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Conserved domains on  [gi|17559346|ref|NP_504982|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
11-305 3.68e-94

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 281.74  E-value: 3.68e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    11 SPDFLKMTFHVITGLATPIHAFGFYCIVKKTPIHMKPVKWLLFNMHCWCILLDITISFLGIPYIIFPAMAGWGLGPIESP 90
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    91 GLF----FYLGVTFITGVTTSVFVTFENRFFLLFG--ERTFWIHLRKYAIVASYVIVPLYYLPVQFVLPDQEIGREFSWT 164
Cdd:pfam10318  82 GVPtpiqFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346   165 LLECMPELPSDGRPLFVLATDITAPAIGIGVSCFVPTVQCGSFLTLNIYNLIFARPSGISKRTIEMQHKLVIALIVQSSV 244
Cdd:pfam10318 162 KLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17559346   245 TFVLFIVPVQCIVTFVYFHHQNQFHNNLIFFALAIHGIASTLIMIFAHKPYRDFVLSPIYR 305
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
11-305 3.68e-94

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 281.74  E-value: 3.68e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    11 SPDFLKMTFHVITGLATPIHAFGFYCIVKKTPIHMKPVKWLLFNMHCWCILLDITISFLGIPYIIFPAMAGWGLGPIESP 90
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    91 GLF----FYLGVTFITGVTTSVFVTFENRFFLLFG--ERTFWIHLRKYAIVASYVIVPLYYLPVQFVLPDQEIGREFSWT 164
Cdd:pfam10318  82 GVPtpiqFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346   165 LLECMPELPSDGRPLFVLATDITAPAIGIGVSCFVPTVQCGSFLTLNIYNLIFARPSGISKRTIEMQHKLVIALIVQSSV 244
Cdd:pfam10318 162 KLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17559346   245 TFVLFIVPVQCIVTFVYFHHQNQFHNNLIFFALAIHGIASTLIMIFAHKPYRDFVLSPIYR 305
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
11-305 3.68e-94

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 281.74  E-value: 3.68e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    11 SPDFLKMTFHVITGLATPIHAFGFYCIVKKTPIHMKPVKWLLFNMHCWCILLDITISFLGIPYIIFPAMAGWGLGPIESP 90
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    91 GLF----FYLGVTFITGVTTSVFVTFENRFFLLFG--ERTFWIHLRKYAIVASYVIVPLYYLPVQFVLPDQEIGREFSWT 164
Cdd:pfam10318  82 GVPtpiqFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346   165 LLECMPELPSDGRPLFVLATDITAPAIGIGVSCFVPTVQCGSFLTLNIYNLIFARPSGISKRTIEMQHKLVIALIVQSSV 244
Cdd:pfam10318 162 KLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17559346   245 TFVLFIVPVQCIVTFVYFHHQNQFHNNLIFFALAIHGIASTLIMIFAHKPYRDFVLSPIYR 305
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
12-299 4.98e-15

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 74.50  E-value: 4.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    12 PDFLKMTFHVITGLATPIHAFGFYCIVKKTPIhMKPVKWLLFNMHCWCILLDITISFLGIPYIIFPAMAGWGLGPiespg 91
Cdd:pfam10327   8 PFWLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGF----- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    92 LFFYLGVTFITGVTTSVFVTFENRFFLLFGerTFWIH-----------LRKYAIVASYVIVPLYYLPVQFVLPDQEIGRE 160
Cdd:pfam10327  82 LATVFGISSHYLMTIFVFLLSFQLESLLLC--FVRKHqaiakilskhvIPKWLYIFLYILCHIFPFLTAFLFYQSGLSRE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346   161 FSWTLL-----ECMPELPS-DGRPLFVLATDITAPAIGIGVSCFVPTVqCGSFLTLNIYNLIFARPSGISKRTIEMQHKL 234
Cdd:pfam10327 160 EQLEYVkenypEYLSQFSSlPNFAIYDYNPWLIVFGILAIFGGSLSFL-ILVYLTVDMFRMLKRLRKKISAQTYQKHRAA 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17559346   235 VIALIVQSSVTFVlFIVPVQCIVTFVYFHHQN-QFHNNLIFFALAIHGIASTLIMIFAHKPYRDFV 299
Cdd:pfam10327 239 LRSLIAQFATSPV-CILPPFAFVVVVLFPIEYsQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
191-300 8.13e-05

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 43.60  E-value: 8.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346   191 IGIGVSCFVPTVQ------CGSFLTLNIYNLIfarpSGISKRTIEMQHKLVIALIVQSSVTFVLFIVPVQCIVTFVYFHH 264
Cdd:pfam10326 196 IGLLIMTFIIGISfsiiiyCGIKMYFKMKKLK----SLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNI 271
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 17559346   265 QNQFHNNLIFFALAIHGIASTLIMIFAHKPYRDFVL 300
Cdd:pfam10326 272 EIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
19-300 3.00e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 41.77  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    19 FHVITGLATPIHAFGFYCIVKKTPIHMKPVKWLLFNMhCWCILLDITISFLGIPYIIFP--AMAGWGLGPIESPGLFF-Y 95
Cdd:pfam10317   5 YPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNT-AITQIISCILAFFTQQRIIPNgvSMALISYGPCKYFGPWFcY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346    96 LG----VTFITGVTTSVFVTFENRFFLLFGERTFWIHLRKYAIV---ASYVIVPLYYLPVQFVLPDQEIGREFSwtllec 168
Cdd:pfam10317  84 SGysllQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIhyiPSLSQLIVIFLSPTDFLPVEALTKELH------ 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559346   169 mPELPSDGRP------LFVLATDITAPAIGIGVscfVPTVQCGSFLTLNIYNLIFARPSGISKRTIEMQHKLVIALIVQS 242
Cdd:pfam10317 158 -PNYNLTDYTvtgfsdLQSFPALINTLIMTIPV---FPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQA 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17559346   243 SVTFVLFIVPVQCIVTFVYFHHQNQFHNNLIFFALAIHGIASTLIMIFAHKPYRDFVL 300
Cdd:pfam10317 234 LLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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