|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
44-830 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 1023.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 44 IFSFGILNMRTEDDLRFLYSPEHSLSREEYQVHKDFSGDSKNNSFVSITIQTSSEDkNLLKKDLAQKLIQLNKYVLEKME 123
Cdd:pfam02460 1 VLSSDIVYTRTPDDARSFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNS-NILDISYLNDIYQLNDYISTNVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 124 IQVDGkIINFGKEVCSRMKQCELSNTIATIFldtfWSEKLRKDPRIKIEYPTMKFFDNKFFLPTHFYGVQPGGPlGIESI 203
Cdd:pfam02460 80 IQVDG-IIISFKDLCSRYCDLNCPVNKHYNG----MLLSRRHNTRIDITYPIMPVLGTPIYLGPHFGGVDFEPP-GNISY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 204 DMVHFVYQIPAYNEHTSEEMSKIFEQSLTALLENQTTFD---TSMFSLSILKDEMQKNSTYTMPFISLTILLLLCFTVAS 280
Cdd:pfam02460 154 AKAIVLWYFLKFDEEEVEEDSKEWEDELSQLLHNKYASEhiqFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 281 CMTDN-----WVTSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTVMPFIALAIGVDDVYVMLGAWQDTRRTLDAK 355
Cdd:pfam02460 234 SVTLSsytidWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVK 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 356 KRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVW- 434
Cdd:pfam02460 314 KRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWa 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 435 ----KRCDREEIAKAKNENAISPTRYFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQLVVDDSPLV 510
Cdd:pfam02460 394 tsspQRIDSEGSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLV 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 511 PYLNLAEKKIWAEGLIGRIYVNNAPDFSkNPEMVDRMLQMVNELESTPYSMGPNSTNFWLNEFNNY---RQFFFQEDAK- 586
Cdd:pfam02460 474 EYLSLREKHFWPEGLQIQVAVNNPPNLT-IPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFlstLNMEEEEDEEk 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 587 --FYETLKSFLKVSFNSHWETDLVWDtpdkssKGGTKVEKFVFTTA-FKISNWNIRTSLLLTWRNITSSYPEFDALVFDE 663
Cdd:pfam02460 553 ewSYGNLPSFLKAPGNSHWAGDLVWD------DNTTMVTKFRFTLAgKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDE 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 664 NNFYSDQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWVVCTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQC 743
Cdd:pfam02460 627 DAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFS 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 744 IDFATHVGIRIYRSEYSDPDERIRDAMGAIGWPVVQAGTSTLLAIVVMLMVPSSAVRMFARTSVLVVGTGFFHGLIILPI 823
Cdd:pfam02460 707 VDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPI 786
|
....*..
gi 17562810 824 IVRSFAT 830
Cdd:pfam02460 787 ILSLFVT 793
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
8-824 |
7.18e-35 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 143.90 E-value: 7.18e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 8 PSGILQeylaHLFYQYGLFIYDRPRFFTLGPLILTIIFSFGILNMRTEDDLRFLYSPEHSLSREEYQ-VHKDFSGDSKNN 86
Cdd:TIGR00917 305 VQGHLA----RFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQyFDTHFGPFYRIE 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 87 SFVSITIQTSSEDK--NLLKKDLAQKLIQLNKyVLEKMEIQVDGKIINFGKEVCSRMK--QCELSNTIATIFLDTFWSEK 162
Cdd:TIGR00917 381 QLIIATVQTSSHEKapEILTDDNLKLLFDIQK-KVSQLFANYEGELITLDSPCFKPNHpyNCFIYSTCKKLQNMYSKLKP 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 163 LRKDPRIKIEYptMKFFDNKFFLPTHFYG-----VQP----GGPLGIESIDMVHFVYQIPAYNEHTSEEM-------SKI 226
Cdd:TIGR00917 460 ENYDDYGGVDY--VKYCFEHFTSPESCLSafggpVDPttvlGGFSGNNFSEASAFVVTFPVNNFVNKTNKtekavawEKA 537
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 227 FEQSLTALLENQTTFDTSMFSLSILKDEMQKNSTYTMPFIsLTILLLLCFTVASCMTDN------WVTSKPIEAMIGILV 300
Cdd:TIGR00917 538 FIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITI-AISYLVMFAYISLTLGDSprlkslYVTSKVLLGLSGILI 616
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 301 SSMAIVSAGGLLFALGVPFINQVT-VMPFIALAIGVDDVYVMLGAWQ-----------DTRRTLDAKKRMGLALEEAGSA 368
Cdd:TIGR00917 617 VMLSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLERRLSRALMEVGPS 696
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 369 ITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVwkrCDREEIAKAKNE 448
Cdd:TIGR00917 697 ITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFP---CIKTSKSSISAE 773
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 449 NAISPTR-----YFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQLVVDDSPLVPYL-NLAEKKIWA 522
Cdd:TIGR00917 774 KGSGQRKaglltRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFaSLTPLLEVG 853
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 523 EGLIGRIYVNNAPDFSKNPEMVDRML-----QMVNELESTPYSMGPNSTnfWLNEFNNY--------------------- 576
Cdd:TIGR00917 854 PPFYIVIKGDYNYTDFESQNKLCTMGgcdkdSIVNVFNNLSYIAKPASS--WLDDYLVWlspqascccrkftngtfcngp 931
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 577 -----RQFFFQEDAK-------FYETLKSFLKVSFNShwetdlvwdtpdKSSKGGTKV----------EKFVFTTAFKIS 634
Cdd:TIGR00917 932 dpqcfRCADLSSDAQgrpsttqFKEKLPWFLNALPSA------------DCAKGGHAAyssavdlqgyATIIQASSFRTY 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 635 NWNIRTSL-----LLTWRNITSSYPEFDAL-VFDENNFYS--DQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWV 706
Cdd:TIGR00917 1000 HTPLNTQVdfinaMRAAQEFAAKVSRSSKMeVYPYSVFYVffEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVN 1079
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 707 VCTLISMD-IGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRIYRSEYSDPDERIRDAMGAIGWPVVQAGTSTL 785
Cdd:TIGR00917 1080 LIMSVGMAvVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTK 1159
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 17562810 786 LAIVVMLMVPSSAVRM--FARTSVLVVGTGFFHGLIILPII 824
Cdd:TIGR00917 1160 LVGVVVLGFSRSEIFVvyYFRMYLALVLLGFLHGLVFLPVL 1200
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
18-828 |
3.51e-24 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 108.79 E-value: 3.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 18 HLFYQYGLFIYDRPRFFTLGPLILTIIFSFGILNMRTEDDLRFLYSPEHslsrEEYQVHKDFSGDSKNNSFVSITIQTss 97
Cdd:COG1033 2 RLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDD----PSVQAYDEFEEEFGGDDTVVVAVEG-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 98 eDKNLLKKDLAQKLIQLNkyvlEKMEiQVDGkiinfGKEVCSRMKQCELSNTIATIFLDTFWSEKLRKDP----RIKIEY 173
Cdd:COG1033 76 -KDDIFTPETLEALRELT----EELE-EIPG-----VDSVTSLTNVRATEGTEDGLTVEPLIPDELPASPeelaELREKV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 174 PTMKFFDNKFFLPTHfygvqpggplgiesiDMVHFVYQIPAYNEHTSEEMSKIFEQsLTALLEN--QTTFDTSMFSLSIL 251
Cdd:COG1033 145 LSSPLYVGRLVSPDG---------------KATLIVVTLDPDPLSSDLDRKEVVAE-IRAIIAKyeDPGVEVYLTGFPVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 252 KDEMQKNSTYTMPFISLTILLLLCFTVAscmtdnWVTSKPIEAMIGILVSSMAIVSAGGLLFALGVPfINQVTVM-PFIA 330
Cdd:COG1033 209 RGDIAEAIQSDLAIFFPLALLLILLLLF------LFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIP-LSPLTILvPPLL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 331 LAIGVDD-VYVMLGAWQDTRRTLDAKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQ 409
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 410 LTFFAAVMAMGAKReaagyhcvfvwkrcdreeIAKAKNENAISPTRYFFENIFAPFICRPSVrfcMLNLYVVYIAIAFYG 489
Cdd:COG1033 362 LTLLPALLSLLPRP------------------KPKTRRLKKPPELGRLLAKLARFVLRRPKV---ILVVALVLAVVSLYG 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 490 CSQLTPNLTPSQLVVDDSPLVPYLNLAEKKIwaeGLIGRIYV---NNAPDFSKNPEMVDRMLQMVNELESTPYSMGPNST 566
Cdd:COG1033 421 ISRLKVEYDFEDYLPEDSPIRQDLDFIEENF---GGSDPLEVvvdTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKVLSL 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 567 NFWLNEFNnyrQFFFQEDAKFY------ETLKSFLKVSFNSHWETDLVWDTPDKSSkggTKVEkfVFTTAFKISNWNIRT 640
Cdd:COG1033 498 ADLVKELN---QALNEGDPKYYalpesrELLAQLLLLLSSPPGDDLSRFVDEDYSA---ARVT--VRLKDLDSEEIKALV 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 641 SLLLTWRNITSSYPEFDALVFDENNFYSDQMLELQSTILSSLGTAIILLSAICImfiaesyIVFW----VVCTLISMDIG 716
Cdd:COG1033 570 EEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLL-------LAFRslrlGLISLIPNLLP 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 717 TAGLLSLWGA---DLDPMTVVNILMSIGQCIDFATHVGIRiYRSEYS---DPDERIRDAMGAIGWPVVQAGTSTLLAIVV 790
Cdd:COG1033 643 ILLTFGLMGLlgiPLNIATAVVASIALGIGVDYTIHFLSR-YREERRkggDLEEAIRRALRTTGKAILFTSLTLAAGFGV 721
|
810 820 830
....*....|....*....|....*....|....*...
gi 17562810 791 MLMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSF 828
Cdd:COG1033 722 LLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
44-830 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 1023.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 44 IFSFGILNMRTEDDLRFLYSPEHSLSREEYQVHKDFSGDSKNNSFVSITIQTSSEDkNLLKKDLAQKLIQLNKYVLEKME 123
Cdd:pfam02460 1 VLSSDIVYTRTPDDARSFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNS-NILDISYLNDIYQLNDYISTNVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 124 IQVDGkIINFGKEVCSRMKQCELSNTIATIFldtfWSEKLRKDPRIKIEYPTMKFFDNKFFLPTHFYGVQPGGPlGIESI 203
Cdd:pfam02460 80 IQVDG-IIISFKDLCSRYCDLNCPVNKHYNG----MLLSRRHNTRIDITYPIMPVLGTPIYLGPHFGGVDFEPP-GNISY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 204 DMVHFVYQIPAYNEHTSEEMSKIFEQSLTALLENQTTFD---TSMFSLSILKDEMQKNSTYTMPFISLTILLLLCFTVAS 280
Cdd:pfam02460 154 AKAIVLWYFLKFDEEEVEEDSKEWEDELSQLLHNKYASEhiqFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 281 CMTDN-----WVTSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTVMPFIALAIGVDDVYVMLGAWQDTRRTLDAK 355
Cdd:pfam02460 234 SVTLSsytidWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVK 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 356 KRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVW- 434
Cdd:pfam02460 314 KRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVWa 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 435 ----KRCDREEIAKAKNENAISPTRYFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQLVVDDSPLV 510
Cdd:pfam02460 394 tsspQRIDSEGSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLV 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 511 PYLNLAEKKIWAEGLIGRIYVNNAPDFSkNPEMVDRMLQMVNELESTPYSMGPNSTNFWLNEFNNY---RQFFFQEDAK- 586
Cdd:pfam02460 474 EYLSLREKHFWPEGLQIQVAVNNPPNLT-IPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFlstLNMEEEEDEEk 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 587 --FYETLKSFLKVSFNSHWETDLVWDtpdkssKGGTKVEKFVFTTA-FKISNWNIRTSLLLTWRNITSSYPEFDALVFDE 663
Cdd:pfam02460 553 ewSYGNLPSFLKAPGNSHWAGDLVWD------DNTTMVTKFRFTLAgKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDE 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 664 NNFYSDQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWVVCTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQC 743
Cdd:pfam02460 627 DAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFS 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 744 IDFATHVGIRIYRSEYSDPDERIRDAMGAIGWPVVQAGTSTLLAIVVMLMVPSSAVRMFARTSVLVVGTGFFHGLIILPI 823
Cdd:pfam02460 707 VDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPI 786
|
....*..
gi 17562810 824 IVRSFAT 830
Cdd:pfam02460 787 ILSLFVT 793
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
286-437 |
8.98e-38 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 138.10 E-value: 8.98e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 286 WVTSKPIEAMIGILVSSMAIVSAGGLLFALGVPF-INQVTVMPFIALAIGVDDVYVMLGAWQDTRRTLDAKKRMGLALEE 364
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLtLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17562810 365 AGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVWKRC 437
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
8-824 |
7.18e-35 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 143.90 E-value: 7.18e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 8 PSGILQeylaHLFYQYGLFIYDRPRFFTLGPLILTIIFSFGILNMRTEDDLRFLYSPEHSLSREEYQ-VHKDFSGDSKNN 86
Cdd:TIGR00917 305 VQGHLA----RFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQyFDTHFGPFYRIE 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 87 SFVSITIQTSSEDK--NLLKKDLAQKLIQLNKyVLEKMEIQVDGKIINFGKEVCSRMK--QCELSNTIATIFLDTFWSEK 162
Cdd:TIGR00917 381 QLIIATVQTSSHEKapEILTDDNLKLLFDIQK-KVSQLFANYEGELITLDSPCFKPNHpyNCFIYSTCKKLQNMYSKLKP 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 163 LRKDPRIKIEYptMKFFDNKFFLPTHFYG-----VQP----GGPLGIESIDMVHFVYQIPAYNEHTSEEM-------SKI 226
Cdd:TIGR00917 460 ENYDDYGGVDY--VKYCFEHFTSPESCLSafggpVDPttvlGGFSGNNFSEASAFVVTFPVNNFVNKTNKtekavawEKA 537
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 227 FEQSLTALLENQTTFDTSMFSLSILKDEMQKNSTYTMPFIsLTILLLLCFTVASCMTDN------WVTSKPIEAMIGILV 300
Cdd:TIGR00917 538 FIQLAKDELLPMVQATISFSAERSIEDELKRESTADVITI-AISYLVMFAYISLTLGDSprlkslYVTSKVLLGLSGILI 616
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 301 SSMAIVSAGGLLFALGVPFINQVT-VMPFIALAIGVDDVYVMLGAWQ-----------DTRRTLDAKKRMGLALEEAGSA 368
Cdd:TIGR00917 617 VMLSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLERRLSRALMEVGPS 696
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 369 ITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVwkrCDREEIAKAKNE 448
Cdd:TIGR00917 697 ITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFP---CIKTSKSSISAE 773
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 449 NAISPTR-----YFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQLVVDDSPLVPYL-NLAEKKIWA 522
Cdd:TIGR00917 774 KGSGQRKaglltRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFaSLTPLLEVG 853
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 523 EGLIGRIYVNNAPDFSKNPEMVDRML-----QMVNELESTPYSMGPNSTnfWLNEFNNY--------------------- 576
Cdd:TIGR00917 854 PPFYIVIKGDYNYTDFESQNKLCTMGgcdkdSIVNVFNNLSYIAKPASS--WLDDYLVWlspqascccrkftngtfcngp 931
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 577 -----RQFFFQEDAK-------FYETLKSFLKVSFNShwetdlvwdtpdKSSKGGTKV----------EKFVFTTAFKIS 634
Cdd:TIGR00917 932 dpqcfRCADLSSDAQgrpsttqFKEKLPWFLNALPSA------------DCAKGGHAAyssavdlqgyATIIQASSFRTY 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 635 NWNIRTSL-----LLTWRNITSSYPEFDAL-VFDENNFYS--DQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWV 706
Cdd:TIGR00917 1000 HTPLNTQVdfinaMRAAQEFAAKVSRSSKMeVYPYSVFYVffEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVN 1079
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 707 VCTLISMD-IGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRIYRSEYSDPDERIRDAMGAIGWPVVQAGTSTL 785
Cdd:TIGR00917 1080 LIMSVGMAvVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTK 1159
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 17562810 786 LAIVVMLMVPSSAVRM--FARTSVLVVGTGFFHGLIILPII 824
Cdd:TIGR00917 1160 LVGVVVLGFSRSEIFVvyYFRMYLALVLLGFLHGLVFLPVL 1200
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
18-828 |
3.51e-24 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 108.79 E-value: 3.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 18 HLFYQYGLFIYDRPRFFTLGPLILTIIFSFGILNMRTEDDLRFLYSPEHslsrEEYQVHKDFSGDSKNNSFVSITIQTss 97
Cdd:COG1033 2 RLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDD----PSVQAYDEFEEEFGGDDTVVVAVEG-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 98 eDKNLLKKDLAQKLIQLNkyvlEKMEiQVDGkiinfGKEVCSRMKQCELSNTIATIFLDTFWSEKLRKDP----RIKIEY 173
Cdd:COG1033 76 -KDDIFTPETLEALRELT----EELE-EIPG-----VDSVTSLTNVRATEGTEDGLTVEPLIPDELPASPeelaELREKV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 174 PTMKFFDNKFFLPTHfygvqpggplgiesiDMVHFVYQIPAYNEHTSEEMSKIFEQsLTALLEN--QTTFDTSMFSLSIL 251
Cdd:COG1033 145 LSSPLYVGRLVSPDG---------------KATLIVVTLDPDPLSSDLDRKEVVAE-IRAIIAKyeDPGVEVYLTGFPVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 252 KDEMQKNSTYTMPFISLTILLLLCFTVAscmtdnWVTSKPIEAMIGILVSSMAIVSAGGLLFALGVPfINQVTVM-PFIA 330
Cdd:COG1033 209 RGDIAEAIQSDLAIFFPLALLLILLLLF------LFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIP-LSPLTILvPPLL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 331 LAIGVDD-VYVMLGAWQDTRRTLDAKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQ 409
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 410 LTFFAAVMAMGAKReaagyhcvfvwkrcdreeIAKAKNENAISPTRYFFENIFAPFICRPSVrfcMLNLYVVYIAIAFYG 489
Cdd:COG1033 362 LTLLPALLSLLPRP------------------KPKTRRLKKPPELGRLLAKLARFVLRRPKV---ILVVALVLAVVSLYG 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 490 CSQLTPNLTPSQLVVDDSPLVPYLNLAEKKIwaeGLIGRIYV---NNAPDFSKNPEMVDRMLQMVNELESTPYSMGPNST 566
Cdd:COG1033 421 ISRLKVEYDFEDYLPEDSPIRQDLDFIEENF---GGSDPLEVvvdTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKVLSL 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 567 NFWLNEFNnyrQFFFQEDAKFY------ETLKSFLKVSFNSHWETDLVWDTPDKSSkggTKVEkfVFTTAFKISNWNIRT 640
Cdd:COG1033 498 ADLVKELN---QALNEGDPKYYalpesrELLAQLLLLLSSPPGDDLSRFVDEDYSA---ARVT--VRLKDLDSEEIKALV 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 641 SLLLTWRNITSSYPEFDALVFDENNFYSDQMLELQSTILSSLGTAIILLSAICImfiaesyIVFW----VVCTLISMDIG 716
Cdd:COG1033 570 EEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLL-------LAFRslrlGLISLIPNLLP 642
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 717 TAGLLSLWGA---DLDPMTVVNILMSIGQCIDFATHVGIRiYRSEYS---DPDERIRDAMGAIGWPVVQAGTSTLLAIVV 790
Cdd:COG1033 643 ILLTFGLMGLlgiPLNIATAVVASIALGIGVDYTIHFLSR-YREERRkggDLEEAIRRALRTTGKAILFTSLTLAAGFGV 721
|
810 820 830
....*....|....*....|....*....|....*...
gi 17562810 791 MLMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSF 828
Cdd:COG1033 722 LLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
227-432 |
6.47e-18 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 89.17 E-value: 6.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 227 FEQSLTALLENQTTFDTSMFSLSILKDEMQKNSTYTMPFISLTILLLLCFtvASCMTDNW--VTSKPIEAMIGILVSSMA 304
Cdd:TIGR00918 363 FSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAY--ACLTMLRWdcAKSQGSVGLAGVLLVALS 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 305 IVSAGGLLFALGVPFINQVT-VMPFIALAIGVDDVYVMLGAWQDTRRTLDAKKRMGLALEEAGSAITVTSLTSVLSFGIG 383
Cdd:TIGR00918 441 VAAGLGLCALLGISFNAATTqVLPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMA 520
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 17562810 384 TYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVF 432
Cdd:TIGR00918 521 ALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIF 569
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
16-425 |
2.63e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 67.19 E-value: 2.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 16 LAHLFYQYGLFIYDRPRFFTLGPLILTIIFSFGILNMRTEDDLRFLYSPEHSLSREEYQVHKDFSGDSknnsFVSITIQT 95
Cdd:COG1033 388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSD----PLEVVVDT 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 96 SsEDKNLLKKDLAQKLIQLNKYVLEKMEIQVdgkiinfgkevcsrmkqcelSNTIATI--FLDTFWSEKLRKDPRIkiey 173
Cdd:COG1033 464 G-EPDGLKDPEVLKEIDRLQDYLESLPEVGK--------------------VLSLADLvkELNQALNEGDPKYYAL---- 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 174 PtmkffDNKFFLPTHFYGVQPGGPLGIESI-----DMVHFVYQIPaynEHTSEEMSKIFEQSLTALLENQTT--FDTSMF 246
Cdd:COG1033 519 P-----ESRELLAQLLLLLSSPPGDDLSRFvdedySAARVTVRLK---DLDSEEIKALVEEVRAFLAENFPPdgVEVTLT 590
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 247 SLSILKDEMQKNSTYTMPFISLT----ILLLLCFTVAScmtdnwvtskPIEAMIGILVSSMAIVSAGGLLFALGVPF-IN 321
Cdd:COG1033 591 GSAVLFAAINESVIESQIRSLLLalllIFLLLLLAFRS----------LRLGLISLIPNLLPILLTFGLMGLLGIPLnIA 660
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 322 QVTVMPfIALAIGVDD-VYVMLGAWQDTRRTLDAKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIAL 400
Cdd:COG1033 661 TAVVAS-IALGIGVDYtIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLAL 739
|
410 420
....*....|....*....|....*
gi 17562810 401 AIMFDWFYQLTFFAAVMAMGAKREA 425
Cdd:COG1033 740 GLLVALLAALLLLPALLLLLDPRIA 764
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
248-417 |
4.50e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 60.24 E-value: 4.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 248 LSILKDEM--QKNSTYTMPFISLTILLLLCFTVascmtdnwVTSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTV 325
Cdd:TIGR00921 554 LPVAFAEMheLVNEGMRRMTIAGAILVLMILLA--------VFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMAT 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 326 MPFIALAIGVDDVYVMLGAWQDTRRTLDAKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFD 405
Cdd:TIGR00921 626 TISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSS 705
|
170
....*....|..
gi 17562810 406 WFYQLTFFAAVM 417
Cdd:TIGR00921 706 LTAALVVFPALL 717
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
254-825 |
7.67e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 49.45 E-value: 7.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 254 EMQKNSTYTMPFISLTILLLLCFTVascmtdnwvtSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTVMPFIALAI 333
Cdd:TIGR00921 190 EFGKDMGTTMAISGILVVLVLLLDF----------KRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 334 GVDDVYVMLGAWQDTRrtlDAKKRMGLALEEA----GSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQ 409
Cdd:TIGR00921 260 GIDYGIQTLNRYEEER---DIGRAKGEAIVTAvrrtGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLT 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 410 LTFFAAVMAMgakreaagyhcVFVWKRCDREEIAKAKNEnaiSPTRYFFENIFAPFICRPSVRFCMLNLYVVyiAIAFYG 489
Cdd:TIGR00921 337 LLVLPALLQS-----------IDIGREKVKKEIIAIGGK---SSEIEEELSKVLSITVRHPVPALVAALIIT--GLGLYG 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 490 CSQLTPNLTPSQLVVDDSPLVPYLNLAEKKIWAEGLIGRIYVNnaPDFSKNPEMVDRMLQMVNELESTPYSMGPNSTNFW 569
Cdd:TIGR00921 401 AAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGSHDFATILVK--ADDVRDPELVRFMDELSRDIKATGVAARVFGAPSI 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 570 LNEFNNYRQFFFQE----DAKFYETLKSFL-----KVSFNShwetdlVWDTPDKSSKGGTKVEKFV----FTTAFKISnw 636
Cdd:TIGR00921 479 IDLVKEVEGLPAPErsalEPIPEDEEGGYIsggqiKVAVIQ------VQLKQGEPKVQGRKILRDVqhehPPPGVKVG-- 550
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 637 nirtsllltwrnITSsypefDALVFDENNfysDQMLELQSTIlSSLGTAIILLsaicIMFIAESYIVFWVVcTLISMDIG 716
Cdd:TIGR00921 551 ------------VTG-----LPVAFAEMH---ELVNEGMRRM-TIAGAILVLM----ILLAVFRNPIKAVF-PLIAIGSG 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 717 ---TAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRiYRSEYSD--PDERIRDAMGAIGWPVVQAGTSTLLAIVVM 791
Cdd:TIGR00921 605 ilwAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAER-YFEERKEhgPKEAITHTMERTGPGILFSGLTTAGGFLSL 683
|
570 580 590
....*....|....*....|....*....|....
gi 17562810 792 LMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIV 825
Cdd:TIGR00921 684 LLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
673-828 |
2.09e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 673 ELQSTILSSLGTAIILLSAICIMFIAESYIVFWVVCTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGI 752
Cdd:TIGR00921 190 EFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLN 269
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17562810 753 RIY--RSEYSDPDERIRDAMGAIGWPVVQAGTSTLLAIVVMLMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSF 828
Cdd:TIGR00921 270 RYEeeRDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSI 347
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
659-802 |
8.88e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 43.17 E-value: 8.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 659 LVFDENNFYSDQMLELQSTILsslgTAIILLSAICIMFIAESYIVFWVVCTL-ISMdIGTAGLLSLWGADLDPMTVVNIL 737
Cdd:COG0841 318 IVYDQSEFIRASIEEVVKTLL----EAILLVVLVVFLFLRSWRATLIPAVAIpVSL-IGTFAVMYLLGFSLNILTLFALV 392
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17562810 738 MSIGQCIDFATHVGIRIYR--SEYSDPDERIRDAMGAIGWPVVqAGTSTLLAIVV-MLMVPSSAVRMF 802
Cdd:COG0841 393 LAIGIVVDDAIVVVENIERhmEEGLSPLEAAIKGAREVAGAVI-ASTLTLVAVFLpLAFMGGITGQLF 459
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
249-436 |
1.20e-03 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 41.89 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 249 SILKDeMQKNSTYTMPFISLTILLLLcFTVASCMTDNWVTSKPIEAMIGI-LVSSMAIVSagGLLFALGVPFINQVTVMP 327
Cdd:pfam03176 131 ATVAD-LRDAGDRDLGLIEAVTLVVI-FIILLIVYRSVVAALLPLLTVGLsLGAAQGLVA--ILAHILGIGLSTFALNLL 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 328 F-IALAIGVDdvYVML--GAWQDTRRT-LDAKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIM 403
Cdd:pfam03176 207 VvLLIAVGTD--YALFlvSRYREELRAgEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVL 284
|
170 180 190
....*....|....*....|....*....|....*.
gi 17562810 404 FDWFYQLTFFAAVMAMGAKR---EAAGYHCVFVWKR 436
Cdd:pfam03176 285 VDVLAALTLLPALLALLGRWglwPPKRDRTARWWRR 320
|
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| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
676-838 |
3.57e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 41.14 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 676 STILSSLGTAIILLSAIcimfiaESY-IVFWVVCTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRi 754
Cdd:TIGR03480 274 AGLLSFVLVLVLLWLAL------RSPrLVFAVLVTLIVGLILTAAFATLAVGHLNLISVAFAVLFIGLGVDFAIQFSLR- 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562810 755 YRSE-YSDPDER--IRDAMGAIGWPVVQAGTSTllAIVVMLMVPSSavrmFARTSVL--VVGTG----FFHGLIILPIIV 825
Cdd:TIGR03480 347 YREErFRGGNHReaLSVAARRMGAALLLAALAT--AAGFFAFLPTD----YKGVSELgiIAGTGmfiaLFVTLTVLPALL 420
|
170
....*....|...
gi 17562810 826 RSFATNAKALAPS 838
Cdd:TIGR03480 421 RLLRPPRRRKPPG 433
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
359-419 |
5.68e-03 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 40.22 E-value: 5.68e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17562810 359 GLALeeAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAM 419
Cdd:TIGR00920 160 GMAI--LGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTFFPACLSL 218
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