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Conserved domains on  [gi|392919642|ref|NP_505090|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-309 1.12e-107

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 316.70  E-value: 1.12e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642    4 LHVIQYFGFLGSQLANSFLVYLIMTKARKLFGMYRFVMLGFAFFFLIYSWIEILTQPVIHIKSPVCIVFMDSS-LKYFKT 82
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKdLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   83 LGFNLTCLYCACFALVISLLSAQFFYRFLAVCKPHSLSHGEERILFYLFFPCVLCFIAWFGFVYWGMANTVEKQLYMKNE 162
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  163 LAEKYNEDSENVAFIAVMYWSLDKNGQKIWKIWDIALLLACVATIGGCFMTIVYCASRIYRKMKDTSSHMSERTLELNRQ 242
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392919642  243 LFITLTIQTILPLFMMYIPVGLATSLPIFEIKNGRIANFTAASLAVYPFLEPLVPMICIKEFKKVIL 309
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-309 1.12e-107

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 316.70  E-value: 1.12e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642    4 LHVIQYFGFLGSQLANSFLVYLIMTKARKLFGMYRFVMLGFAFFFLIYSWIEILTQPVIHIKSPVCIVFMDSS-LKYFKT 82
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKdLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   83 LGFNLTCLYCACFALVISLLSAQFFYRFLAVCKPHSLSHGEERILFYLFFPCVLCFIAWFGFVYWGMANTVEKQLYMKNE 162
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  163 LAEKYNEDSENVAFIAVMYWSLDKNGQKIWKIWDIALLLACVATIGGCFMTIVYCASRIYRKMKDTSSHMSERTLELNRQ 242
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392919642  243 LFITLTIQTILPLFMMYIPVGLATSLPIFEIKNGRIANFTAASLAVYPFLEPLVPMICIKEFKKVIL 309
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-309 1.12e-107

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 316.70  E-value: 1.12e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642    4 LHVIQYFGFLGSQLANSFLVYLIMTKARKLFGMYRFVMLGFAFFFLIYSWIEILTQPVIHIKSPVCIVFMDSS-LKYFKT 82
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKdLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   83 LGFNLTCLYCACFALVISLLSAQFFYRFLAVCKPHSLSHGEERILFYLFFPCVLCFIAWFGFVYWGMANTVEKQLYMKNE 162
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  163 LAEKYNEDSENVAFIAVMYWSLDKNGQKIWKIWDIALLLACVATIGGCFMTIVYCASRIYRKMKDTSSHMSERTLELNRQ 242
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392919642  243 LFITLTIQTILPLFMMYIPVGLATSLPIFEIKNGRIANFTAASLAVYPFLEPLVPMICIKEFKKVIL 309
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 10-308 1.17e-41

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 147.00  E-value: 1.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   10 FGFLgSQLANSFLVYLIMTKARKLFGMYRFVMLGFAFFFLIYSWIEILTQPVIHIKSPVCIVFM-DSSLKYFKTLGFNLT 88
Cdd:pfam10319  14 FGVL-SFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVsDGPFFEYSELGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   89 CLYCACFALVISLLSAQFFYRFLAVCKPHSLSHGEERI-LFYLFFPCVLCFIAWFGFVYWGMANTVEKQLYMKNELAEKY 167
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWgILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  168 NEDSENVAFIAVMYWslDKNGQKIWKIWDIALLLACVATIGGCFmtIVYCASRIYRKMKDTSSHMSERTLELNRQLFITL 247
Cdd:pfam10319 173 GVDSMDINMLGALYW--EASDETVFRSWLGILLLTVISVYSIIL--YIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKAL 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392919642  248 TIQTILPLFMMYIPVGLATSLPIFEIKNGRIANFTAAS-LAVYPFLEPLVPMICIKEFKKVI 308
Cdd:pfam10319 249 IVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 10-309 1.52e-17

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 81.44  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   10 FGFLGSqLANSFLVYLIMTKARKLFGMYRFVMLGFAFFFLIYSWIEILTQP-VIHIKSPVCIVFmDSSLKYFK-TLGFNL 87
Cdd:pfam10317   8 FFILGL-ILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQrIIPNGVSMALIS-YGPCKYFGpWFCYSG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   88 TCLYCACFALVISLLSAQFFYRFLAVCKPHSLSHGEERILFYLFFPCVLCFIawfgfVYWGMANTVEKQLYMKNELAEKY 167
Cdd:pfam10317  86 YSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLI-----VIFLSPTDFLPVEALTKELHPNY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  168 NEDSENV-AFIAVMYWSLDkngqkiwkiwdIALLLACVATIGGCFMtIVYCASRIYRKMKDTSSHMSERTLELNRQLFIT 246
Cdd:pfam10317 161 NLTDYTVtGFSDLQSFPAL-----------INTLIMTIPVFPIPII-ILILRRKILKLLNSNSVNMSPTTKAQHRQLIKG 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392919642  247 LTIQTILPLFmMYIPVGLATSLPIFEIKNGRIA-NFTAASLAVYPFLEPLVPMICIKEFKKVIL 309
Cdd:pfam10317 229 LTIQALLPLF-SYIPGVTLYLLSQLTGTEFLILeYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 24-301 7.59e-10

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 59.09  E-value: 7.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   24 YLIMTKARKLFGMYRFVMLGFAFFFLIYS-WIEILTQPVIHIksPVCIVFMDSSLKYFKTLGFNLTCLYCACFALVISLL 102
Cdd:pfam10318  26 YCILFKTPKKMKSVKWSLLNLHFWSALLDlSLSFLTIPYIFL--PALAGYPLGLLSYLGVPTPIQFYIGVTSLALVGVSI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  103 SAQFFYRFLAVCKPHSLSHGEERILFYLFFPCVLCFIAWFGFVYwgmanTVEKQLYMKNELAEKYNEDSENVAFIAVMY- 181
Cdd:pfam10318 104 ILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYL-----NIPDQEAAKLKVLKKLPCLPPEFFDNPPVFv 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  182 WSLDKNgqkiwkiwdIALLLACVATIGGCFMTIVYCASRIYRKMKDTSSHMSERTLELNRQLFITLTIQTILPLFMMYIP 261
Cdd:pfam10318 179 LAIDST---------YFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIP 249

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 392919642  262 VGLATSLPIFEIKNGRIANFTAASLAVYPFLEPLVpMICI 301
Cdd:pfam10318 250 LIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIA-MLLV 288
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 1-284 1.48e-05

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 46.00  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642    1 MLYLHVIQYFgflgSQLANSFLVYLIMTKARKLfGMYRFVMLGFAFFFLIYSW-IEILTQPVIHIksPVCIVFMDSSLKY 79
Cdd:pfam10327  12 ILYYHIIGTI----SLILNLLGIYLIIFKSGKI-DNFRYYLLYFQISCTLTDIhLTFLMQPIPLF--PIIAGYCNGFLAT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642   80 FktlgFNLTCLYcaCFALVISLLSAQ-------FFYRFLAVCKPHSlSHGEERILFYLFFPCVLCFIAWFGFVYWGMANT 152
Cdd:pfam10327  85 V----FGISSHY--LMTIFVFLLSFQleslllcFVRKHQAIAKILS-KHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919642  153 VEKQL-YMKNELAEKYNEDSENVAFiaVMYwsldkngqkIWKIWDIALLLACVATIGGCFMTIVYCASRIYRKMKDTSSH 231
Cdd:pfam10327 158 REEQLeYVKENYPEYLSQFSSLPNF--AIY---------DYNPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKK 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 392919642  232 MSERTLELNRQLFITLTIQTILPlFMMYIPVGLATSLPIFEIKNGR-IANFTAA 284
Cdd:pfam10327 227 ISAQTYQKHRAALRSLIAQFATS-PVCILPPFAFVVVVLFPIEYSQeISEILLA 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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