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Conserved domains on  [gi|808358576|ref|NP_504996|]
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DUF19 domain-containing protein [Caenorhabditis elegans]

Protein Classification

DUF19 domain-containing protein( domain architecture ID 3606)

DUF19 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF19 super family cl03272
Domain of unknown function (DUF19); This presumed domain has no known function. It is found in ...
 113-244 7.72e-08

Domain of unknown function (DUF19); This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.


The actual alignment was detected with superfamily member pfam01579:

Pssm-ID: 426332  Cd Length: 154  Bit Score: 50.55  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808358576  113 YNMFKCASMMESVADQTSMLstiKTINDTRMIKAIDQCNDVKVCMAP-SCYAFES---ERQIVATACKSIEMQNTGFMFC 188
Cdd:pfam01579   7 LKAGKCLPRLGDFLEKTDEL---DIKDKDELKKFNKSCESFLSCFKTlKCLEDDEavkAKNKIEKYCDAVKFLSTDFAEC 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808358576  189 LKKIGREKPdlsNYKCIGNYDFSM------TTSEMFTTKKWCTKWIMRKICGNRAVTNFQKY 244
Cdd:pfam01579  84 MEKLYKAKK---NSECFKDWDPFPkdeklkEKCKNYFGKDNCMKKEITETCGKEEWEYFKKH 142
DUF19 super family cl03272
Domain of unknown function (DUF19); This presumed domain has no known function. It is found in ...
 29-97 2.07e-07

Domain of unknown function (DUF19); This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.


The actual alignment was detected with superfamily member pfam01579:

Pssm-ID: 426332  Cd Length: 154  Bit Score: 49.39  E-value: 2.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808358576   29 VECISLFYSASYKEDCSKNLDFLSTDLSAQ--RKTFTSGKSCVLKITKSKCTSSDYQYLSANYDKIVNDIT 97
Cdd:pfam01579  81 AECMEKLYKAKKNSECFKDWDPFPKDEKLKekCKNYFGKDNCMKKEITETCGKEEWEYFKKHYLKLNDILK 151
 
Name Accession Description Interval E-value
DUF19 pfam01579
Domain of unknown function (DUF19); This presumed domain has no known function. It is found in ...
 113-244 7.72e-08

Domain of unknown function (DUF19); This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.


Pssm-ID: 426332  Cd Length: 154  Bit Score: 50.55  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808358576  113 YNMFKCASMMESVADQTSMLstiKTINDTRMIKAIDQCNDVKVCMAP-SCYAFES---ERQIVATACKSIEMQNTGFMFC 188
Cdd:pfam01579   7 LKAGKCLPRLGDFLEKTDEL---DIKDKDELKKFNKSCESFLSCFKTlKCLEDDEavkAKNKIEKYCDAVKFLSTDFAEC 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808358576  189 LKKIGREKPdlsNYKCIGNYDFSM------TTSEMFTTKKWCTKWIMRKICGNRAVTNFQKY 244
Cdd:pfam01579  84 MEKLYKAKK---NSECFKDWDPFPkdeklkEKCKNYFGKDNCMKKEITETCGKEEWEYFKKH 142
DUF19 pfam01579
Domain of unknown function (DUF19); This presumed domain has no known function. It is found in ...
 29-97 2.07e-07

Domain of unknown function (DUF19); This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.


Pssm-ID: 426332  Cd Length: 154  Bit Score: 49.39  E-value: 2.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808358576   29 VECISLFYSASYKEDCSKNLDFLSTDLSAQ--RKTFTSGKSCVLKITKSKCTSSDYQYLSANYDKIVNDIT 97
Cdd:pfam01579  81 AECMEKLYKAKKNSECFKDWDPFPKDEKLKekCKNYFGKDNCMKKEITETCGKEEWEYFKKHYLKLNDILK 151
 
Name Accession Description Interval E-value
DUF19 pfam01579
Domain of unknown function (DUF19); This presumed domain has no known function. It is found in ...
 113-244 7.72e-08

Domain of unknown function (DUF19); This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.


Pssm-ID: 426332  Cd Length: 154  Bit Score: 50.55  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808358576  113 YNMFKCASMMESVADQTSMLstiKTINDTRMIKAIDQCNDVKVCMAP-SCYAFES---ERQIVATACKSIEMQNTGFMFC 188
Cdd:pfam01579   7 LKAGKCLPRLGDFLEKTDEL---DIKDKDELKKFNKSCESFLSCFKTlKCLEDDEavkAKNKIEKYCDAVKFLSTDFAEC 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808358576  189 LKKIGREKPdlsNYKCIGNYDFSM------TTSEMFTTKKWCTKWIMRKICGNRAVTNFQKY 244
Cdd:pfam01579  84 MEKLYKAKK---NSECFKDWDPFPkdeklkEKCKNYFGKDNCMKKEITETCGKEEWEYFKKH 142
DUF19 pfam01579
Domain of unknown function (DUF19); This presumed domain has no known function. It is found in ...
 29-97 2.07e-07

Domain of unknown function (DUF19); This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins. It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges. The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.


Pssm-ID: 426332  Cd Length: 154  Bit Score: 49.39  E-value: 2.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808358576   29 VECISLFYSASYKEDCSKNLDFLSTDLSAQ--RKTFTSGKSCVLKITKSKCTSSDYQYLSANYDKIVNDIT 97
Cdd:pfam01579  81 AECMEKLYKAKKNSECFKDWDPFPKDEKLKekCKNYFGKDNCMKKEITETCGKEEWEYFKKHYLKLNDILK 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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