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Conserved domains on  [gi|17564374|ref|NP_505312|]
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TPR_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 18643657)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1096-1274 1.58e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.40  E-value: 1.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1096 LLGLGHIPAFALSDQFLFYQPEKALAEALKSLGNERdtiEHVAARLHAAmlhsnAKDGHVSWVLCVLSSLYwRVTGNAEN 1175
Cdd:COG3914   60 LALAAGEAAAAAAALLLLAALLELAALLLQALGRYE---EALALYRRAL-----ALNPDNAEALFNLGNLL-LALGRLEE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1176 AIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLS 1255
Cdd:COG3914  131 ALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208

                        170
                 ....*....|....*....
gi 17564374 1256 LqanfQPAKDKIRTIYCHA 1274
Cdd:COG3914  209 L----DPDNADAHSNLLFA 223
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 689-833 1.32e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374  689 EHEMAARI-QLLMKHTIGPRWVSLNLAGLYWRiQGNPHQATKCLLGAfLDKPEESFVSIVQLAQVMLKsTRMVNDAHGFL 767
Cdd:COG2956   57 EYDRAIRIhQKLLERDPDRAEALLELAQDYLK-AGLLDRAEELLEKL-LELDPDDAEALRLLAEIYEQ-EGDWEKAIEVL 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564374  768 NQQLNLLGYSEPlFHYVQGRMKLLLHDVDKAIQHLKDAMDKDPNNLVIQEDLLKIACSGKSTKSAI 833
Cdd:COG2956  134 ERLLKLGPENAH-AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1096-1274 1.58e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.40  E-value: 1.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1096 LLGLGHIPAFALSDQFLFYQPEKALAEALKSLGNERdtiEHVAARLHAAmlhsnAKDGHVSWVLCVLSSLYwRVTGNAEN 1175
Cdd:COG3914   60 LALAAGEAAAAAAALLLLAALLELAALLLQALGRYE---EALALYRRAL-----ALNPDNAEALFNLGNLL-LALGRLEE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1176 AIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLS 1255
Cdd:COG3914  131 ALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208

                        170
                 ....*....|....*....
gi 17564374 1256 LqanfQPAKDKIRTIYCHA 1274
Cdd:COG3914  209 L----DPDNADAHSNLLFA 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1115-1263 8.58e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 8.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374   1115 QPEKALAEALKSLGNERDTIEHVA--ARLH-AAMLHSNAKDGHVSWV---------LCVLSSLYWRVTgNAENAIGCLRC 1182
Cdd:TIGR02917  582 QLKKALAILNEAADAAPDSPEAWLmlGRAQlAAGDLNKAVSSFKKLLalqpdsalaLLLLADAYAVMK-NYAKAITSLKR 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374   1183 ALhTAPPHMRDvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQP 1262
Cdd:TIGR02917  661 AL-ELKPDNTE-AQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQN 738


                   .
gi 17564374   1263 A 1263
Cdd:TIGR02917  739 A 739
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 689-833 1.32e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374  689 EHEMAARI-QLLMKHTIGPRWVSLNLAGLYWRiQGNPHQATKCLLGAfLDKPEESFVSIVQLAQVMLKsTRMVNDAHGFL 767
Cdd:COG2956   57 EYDRAIRIhQKLLERDPDRAEALLELAQDYLK-AGLLDRAEELLEKL-LELDPDDAEALRLLAEIYEQ-EGDWEKAIEVL 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564374  768 NQQLNLLGYSEPlFHYVQGRMKLLLHDVDKAIQHLKDAMDKDPNNLVIQEDLLKIACSGKSTKSAI 833
Cdd:COG2956  134 ERLLKLGPENAH-AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1096-1274 1.58e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.40  E-value: 1.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1096 LLGLGHIPAFALSDQFLFYQPEKALAEALKSLGNERdtiEHVAARLHAAmlhsnAKDGHVSWVLCVLSSLYwRVTGNAEN 1175
Cdd:COG3914   60 LALAAGEAAAAAAALLLLAALLELAALLLQALGRYE---EALALYRRAL-----ALNPDNAEALFNLGNLL-LALGRLEE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1176 AIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLS 1255
Cdd:COG3914  131 ALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208

                        170
                 ....*....|....*....
gi 17564374 1256 LqanfQPAKDKIRTIYCHA 1274
Cdd:COG3914  209 L----DPDNADAHSNLLFA 223
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1120-1276 2.26e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 2.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1120 LAEALKSLGNERDTIEHvaarLHAAMlhsnAKDGHVSWVLCVLSSLYWRvTGNAENAIGCLRCALHTAPPHMRdvALVSL 1199
Cdd:COG0457   14 LGLAYRRLGRYEEAIED----YEKAL----ELDPDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDDAE--ALNNL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17564374 1200 ANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQPAKDKIRTIYCHAGK 1276
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1119-1259 1.83e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1119 ALAEALKSLGNERDTIEhVAARLhaamLHSNAKDGHVswvLCVLSSLYWRvTGNAENAIGCLRCALHTAPPHMRdvALVS 1198
Cdd:COG2956  115 LLAEIYEQEGDWEKAIE-VLERL----LKLGPENAHA---YCELAELYLE-QGDYDEAIEALEKALKLDPDCAR--ALLL 183

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17564374 1199 LANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQAN 1259
Cdd:COG2956  184 LAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS 244
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1105-1276 2.69e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.58  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1105 FALSDQFLFY-QPEKALAEALKSLGNERDTIE-HVA-ARLH--------AAMLHSNA--KDGHVSWVLCVLSSLYWRvTG 1171
Cdd:COG2956   12 YFKGLNYLLNgQPDKAIDLLEEALELDPETVEaHLAlGNLYrrrgeydrAIRIHQKLleRDPDRAEALLELAQDYLK-AG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1172 NAENAIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYY 1251
Cdd:COG2956   91 LLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALE 168

                        170       180
                 ....*....|....*....|....*
gi 17564374 1252 STLSLQANFQPAKDKIRTIYCHAGK 1276
Cdd:COG2956  169 KALKLDPDCARALLLLAELYLEQGD 193
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1171-1276 8.76e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.81  E-value: 8.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1171 GNAENAIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFY 1250
Cdd:COG4783   18 GDYDEAEALLEKALELDPDNPE--AFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALL 95

                         90       100
                 ....*....|....*....|....*.
gi 17564374 1251 YSTLSLQANFQPAKDKIRTIYCHAGK 1276
Cdd:COG4783   96 EKALKLDPEHPEAYLRLARAYRALGR 121
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1104-1280 1.25e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1104 AFALSDQFLFYQPEkaLAEALKSLGN-ERdtiehvAARLHAAMLHSNAKDGHVswvLCVLSSLYwRVTGNAENAIGCLRC 1182
Cdd:COG2956   68 LLERDPDRAEALLE--LAQDYLKAGLlDR------AEELLEKLLELDPDDAEA---LRLLAEIY-EQEGDWEKAIEVLER 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1183 ALHTAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQP 1262
Cdd:COG2956  136 LLKLGPENAH--AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                        170
                 ....*....|....*...
gi 17564374 1263 AKDKIRTIYCHAGKEFEF 1280
Cdd:COG2956  214 ALPRLAELYEKLGDPEEA 231
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1119-1250 1.99e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1119 ALAEALKSLGNERDTIEHvaarLHAAMlhsnAKDGHVSWVLCVLSSLYWRvTGNAENAIGCLRCALHTAPPHMRdvALVS 1198
Cdd:COG0457   47 NLGLAYLRLGRYEEALAD----YEQAL----ELDPDDAEALNNLGLALQA-LGRYEEALEDYDKALELDPDDAE--ALYN 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17564374 1199 LANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFY 1250
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELL 167
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1115-1260 2.57e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.26  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1115 QPEKALAEALKSLGNERDtiehvAARLHAAMLhsnAKDGHVSWVLCVLSSLYWRvTGNAENAIGCLRCALHTAPPHMRdv 1194
Cdd:COG4783    5 EALYALAQALLLAGDYDE-----AEALLEKAL---ELDPDNPEAFALLGEILLQ-LGDLDEAIVLLHEALELDPDEPE-- 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564374 1195 ALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANF 1260
Cdd:COG4783   74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1106-1257 3.71e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.42  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1106 ALSDQFLFYQPEKALAEALKSLGNERDTIEHVAARLHAAMLHSNAKDGHVSWVLCVLSSLYWRvTGNAENAIGCLRCALH 1185
Cdd:COG5010    4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNK-LGDFEESLALLEQALQ 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17564374 1186 TAPPHMRdvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQ 1257
Cdd:COG5010   83 LDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1138-1250 9.44e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 9.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1138 AARLHAAmLHSNAKDGHvSWVLcvLSSLYWRvTGNAENAIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSALISAG 1217
Cdd:COG4235    3 IARLRQA-LAANPNDAE-GWLL--LGRAYLR-LGRYDEALAAYEKALRLDPDNAD--ALLDLAEALLAAGDTEEAEELLE 75

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17564374 1218 AALSASPRLVAIHFTLGNIYASIGDYQRALNFY 1250
Cdd:COG4235   76 RALALDPDNPEALYLLGLAAFQQGDYAEAIAAW 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1195-1276 2.55e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.31  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1195 ALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQPAKDKIRTIYCHA 1274
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89


                 ..
gi 17564374 1275 GK 1276
Cdd:COG0457   90 GR 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1115-1263 8.58e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 8.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374   1115 QPEKALAEALKSLGNERDTIEHVA--ARLH-AAMLHSNAKDGHVSWV---------LCVLSSLYWRVTgNAENAIGCLRC 1182
Cdd:TIGR02917  582 QLKKALAILNEAADAAPDSPEAWLmlGRAQlAAGDLNKAVSSFKKLLalqpdsalaLLLLADAYAVMK-NYAKAITSLKR 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374   1183 ALhTAPPHMRDvALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQP 1262
Cdd:TIGR02917  661 AL-ELKPDNTE-AQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQN 738


                   .
gi 17564374   1263 A 1263
Cdd:TIGR02917  739 A 739
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 689-833 1.32e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374  689 EHEMAARI-QLLMKHTIGPRWVSLNLAGLYWRiQGNPHQATKCLLGAfLDKPEESFVSIVQLAQVMLKsTRMVNDAHGFL 767
Cdd:COG2956   57 EYDRAIRIhQKLLERDPDRAEALLELAQDYLK-AGLLDRAEELLEKL-LELDPDDAEALRLLAEIYEQ-EGDWEKAIEVL 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564374  768 NQQLNLLGYSEPlFHYVQGRMKLLLHDVDKAIQHLKDAMDKDPNNLVIQEDLLKIACSGKSTKSAI 833
Cdd:COG2956  134 ERLLKLGPENAH-AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1171-1259 1.39e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.08  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1171 GNAENAIGCLRCALHTAPPHMRdvALVSLANICHQAGLFNSAlISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFY 1250
Cdd:COG3063    6 GDLEEAEEYYEKALELDPDNAD--ALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYL 82


                 ....*....
gi 17564374 1251 YSTLSLQAN 1259
Cdd:COG3063   83 ERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1201-1276 1.83e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 1.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564374 1201 NICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQPAKDKIRTIYCHAGK 1276
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1195-1276 8.96e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 8.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564374 1195 ALVSLANICHQAGLFNSALISAGAALSASPRLVAIHFTLGNIYASIGDYQRALNFYYSTLSLQANFQPAKDKIRTIYCHA 1274
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85


                 ..
gi 17564374 1275 GK 1276
Cdd:COG4783   86 GD 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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