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Conserved domains on  [gi|392919222|ref|NP_504617|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
21-458 2.41e-105

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 318.38  E-value: 2.41e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  21 MWIAIVMQFVVGVQISVYYMSMWPYLSGLDKTADFDFLGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGFLIAAVG 100
Cdd:cd17326    1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 101 QLWYALLGFFG-NVKWFMLCARFLTGLGVGNIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLGEEG 179
Cdd:cd17326   81 NILYALAEYFPsNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 180 IQFGG-FILNMYTIVSYLMVLICLSACLVVYLFFKEsyagivtkeekekdevevpmfdipasLICIYLFMIVNMTATNIE 258
Cdd:cd17326  161 YVIGIkLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------VVCIFLFFVVLFIFANLE 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 259 VMSSPLTTVLYDWKDSDSIFYNGIALAISSAISVAFNIAQGSTRIGRIDKRKQMLFGLTFFLLYQLFMYPWGfysgplnf 338
Cdd:cd17326  215 TIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWG-------- 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 339 lpkgvetkvaggcyseylwcndttrvplfiylFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVI 418
Cdd:cd17326  287 --------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTL 334
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 392919222 419 ASISSTAIFKYSGYRYVIVLQASTLLVAIVLILIFYKRLV 458
Cdd:cd17326  335 GPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
21-458 2.41e-105

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 318.38  E-value: 2.41e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  21 MWIAIVMQFVVGVQISVYYMSMWPYLSGLDKTADFDFLGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGFLIAAVG 100
Cdd:cd17326    1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 101 QLWYALLGFFG-NVKWFMLCARFLTGLGVGNIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLGEEG 179
Cdd:cd17326   81 NILYALAEYFPsNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 180 IQFGG-FILNMYTIVSYLMVLICLSACLVVYLFFKEsyagivtkeekekdevevpmfdipasLICIYLFMIVNMTATNIE 258
Cdd:cd17326  161 YVIGIkLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------VVCIFLFFVVLFIFANLE 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 259 VMSSPLTTVLYDWKDSDSIFYNGIALAISSAISVAFNIAQGSTRIGRIDKRKQMLFGLTFFLLYQLFMYPWGfysgplnf 338
Cdd:cd17326  215 TIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWG-------- 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 339 lpkgvetkvaggcyseylwcndttrvplfiylFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVI 418
Cdd:cd17326  287 --------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTL 334
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 392919222 419 ASISSTAIFKYSGYRYVIVLQASTLLVAIVLILIFYKRLV 458
Cdd:cd17326  335 GPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_1 pfam07690
Major Facilitator Superfamily;
25-420 3.96e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.52  E-value: 3.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222   25 IVMQFVVGVQISVYYMSMWPYLSGlDKTADFDFLGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGqlwy 104
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALG---- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  105 ALLGFFGNVKWFMLCARFLTGLGVGNI-AALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLGEegiqfg 183
Cdd:pfam07690  76 LLLLLFASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------ 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  184 gfilnmYTIVSYLMVLICLSACLVVYLFFKESYAGIVTKEEKEKDEVEVPMFDIPASLICIYLFMIV-NMTATNIEVMSS 262
Cdd:pfam07690 150 ------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLlFGFAFFGLLTYL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  263 PLTTVLYDWkdsdSIFYNGIALAISSAISVAFNIAQGSTrIGRIDKRKQMLFGLTFFLLYQLFMYPWGFYSGPLnflpkg 342
Cdd:pfam07690 224 PLYQEVLGL----SALLAGLLLGLGGLLGAIGRLLLGRL-SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL------ 292
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392919222  343 vetkvaggcyseylwcndttrvplfiYLFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIAS 420
Cdd:pfam07690 293 --------------------------WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-415 4.14e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 4.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  12 AEKRTDWRSMWIAIVMQFVVGVQISVYYMSMWPYLSGLDktADFDFLGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVI 91
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG--ASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  92 TGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVG-NIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVIss 170
Cdd:COG2814   80 LGLLLFALGSLLCALAPSL----WLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 171 iftplgeegiqfGGFILNMY--TIVSYLMVLICLSACLVVYLFFKESYAgivtKEEKEKDEVEVPMFDIPASLICIYLFM 248
Cdd:COG2814  154 ------------GGLLADLFgwRWVFLVNAVLALLALLLLLRLLPESRP----AARARLRGSLRELLRRPRLLLLLLLAF 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 249 IVNMTATNIEVMSSPLTTVLYDWKDSDSifynGIALAISSAISVAFNIAQGStRIGRIDKRKQMLFGLTFFLLYQLFMyp 328
Cdd:COG2814  218 LLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGR-LADRFGRRRLLLIGLLLLALGLLLL-- 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 329 wgfysgplnflpkgvetkvaggcyseylwcndtTRVPLFIYLFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFF 408
Cdd:COG2814  291 ---------------------------------ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLY 337

                 ....*..
gi 392919222 409 SFGGSLA 415
Cdd:COG2814  338 NSAFFLG 344
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
21-458 2.41e-105

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 318.38  E-value: 2.41e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  21 MWIAIVMQFVVGVQISVYYMSMWPYLSGLDKTADFDFLGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGFLIAAVG 100
Cdd:cd17326    1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 101 QLWYALLGFFG-NVKWFMLCARFLTGLGVGNIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLGEEG 179
Cdd:cd17326   81 NILYALAEYFPsNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 180 IQFGG-FILNMYTIVSYLMVLICLSACLVVYLFFKEsyagivtkeekekdevevpmfdipasLICIYLFMIVNMTATNIE 258
Cdd:cd17326  161 YVIGIkLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------------VVCIFLFFVVLFIFANLE 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 259 VMSSPLTTVLYDWKDSDSIFYNGIALAISSAISVAFNIAQGSTRIGRIDKRKQMLFGLTFFLLYQLFMYPWGfysgplnf 338
Cdd:cd17326  215 TIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWG-------- 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 339 lpkgvetkvaggcyseylwcndttrvplfiylFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVI 418
Cdd:cd17326  287 --------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTL 334
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 392919222 419 ASISSTAIFKYSGYRYVIVLQASTLLVAIVLILIFYKRLV 458
Cdd:cd17326  335 GPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_1 pfam07690
Major Facilitator Superfamily;
25-420 3.96e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.52  E-value: 3.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222   25 IVMQFVVGVQISVYYMSMWPYLSGlDKTADFDFLGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGqlwy 104
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALG---- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  105 ALLGFFGNVKWFMLCARFLTGLGVGNI-AALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLGEegiqfg 183
Cdd:pfam07690  76 LLLLLFASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------ 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  184 gfilnmYTIVSYLMVLICLSACLVVYLFFKESYAGIVTKEEKEKDEVEVPMFDIPASLICIYLFMIV-NMTATNIEVMSS 262
Cdd:pfam07690 150 ------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLlFGFAFFGLLTYL 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  263 PLTTVLYDWkdsdSIFYNGIALAISSAISVAFNIAQGSTrIGRIDKRKQMLFGLTFFLLYQLFMYPWGFYSGPLnflpkg 342
Cdd:pfam07690 224 PLYQEVLGL----SALLAGLLLGLGGLLGAIGRLLLGRL-SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL------ 292
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392919222  343 vetkvaggcyseylwcndttrvplfiYLFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIAS 420
Cdd:pfam07690 293 --------------------------WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
58-454 3.20e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 67.99  E-value: 3.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  58 LGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVG-NIAALRV 136
Cdd:cd17325   33 IGLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFAFATSY----WQLLLARFLQGLASAaVWPAAMA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 137 YAAMASTPKDRMRAISFGTGGFVLGFSFGPVIssiftplgeegiqfGGFILNMYTIVS-YLMVLICLSACLVVYLFFKES 215
Cdd:cd17325  108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLL--------------GGLLADALGYRApFLVCAALALLALVLALLLLPE 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 216 YAGIVTKEEKEKDEVEVPMFDI---PASLICIYLFMIVNMTATNIEVMSSPLTTVLYDWkdsdSIFYNGIALAISSAISV 292
Cdd:cd17325  174 PRPPPNKRAVSAARLRSGLRLLlrdRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL----SPAQIGLLFGAQGLASA 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 293 AFNIAQG--STRIGRidkRKQMLFGLTFFLlyqLFMYPWGFysgplnflpkgvetkvaggcyseylwcndttrVPLFIYL 370
Cdd:cd17325  250 LSQPPAGklSDRIGR---KPLILIGLLLSA---VALLLLPL--------------------------------ATSFWLL 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 371 FCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSGYRYVIVLQASTLLVAIVLI 450
Cdd:cd17325  292 LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371

                 ....
gi 392919222 451 LIFY 454
Cdd:cd17325  372 LLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
12-415 4.14e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 4.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  12 AEKRTDWRSMWIAIVMQFVVGVQISVYYMSMWPYLSGLDktADFDFLGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVI 91
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG--ASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  92 TGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVG-NIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVIss 170
Cdd:COG2814   80 LGLLLFALGSLLCALAPSL----WLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 171 iftplgeegiqfGGFILNMY--TIVSYLMVLICLSACLVVYLFFKESYAgivtKEEKEKDEVEVPMFDIPASLICIYLFM 248
Cdd:COG2814  154 ------------GGLLADLFgwRWVFLVNAVLALLALLLLLRLLPESRP----AARARLRGSLRELLRRPRLLLLLLLAF 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 249 IVNMTATNIEVMSSPLTTVLYDWKDSDSifynGIALAISSAISVAFNIAQGStRIGRIDKRKQMLFGLTFFLLYQLFMyp 328
Cdd:COG2814  218 LLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGR-LADRFGRRRLLLIGLLLLALGLLLL-- 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 329 wgfysgplnflpkgvetkvaggcyseylwcndtTRVPLFIYLFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFF 408
Cdd:COG2814  291 ---------------------------------ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLY 337

                 ....*..
gi 392919222 409 SFGGSLA 415
Cdd:COG2814  338 NSAFFLG 344
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
57-452 2.90e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 64.52  E-value: 2.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  57 FLGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVGNIAALRV 136
Cdd:cd17330   35 YVGLLQSSYSLGQFLASPLWGRLSDR-YGRKPVLLLSLAGSAVSYVLLGLSRNL----WLLFLARFLDGLTGGNVSVAQA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 137 YAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPlgeegiqfggfiLNMYTIVSYLMVLICLSACLVVYLFFKesy 216
Cdd:cd17330  110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLST------------PYGYALPFLVAAALALLNLVLVLFFLP--- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 217 agivtkeekekdevevpmfdiPASLICIyLFMIVNMTATNIEVMSSPLTTVLYDWkdsdSIFYNGIALAISSAISVAFNI 296
Cdd:cd17330  175 ---------------------PLRRLLL-VYFLIALAFAGLESVFSLFLKDRFGF----SPSQIGLLLALVGIAGILAQL 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 297 AQGSTRIGRIDKRKQMLFGLtFFLLYQLFMYPWGfysgplnflpkgvetkvaggcyseylwcndttrvPLFIYLFCFIVF 376
Cdd:cd17330  229 LLIPRLAKRLGERKLLRLGL-LLAIIGLLLLPFA----------------------------------SSVPLLVLAAAI 273
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919222 377 FGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSGYRYVIVLQASTLLVAIVLILI 452
Cdd:cd17330  274 LAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
19-213 1.32e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.19  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  19 RSMWIAIVMQFVVGVQISVYYMsMWPYLSGLDKTADFDF----LGWVVASCSIGCTIANPIYGYWNQKTmSVKWPVITGF 94
Cdd:cd17504  177 RNVLLANITALLAGFGMFMVFQ-LLPQLLQLPTPTGFGLgiteAGLLLLPGALVMLIAGPLAGRLIARV-GPRRVLLIGL 254
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  95 LIAAVGqlwYALLGFFGNVKWFMLCARFLTGLGVGNIAALRVYAAMASTPKDRM-RAISFGTGGFVLGFSFGPVISSIFT 173
Cdd:cd17504  255 VISAVG---LLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTgIATGMNTVLRTIGSAIGPAIAGAIL 331
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 392919222 174 PLGEEGIQFGGFILNMYTIVSYLMVLICLSACLVVYLFFK 213
Cdd:cd17504  332 TTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
58-456 5.57e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 5.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  58 LGWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVGNIAALRVY 137
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDR-FGPRRVLLIGLLLLGIGLLLLALAVSY----WLLLLLGLLLGIGGGGSFAVGIA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 138 AAMASTPKDRMraiSFGTGGFVLGFSFGPVISSIFTPLgeeGIQFGGfilnmYTIVSYLMVLICLSACLVVYLFFKESYA 217
Cdd:COG2223  117 LVSKWFPPDRR---GLALGLAAGGGNLGAAVAAFLAPL---LIAAFG-----WRNAFLILGILLLVVAVLAWLFLRDPPA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 218 GIVTKEEKEKDEVEVPMFDIPASLICIYLFMIVNMTATNIEVMsSPLTTVLYDWKDSDSIFYNGIALAISSAISVAFNIA 297
Cdd:COG2223  186 GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWL-PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWL 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 298 qgSTRIGRidkRKQMLFgltFFLLYQLFMYPWGFYSGPLnflpkgvetkvaggcyseylwcndttrvPLFIYLFcfiVFF 377
Cdd:COG2223  265 --SDRIGG---RRVLLI---VFALMALGLLLLALALGSL----------------------------WLFLVLF---LLL 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 378 GVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSG-YRYVIVLQASTLLVAIVLILIFYKR 456
Cdd:COG2223  306 GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
7-175 8.46e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.42  E-value: 8.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222   7 SEKIEAEKRTDWRSMWIAIVMQFVVGVQISVYYMSMWPYLSGLDktADFDFLGWVVASCSIGCTIANPIYGYWNQKtMSV 86
Cdd:COG0477    2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLG--ASSAQLGWIVSAYLLGRAIGLLLFGRLGDR-YGR 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  87 KWPVITGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVG-NIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFG 165
Cdd:COG0477   79 KRVLLIGLLLFGLASLLCGLAPSP----ELLIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGLALG 154
                        170
                 ....*....|
gi 392919222 166 PVISSIFTPL 175
Cdd:COG0477  155 PLLGGLLVAA 164
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
99-455 3.61e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  99 VGQLWYALLGFFGnvkwfmlcarFLTGLGVGNIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLgee 178
Cdd:COG2211  107 TGKLIYALVTYLL----------LGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAA--- 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 179 giqFGGFILNMYTIVSYLMVLICLSACLVVYLFFKESYAGIVTKEEKEKDEVEvpMFDIPAsLICIYLFMIVNMTATNIe 258
Cdd:COG2211  174 ---FGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKA--LLKNRP-FLLLLLAYLLFFLALAL- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 259 VMSSPLTTVLYDWKDSDSIFynGIALAISSAISVAFNIAqgSTRIG-RIDKRKQMLFGLTFFLLYQLFMYPWGFYSgpln 337
Cdd:COG2211  247 VAALLLYYFKYVLGLSAALV--GLLLALYFLAALLGAPL--WPRLAkRFGKKKAFIIGLLLAALGLLLLFFLGPGN---- 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 338 flpkgvetkvaggcyseylwcndttrvPLFIYLFCFIVFFGVAFPFVetPAPALFSEIL-------GPRKQGTMQGFFSF 410
Cdd:COG2211  319 ---------------------------LWLLLVLAALAGIGLGAILV--LPWAMLADVVdydewktGRRREGLYFGIFTF 369
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 392919222 411 GGSLAPVIASISSTAIFKYSGY--------------RYVIVLQASTLLVAIVLILIFYK 455
Cdd:COG2211  370 AIKLGQALAGALAGLLLALFGYvagaaqspsaltgiRLLFFLLPAVLLLLAALLLLFYP 428
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
59-210 7.32e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 7.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  59 GWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGQLWYALLGfFGNVKWFMLCARFLTGLGVGNIAALRVYA 138
Cdd:cd17321  207 GLALLPLALAMLVAAPLAGRLADR-FGPRLVLVAGLLLTAVGLLLLALLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNA 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 139 AMASTPKDR----------MRAISFGTGGFVLGFSFGPVISSIFTPLGEEGIQF--GGFILNMYTIVSYLMVLICLSACL 206
Cdd:cd17321  285 ALSSVPKEKagaasgilntARQLGGALGVALLGALLTAGLSANLGDSGVAALLSaaAAAFAAGFHLAFLVAAALALLAAL 364

                 ....
gi 392919222 207 VVYL 210
Cdd:cd17321  365 LALL 368
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
58-211 9.02e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 9.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  58 LGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGFLIAAvgqLWYALLGFFGNVkWFMLCARFLTGLGVG-NIAALRV 136
Cdd:cd17474  236 IGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYA---LSLLLLGFVPSL-ALLLIAIVLFGLGLGlNLPLLTT 311
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392919222 137 YAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIftplgeegiqfgGFILNMYTIVSYLMVLICLSACLVVYLF 211
Cdd:cd17474  312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL------------LLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
19-172 9.68e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.40  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  19 RSMWIAIVMQFVVGVQ--ISVYYMSMWpYLSGLDKTADFDflGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGFLI 96
Cdd:cd17502  167 RTILLSSIFGFLFGGAlfGLIYYLPLY-FQLVLGDSATKS--GVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTIL 243
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392919222  97 AAVGQLWYALLGFFGNVKWFMLCArFLTGLGVGNIAALRVYAAMASTPKDRM-RAISFGTGGFVLGFSFGPVISSIF 172
Cdd:cd17502  244 MSVGAGLLTTLTLDTSKWLLIGYL-ILLGLGLGIGFQQPLVAVQNAVPPADVgVATATNTFFRSLGGTLGVAITDVF 319
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
19-206 1.14e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  19 RSMWIAIVMQFVVGVQISVYYMSMWPYLSGLDKTADfDFLGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGFLIAA 98
Cdd:cd17324  198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS-SAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  99 vgqlwYALLGFFGNVKWFMLCARFLTGLGVGNIAALRVYAAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFtplgee 178
Cdd:cd17324  277 -----LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLV------ 345
                        170       180
                 ....*....|....*....|....*...
gi 392919222 179 giqFGGFILNMYTIVSYLMVLICLSACL 206
Cdd:cd17324  346 ---LDHGGWAGVGWVGAALLLLALLLAL 370
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
13-207 1.17e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  13 EKRTDWRSMWIAIVMQFVVGVQISVYyMSMWPYLS---GLDKTAdfdfLGWVVASCSIGCTIANPIYGYWNQKtMSVKWP 89
Cdd:COG0738    2 SKKNYRRALIAIYLLFFLWGFATALW-GPLIPALKdafGLSDAQ----AGLLLFAFFLGYLLASLPAGRLIDR-FGYKRG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  90 VITGFLIAAVGQLWYALLGFFgnvkWFMLCARFLTGLGVGNI-AALRVYAAMAStPKDRMRAISFGTGGFVLGFSFGPVI 168
Cdd:COG0738   76 LLLGLLLMALGLLLFALAPSY----PLLLLALFLLGLGLGLLdVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLL 150
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 392919222 169 SSIFTPLGeegiqFGGFILNMYTIVSYLMVLICLSACLV 207
Cdd:COG0738  151 GGLLILLG-----LSLSWHLPYLILAVLLLLLALLFLRS 184
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
365-457 1.79e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 365 PLFIYLFCFIVFFGVAFPFveTPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSGYRYVIVLQASTLL 444
Cdd:COG2271  271 PALAIALLFLAGFGLGGAF--GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348
                         90
                 ....*....|...
gi 392919222 445 VAIVLILIFYKRL 457
Cdd:COG2271  349 LAALLALLLLRET 361
MFS_1 pfam07690
Major Facilitator Superfamily;
367-453 2.39e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  367 FIYLFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSGYRYVIVLQASTLLVA 446
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLA 164

                  ....*..
gi 392919222  447 IVLILIF 453
Cdd:pfam07690 165 AVLLLLP 171
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
17-173 4.08e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.53  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  17 DWRSMWIAIVMQFVVGvqiSVYYMS--MWPYLSGLDKTADFDFLGWVVASCSIGCTIANPIYGYWNQKTMSVKWPVITGF 94
Cdd:cd06179  260 RGRNFALILIVAFVEG---MIFYSLniFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGF 336
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392919222  95 LIAAVGQLWYALLGffGNVKWFMLCARFLTGLGVGNIAALRVYAAMASTPKdrmRAISFGTGgfvLGFSFGPVISSIFT 173
Cdd:cd06179  337 VLFTAFLALLALIT--PDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPP---EDIGTASG---LLGSARALGGAVGT 407
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
59-454 4.64e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 4.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222  59 GWVVASCSIGCTIANPIYGYWNQKtMSVKWPVITGFLIAAVGqlwYALLGFFGNVKWFMLcARFLTGLGVG-NIAALRVY 137
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADR-FGRKPVMLAGLLLRALG---FALLGFAHSPWLFAI-ALVLTGFGGGlFEPASEAM 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 138 AAMASTPKDRMRAISFGTGGFVLGFSFGPVISSIFTPLGeegiqfggfilnmYTIVSYLMVLICLSACLVVYLFFKESYA 217
Cdd:cd17329  113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-------------FRLLFLAAAVLFLLAALVLLFLLPETRP 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 218 GIVTKEEKEKDEVEVPMFDIPAslicIYLFMIVNMTATNIEVMSSPLTTVLYDWKDSDSIFYNGIALAISSAISVAFNIA 297
Cdd:cd17329  180 KRRAAEKTEILRGYKIVLRDRA----FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFP 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 298 QgSTRIGRIDKRKQMLFGltfFLLYQLFMYPWGFysgplnflpkgvetkvaggcyseylwcndttrVPLFIYLFCFIVFF 377
Cdd:cd17329  256 V-ARLVERFRLRKILMIG---ILLFAIGFAVLAF--------------------------------ANTLAVLILAMIVL 299
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392919222 378 GVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSGYRYVIVLQASTLLVAIVLILIFY 454
Cdd:cd17329  300 TLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
367-459 6.44e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919222 367 FIYLFCFIVFFGVAFPFVETPAPALFSEILGPRKQGTMQGFFSFGGSLAPVIASISSTAIFKYSGYRYVIVLQASTLLVA 446
Cdd:COG2814   98 LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177
                         90
                 ....*....|...
gi 392919222 447 IVLILIFYKRLVP 459
Cdd:COG2814  178 LLLLLRLLPESRP 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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