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Conserved domains on  [gi|17559210|ref|NP_505431|]
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CHK domain-containing protein [Caenorhabditis elegans]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 1-132 1.34e-61

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member pfam07914:

Pssm-ID: 473864  Cd Length: 413  Bit Score: 194.42  E-value: 1.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559210     1 MLHCLDEFGNLKLKAIIDWQGVSTLPPGLDLSRLLMGCLSAHERRERGLEMLKLYHETFNQVLG--KELFSFQELQDSYN 78
Cdd:pfam07914 280 ILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLLLSCLSGADRRAHWEELLEQYYETFTKALGdnEEPYTLEQLKDSYN 359

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17559210    79 LYYPMMAMALLPLVSSLAENSQVSEVEKAQIRFKTETKLVAMMEDLIEVHEYNL 132
Cdd:pfam07914 360 LYFPMMSLLLLPLIGPFLDMKSMSEEEKEEYREVVIEKMEALLEDLIKVHEYNL 413
 
Name Accession Description Interval E-value
DUF1679 pfam07914
Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number ...
 1-132 1.34e-61

Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number of C. elegans proteins, in one case as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).


Pssm-ID: 369592  Cd Length: 413  Bit Score: 194.42  E-value: 1.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559210     1 MLHCLDEFGNLKLKAIIDWQGVSTLPPGLDLSRLLMGCLSAHERRERGLEMLKLYHETFNQVLG--KELFSFQELQDSYN 78
Cdd:pfam07914 280 ILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLLLSCLSGADRRAHWEELLEQYYETFTKALGdnEEPYTLEQLKDSYN 359

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17559210    79 LYYPMMAMALLPLVSSLAENSQVSEVEKAQIRFKTETKLVAMMEDLIEVHEYNL 132
Cdd:pfam07914 360 LYFPMMSLLLLPLIGPFLDMKSMSEEEKEEYREVVIEKMEALLEDLIKVHEYNL 413
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
 1-65 9.51e-17

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 72.75  E-value: 9.51e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17559210      1 MLHCLDEFGNLKLKAIIDWQGVSTLPPGLDLSRLLMGCLSAHERRERGLEMLKLYHETFNQVLGK 65
Cdd:smart00587 132 IMFKYDDEGKPEDVALIDFQLSHYGSPAEDLHYFLLTSLSVEIRREHFDELLKFYYETLVETLKK 196
 
Name Accession Description Interval E-value
DUF1679 pfam07914
Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number ...
 1-132 1.34e-61

Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number of C. elegans proteins, in one case as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).


Pssm-ID: 369592  Cd Length: 413  Bit Score: 194.42  E-value: 1.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559210     1 MLHCLDEFGNLKLKAIIDWQGVSTLPPGLDLSRLLMGCLSAHERRERGLEMLKLYHETFNQVLG--KELFSFQELQDSYN 78
Cdd:pfam07914 280 ILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLLLSCLSGADRRAHWEELLEQYYETFTKALGdnEEPYTLEQLKDSYN 359

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17559210    79 LYYPMMAMALLPLVSSLAENSQVSEVEKAQIRFKTETKLVAMMEDLIEVHEYNL 132
Cdd:pfam07914 360 LYFPMMSLLLLPLIGPFLDMKSMSEEEKEEYREVVIEKMEALLEDLIKVHEYNL 413
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
 1-65 9.51e-17

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 72.75  E-value: 9.51e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17559210      1 MLHCLDEFGNLKLKAIIDWQGVSTLPPGLDLSRLLMGCLSAHERRERGLEMLKLYHETFNQVLGK 65
Cdd:smart00587 132 IMFKYDDEGKPEDVALIDFQLSHYGSPAEDLHYFLLTSLSVEIRREHFDELLKFYYETLVETLKK 196
EcKL pfam02958
Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme ...
 6-65 4.51e-03

Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterized substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes.


Pssm-ID: 397213 [Multi-domain]  Cd Length: 293  Bit Score: 35.71  E-value: 4.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559210     6 DEFGNLKLKAIIDWQGVSTLPPGLDLSRLLMGCLSAHERRERGLEMLKLYHETFNQVLGK 65
Cdd:pfam02958 231 DDEGEPEDVILVDFQLSRYGSPAIDLNYFLYTSTELELRLEHFDELLRYYHSSLVETLKK 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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