Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]
MFSD8-like MFS transporter( domain architecture ID 13023588)
MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients
List of domain hits
Name | Accession | Description | Interval | E-value | |||||||
MFS_MFSD8 | cd17326 | Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
21-458 | 2.41e-105 | |||||||
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. : Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 318.38 E-value: 2.41e-105
|
|||||||||||
Name | Accession | Description | Interval | E-value | |||||||
MFS_MFSD8 | cd17326 | Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
21-458 | 2.41e-105 | |||||||
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 318.38 E-value: 2.41e-105
|
|||||||||||
MFS_1 | pfam07690 | Major Facilitator Superfamily; |
25-420 | 3.96e-13 | |||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.52 E-value: 3.96e-13
|
|||||||||||
AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-415 | 4.14e-12 | |||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 67.31 E-value: 4.14e-12
|
|||||||||||
Name | Accession | Description | Interval | E-value | |||||||
MFS_MFSD8 | cd17326 | Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
21-458 | 2.41e-105 | |||||||
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 318.38 E-value: 2.41e-105
|
|||||||||||
MFS_1 | pfam07690 | Major Facilitator Superfamily; |
25-420 | 3.96e-13 | |||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.52 E-value: 3.96e-13
|
|||||||||||
MFS_MdtG_SLC18_like | cd17325 | bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
58-454 | 3.20e-12 | |||||||
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 3.20e-12
|
|||||||||||
AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-415 | 4.14e-12 | |||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 67.31 E-value: 4.14e-12
|
|||||||||||
MFS_SLC46_TetA_like | cd17330 | Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
57-452 | 2.90e-11 | |||||||
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 64.52 E-value: 2.90e-11
|
|||||||||||
MFS_MMR_MDR_like | cd17504 | Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-213 | 1.32e-05 | |||||||
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 47.19 E-value: 1.32e-05
|
|||||||||||
NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
58-456 | 5.57e-05 | |||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 5.57e-05
|
|||||||||||
ProP | COG0477 | MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-175 | 8.46e-05 | |||||||
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.42 E-value: 8.46e-05
|
|||||||||||
MelB | COG2211 | Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
99-455 | 3.61e-04 | |||||||
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 3.61e-04
|
|||||||||||
MFS_MMR_MDR_like | cd17321 | Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
59-210 | 7.32e-04 | |||||||
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 7.32e-04
|
|||||||||||
MFS_YfmO_like | cd17474 | Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-211 | 9.02e-04 | |||||||
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 9.02e-04
|
|||||||||||
MFS_Azr1_MDR_like | cd17502 | Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-172 | 9.68e-04 | |||||||
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 9.68e-04
|
|||||||||||
MFS_NepI_like | cd17324 | Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-206 | 1.14e-03 | |||||||
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.14e-03
|
|||||||||||
FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
13-207 | 1.17e-03 | |||||||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.17e-03
|
|||||||||||
UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
365-457 | 1.79e-03 | |||||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.62 E-value: 1.79e-03
|
|||||||||||
MFS_1 | pfam07690 | Major Facilitator Superfamily; |
367-453 | 2.39e-03 | |||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.39e-03
|
|||||||||||
MFS_TRI12_like | cd06179 | Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
17-173 | 4.08e-03 | |||||||
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 4.08e-03
|
|||||||||||
MFS_MdtH_MDR_like | cd17329 | Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
59-454 | 4.64e-03 | |||||||
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.64e-03
|
|||||||||||
AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
367-459 | 6.44e-03 | |||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.80 E-value: 6.44e-03
|
|||||||||||
Blast search parameters | ||||
|