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Conserved domains on  [gi|17563518|ref|NP_503782|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 6-306 5.23e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 294.36  E-value: 5.23e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518     6 FEFITVTSFFATLFSNLLLIFITTFYVKQIVGSYKKMIILFAGLGIIFSIVERIAKPFIHNYNKGLMYFsLGESWFKIPK 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVF-VDLKDLGLSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    86 DVVTISLVVYVTIYAVVVTFLAVQFAFRYVSLFNPDLTKLFENYGAIAWSMYPVFIGSVNGAAIWCLTRPDEFSDDYMRN 165
Cdd:pfam10326  80 SVGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518   166 EIFEVYELDISTLPRLLIVPYDQNGN----VRINNVLYLCIGTFLLSSQYLIIVYCGLQMHFQMQKELQKFSVANRKLQQ 241
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563518   242 QFFKALVVQVTVPTITFVLPAMPLLLGPLFDLKMSFKSGVICALLGIYPFIDSILFMLIVTEYRK 306
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRN 304
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 6-306 5.23e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 294.36  E-value: 5.23e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518     6 FEFITVTSFFATLFSNLLLIFITTFYVKQIVGSYKKMIILFAGLGIIFSIVERIAKPFIHNYNKGLMYFsLGESWFKIPK 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVF-VDLKDLGLSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    86 DVVTISLVVYVTIYAVVVTFLAVQFAFRYVSLFNPDLTKLFENYGAIAWSMYPVFIGSVNGAAIWCLTRPDEFSDDYMRN 165
Cdd:pfam10326  80 SVGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518   166 EIFEVYELDISTLPRLLIVPYDQNGN----VRINNVLYLCIGTFLLSSQYLIIVYCGLQMHFQMQKELQKFSVANRKLQQ 241
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563518   242 QFFKALVVQVTVPTITFVLPAMPLLLGPLFDLKMSFKSGVICALLGIYPFIDSILFMLIVTEYRK 306
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRN 304
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 6-306 5.23e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 294.36  E-value: 5.23e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518     6 FEFITVTSFFATLFSNLLLIFITTFYVKQIVGSYKKMIILFAGLGIIFSIVERIAKPFIHNYNKGLMYFsLGESWFKIPK 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVF-VDLKDLGLSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    86 DVVTISLVVYVTIYAVVVTFLAVQFAFRYVSLFNPDLTKLFENYGAIAWSMYPVFIGSVNGAAIWCLTRPDEFSDDYMRN 165
Cdd:pfam10326  80 SVGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518   166 EIFEVYELDISTLPRLLIVPYDQNGN----VRINNVLYLCIGTFLLSSQYLIIVYCGLQMHFQMQKELQKFSVANRKLQQ 241
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563518   242 QFFKALVVQVTVPTITFVLPAMPLLLGPLFDLKMSFKSGVICALLGIYPFIDSILFMLIVTEYRK 306
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRN 304
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 5-306 4.25e-21

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 91.54  E-value: 4.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518     5 VFEFITVTSFFATLFSNLLLIFITTFYVKQIVGSYKKMIILFAGLGIIFSIVERIAKPFIHNYNKGLMYFsLGESWFKIP 84
Cdd:pfam10319   6 AHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF-VSDGPFFEY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    85 KDVVTISLVVYVTIYAVVVTFLAVQFAFRYVSLFNPDLT-KLFENYGAIAWSMYPVFIGSVNGAAIWCLTRPDEFSDDYM 163
Cdd:pfam10319  85 SELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518   164 RNEIFEVYELDISTLPRLLIVPYDQNGNVRINNVLYLCIGTFLLSSQYLIIVYCGLQMHFQMQKELQKFSVANRKLQQQF 243
Cdd:pfam10319 165 REDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQL 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563518   244 FKALVVQVTVPTITFVLPAMPLLLGPLF--DLKMSFKSGVICAlLGIYPFIDSILFMLIVTEYRK 306
Cdd:pfam10319 245 LKALIVQTIIPICISFSPCVLAWYSPIFgiDLGRWNNYLEVIA-LSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 79-272 6.80e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 40.99  E-value: 6.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    79 SWFKIPKDVVTIslVVYVTIYAVVVTFLAVqFAFRYVSLFNPDlTKLFENYGAIAWSMYPVFIGSVNGAAIWCLTrPDEf 158
Cdd:pfam10318  79 SYLGVPTPIQFY--IGVTSLALVGVSIILL-FENRYSILFTNK-KRITWKKTRVLYLIFNYIIALLFLIPIYLNI-PDQ- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518   159 sdDYMRNEIFEVY---ELDISTLPRLLIVPYDQNGNVrinnvLYLCIGTFLLSSQYLI-IVYCGLQMHFQMQKELqkfSV 234
Cdd:pfam10318 153 --EAAKLKVLKKLpclPPEFFDNPPVFVLAIDSTYFL-----ICIVLLILILIIQILFfVFLTIYYLFKSVKSSL---SK 222

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 17563518   235 ANRKLQQQFFKALVVQVTVPTITFVLPAMPLLLGPLFD 272
Cdd:pfam10318 223 KTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 14-306 1.94e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 39.46  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    14 FFATLFSNLLLIFITTFYVKQIVGSYKKMIILFAGLGIIFSIVERIAKPFIHNYNKGLMYFSLGESWFkIPKDVVTISLV 93
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKY-FGPWFCYSGYS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518    94 VYVTIYAVVVTFLAVQFAFRYVSLFNPDLTKlfENYGAIAWSMYPVFIGSvngaAIWCLTRPDEFsddymrneiFEVYEL 173
Cdd:pfam10317  88 LLQHFLLHSGWSLLLTFYYRYYILKHVDPKR--KKLILLIIIHYIPSLSQ----LIVIFLSPTDF---------LPVEAL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563518   174 DISTLPRLLIVPYDQNGNVRIN------NVLYLCIGTFLLssqYLIIVYCGLQMHFQMQKELQKFSVANRKLQQQFFKAL 247
Cdd:pfam10317 153 TKELHPNYNLTDYTVTGFSDLQsfpaliNTLIMTIPVFPI---PIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGL 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17563518   248 VVQVTVPTITFVLPAMPLLLGPLFDLKMSFKSGVICALLGIYPFIDSILFMLIVTEYRK 306
Cdd:pfam10317 230 TIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRR 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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