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Conserved domains on  [gi|71997488|ref|NP_503799|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

Srw family chemoreceptor( domain architecture ID 10563412)

Srw family chemoreceptor belongs to the G-protein coupled receptor (GPCR) superfamily and plays a role in chemoreception

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
39-345 2.55e-112

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


:

Pssm-ID: 402097  Cd Length: 318  Bit Score: 330.32  E-value: 2.55e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488    39 YESIISITCILVNILHSAILTRKSMRNSSINIIMTAVAILDICTFFSELKKIVERFLRDY--YDCFQSETYTFVIIETSF 116
Cdd:pfam10324   2 VEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYenSECIPPDSYLKVLLDWIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488   117 QVLQDYSRRCSTWLCFLIALIRTLVIRNPLNQSYQKLAGPALSGFAILGILFLSLPISVVFSLEYELMK----SSVPSFC 192
Cdd:pfam10324  82 ESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEvggiWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488   193 -----NSTETTYYTVISDMFADNDGYYLKIFSIVNGLVSNIIPCVLFPIVTFLLVVELWKSDKKRKNLSSTANvNDSRKT 267
Cdd:pfam10324 162 agfppNYTETRYVLVVSELFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSK-NKSDRT 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71997488   268 TRLVFYISITFFIAEFPLGITLGATWFFLDVPGMKSIMSYFYYNFSLLLSANTATHCIVCFFMSSQYRIAAKQVVSCG 345
Cdd:pfam10324 241 TKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFGCK 318
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
39-345 2.55e-112

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 330.32  E-value: 2.55e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488    39 YESIISITCILVNILHSAILTRKSMRNSSINIIMTAVAILDICTFFSELKKIVERFLRDY--YDCFQSETYTFVIIETSF 116
Cdd:pfam10324   2 VEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYenSECIPPDSYLKVLLDWIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488   117 QVLQDYSRRCSTWLCFLIALIRTLVIRNPLNQSYQKLAGPALSGFAILGILFLSLPISVVFSLEYELMK----SSVPSFC 192
Cdd:pfam10324  82 ESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEvggiWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488   193 -----NSTETTYYTVISDMFADNDGYYLKIFSIVNGLVSNIIPCVLFPIVTFLLVVELWKSDKKRKNLSSTANvNDSRKT 267
Cdd:pfam10324 162 agfppNYTETRYVLVVSELFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSK-NKSDRT 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71997488   268 TRLVFYISITFFIAEFPLGITLGATWFFLDVPGMKSIMSYFYYNFSLLLSANTATHCIVCFFMSSQYRIAAKQVVSCG 345
Cdd:pfam10324 241 TKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFGCK 318
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-335 5.65e-43

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 151.25  E-value: 5.65e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488  39 YESIISITCILVNILHSAILTRKSMRnSSINIIMTAVAILDICTFFSELKKIVERFLRDYYDCFQSETYTFVIIetSFQV 118
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMR-SSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLP--YIYP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488 119 LQDYSRRCSTWLCFLIALIRTLVIRNPLNqsYQKLAGPALSGFAILGILFLSLPISVVFSLEYELMKSsvpsfCNSTETT 198
Cdd:cd14978  83 LANTFQTASVWLTVALTVERYIAVCHPLK--ARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVEC-----ENCNNNS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488 199 YYTVISDMFADNDGYYLKIFSIVNGLVSNIIPCVLFPIVTFLLVVELWKSDKKRKNLS-----STANVNDSRKTTRLVFY 273
Cdd:cd14978 156 YYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRrrrrlLSRSQRRERRTTIMLIA 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71997488 274 ISITFFIAEFPLGITLGATWFFLDVPGMkSIMSYFYYNFSLLLSANTATHCIVCFFMSSQYR 335
Cdd:cd14978 236 VVIVFLICNLPAGILNILEAIFGESFLS-PIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFR 296
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
39-345 2.55e-112

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 330.32  E-value: 2.55e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488    39 YESIISITCILVNILHSAILTRKSMRNSSINIIMTAVAILDICTFFSELKKIVERFLRDY--YDCFQSETYTFVIIETSF 116
Cdd:pfam10324   2 VEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYenSECIPPDSYLKVLLDWIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488   117 QVLQDYSRRCSTWLCFLIALIRTLVIRNPLNQSYQKLAGPALSGFAILGILFLSLPISVVFSLEYELMK----SSVPSFC 192
Cdd:pfam10324  82 ESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEvggiWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488   193 -----NSTETTYYTVISDMFADNDGYYLKIFSIVNGLVSNIIPCVLFPIVTFLLVVELWKSDKKRKNLSSTANvNDSRKT 267
Cdd:pfam10324 162 agfppNYTETRYVLVVSELFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSK-NKSDRT 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71997488   268 TRLVFYISITFFIAEFPLGITLGATWFFLDVPGMKSIMSYFYYNFSLLLSANTATHCIVCFFMSSQYRIAAKQVVSCG 345
Cdd:pfam10324 241 TKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFGCK 318
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-335 5.65e-43

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 151.25  E-value: 5.65e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488  39 YESIISITCILVNILHSAILTRKSMRnSSINIIMTAVAILDICTFFSELKKIVERFLRDYYDCFQSETYTFVIIetSFQV 118
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMR-SSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLP--YIYP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488 119 LQDYSRRCSTWLCFLIALIRTLVIRNPLNqsYQKLAGPALSGFAILGILFLSLPISVVFSLEYELMKSsvpsfCNSTETT 198
Cdd:cd14978  83 LANTFQTASVWLTVALTVERYIAVCHPLK--ARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVEC-----ENCNNNS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488 199 YYTVISDMFADNDGYYLKIFSIVNGLVSNIIPCVLFPIVTFLLVVELWKSDKKRKNLS-----STANVNDSRKTTRLVFY 273
Cdd:cd14978 156 YYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRrrrrlLSRSQRRERRTTIMLIA 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71997488 274 ISITFFIAEFPLGITLGATWFFLDVPGMkSIMSYFYYNFSLLLSANTATHCIVCFFMSSQYR 335
Cdd:cd14978 236 VVIVFLICNLPAGILNILEAIFGESFLS-PIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFR 296
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
133-337 8.31e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 40.91  E-value: 8.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488 133 LIALIRTLVIRNPLNQSYQKLAGPALSGFAILGILFLSLPISVVFSLEYELMKSSVPSFCNstettyytvisdmFADNDG 212
Cdd:cd14971  93 AMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCS-------------EAWPSR 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997488 213 YYLKIFSIVNGLVSNIIPCVLFPIVTFLLVVELWKSdKKRKNLSSTANVNdSRKTTRLVFYISITFFIAEFPLGITLGAT 292
Cdd:cd14971 160 AHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRV-AVRPVLSEGSRRA-KRKVTRLVLVVVVLFAACWGPIHAILLLV 237
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 71997488 293 WFfldVPGMKSIMSYFYYNFSLLLS-ANTATHCIVCFFMSSQYRIA 337
Cdd:cd14971 238 AL---GPFPLTYATYALRIWAHCLAySNSAVNPVLYAFLSEHFRKA 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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