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Conserved domains on  [gi|71987522|ref|NP_504936|]
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G_PROTEIN_RECEP_F1_2 domain-containing protein [Caenorhabditis elegans]

Protein Classification

class alpha serpentine receptor( domain architecture ID 140224)

class alpha serpentine receptor (Sra) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Sra super family cl20025
Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis ...
 125-396 5.49e-10

Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam02117:

Pssm-ID: 111054  Cd Length: 328  Bit Score: 60.05  E-value: 5.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   125 IILIL-MFTHSIDMIIFHVYHIFRSYKA--VESDPCSVRVKISFCAPFRYIYSFCTLGLAFCQYCVYIDRLLCALYKEYI 201
Cdd:pfam02117  57 ILLFQnLFYANLHQIFYGIEAIRMLYKSffMLSEPCNILITEIDCAPYLEVLVAGISGMIYGQTGLLIERACATFIKKYK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   202 KYQK----VIQYLLVILWVIVTTGVVVWvyrDANLDAYLLSCLNVPLDSMLDLSYVTATVFPINIGCCFLSMVMFRHFKK 277
Cdd:pfam02117 137 KKKSalpgVIISILVLICSIATGKIIIW---DDPLDGYVLACFIFPSKSVPRSNTFLSICTVLSLFNLVISVLILYYNKK 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   278 KENKSRFEIISHFTASVDVDSSEFLYIVTISQAVFIVVYPVLSLSMRYFYAE-TYRPVHLTIAtLVYVFDIYCFVVPLAM 356
Cdd:pfam02117 214 LEYSTRFKVGARFQKREVIDSTSTICFLTFSQFIFMFIYSFGVLTLRSIRENiSPEQYYLWVV-WLYTVPFIALSFPLLL 292

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 71987522   357 VnYGRNRTDTRRAKIwshVKIKSVGKEGADNYFGMMKSQW 396
Cdd:pfam02117 293 I-YRIRSTRSNRTRK---IKEITSTKQTQEEHIKQMKNMW 328
 
Name Accession Description Interval E-value
7TM_GPCR_Sra pfam02117
Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis ...
 125-396 5.49e-10

Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 111054  Cd Length: 328  Bit Score: 60.05  E-value: 5.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   125 IILIL-MFTHSIDMIIFHVYHIFRSYKA--VESDPCSVRVKISFCAPFRYIYSFCTLGLAFCQYCVYIDRLLCALYKEYI 201
Cdd:pfam02117  57 ILLFQnLFYANLHQIFYGIEAIRMLYKSffMLSEPCNILITEIDCAPYLEVLVAGISGMIYGQTGLLIERACATFIKKYK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   202 KYQK----VIQYLLVILWVIVTTGVVVWvyrDANLDAYLLSCLNVPLDSMLDLSYVTATVFPINIGCCFLSMVMFRHFKK 277
Cdd:pfam02117 137 KKKSalpgVIISILVLICSIATGKIIIW---DDPLDGYVLACFIFPSKSVPRSNTFLSICTVLSLFNLVISVLILYYNKK 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   278 KENKSRFEIISHFTASVDVDSSEFLYIVTISQAVFIVVYPVLSLSMRYFYAE-TYRPVHLTIAtLVYVFDIYCFVVPLAM 356
Cdd:pfam02117 214 LEYSTRFKVGARFQKREVIDSTSTICFLTFSQFIFMFIYSFGVLTLRSIRENiSPEQYYLWVV-WLYTVPFIALSFPLLL 292

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 71987522   357 VnYGRNRTDTRRAKIwshVKIKSVGKEGADNYFGMMKSQW 396
Cdd:pfam02117 293 I-YRIRSTRSNRTRK---IKEITSTKQTQEEHIKQMKNMW 328
 
Name Accession Description Interval E-value
7TM_GPCR_Sra pfam02117
Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis ...
 125-396 5.49e-10

Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 111054  Cd Length: 328  Bit Score: 60.05  E-value: 5.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   125 IILIL-MFTHSIDMIIFHVYHIFRSYKA--VESDPCSVRVKISFCAPFRYIYSFCTLGLAFCQYCVYIDRLLCALYKEYI 201
Cdd:pfam02117  57 ILLFQnLFYANLHQIFYGIEAIRMLYKSffMLSEPCNILITEIDCAPYLEVLVAGISGMIYGQTGLLIERACATFIKKYK 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   202 KYQK----VIQYLLVILWVIVTTGVVVWvyrDANLDAYLLSCLNVPLDSMLDLSYVTATVFPINIGCCFLSMVMFRHFKK 277
Cdd:pfam02117 137 KKKSalpgVIISILVLICSIATGKIIIW---DDPLDGYVLACFIFPSKSVPRSNTFLSICTVLSLFNLVISVLILYYNKK 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71987522   278 KENKSRFEIISHFTASVDVDSSEFLYIVTISQAVFIVVYPVLSLSMRYFYAE-TYRPVHLTIAtLVYVFDIYCFVVPLAM 356
Cdd:pfam02117 214 LEYSTRFKVGARFQKREVIDSTSTICFLTFSQFIFMFIYSFGVLTLRSIRENiSPEQYYLWVV-WLYTVPFIALSFPLLL 292

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 71987522   357 VnYGRNRTDTRRAKIwshVKIKSVGKEGADNYFGMMKSQW 396
Cdd:pfam02117 293 I-YRIRSTRSNRTRK---IKEITSTKQTQEEHIKQMKNMW 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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