Caenorhabditis elegans]

Protein Classification

GNAT family protein( domain architecture ID 106742)

GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

PubMed:  15581578

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 20-154 3.04e-45

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member PLN02706:

Pssm-ID: 473072 [Multi-domain]  Cd Length: 150  Bit Score: 145.62  E-value: 3.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234   20 DNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRtSVPNYH-IVVIEDSNSQKVVASASLVVEMKFIHGAG 98
Cdd:PLN02706   5 EKFKVRRLEISDKSKGFLELLQQLTVVGDVTEEEFEARFQELA-SLGDDHlICVIEDAASGRIIATGSVFVERKFIRNCG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 17557234   99 SRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGF 154
Cdd:PLN02706  84 KVGHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGY 139
 
Name Accession Description Interval E-value
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 20-154 3.04e-45

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 145.62  E-value: 3.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234   20 DNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRtSVPNYH-IVVIEDSNSQKVVASASLVVEMKFIHGAG 98
Cdd:PLN02706   5 EKFKVRRLEISDKSKGFLELLQQLTVVGDVTEEEFEARFQELA-SLGDDHlICVIEDAASGRIIATGSVFVERKFIRNCG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 17557234   99 SRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGF 154
Cdd:PLN02706  84 KVGHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGY 139
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
24-155 3.91e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.49  E-value: 3.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234  24 VRPLAKDDfskgyVDLLSQLTsvgnldQEAF-----EKRFEAMRTSVPNYHIVVIEDSNsqKVVASASLvvEMKFIHGAG 98
Cdd:COG3153   1 IRPATPED-----AEAIAALL------RAAFgpgreAELVDRLREDPAAGLSLVAEDDG--EIVGHVAL--SPVDIDGEG 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17557234  99 SRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQ 155
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFR 122
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 62-154 3.29e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 54.45  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234    62 RTSVPNYHIVVIEDSNsqKVVASASLvvemKFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLEC 141
Cdd:pfam00583  27 WDEDASEGFFVAEEDG--ELVGFASL----SIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEV 100

                          90
                  ....*....|....*.
gi 17557234   142 VPELLP---FYSQFGF 154
Cdd:pfam00583 101 AADNLAaiaLYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 70-140 3.28e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 3.28e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17557234  70 IVVIEDSNsqKVVASASLVvemkFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLE 140
Cdd:cd04301   1 FLVAEDDG--EIVGFASLS----PDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 20-154 3.04e-45

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 145.62  E-value: 3.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234   20 DNFKVRPLAKDDFSKGYVDLLSQLTSVGNLDQEAFEKRFEAMRtSVPNYH-IVVIEDSNSQKVVASASLVVEMKFIHGAG 98
Cdd:PLN02706   5 EKFKVRRLEISDKSKGFLELLQQLTVVGDVTEEEFEARFQELA-SLGDDHlICVIEDAASGRIIATGSVFVERKFIRNCG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 17557234   99 SRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGF 154
Cdd:PLN02706  84 KVGHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGY 139
PTZ00330 PTZ00330
acetyltransferase; Provisional
 24-155 2.28e-23

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 89.52  E-value: 2.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234   24 VRPLAKDDFSKgYVDLLSQLTSVGNLDQEAFE-----KRFEAMRTSVpnyhivvIEDSNSQKVVASASLVVEMKFIHGAG 98
Cdd:PTZ00330   9 LRDLEEGDLGS-VLELLSHLTSAPALSQEELEqiaarRRLAGVVTRV-------FVHSPTQRIVGTASLFVEPKFTRGGK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17557234   99 SRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQ 155
Cdd:PTZ00330  81 CVGHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFR 137
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
24-155 3.91e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.49  E-value: 3.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234  24 VRPLAKDDfskgyVDLLSQLTsvgnldQEAF-----EKRFEAMRTSVPNYHIVVIEDSNsqKVVASASLvvEMKFIHGAG 98
Cdd:COG3153   1 IRPATPED-----AEAIAALL------RAAFgpgreAELVDRLREDPAAGLSLVAEDDG--EIVGHVAL--SPVDIDGEG 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17557234  99 SRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLPFYSQFGFQ 155
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFR 122
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 50-155 3.25e-10

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 55.00  E-value: 3.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234  50 DQEAFEKRFEAMRTSVPNYHIVVIEDSNsqKVVASASLVVEmkfihgAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLG 129
Cdd:COG1246  10 DVPAILELIRPYALEEEIGEFWVAEEDG--EIVGCAALHPL------DEDLAELRSLAVHPDYRGRGIGRRLLEALLAEA 81

                        90       100
                ....*....|....*....|....*.
gi 17557234 130 KSLGVYKISLECVPELLPFYSQFGFQ 155
Cdd:COG1246  82 RELGLKRLFLLTTSAAIHFYEKLGFE 107
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 62-154 3.29e-10

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 54.45  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234    62 RTSVPNYHIVVIEDSNsqKVVASASLvvemKFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLEC 141
Cdd:pfam00583  27 WDEDASEGFFVAEEDG--ELVGFASL----SIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEV 100

                          90
                  ....*....|....*.
gi 17557234   142 VPELLP---FYSQFGF 154
Cdd:pfam00583 101 AADNLAaiaLYEKLGF 116
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
68-155 5.40e-10

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 54.42  E-value: 5.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234  68 YHIVVIEDsnsQKVVASASLVVEmkfihgAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPELLP 147
Cdd:COG2153  35 RHLLAYDD---GELVATARLLPP------GDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAHAVG 105


                ....*...
gi 17557234 148 FYSQFGFQ 155
Cdd:COG2153 106 FYEKLGFV 113
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 66-155 1.51e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 52.07  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234    66 PNYHIVVIEDSNsqKVVASASLVvemkfIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPEL 145
Cdd:pfam13508   1 PGGRFFVAEDDG--KIVGFAALL-----PLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRA 73

                          90
                  ....*....|
gi 17557234   146 LPFYSQFGFQ 155
Cdd:pfam13508  74 AAFYEKLGFE 83
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 93-155 5.68e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 45.42  E-value: 5.68e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17557234  93 FIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLECVPE---LLPFYSQFGFQ 155
Cdd:COG0456   6 GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaAIALYEKLGFE 71
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 70-140 3.28e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 3.28e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17557234  70 IVVIEDSNsqKVVASASLVvemkFIHGAGSRGRVEDVVVDTEMRRQKLGAVLLKTLVSLGKSLGVYKISLE 140
Cdd:cd04301   1 FLVAEDDG--EIVGFASLS----PDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 49-156 3.38e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 38.41  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557234    49 LDQEAFEKRFEAmrtsvPNYHIVVIEDSNsqKVVAsaslVVEMKfihgagSRGRVEDVVVDTEMRRQKLGAVLLKTLVSL 128
Cdd:pfam13673  17 ISPEALRERIDQ-----GEYFFFVAFEGG--QIVG----VIALR------DRGHISLLFVDPDYQGQGIGKALLEAVEDY 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 17557234   129 GK--SLGVYKISLECVPELLPFYSQFGFQD 156
Cdd:pfam13673  80 AEkdGIKLSELTVNASPYAVPFYEKLGFRA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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