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Conserved domains on  [gi|17563640|ref|NP_503436|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-316 2.60e-91

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 275.10  E-value: 2.60e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    10 LVQKVCAPLALAINILLIYLILRHSPKSLGFYKYLMIYIALFEMIYAIVDIISAPDLYCFDSMFLVITFYENSSLPRWIY 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    90 KVINVVFCTFFAVSMAIFALHFIYRYLAVSGSSYVKSYSFGKSFVWFFSPILYGIFYATAIEFTLSENEKTNMVLRKTYL 169
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   170 SNRTLKVENLIYIGQNYWFTDEKGNVAINLMSWFGIAVPIFTVILSSSTMLIFGTLSYRAVASFAKNTsnSKQYHSMQLQ 249
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563640   250 LLNALVLQALIPVFLMQLPSFIAFTSPIFHKGNEMAGAVLGIAVALYPVLDPLPTLIIIKNFRNALF 316
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-316 2.60e-91

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 275.10  E-value: 2.60e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    10 LVQKVCAPLALAINILLIYLILRHSPKSLGFYKYLMIYIALFEMIYAIVDIISAPDLYCFDSMFLVITFYENSSLPRWIY 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    90 KVINVVFCTFFAVSMAIFALHFIYRYLAVSGSSYVKSYSFGKSFVWFFSPILYGIFYATAIEFTLSENEKTNMVLRKTYL 169
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   170 SNRTLKVENLIYIGQNYWFTDEKGNVAINLMSWFGIAVPIFTVILSSSTMLIFGTLSYRAVASFAKNTsnSKQYHSMQLQ 249
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563640   250 LLNALVLQALIPVFLMQLPSFIAFTSPIFHKGNEMAGAVLGIAVALYPVLDPLPTLIIIKNFRNALF 316
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-316 2.60e-91

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 275.10  E-value: 2.60e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    10 LVQKVCAPLALAINILLIYLILRHSPKSLGFYKYLMIYIALFEMIYAIVDIISAPDLYCFDSMFLVITFYENSSLPRWIY 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    90 KVINVVFCTFFAVSMAIFALHFIYRYLAVSGSSYVKSYSFGKSFVWFFSPILYGIFYATAIEFTLSENEKTNMVLRKTYL 169
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   170 SNRTLKVENLIYIGQNYWFTDEKGNVAINLMSWFGIAVPIFTVILSSSTMLIFGTLSYRAVASFAKNTsnSKQYHSMQLQ 249
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563640   250 LLNALVLQALIPVFLMQLPSFIAFTSPIFHKGNEMAGAVLGIAVALYPVLDPLPTLIIIKNFRNALF 316
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 34-315 4.86e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 113.88  E-value: 4.86e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    34 SPKSLGFYKYLMIYIALFEMIYAIVDIISAPDLYCFDSMFLVIT----FYENSSLPRWIYkvinVVFCTFFAVSMAIFAL 109
Cdd:pfam10319  33 KSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVsdgpFFEYSELGQHAL----SARCSFISASYAVLLI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   110 HFIYRYLAVSGSSYVKSYSFGKS-FVWFFSPILYGIFYATAIEFTLSENEKTNMVLRKTYLSNRTLKVENLIYIGQNYWf 188
Cdd:pfam10319 109 HFIYRYLVLFNPQLTRHYFRPWGiLISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDSMDINMLGALYW- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   189 tdeKGNVAINLMSWFGIAvpIFTVIlSSSTMLIFGTLSYRAVASFAKNTSN-SKQYHSMQLQLLNALVLQALIPVFLMQL 267
Cdd:pfam10319 188 ---EASDETVFRSWLGIL--LLTVI-SVYSIILYIVLGYKIMRKLNKMSVTmSKKTKRLQKQLLKALIVQTIIPICISFS 261

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 17563640   268 PSFIAFTSPIFH-KGNEMAGAVLGIAVALYPVLDPLPTLIIIKNFRNAL 315
Cdd:pfam10319 262 PCVLAWYSPIFGiDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 32-317 5.47e-07

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 50.24  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    32 RHSPKSLGFYKYLMIYIALFEMIYAIVDIISAPDLYCFDSMFLVITFYENSSLPRWIYKVINVVFCTFFAVSMAIFALHF 111
Cdd:pfam10317  25 FKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLLQHFLLHSGWSLLLTF 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   112 IYRYLAVsgssYVKSYSFGKSFVWFFspILYGIFYATAIEFTLSENEkTNMVLRKTYLSNRTLKVENLIYIGqnywFTD- 190
Cdd:pfam10317 105 YYRYYIL----KHVDPKRKKLILLII--IHYIPSLSQLIVIFLSPTD-FLPVEALTKELHPNYNLTDYTVTG----FSDl 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   191 EKGNVAINLMSWFGIAVPIFTVILssstmlifgTLSYRAVASFAKNTSN-SKQYHSMQLQLLNALVLQALIPVFLMQLPS 269
Cdd:pfam10317 174 QSFPALINTLIMTIPVFPIPIIIL---------ILRRKILKLLNSNSVNmSPTTKAQHRQLIKGLTIQALLPLFSYIPGV 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 17563640   270 FIAFTSPIFHKGNEMAGAVLGIAVALYPVLDPLPTLIIIKNFRNALFK 317
Cdd:pfam10317 245 TLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 94-321 8.90e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 49.85  E-value: 8.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640    94 VVFCTFFAVSMAIFALhFIYRYLAVSGSSYVKSYSFGKsFVWFFSPILYGIFYATAIEFTLSENEKTNMVLRKTY--LSN 171
Cdd:pfam10318  91 IGVTSLALVGVSIILL-FENRYSILFTNKKRITWKKTR-VLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLKKLpcLPP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   172 RTLKVENLIYIGQNYWftdekgnvainlmsWFGIAVPIFTVILSSSTMLIFGTLSYRAvaSFAKNTSNSKQYHSMQLQLL 251
Cdd:pfam10318 169 EFFDNPPVFVLAIDST--------------YFLICIVLLILILIIQILFFVFLTIYYL--FKSVKSSLSKKTRKLQKKFF 232

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563640   252 NALVLQALIPVFLMQLPSFIAFTSPIFHKGNEMAGAVLGIAVALYPVLDPLPTLIIIKNFRNALFKPCTR 321
Cdd:pfam10318 233 IALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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