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Conserved domains on  [gi|72000387|ref|NP_505483|]
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G protein-coupled receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 5-344 3.24e-16

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10317:

Pssm-ID: 419896  Cd Length: 292  Bit Score: 77.98  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387     5 FSWYCYICNGIAIFLNGILLFLSSHKSIETIRELRYFLSNIAASGIVFGASLLLLQPQTVTRGSMTIRVIHGPAQYLPEN 84
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387    85 ALKAVGCVSVISYLYAILSFPLFFFYRSMILANSNMfgqyftKNTLLITFVVIFILCCIESVFFYYSSIPYADLLdranr 164
Cdd:pfam10317  81 FCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDP------KRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPV----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   165 ttsiveefensTLILTQHLRNIDINsqhttsssnnvssgviqtqeelslgkhHLSLFGDDYSRNPLIIIFHGTLLVCHVL 244
Cdd:pfam10317 150 -----------EALTKELHPNYNLT---------------------------DYTVTGFSDLQSFPALINTLIMTIPVFP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   245 SYLIILICAHFMLNTLKRKQGTMSQDTFLENELLVHSVFAEAFVPLLFSAPVGANAVLVTVFENSLKWQEFLPAYCMSMV 324
Cdd:pfam10317 192 IPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALP 271

                         330       340
                  ....*....|....*....|
gi 72000387   325 PVLSPLCTIIFIEPYRRAIL 344
Cdd:pfam10317 272 PLLDPLITIYFVTPYRRAIL 291
 
Name Accession Description Interval E-value
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 5-344 3.24e-16

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 77.98  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387     5 FSWYCYICNGIAIFLNGILLFLSSHKSIETIRELRYFLSNIAASGIVFGASLLLLQPQTVTRGSMTIRVIHGPAQYLPEN 84
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387    85 ALKAVGCVSVISYLYAILSFPLFFFYRSMILANSNMfgqyftKNTLLITFVVIFILCCIESVFFYYSSIPYADLLdranr 164
Cdd:pfam10317  81 FCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDP------KRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPV----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   165 ttsiveefensTLILTQHLRNIDINsqhttsssnnvssgviqtqeelslgkhHLSLFGDDYSRNPLIIIFHGTLLVCHVL 244
Cdd:pfam10317 150 -----------EALTKELHPNYNLT---------------------------DYTVTGFSDLQSFPALINTLIMTIPVFP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   245 SYLIILICAHFMLNTLKRKQGTMSQDTFLENELLVHSVFAEAFVPLLFSAPVGANAVLVTVFENSLKWQEFLPAYCMSMV 324
Cdd:pfam10317 192 IPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALP 271

                         330       340
                  ....*....|....*....|
gi 72000387   325 PVLSPLCTIIFIEPYRRAIL 344
Cdd:pfam10317 272 PLLDPLITIYFVTPYRRAIL 291
 
Name Accession Description Interval E-value
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 5-344 3.24e-16

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 77.98  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387     5 FSWYCYICNGIAIFLNGILLFLSSHKSIETIRELRYFLSNIAASGIVFGASLLLLQPQTVTRGSMTIRVIHGPAQYLPEN 84
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387    85 ALKAVGCVSVISYLYAILSFPLFFFYRSMILANSNMfgqyftKNTLLITFVVIFILCCIESVFFYYSSIPYADLLdranr 164
Cdd:pfam10317  81 FCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDP------KRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPV----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   165 ttsiveefensTLILTQHLRNIDINsqhttsssnnvssgviqtqeelslgkhHLSLFGDDYSRNPLIIIFHGTLLVCHVL 244
Cdd:pfam10317 150 -----------EALTKELHPNYNLT---------------------------DYTVTGFSDLQSFPALINTLIMTIPVFP 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   245 SYLIILICAHFMLNTLKRKQGTMSQDTFLENELLVHSVFAEAFVPLLFSAPVGANAVLVTVFENSLKWQEFLPAYCMSMV 324
Cdd:pfam10317 192 IPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALP 271

                         330       340
                  ....*....|....*....|
gi 72000387   325 PVLSPLCTIIFIEPYRRAIL 344
Cdd:pfam10317 272 PLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-344 3.72e-06

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 48.22  E-value: 3.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387    10 YICNGIAIFLNGILLFLSSHKSIETIRELRYFLSNIAASGIVFGASLLLLQPQTVTRGSMTIRVIHGPAQYLPENALKAV 89
Cdd:pfam10326   6 YIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQIL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387    90 GCVSVISYLYAILSFPLFFFYRSMILANSNMFgQYFTKNTLLITFVVIFILCCIESVFFYY--SSIPYADLLDRanrtts 167
Cdd:pfam10326  86 LALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFflGPDEETDEYLR------ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   168 ivEEFENStliltqhlRNIDINSqhttsssnnVSSGVIQTQEELSLGKHHLSLfgddysrNPLIIIFHGTLLVChvLSYL 247
Cdd:pfam10326 159 --EELLEN--------YNLDIDE---------VAYVGPVYYPTDENGSKVIRW-------RSLIGLLIMTFIIG--ISFS 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000387   248 IILICAHFMLNTLKRKQGTMSQDTF-LENEL---LVhsvfAEAFVP-LLFSAPVGAnAVLVTVFENSLKWQEFLPAYCMS 322
Cdd:pfam10326 211 IIIYCGIKMYFKMKKLKSLGSEKTRkLQKQLfkaLV----IQTLIPtILMYIPVGI-LFLLPLFNIEIGFLSGIITATIA 285

                         330       340
                  ....*....|....*....|..
gi 72000387   323 MVPVLSPLCTIIFIEPYRRAIL 344
Cdd:pfam10326 286 LYPAIDPLPAMFIIKEYRNAIK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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