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Conserved domains on  [gi|17563528|ref|NP_503907|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-305 4.32e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 263.93  E-value: 4.32e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528     7 STVISALGFILNLIVNGVFFYLTLFKIKKMHGTYKRMVITFTVLGTIFSLWEIIAEPFAHNYKNSLLYFSCNTWLG-SKT 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGlSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    86 WLRYMLAMWSGCHTLIIWFIAMQFIYRLVCLIDTNNIKKLDGIYGYLMIIVPFVIGGFFAVMVEMLIAKDKMLDDNLSKL 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528   166 IFENYQLLISELSKYNITPY--NFDGS--VNWGNFGLLVIAVFLNSLGYLVILYCGVQMHLNMKKELAKLSISNQELQRQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17563528   242 FFKALIAQSIGPTIFLVLPMGPFLLSPLIpGLNVNWQSGWIFCLVGAYSPFDTIMFMMIVSEYR 305
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLF-NIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-305 4.32e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 263.93  E-value: 4.32e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528     7 STVISALGFILNLIVNGVFFYLTLFKIKKMHGTYKRMVITFTVLGTIFSLWEIIAEPFAHNYKNSLLYFSCNTWLG-SKT 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGlSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    86 WLRYMLAMWSGCHTLIIWFIAMQFIYRLVCLIDTNNIKKLDGIYGYLMIIVPFVIGGFFAVMVEMLIAKDKMLDDNLSKL 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528   166 IFENYQLLISELSKYNITPY--NFDGS--VNWGNFGLLVIAVFLNSLGYLVILYCGVQMHLNMKKELAKLSISNQELQRQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17563528   242 FFKALIAQSIGPTIFLVLPMGPFLLSPLIpGLNVNWQSGWIFCLVGAYSPFDTIMFMMIVSEYR 305
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLF-NIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-305 4.32e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 263.93  E-value: 4.32e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528     7 STVISALGFILNLIVNGVFFYLTLFKIKKMHGTYKRMVITFTVLGTIFSLWEIIAEPFAHNYKNSLLYFSCNTWLG-SKT 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGlSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    86 WLRYMLAMWSGCHTLIIWFIAMQFIYRLVCLIDTNNIKKLDGIYGYLMIIVPFVIGGFFAVMVEMLIAKDKMLDDNLSKL 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528   166 IFENYQLLISELSKYNITPY--NFDGS--VNWGNFGLLVIAVFLNSLGYLVILYCGVQMHLNMKKELAKLSISNQELQRQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17563528   242 FFKALIAQSIGPTIFLVLPMGPFLLSPLIpGLNVNWQSGWIFCLVGAYSPFDTIMFMMIVSEYR 305
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLF-NIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 10-305 2.15e-10

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 60.72  E-value: 2.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    10 ISALGFILNLIVNGVFFYLTLFKIKKMHGTYKRMVITFTVLGTIFSLWEIIAEPFAHNYKNSLLYFSCNTWL-GSKTWLR 88
Cdd:pfam10319  10 IPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFfEYSELGQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    89 YMLAMWSGCHTLIIWFIAMQFIYRLVCLIDTNNI-KKLDGIYGYLMIIVPFVIGGFFAVMVEMLIAKDKMLDDNLSKLIF 167
Cdd:pfam10319  90 HALSARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528   168 ENYQlliSELSKYNITPYNFDGSVN------WGNFGLLVIAVFLNSLGYLVIlycGVQMHLNMKKELAKLSISNQELQRQ 241
Cdd:pfam10319 170 ETYG---VDSMDINMLGALYWEASDetvfrsWLGILLLTVISVYSIILYIVL---GYKIMRKLNKMSVTMSKKTKRLQKQ 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563528   242 FFKALIAQSIGPTIFLVLPMGPFLLSPLIpGLNVNWQSGWIF-CLVGAYSPFDTIMFMMIVSEYR 305
Cdd:pfam10319 244 LLKALIVQTIIPICISFSPCVLAWYSPIF-GIDLGRWNNYLEvIALSAFPFIDPLAIILCLPVYR 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 6-267 6.79e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 56.02  E-value: 6.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528     6 YSTVISALGFILNLIVngvfFYLTLFKIKKMHGTYKRMVITFTVLGTIFSLWEIIAEPFAHNYKNSLLYFS---CnTWLG 82
Cdd:pfam10317   4 YYPIFFILGLILNLLL----LYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISygpC-KYFG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    83 SktWLRYML-AMWSGCHTLIIWFIAMQFIYRLVCLidTNNIKKLDGIYGYLMIIVPFviggFFAVMVEMLIAKDKMLddn 161
Cdd:pfam10317  79 P--WFCYSGySLLQHFLLHSGWSLLLTFYYRYYIL--KHVDPKRKKLILLIIIHYIP----SLSQLIVIFLSPTDFL--- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528   162 lsklifENYQLLISELSKYNITPYNFDGSVNWGNFGLLVIAVFLNS---LGYLVILYCGVQMHLNMKKELAKLSISNQEL 238
Cdd:pfam10317 148 ------PVEALTKELHPNYNLTDYTVTGFSDLQSFPALINTLIMTIpvfPIPIIILILRRKILKLLNSNSVNMSPTTKAQ 221

                         250       260
                  ....*....|....*....|....*....
gi 17563528   239 QRQFFKALIAQSIGPTIFLVLPMGPFLLS 267
Cdd:pfam10317 222 HRQLIKGLTIQALLPLFSYIPGVTLYLLS 250
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 6-308 5.42e-08

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 53.32  E-value: 5.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528     6 YSTVISALGFILNLIVngvfFYLTLFKIKKMHGtYKR-----------MVITFTVLGTIFSLWEIIAepfahNYKNSLLY 74
Cdd:pfam10327  14 YYHIIGTISLILNLLG----IYLIIFKSGKIDN-FRYyllyfqisctlTDIHLTFLMQPIPLFPIIA-----GYCNGFLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528    75 fscnTWLGSktWLRYMLAMWSGCHTLIIWFIAMQFIYR---LVCLIDTNNIKKLDGIYGY-LMIIVPFVIGGFFAVMVem 150
Cdd:pfam10327  84 ----TVFGI--SSHYLMTIFVFLLSFQLESLLLCFVRKhqaIAKILSKHVIPKWLYIFLYiLCHIFPFLTAFLFYQSG-- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563528   151 lIAKDKMLDdnlskLIFENYQLLISELSKY-NITPYNFdgsvNWGNFGLLVIAVFLNSLGYLVILYCGVQMHLNMKKELA 229
Cdd:pfam10327 156 -LSREEQLE-----YVKENYPEYLSQFSSLpNFAIYDY----NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRK 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563528   230 KLSISNQELQRQFFKALIAQSIGPTIFlVLPMGPFLLSPLIPGLNVNWQSGWIFCLVGAYSPFDTIMFMMIVSEYRSLL 308
Cdd:pfam10327 226 KISAQTYQKHRAALRSLIAQFATSPVC-ILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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