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Conserved domains on  [gi|17566890|ref|NP_505402|]
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Leucine-rich repeat-containing protein 15-like [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-441 1.36e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  59 IPIDSLTILDTAIPTIPANAFQSFTILRLVLNRNTLQNIDDQAFNGPLLDSLIELDLNDNNLgqIPQTGIPRLRNLRKLY 138
Cdd:COG4886  25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL--LGLTDLGDLTNLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 139 LNRNR-INQLSStafnafesrdlLLKLELAGNRLTDatLGDAtvFRPLTLLQELSLETNSLTSIPS--SALVNqrntLTN 215
Cdd:COG4886 103 LSGNEeLSNLTN-----------LESLDLSGNQLTD--LPEE--LANLTNLKELDLSNNQLTDLPEplGNLTN----LKS 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 216 LNLGLNSINEVPVGALDFPVLSSLSLEFNGITVIPPqAFQGVPNLQFLYMTGNKFPSwAPEMFRYITQLKTLGIGETPIS 295
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 296 VIPNnaFMHIPNLIRLEMSEAAVDTIerGAFQRTPQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNRIDNvqPLGFA 375
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL--LELLI 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17566890 376 NLPAISHLDISYNLLQTMPSNVFQNSFLPQPNDRRVIYACGNPWYCNSELEWFRTLLRDNLDIDVE 441
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-441 1.36e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  59 IPIDSLTILDTAIPTIPANAFQSFTILRLVLNRNTLQNIDDQAFNGPLLDSLIELDLNDNNLgqIPQTGIPRLRNLRKLY 138
Cdd:COG4886  25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL--LGLTDLGDLTNLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 139 LNRNR-INQLSStafnafesrdlLLKLELAGNRLTDatLGDAtvFRPLTLLQELSLETNSLTSIPS--SALVNqrntLTN 215
Cdd:COG4886 103 LSGNEeLSNLTN-----------LESLDLSGNQLTD--LPEE--LANLTNLKELDLSNNQLTDLPEplGNLTN----LKS 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 216 LNLGLNSINEVPVGALDFPVLSSLSLEFNGITVIPPqAFQGVPNLQFLYMTGNKFPSwAPEMFRYITQLKTLGIGETPIS 295
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 296 VIPNnaFMHIPNLIRLEMSEAAVDTIerGAFQRTPQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNRIDNvqPLGFA 375
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL--LELLI 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17566890 376 NLPAISHLDISYNLLQTMPSNVFQNSFLPQPNDRRVIYACGNPWYCNSELEWFRTLLRDNLDIDVE 441
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 107-407 1.40e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 1.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  107 LDSLIELDLNDNNL-GQIPQTgIPRLRNLRKLYLNRNrinQLSSTAFNAFESRDLLLKLELAGNRLTDATLGDATVFRPL 185
Cdd:PLN00113 283 LQKLISLDLSDNSLsGEIPEL-VIQLQNLEILHLFSN---NFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  186 TLLqelSLETNSLTSIPSSALVNQRNtLTNLNLGLNSIN-EVPVGALDFPVLSSLSLEFNGITVIPPQAFQGVPNLQFLY 264
Cdd:PLN00113 359 TVL---DLSTNNLTGEIPEGLCSSGN-LFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLD 434

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  265 MTGNKFPSWAPEMFRYITQLKTLgigetpiSVIPNNAFMHIP------NLIRLEMSEAAVDTIERGAFQRTPQIQAIVLN 338
Cdd:PLN00113 435 ISNNNLQGRINSRKWDMPSLQML-------SLARNKFFGGLPdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  339 KNRLSQVRADFFEGLNDLYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLLQ-TMPSNVFQNSFLPQPN 407
Cdd:PLN00113 508 ENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVN 577
LRR_8 pfam13855
Leucine rich repeat;
86-144 5.59e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.59e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17566890    86 RLVLNRNTLQNIDDQAFNGplLDSLIELDLNDNNLGQIPQTGIPRLRNLRKLYLNRNRI 144
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 109-294 1.96e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 109 SLIELDLNDNNLGQIPQ------TGIPRLRNLRKLYLNRNRINQLSSTAFNAFESRDLLLKLELAGNRLTDATLG-DATV 181
Cdd:cd00116  52 SLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRlLAKG 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 182 FRPLTL-LQELSLETNSLTSIPSSALVN---QRNTLTNLNLGLNSINEVPVGAL-----DFPVLSSLSLEFNGITVIPPQ 252
Cdd:cd00116 132 LKDLPPaLEKLVLGRNRLEGASCEALAKalrANRDLKELNLANNGIGDAGIRALaeglkANCNLEVLDLNNNGLTDEGAS 211

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 17566890 253 AFQGVP----NLQFLYMTGNKFPSW-----APEMFRYITQLKTLGIGETPI 294
Cdd:cd00116 212 ALAETLaslkSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDI 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-441 1.36e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  59 IPIDSLTILDTAIPTIPANAFQSFTILRLVLNRNTLQNIDDQAFNGPLLDSLIELDLNDNNLgqIPQTGIPRLRNLRKLY 138
Cdd:COG4886  25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL--LGLTDLGDLTNLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 139 LNRNR-INQLSStafnafesrdlLLKLELAGNRLTDatLGDAtvFRPLTLLQELSLETNSLTSIPS--SALVNqrntLTN 215
Cdd:COG4886 103 LSGNEeLSNLTN-----------LESLDLSGNQLTD--LPEE--LANLTNLKELDLSNNQLTDLPEplGNLTN----LKS 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 216 LNLGLNSINEVPVGALDFPVLSSLSLEFNGITVIPPqAFQGVPNLQFLYMTGNKFPSwAPEMFRYITQLKTLGIGETPIS 295
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 296 VIPNnaFMHIPNLIRLEMSEAAVDTIerGAFQRTPQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNRIDNvqPLGFA 375
Cdd:COG4886 242 DLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL--LELLI 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17566890 376 NLPAISHLDISYNLLQTMPSNVFQNSFLPQPNDRRVIYACGNPWYCNSELEWFRTLLRDNLDIDVE 441
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-409 1.97e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 1.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  92 NTLQNIDDQAFNGPLLDSLIELDLNDNNLGQIPQTGIPRLRNLRKLYLNRNRINQLSSTAFNAFESRDLLLKLELAGNRL 171
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 172 TDATLGDATVFRPLTLLQELSLETNSltsiPSSALVNqrntLTNLNLGLNSINEVPVGALDFPVLSSLSLEFNGITVIPP 251
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTN----LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 252 qAFQGVPNLQFLYMTGNKFPSwAPEMFRYITQLKTLGIGETPISVIPnNAFMHIPNLIRLEMSEAAVDTIERgAFQRTPQ 331
Cdd:COG4886 154 -PLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTN 229

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17566890 332 IQAIVLNKNRLSQVraDFFEGLNDLYSIDLQGNRIDNVQPLGfaNLPAISHLDISYNLLQTMPSNVFQNSFLPQPNDR 409
Cdd:COG4886 230 LETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-403 1.14e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  46 LQNAIQAIQAARDIPIDSLTILDTAIPTIPANAFQSFTILRLVLNRNTLQNIDDQAFNGPL-----LDSLIELDLNDNNl 120
Cdd:COG4886  29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLtdlgdLTNLTELDLSGNE- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 121 gqipqtGIPRLRNLRKLYLNRNRINQLSStAFNAFESrdlLLKLELAGNRLTDATlgdaTVFRPLTLLQELSLETNSLTS 200
Cdd:COG4886 108 ------ELSNLTNLESLDLSGNQLTDLPE-ELANLTN---LKELDLSNNQLTDLP----EPLGNLTNLKSLDLSNNQLTD 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 201 IPSSalVNQRNTLTNLNLGLNSINEVPVGALDFPVLSSLSLEFNGITVIPPqAFQGVPNLQFLYMTGNKFPSWaPEMFRy 280
Cdd:COG4886 174 LPEE--LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL-PELGN- 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 281 ITQLKTLGIGETPISVIPNNAfmHIPNLIRLEMSEAAVDTIERGAFQRTPQIQAIVLNKNRLSQvrADFFEGLNDLYSID 360
Cdd:COG4886 249 LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL--LELLILLLLLTTLL 324

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 17566890 361 LQGNRIDNVQPLGFANLPAISHLDISYNLLQTMPSNVFQNSFL 403
Cdd:COG4886 325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 107-407 1.40e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 1.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  107 LDSLIELDLNDNNL-GQIPQTgIPRLRNLRKLYLNRNrinQLSSTAFNAFESRDLLLKLELAGNRLTDATLGDATVFRPL 185
Cdd:PLN00113 283 LQKLISLDLSDNSLsGEIPEL-VIQLQNLEILHLFSN---NFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  186 TLLqelSLETNSLTSIPSSALVNQRNtLTNLNLGLNSIN-EVPVGALDFPVLSSLSLEFNGITVIPPQAFQGVPNLQFLY 264
Cdd:PLN00113 359 TVL---DLSTNNLTGEIPEGLCSSGN-LFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLD 434

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  265 MTGNKFPSWAPEMFRYITQLKTLgigetpiSVIPNNAFMHIP------NLIRLEMSEAAVDTIERGAFQRTPQIQAIVLN 338
Cdd:PLN00113 435 ISNNNLQGRINSRKWDMPSLQML-------SLARNKFFGGLPdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  339 KNRLSQVRADFFEGLNDLYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLLQ-TMPSNVFQNSFLPQPN 407
Cdd:PLN00113 508 ENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVN 577
LRR_8 pfam13855
Leucine rich repeat;
86-144 5.59e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.59e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17566890    86 RLVLNRNTLQNIDDQAFNGplLDSLIELDLNDNNLGQIPQTGIPRLRNLRKLYLNRNRI 144
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
330-390 3.49e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.49e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17566890   330 PQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLL 390
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
212-270 5.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 5.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890   212 TLTNLNLGLNSINEVPVGAL-DFPVLSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKF 270
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-376 9.11e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 9.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890   96 NIDDQAFNGPLLD-------SLIELDLNDNNL-GQIPQTGIPrlrNLRKLYLNRNrinQLSSTAFNAFESRDLLLKLELA 167
Cdd:PLN00113  99 NLSNNQLSGPIPDdifttssSLRYLNLSNNNFtGSIPRGSIP---NLETLDLSNN---MLSGEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  168 GNRLTDATLGDATvfrPLTLLQELSLETNSLT-SIPSSalVNQRNTLTNLNLGLNSIN-EVPVGALDFPVLSSLSLEFNG 245
Cdd:PLN00113 173 GNVLVGKIPNSLT---NLTSLEFLTLASNQLVgQIPRE--LGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNN 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  246 ITVIPPQAFQGVPNLQFLYMTGNKFPSWAPEMFRYITQLKTLGIGETPISvipnnafMHIPNLI----RLEM----SEAA 317
Cdd:PLN00113 248 LTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS-------GEIPELViqlqNLEIlhlfSNNF 320

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  318 VDTIERgAFQRTPQIQAIVLNKNRLS-QVRADFFEGlNDLYSIDLQGNRIDNVQPLGFAN 376
Cdd:PLN00113 321 TGKIPV-ALTSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPEGLCS 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-300 1.73e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  63 SLTILDTAIPTIPAnAFQSFTILR-LVLNRNTLQNIDDQAFNgplLDSLIELDLNDNNLGQIPQtgIPRLRNLRKLYLNR 141
Cdd:COG4886 186 ELDLSNNQITDLPE-PLGNLTNLEeLDLSGNQLTDLPEPLAN---LTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSN 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 142 NRINQLSSTAFNafesrDLLLKLELAGNRLTDATLGDATVFRPLTLLQELSLETNSLTSIPSSALVNQRNTLTNLNLGLN 221
Cdd:COG4886 260 NQLTDLPPLANL-----TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17566890 222 SINEVPVGALDFPVLSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKFPSWAPEMFRYITQLKTLGIGETPISVIPNN 300
Cdd:COG4886 335 VTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 109-294 1.96e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 109 SLIELDLNDNNLGQIPQ------TGIPRLRNLRKLYLNRNRINQLSSTAFNAFESRDLLLKLELAGNRLTDATLG-DATV 181
Cdd:cd00116  52 SLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRlLAKG 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 182 FRPLTL-LQELSLETNSLTSIPSSALVN---QRNTLTNLNLGLNSINEVPVGAL-----DFPVLSSLSLEFNGITVIPPQ 252
Cdd:cd00116 132 LKDLPPaLEKLVLGRNRLEGASCEALAKalrANRDLKELNLANNGIGDAGIRALaeglkANCNLEVLDLNNNGLTDEGAS 211

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 17566890 253 AFQGVP----NLQFLYMTGNKFPSW-----APEMFRYITQLKTLGIGETPI 294
Cdd:cd00116 212 ALAETLaslkSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 109-244 1.99e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 109 SLIELDLNDNNLG----QIPQTGIPRLR-NLRKLYLNRNRINQLSSTAF-NAFESRDLLLKLELAGNRLTDA-------- 174
Cdd:cd00116 109 SLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALaKALRANRDLKELNLANNGIGDAgiralaeg 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 175 ---------------TLGD------ATVFRPLTLLQELSLETNSLTSIPSSALVNQ----RNTLTNLNLGLNSINEVPVG 229
Cdd:cd00116 189 lkancnlevldlnnnGLTDegasalAETLASLKSLEVLNLGDNNLTDAGAAALASAllspNISLLTLSLSCNDITDDGAK 268

                       170       180
                ....*....|....*....|
gi 17566890 230 AL-----DFPVLSSLSLEFN 244
Cdd:cd00116 269 DLaevlaEKESLLELDLRGN 288
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
108-315 2.35e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 2.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  108 DSLIELDLNDNNLGQIPQTgiprLR-NLRKLYLNRNRINQLSSTAfnafesRDLLLKLELAGNRLTD------ATLGDAT 180
Cdd:PRK15370 199 EQITTLILDNNELKSLPEN----LQgNIKTLYANSNQLTSIPATL------PDTIQEMELSINRITElperlpSALQSLD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  181 VFR------PLTL---LQELSLETNSLTSIPS---SALVN---QRNTLTNL------NL-----GLNSINEVPVGALdfP 234
Cdd:PRK15370 269 LFHnkisclPENLpeeLRYLSVYDNSIRTLPAhlpSGITHlnvQSNSLTALpetlppGLktleaGENALTSLPASLP--P 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  235 VLSSLSLEFNGITVIPPQAfqgVPNLQFLYMTGN---KFPSWAPEMFRYI----TQLKTL--------GIGETPISV-IP 298
Cdd:PRK15370 347 ELQVLDVSKNQITVLPETL---PPTITTLDVSRNaltNLPENLPAALQIMqasrNNLVRLpeslphfrGEGPQPTRIiVE 423

                        250
                 ....*....|....*....
gi 17566890  299 NNAFMH--IPNLIRLEMSE 315
Cdd:PRK15370 424 YNPFSErtIQNMQRLMSSV 442
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
188-397 4.10e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 4.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  188 LQELSLETNSLTSIPSSAlvnqRNTLTNLNLGLNSINEVPVgalDFP-VLSSLSLEFNGITVIPPQAFQGvpnLQFLYMT 266
Cdd:PRK15370 222 IKTLYANSNQLTSIPATL----PDTIQEMELSINRITELPE---RLPsALQSLDLFHNKISCLPENLPEE---LRYLSVY 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  267 GNKFPSWAPEMFRYITQLKtlgigetpisvIPNNAFMHIPNLIrlemseaavdtiergafqrTPQIQAIVLNKNRLSQVR 346
Cdd:PRK15370 292 DNSIRTLPAHLPSGITHLN-----------VQSNSLTALPETL-------------------PPGLKTLEAGENALTSLP 341

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 17566890  347 ADFFEGLNDLysiDLQGNRIdNVQPLGFAnlPAISHLDISYNLLQTMPSNV 397
Cdd:PRK15370 342 ASLPPELQVL---DVSKNQI-TVLPETLP--PTITTLDVSRNALTNLPENL 386
LRR_8 pfam13855
Leucine rich repeat;
234-289 7.23e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 7.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17566890   234 PVLSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKFPSWAPEMFRYITQLKTLGI 289
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR_8 pfam13855
Leucine rich repeat;
356-400 8.21e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 8.21e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 17566890   356 LYSIDLQGNRIDNVQPLGFANLPAISHLDISYNLLQTMPSNVFQN 400
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
LRR_8 pfam13855
Leucine rich repeat;
109-171 9.80e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17566890   109 SLIELDLNDNNLGQIPQTGIPRLRNLRKLYLNRNRINQLSSTAFNAFESrdlLLKLELAGNRL 171
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS---LRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 107-218 1.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 107 LDSLIELDLNDNNLGQIPqtGIPRLRNLRKLYLNRNRI------------------NQ-LSSTAFNAFESRDL------L 161
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIsvveglenltnleelhieNQrLPPGEKLTFDPRSLaalsnsL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17566890 162 LKLELAGNRLTDatLGDatvFRPLTLLQELSLETNSLTSIPS-SALVNQRNTLTNLNL 218
Cdd:cd21340 123 RVLNISGNNIDS--LEP---LAPLRNLEQLDASNNQISDLEElLDLLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
132-198 2.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17566890   132 RNLRKLYLNRNRINQLSSTAFNAFESrdlLLKLELAGNRLTdaTLgDATVFRPLTLLQELSLETNSL 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSN---LKVLDLSNNLLT--TL-SPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-270 2.57e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 2.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890   80 QSFTILRLV----LNRNTLQ-NIDDQAFNGPlldSLIELDLNDNN-LGQIPQTGipRLRNLRKLYLNRNRINQLSSTAFN 153
Cdd:PLN00113 422 SEFTKLPLVyfldISNNNLQgRINSRKWDMP---SLQMLSLARNKfFGGLPDSF--GSKRLENLDLSRNQFSGAVPRKLG 496

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  154 AFESrdlLLKLELAGNRLTdatlGDatvfrpltLLQELSLETNsltsipssalvnqrntLTNLNLGLNSIN-EVPVGALD 232
Cdd:PLN00113 497 SLSE---LMQLKLSENKLS----GE--------IPDELSSCKK----------------LVSLDLSHNQLSgQIPASFSE 545

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 17566890  233 FPVLSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKF 270
Cdd:PLN00113 546 MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 186-309 2.13e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 41.38  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890   186 TLLQELSLeTNSLTSIPSSALVNQRNtLTNLNLGlNSINEVPVGALDFPVLSSLSLEfNGITVIPPQAFQGVPNLQFLYM 265
Cdd:pfam13306  11 CSLTSITI-PSSLTSIGEYAFSNCTS-LKSITLP-SSLTSIGSYAFYNCSLTSITIP-SSLTSIGEYAFSNCSNLKSITL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 17566890   266 TGN--KFPSWApemFRYiTQLKTLGIGETpISVIPNNAFMHIPNLI 309
Cdd:pfam13306  87 PSNltSIGSYA---FSN-CSLKSITIPSS-VTTIGSYAFSNCSNLK 127
LRR_8 pfam13855
Leucine rich repeat;
282-342 3.94e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17566890   282 TQLKTLGIGETPISVIPNNAFMHIPNLIRLEMSEAAVDTIERGAFQRTPQIQAIVLNKNRL 342
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 66-174 5.59e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 5.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  66 ILDTAIPTIpANAFQSFTILR-LVLNRNTLQNIDDQAFNGPLLD--SLIELDLNDNNLGQIP----QTGIPRL-RNLRKL 137
Cdd:cd00116 177 IGDAGIRAL-AEGLKANCNLEvLDLNNNGLTDEGASALAETLASlkSLEVLNLGDNNLTDAGaaalASALLSPnISLLTL 255

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 17566890 138 YLNRNRINQLSSTAF-NAFESRDLLLKLELAGNRLTDA 174
Cdd:cd00116 256 SLSCNDITDDGAKDLaEVLAEKESLLELDLRGNKFGEE 293
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 96-264 5.66e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 5.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  96 NIDDQAFNGpLLDSLIE------LDLNDNNLG----QIPQTGIPRLRNLRKLYLNRNRINQLSSTAF-NAFESRDLLLKL 164
Cdd:COG5238 247 QIGDEGVIA-LAEALKNnttvetLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGDEGAIALaEGLQGNKTLHTL 325

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 165 ELAGNRLTDA-TLGDATVFRPLTLLQELSLETNSLTSIPSSAL---VNQRNTLTNLNLGLNSINEVPV----GALDFPVL 236
Cdd:COG5238 326 NLAYNGIGAQgAIALAKALQENTTLHSLDLSDNQIGDEGAIALakyLEGNTTLRELNLGKNNIGKQGAealiDALQTNRL 405

                       170       180
                ....*....|....*....|....*....
gi 17566890 237 SSLSLEFNGITVIPPQA-FQGVPNLQFLY 264
Cdd:COG5238 406 HTLILDGNLIGAEAQQRlEQLLERIKSVY 434
LRR_8 pfam13855
Leucine rich repeat;
306-366 9.01e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17566890   306 PNLIRLEMSEAAVDTIERGAFQRTPQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNRI 366
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
104-202 9.34e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.52  E-value: 9.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890   104 GPLLDSLIELDLNDNNLGQIpqTGIPRLRNLRKLYLNRNRINQLSStafNAFESRDLLLKLELAGNRLTDatLGDATVFR 183
Cdd:pfam14580  38 GATLDQFDTIDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGE---GLGEALPNLTELILTNNNLQE--LGDLDPLA 110

                          90
                  ....*....|....*....
gi 17566890   184 PLTLLQELSLETNSLTSIP 202
Cdd:pfam14580 111 SLKKLTFLSLLRNPVTNKP 129
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 109-268 2.75e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 109 SLIELDLNDNNLGQIPqtGIPRLRNLRKLYLNRNRINQLSStafnaFESRDLLLKLELAGNRLTdatlgdaTV--FRPLT 186
Cdd:cd21340  25 NLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN-----LENLVNLKKLYLGGNRIS-------VVegLENLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890 187 LLQELSLE------TNSLTSIPSSaLVNQRNTLTNLNLGLNSINEV-PVGALDFpvLSSLSLEFNGITVIPP--QAFQGV 257
Cdd:cd21340  91 NLEELHIEnqrlppGEKLTFDPRS-LAALSNSLRVLNISGNNIDSLePLAPLRN--LEQLDASNNQISDLEEllDLLSSW 167

                       170
                ....*....|.
gi 17566890 258 PNLQFLYMTGN 268
Cdd:cd21340 168 PSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
63-120 7.79e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 7.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17566890    63 SLTILD---TAIPTIPANAFQSFTILR-LVLNRNTLQNIDDQAFNGplLDSLIELDLNDNNL 120
Cdd:pfam13855   2 NLRSLDlsnNRLTSLDDGAFKGLSNLKvLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 113-204 8.97e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 8.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566890  113 LDLNDNNL-GQIPQTgIPRLRNLRKLYLNRNRINQLSSTAFNAFESrdlLLKLELAGNRLTD---ATLGDatvfrpLTLL 188
Cdd:PLN03150 423 LGLDNQGLrGFIPND-ISKLRHLQSINLSGNSIRGNIPPSLGSITS---LEVLDLSYNSFNGsipESLGQ------LTSL 492

                         90
                 ....*....|....*..
gi 17566890  189 QELSLETNSLTS-IPSS 204
Cdd:PLN03150 493 RILNLNGNSLSGrVPAA 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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