HIT-type domain-containing protein [Caenorhabditis elegans]
Protein Classification
IES6 family protein( domain architecture ID 7366)
IES6 family protein similar to Saccharomyces cerevisiae chromatin-remodeling complex subunit IES6 and Homo sapiens INO80 complex subunit C
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| zf-HIT super family | cl04519 | zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ... |
77-104 | 1.57e-08 | ||
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes. The actual alignment was detected with superfamily member cd21437: Pssm-ID: 471044 Cd Length: 43 Bit Score: 46.84 E-value: 1.57e-08
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| YL1_C super family | cl02154 | YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. ... |
29-101 | 9.41e-04 | ||
YL1 nuclear protein C-terminal domain; This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins. The actual alignment was detected with superfamily member COG5195: Pssm-ID: 470478 [Multi-domain] Cd Length: 118 Bit Score: 36.12 E-value: 9.41e-04
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| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_ZNHIT1_like | cd21437 | HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ... |
77-104 | 1.57e-08 | ||
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion. Pssm-ID: 467791 Cd Length: 43 Bit Score: 46.84 E-value: 1.57e-08
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| COG5195 | COG5195 | Uncharacterized conserved protein [Function unknown]; |
29-101 | 9.41e-04 | ||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227522 [Multi-domain] Cd Length: 118 Bit Score: 36.12 E-value: 9.41e-04
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| zf-HIT | pfam04438 | HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
83-102 | 1.50e-03 | ||
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor. Pssm-ID: 461310 Cd Length: 30 Bit Score: 33.76 E-value: 1.50e-03
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| Name | Accession | Description | Interval | E-value | ||
| zf-HIT_ZNHIT1_like | cd21437 | HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ... |
77-104 | 1.57e-08 | ||
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion. Pssm-ID: 467791 Cd Length: 43 Bit Score: 46.84 E-value: 1.57e-08
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| COG5195 | COG5195 | Uncharacterized conserved protein [Function unknown]; |
29-101 | 9.41e-04 | ||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227522 [Multi-domain] Cd Length: 118 Bit Score: 36.12 E-value: 9.41e-04
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| zf-HIT | pfam04438 | HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ... |
83-102 | 1.50e-03 | ||
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor. Pssm-ID: 461310 Cd Length: 30 Bit Score: 33.76 E-value: 1.50e-03
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| Blast search parameters | ||||
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