NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17564934|ref|NP_504797|]
View 

Laminin EGF-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NPA super family cl24891
Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a ...
 309-429 2.57e-13

Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a lipid-binding protein comprising multiple tandem repeats of this domain.


The actual alignment was detected with superfamily member pfam16469:

Pssm-ID: 406784 [Multi-domain]  Cd Length: 116  Bit Score: 66.58  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   309 ADLMSWLRPAQRFRIAEMiQDREVNDSQVYEKLYEFFNQASGDAKDDADEVITLGCRKFIAHHLGDQVAEDIEDLRVAGG 388
Cdd:pfam16469   2 EKYLDWLTEEQKGEITAL-KAEGKDSDEILKKILEFYEQLPAEKKEEAREKLKGACKEYFAPLLGEEEAEEIKKLKDKGA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 17564934   389 tgsshhTAAMLLVKHNEIAEAGALAHQKRI-EESVSICKRIY 429
Cdd:pfam16469  81 ------DATLLKAKLDELIGELEDEKKKAKaEAVLKICKKVY 116
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 487-531 4.97e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.27  E-value: 4.97e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17564934 487 CFCNSH---SYEC--TDGICtDCENNTTGDHCELCDIGFYGDPTMGRGCT 531
Cdd:cd00055   2 CDCNGHgslSGQCdpGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
NPA super family cl24891
Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a ...
 188-301 5.10e-04

Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a lipid-binding protein comprising multiple tandem repeats of this domain.


The actual alignment was detected with superfamily member pfam16469:

Pssm-ID: 406784 [Multi-domain]  Cd Length: 116  Bit Score: 40.00  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   188 DMLSWQTPRHKNVLNKQKLTKGSQWDAMNTIGDQYYHLRKAVRVKYDGKFMKYCNESLLEIIGRDNFATLEEMVQDSEQV 267
Cdd:pfam16469   3 KYLDWLTEEQKGEITALKAEGKDSDEILKKILEFYEQLPAEKKEEAREKLKGACKEYFAPLLGEEEAEEIKKLKDKGADA 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17564934   268 EHIWNKYHQIIGYLKNEEDQLTAEHYGQFCRKIY 301
Cdd:pfam16469  83 TLLKAKLDELIGELEDEKKKAKAEAVLKICKKVY 116
VSP super family cl31427
Giardia variant-specific surface protein;
448-564 1.45e-03

Giardia variant-specific surface protein;


The actual alignment was detected with superfamily member pfam03302:

Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 41.11  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   448 KTHVCQNCTGGTLGIqCEKCPEDLRLDKTGKCVPGLD--PDCFCNSHSY------ECTDGICTDCENNTTgdhCELCDIG 519
Cdd:pfam03302  24 KTENCKACSNDKREV-CEECNSNNYLTPTSQCIDDCAkiGNYYYTTNANnkkickECTVANCKTCEDQGQ---CQACNDG 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17564934   520 FYGDptmGRGCTKC--PCPKngeCSYNTVTNRIEC---------NDCPKGHIGERC 564
Cdd:pfam03302 100 FYKS---GDACSPCheSCKT---CSGGTASDCTECltgkalrygNDGTKGTCGEGC 149
 
Name Accession Description Interval E-value
NPA pfam16469
Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a ...
 309-429 2.57e-13

Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a lipid-binding protein comprising multiple tandem repeats of this domain.


Pssm-ID: 406784 [Multi-domain]  Cd Length: 116  Bit Score: 66.58  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   309 ADLMSWLRPAQRFRIAEMiQDREVNDSQVYEKLYEFFNQASGDAKDDADEVITLGCRKFIAHHLGDQVAEDIEDLRVAGG 388
Cdd:pfam16469   2 EKYLDWLTEEQKGEITAL-KAEGKDSDEILKKILEFYEQLPAEKKEEAREKLKGACKEYFAPLLGEEEAEEIKKLKDKGA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 17564934   389 tgsshhTAAMLLVKHNEIAEAGALAHQKRI-EESVSICKRIY 429
Cdd:pfam16469  81 ------DATLLKAKLDELIGELEDEKKKAKaEAVLKICKKVY 116
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 487-531 4.97e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.27  E-value: 4.97e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17564934 487 CFCNSH---SYEC--TDGICtDCENNTTGDHCELCDIGFYGDPTMGRGCT 531
Cdd:cd00055   2 CDCNGHgslSGQCdpGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 489-530 3.58e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 3.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17564934   489 CNSHSYECtdgictDCENNTTGDHCELCDIGFYGDP-TMGRGC 530
Cdd:pfam00053  13 CDPETGQC------LCKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
487-530 1.36e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.60  E-value: 1.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17564934    487 CFCN---SHSYEC--TDGICtDCENNTTGDHCELCDIGFYGDPtmGRGC 530
Cdd:smart00180   1 CDCDpggSASGTCdpDTGQC-ECKPNVTGRRCDRCAPGYYGDG--PPGC 46
NPA pfam16469
Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a ...
 188-301 5.10e-04

Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a lipid-binding protein comprising multiple tandem repeats of this domain.


Pssm-ID: 406784 [Multi-domain]  Cd Length: 116  Bit Score: 40.00  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   188 DMLSWQTPRHKNVLNKQKLTKGSQWDAMNTIGDQYYHLRKAVRVKYDGKFMKYCNESLLEIIGRDNFATLEEMVQDSEQV 267
Cdd:pfam16469   3 KYLDWLTEEQKGEITALKAEGKDSDEILKKILEFYEQLPAEKKEEAREKLKGACKEYFAPLLGEEEAEEIKKLKDKGADA 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17564934   268 EHIWNKYHQIIGYLKNEEDQLTAEHYGQFCRKIY 301
Cdd:pfam16469  83 TLLKAKLDELIGELEDEKKKAKAEAVLKICKKVY 116
VSP pfam03302
Giardia variant-specific surface protein;
448-564 1.45e-03

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 41.11  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   448 KTHVCQNCTGGTLGIqCEKCPEDLRLDKTGKCVPGLD--PDCFCNSHSY------ECTDGICTDCENNTTgdhCELCDIG 519
Cdd:pfam03302  24 KTENCKACSNDKREV-CEECNSNNYLTPTSQCIDDCAkiGNYYYTTNANnkkickECTVANCKTCEDQGQ---CQACNDG 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17564934   520 FYGDptmGRGCTKC--PCPKngeCSYNTVTNRIEC---------NDCPKGHIGERC 564
Cdd:pfam03302 100 FYKS---GDACSPCheSCKT---CSGGTASDCTECltgkalrygNDGTKGTCGEGC 149
 
Name Accession Description Interval E-value
NPA pfam16469
Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a ...
 309-429 2.57e-13

Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a lipid-binding protein comprising multiple tandem repeats of this domain.


Pssm-ID: 406784 [Multi-domain]  Cd Length: 116  Bit Score: 66.58  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   309 ADLMSWLRPAQRFRIAEMiQDREVNDSQVYEKLYEFFNQASGDAKDDADEVITLGCRKFIAHHLGDQVAEDIEDLRVAGG 388
Cdd:pfam16469   2 EKYLDWLTEEQKGEITAL-KAEGKDSDEILKKILEFYEQLPAEKKEEAREKLKGACKEYFAPLLGEEEAEEIKKLKDKGA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 17564934   389 tgsshhTAAMLLVKHNEIAEAGALAHQKRI-EESVSICKRIY 429
Cdd:pfam16469  81 ------DATLLKAKLDELIGELEDEKKKAKaEAVLKICKKVY 116
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 487-531 4.97e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 49.27  E-value: 4.97e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17564934 487 CFCNSH---SYEC--TDGICtDCENNTTGDHCELCDIGFYGDPTMGRGCT 531
Cdd:cd00055   2 CDCNGHgslSGQCdpGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 489-530 3.58e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 3.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17564934   489 CNSHSYECtdgictDCENNTTGDHCELCDIGFYGDP-TMGRGC 530
Cdd:pfam00053  13 CDPETGQC------LCKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
487-530 1.36e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.60  E-value: 1.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17564934    487 CFCN---SHSYEC--TDGICtDCENNTTGDHCELCDIGFYGDPtmGRGC 530
Cdd:smart00180   1 CDCDpggSASGTCdpDTGQC-ECKPNVTGRRCDRCAPGYYGDG--PPGC 46
NPA pfam16469
Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a ...
 188-301 5.10e-04

Nematode polyprotein allergen ABA-1; The nematode polyprotein allergen ABA-1 is a lipid-binding protein comprising multiple tandem repeats of this domain.


Pssm-ID: 406784 [Multi-domain]  Cd Length: 116  Bit Score: 40.00  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   188 DMLSWQTPRHKNVLNKQKLTKGSQWDAMNTIGDQYYHLRKAVRVKYDGKFMKYCNESLLEIIGRDNFATLEEMVQDSEQV 267
Cdd:pfam16469   3 KYLDWLTEEQKGEITALKAEGKDSDEILKKILEFYEQLPAEKKEEAREKLKGACKEYFAPLLGEEEAEEIKKLKDKGADA 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17564934   268 EHIWNKYHQIIGYLKNEEDQLTAEHYGQFCRKIY 301
Cdd:pfam16469  83 TLLKAKLDELIGELEDEKKKAKAEAVLKICKKVY 116
VSP pfam03302
Giardia variant-specific surface protein;
448-564 1.45e-03

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 41.11  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564934   448 KTHVCQNCTGGTLGIqCEKCPEDLRLDKTGKCVPGLD--PDCFCNSHSY------ECTDGICTDCENNTTgdhCELCDIG 519
Cdd:pfam03302  24 KTENCKACSNDKREV-CEECNSNNYLTPTSQCIDDCAkiGNYYYTTNANnkkickECTVANCKTCEDQGQ---CQACNDG 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17564934   520 FYGDptmGRGCTKC--PCPKngeCSYNTVTNRIEC---------NDCPKGHIGERC 564
Cdd:pfam03302 100 FYKS---GDACSPCheSCKT---CSGGTASDCTECltgkalrygNDGTKGTCGEGC 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH